Saturday, 9 September 2023

#Turmeric Inhibits #Psoriasis through Its Immune Modulation and Anti-Inflammatory Therapy

Kyle J. Norton


Psoriasis is a skin condition characterized by the speed-up of the life cycle of skin cells, leading to cells building up rapidly on the surface of the skin.

Symptoms of psoriasis are caused by the extra skin cells forming scales and red patches can be itchy and painful.

Epidemiologically, psoriasis patches can range from a few spots or large areas. The most common form of psoriasis is plaque psoriasis, a condition that induces dry, raised, red skin lesions (plaques) covered with silvery scales.

The causes of psoriasis are not identified. Researchers do not know why people with
the same health conditions in the same family, some are prone to psoriasis while others do not.


Certain risk factors such as family history, viral and bacterial infections, weakened immune systems, persistent stress, smoking, and obesity are associated with the risk of psoriasis.


Conventionally, topical corticosteroids are the most commonly prescribed medication for the treatment of the condition, particularly in patients with mild to moderate psoriasis.


If you are using corticosteroids for the treatment of psoriasis, please make sure you know all the side effects for preventive measures.


Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential ingredient for the treatment of psoriasis, an autoimmune and recurrent chronic inflammatory skin disorder, researchers examined a turmeric tonic as immune modulation and anti-inflammatory therapy on scalp psoriasis.

The study included a total of 40 patients with mild-to-moderate scalp psoriasis who fulfilled the inclusion criteria and were randomly allocated into two groups.


The treatment group received turmeric tonic twice a day for 9 weeks, whereas the other group received a placebo applied in the same manner.


Based on the results from the assessment of baseline, weeks 3, 6, and 9, the treatment group not only significantly reduced the erythema, scaling, and the duration of lesions (PASI score), but also improved the patient's quality of life. compared to a placebo.


Researchers after taking other factors into account wrote, "The clinical effects of turmeric tonic on scalp psoriasis were satisfactory overall. This formulation could be considered as a treatment for scalp psoriasis".


In order to reveal more information about turmeric anti-psoriasis activity, researchers reviewed the effect of turmeric in the inhibition of inflammatory enzymes mainly involved in the inflammatory process of psoriasis.

The study included the examination of the randomized, clinical, and therapeutic benefit of a novel topical formulation, including turmeric on 34 patients with mild to moderate plaque psoriasis.

The treatment group showed a significant improvement in the symptoms of psoriasis and
the clinical and quality of life parameters compared to the untreated group.


Based on the findings, Dr. the lead scientist said, "The proposed microemulgel may well be considered as an alternative in some patients and most likely as an add-on therapeutic option for many patients suffering from plaque psoriasis".


Taken altogether, turmeric processed bioactive ingredient curcumin may be considered  asupplement for the treatment of psoriasis,, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before It's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Turmeric tonic as a treatment in scalp psoriasis: A randomized placebo-control clinical trial by Bahraini P1, Rajabi M1, Mansouri P2, Sarafian G1, Chalangari R3, Azizian Z. (PubMed)
(2) Topical Turmeric Microemulgel in the Management of Plaque Psoriasis; A Clinical Evaluation by Sarafian G1, Afshar M2, Mansouri P3, Asgarpanah J4, Raoufinejad K1, Rajabi M. (PubMed)

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