Kyle J. Norton
A glioma is a type of tumor that starts in the glial cells of the brain or the spine.
Glioma cells can be classified into
* Astrocytomas are a type of brain cancer that originates in a particular kind of glial cells, star-shaped brain cells in the cerebrum called astrocytes.
* Ependymomas, are a type of cancer that grows in your brain or any part of the spine, including your neck and upper and lower back.
* Oligodendrogliomas are a type of glioma that starts in glial cells called oligodendrocytes.
Primary glioblastoma is one of the most aggressive cancers that begins within the brain. Cancer may arise as a Grade IV tumor with no evidence.
According to the statistics, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.
In the US, the median age of glioblastoma diagnosed is 64 years and the incidence of the disease onset is 1.6 times higher in males compared to females.
Furthermore, the condition is 2 times higher in Caucasians compared to Africans and Afro-Americans.
Because of the rapid growth, patients diagnosed with primary glioblastoma experience sudden brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, severe headaches, and localized symptoms depending on the location of the tumor.
Conventionally, radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.
The causes of glioblastoma are not identified. However, the increase in age and genetic preposition are the 2 most common risk factors found in patients with the disease.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the inhibition of brain tumors researchers examined the combined active ingredients of Chinese (Helicteres angustifolia) and Indian (Withaniasomnifera) ginseng's effects on glial differentiation potentials.
Based on the tested analysis, the novel combination of Cuc and Wi-N, CucWi-N, showed a significant activity to protect the neuron cells against oxidative stress-induced decrease in DNA damage.
In rat glioblastoma cells, CucWi-N exerted the glial differentiation potential and induced differentiation phenotype.
Proteins are associated with neuron growth and development and a key role in glial differentiation. such as GAP43, MAP2, and GFAP were exhibited by the injection of the combination.
Based on the findings, researchers said, "These data demonstrate anti-stress and glial differentiation potential of CucWi-N (a novel combination of Cuc and Wi-N) that could be recruited in nutraceutical and pharmaceutical avenues and hence warrant further evaluation and mechanistic studies.".
Taken altogether, Ashwagandha may be considered a functional herb that reduces the risk of brain tumors, pending the result of a larger sample size and multicenter study
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Stress and Glial Differentiation Effects of a Novel Combination of Cucurbitacin B and Withanone (CucWi-N): Experimental Evidence by Garg S1,2, Kaul SC1, Wadhwa R. (PubMed)
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