Wednesday, 13 September 2023

#GreenTea #Catechin #Extract Reduces the Risk of #ProstateCancer, According to Studies

Kyle J. Norton

Prostate cancer is a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth with the possibility of spreading to distant parts of the body. Most prostate cancers are slow-growing and prostate cancer may be detected during physical (rectum) exams.

Green tea may be used as a functional food in the prevention and treatment of prostate cancer, a renowned institute study suggested

Green tea, a precious drink processes number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the trick.

According to the Fu Jen Catholic University, New Taipei City, catechin nanoemulsion preparation showed the highest inhibition of growth of PC-3 tumor cells, with concentration being 15.4 μg/mL and 8.5 μg/mL

The inhibition of prostate cancer cell line is observed in cell cycle arrest by regulated proteins involved in cell cycle division, namely cyclin A, cyclin B, cyclin-dependent kinase 2, and cyclin-dependent kinase 1 expression, and activated cell apoptosis and survival.

Dr. Tsai YJ, the lead author said, "Catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (BCL-2) expression and increase in cytochrome c expression( in the induction of apoptosis) for activation of caspase-3, caspase-8, and caspase-9 (involved cell death)".

Furthermore, in the recruited 404 PCA cases and 395 controls from the same hospital who completed data on habitual tea consumption, including green, oolong, black, and pu'er tea regular green drinkers have a significantly reduced risk of prostate cancer development.

The review of the inverse relation of tea drinkers and risk of prostate cancer has shown explicitly:
1. A total of 32 cases and 50 controls reported habitual green tea drinking, showing an adjusted OR of 0.60 (95% confidence interval (CI): 0.37, 0.98).
2. A moderate excess risk was observed among the habitual pu'er tea drinkers (OR=1.44, 95% CI: 1.02, 1.91).
3. A significantly lower intake of EGCG was observed among cases (54.4 mg) than the controls (72.5 mg).

Additionally, the differentiation of 7 observational studies and 3 randomized controlled trials was retrieved from Cochrane Library, PubMed, ScienceDirect Online, and hand searching. the database, also reveals an interest correlated incidence of PCa decreases with each 1 cup/day increase of green tea.

According to the study, "higher green tea consumption was linearly reduced PCa risk with more than 7 cups/day and green tea catechins were effective for preventing PCa".

Collectively, green tea consumption is associated inversely with the risk of PCA but the injection of a large amount of green tea supplement should be taken with care to prevent toxicity.


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Sources
(1) Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3 by Tsai YJ1, Chen BH1.(PubMed)
(2)Reduced prostate cancer risk with green tea and epigallocatechin 3-gallate intake among Hong Kong Chinese men by Lee PMY1, Ng CF2, Liu ZM3, Ho WM4, Lee MK5, Wang F1, Kan HD6, He YH7, Ng SSM2, Wong SYS1, Tse LA1.(PubMed)
(3) Green tea and the risk of prostate cancer: A systematic review and meta-analysis by Guo Y1, Zhi F, Chen P, Zhao K, Xiang H, Mao Q, Wang X, Zhang X.(PubMed)

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