#GreenTea #EGCG Reduces Weight Gain, Plasma Glucose, Insulin Level, Liver and Kidney Weight in Obesity, According to Studies

Kyle J. Norton

Green tea is found to consist of an anti-obesity function, a recent study by a popular institute suggested.
Green tea, considered a functional food, has a number of health benefits and has been reported by several renowned research and studies. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But adding a slice of ginger will do the trick.

Obesity is a medical condition of excess body fat accumulated over time. A person is considered obese if excess body weight relative to height is over 30 in the BMI index.

According to the University of the Punjab, Epigallocatechin gallate, a polyphenol found in tea plants exhibited anti obesity effect through modulation of thePPAR[gamma] pathway in metabolism involved fat cells/adipose tissues.

In an animal study, the chemical constituent stopped the adipogenic cell differentiation through different proteins and transcription factors in the expression of adipocyte formation which is considered as fat cell development in contribution to obesity.


Dr. Javaid MS, the lead author in the study said, "Docking analysis of PPAR gamma and epigallocatechin gallate demonstrated that epigallocatechin gallate binds with PPAR gamma at its active site and blocks its activity".


Also, in animals induced by a high-fat diet, green tea Epigallocatechin 3-gallate (EGCG), exerted anti-obesity effects through reduced plasma glucose and alleviated complications of diabetes by attenuating advanced glycation end products (AGEs) formation involved proteins or lipids expression.

Dietary EGCG tested in C57BL/6 mice induced by a high-fat diet with or without ECGC for 17 weeks and compared to a control group placed on a low-fat diet for the same period, also showed a significantly reduced weight gain, plasma glucose, insulin level, liver and kidney weight, which can be seen in obesity in compared control mice.

Importantly, green tea Epigallocatechin 3-gallate (EGCG fed mice ovally decreased the levels of AGEs(advanced glycation end product) in both plasma and liver while inhibiting the receptor for AGE (RAGE) expression of activating Nrf2, antioxidant response, and enhanced anti-oxidative stress ratio of GSH/GSSG.


Other searchers opinionated the effect of green tea in reduced fat/adipose tissue accumulation in obese subjects is a result of the pro-oxidant action of EGCG, in the de-activated cellular production of reactive oxygen species, through the indication of adenosine monophosphate-activated protein kinase in suppressed gene and protein expression of enzymes and transcription factors involved in adipogenesis and lipogenesis(fat and disposed metabolism).

Taken together, green tea with all the phytochemicals may be used as an anti-obesity functional food to help control hyperglycemia, reduce weight, and alleviate diabetes complications.


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Sources
(1) Epigallocatechin Gallate as an anti-obesity therapeutic compound: an in silico approach for structure-based drug designing by Javaid MS1, Latief N1, Ijaz B1, Ashfaq UA2(PubMed).
(2) Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity by Sampath C1, Rashid MR1, Sang S2, Ahmedna M3(PubMed)
(3) Beneficial Effects of Tea and the Green Tea Catechin Epigallocatechin-3-gallate on Obesity by Suzuki T1, Pervin M2, Goto S3, Isemura M4, Nakamura Y5.(PubMed)