Kyle J. Norton
Garlic (Allium sativum) may have a potential effect in the prevention and treatment of cancers by gobbling up cancer cells before they can proliferate to the invasive tumor, some studies suggested.
Cancers are a class of chronic diseases characterized by uncontrollable cells grown in tissue in the body.
At the later stage, the cancerous cells can infect other healthy cells and tissue far away from the original site by traveling through blood and lymph.
The diseases are the second cause of death in the US.
According to statistics, between 2011-2015, the National Cancer Institute, 440 per 100,000 adults are diagnosed with cancers, inducing 163.5 per 100,000 death
Depending on the type of cancer, patients may experience certain general and specific symptoms.
DNA alternation caused by an inherited gene mutation in the induction of abnormal cell proliferation is the major cause of cancers.
The National Cancer Institute suggested that age, excessive alcohol consumption, unhealthy diet and lifestyle, smoking, radiation, viruses, carcinogens, obesity,... and chronic inflammation, are also considered some major risk factors that can cause cancers. (As these factors are accumulated through many studies which all point to a similar association between a potential risk factor and an increased risk of cancer).
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.
The pungent herb has been used popularly in traditional and Chinese medicine for treating common cold and flu, blood pressure cholesterol levels,..... and as a natural antibiotic.
Garlic appears to be generally safe although some people may suffer mild allergic reactions.
A recent study led by author Dr. Oommen S indicated that allicin, the main ingredient found in garlic induces the formation of apoptotic bodies, nuclear condensation, and a typical DNA ladder in cancer cells, causing cell death.
Researchers in the study of the ingredient allicin also showed that the phytochemical is capable of inducing an increase in the rate of apoptosis by obstructing the expression of the cell cycle division and pro-inflammation.
On cancer HL60 and U937 cell lines, allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway by involving the activation of the mitochondrial apoptotic pathway through promoted GSH depletion and changes in the intracellular redox status.
In the research of the function of 20 compounds from garlic, researchers at the Kerala Agricultural University, Kerala, suggested that garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers.
Other compounds found in garlic such as organosulfur, its extract, and phyto-compounds also suppressed cancer cell proliferation and induced cell cycle arrest.
Therefore, people who are at higher risk of the disease may consider adding a portion of garlic whole food into their diet for preventive measures.
However, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of garlic anti-cancer possibilities.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells by Oommen S1, Anto RJ, Srinivas G, Karunagaran D.(PubMed)
(2) Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA by Park SY1, Cho SJ, Kwon HC, Lee KR, Rhee DK, Pyo S.(PubMed)
(3) Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells by Miron T1, Wilchek M, Sharp A, Nakagawa Y, Naoi M, Nozawa Y, Akao Y.(PubMed)
(4) Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study by Roy N1, Davis S, Narayanankutty A, Nazeem P, Babu T, Abida P, Valsala P, Raghavamenon AC.(PubMed)
(5) Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice by Jiang X1, Zhu X1, Huang W1, Xu H1, Zhao Z2, Li S1, Li S3, Cai J3, Cao J3.(PubMed)
(6) Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis by Kim WT1, Seo SP2, Byun YJ1, Kang HW1, Kim YJ1, Lee SC1, Jeong P1, Seo Y3, Choe SY3, Kim DJ4, Kim SK5, Moon SK6, Choi YH7, Lee GT8, Kim IY8, Yun SJ1, Kim WJ1.(PubMed)
(7) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC3.(PubMed)
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