By Kyle J. Norton
In breast cancer patients, Uncaria tomentosa exhibited its bioactive immunomodulators' effects in regulating the immune system against irregular cell growth and inflammation.
Immunomodulatory compounds exerted the above properties found in the cat's claw include ajoene, arctigenin, β-carotene, curcumin, epigallocatechin-3-gallate, ginseng, glabridin, and quinic acid, according to Dr. Baraya YS, the lead researcher.
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A herbal immunomodulators review, in vitro and in vivo, also suggested cat's claw expressed the regulation of informational molecules such as cytokines through the alternation of immune function. Therefore, the medical plant may be a potential therapeutic modality for the treatment of many different conditions involving cytokine, including inflammation and autoimmune diseases.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine for over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc...
Autoimmune diseases are the disorder caused by the immune system attacking the body's healthy cells.
Cat's claw (Uncaria tomentosa) may be the next medical plant used for the treatment of autoimmune diseases through its stimulated immune effects.
Severe dengue is a disease associated with changes in the endothelial barrier function due to the production of inflammatory mediators by immune cells, U. tomentosa exerted antiviral and immunomodulatory activities in the inhibition of antigen and proinflammatory cytokine.
In fact, the significant effect of immunomodulation may introduce Cat's claw, as a promising candidate for clinical application.
The use of this herbal plant should be taken with care as toxicity has been found in some cases of overdoses.
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Sources
(1) Uncaria tomentosa increases growth and immune activity in Oreochromis niloticus challenged with Streptococcus agalactiae by Yunis-Aguinaga J1, Claudiano GS2, Marcusso PF2, Manrique WG2, de Moraes JR3, de Moraes FR4, Fernandes JB1. (PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS3.(PubMed)
(3) Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators by Spelman K1, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M.(PubMed)
(4) Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2 by Reis SR1, Valente LM, Sampaio AL, Siani AC, Gandini M, Azeredo EL, D'Avila LA, Mazzei JL, Henriques Md, Kubelka CF. (PubMed)
(5) Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis by Valerio LG Jr1, Gonzales GF. (PubMed)
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