Andrographis paniculata also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, and upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
Immunomodulatory Activity is the action in regulated immune response or the functioning of the immune system against forming of diseases, including stimulating the production of antibodies and
inhibited white blood cells in induced inflammation,.....
Andrographis processed significant effects in enhanced immune function, through modulation of immune responses, a renowned institute study suggested.
According to the Prin. K. M. Kundnani College of Pharmacy, HN-02, an extract containing a mixture of andrographolides plus 14-deoxy andrographolide and 14-deoxy-11,12-didehydroandrographolide together [12 +/- 3 %]) in pure powder forms at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitro experimental models, demonstrated the ability in enhanced immune function by modulation of immune responses altered during antigen interaction, and to reverse the immunosuppression induced by cyclophosphamide (CYP).
Dr. Naik SR, the lead author said, " HN-02 treatment significant increase in total WBC count" and "elevated the depressed hemagglutination antibody (HA) titer and increased the number of plaque-forming cells (PFCs) in the spleen cells of mice".
Other researchers in the evaluation of the immunomodulatory activity of herbal Andrographis indicated that Andrographis paniculata exhibited the effect through gene expression involved in immune cell activation and migration and various inflammatory responses, including wound healing, angiogenesis, and blood pressure modulation.
The study also identified the chemical compound of lipopolysaccharide in Andrographis paniculata as one of the natural and most active immunostimulatory components.
Additionally, the dichloromethane fraction of the methanolic extract of Andrographis paniculata also expressed an impressive inhibition against testing human cancer and immune cells.
At low concentrations, the dichloromethane extracts enhanced immune function, attenuating the proliferation of HT-29 (colon cancer) cells and human peripheral blood lymphocytes (HPBLs).
Furthermore, the study also found, andrographolide, another major compound in Andrographis paniculata exhibited the immune ability to suppress irregular cell growth and cancer activity on diverse cancer cells in different types of human cancers.
Taking all together, there is no doubt, that Andrographis consists of vigorous immunomodulatory activity in regulated immune responses against a procession of irregular cell growth and overreaction of foreign harmful substances, but intake of large amounts should be taken with care.
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Sources
(1) Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR1, Hule A.(PubMed)
(2) Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals by Denzler KL1, Waters R, Jacobs BL, Rochon Y, Langland JO.(PubMed)
(3) Anticancer and immunostimulatory compounds from Andrographis paniculata by Kumar RA1, Sridevi K, Kumar NV, Nanduri S, Rajagopal S.(PubMed)
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