Thursday 18 May 2023

#Herbal #Burdock in the Inhibition of #Cancers, Researchers Say

By Kyle J. Norton

Burdock is planted in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. It has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and blood-purifying agent to treat wounds and infections stomach ulcers, and other digestive problems.

Cancer is a class of diseases in which a group of cells growing and multiplying in disordered and uncontrollable ways in our body, have become progressively worse and damage other healthy tissues, sometimes spreading to other organs in the body via lymph or blood and results may be in death.

Arctigenin, a dietary phytoestrogen and natural lignan product of Arctium lappa L inhibited human breast cancer MDA-MB-231 cell growth by inducing apoptosis in vitro and in vivo. Another lignan constituent, Arctic of Arctium lappa, induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells, and prostate cancer.

The Side effects
1. Overdose can be poisoning and may lead to symptoms of acute poisoning including phenothiazines, tricyclic antidepressants, and antihistamines.
2. It may cause dermatitis and allergic/inflammatory responses in certain people with contact as a result of the lactones that the plant produces.
3. Do not use burdock if you are pregnant or breastfeeding.



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References
(1) Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation by Hsieh CJ, Kuo PL, Hsu YC, Huang YF, Tsai EM, Hsu YL. (PubMed)
(2) Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression by Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, Sakai T.(PubMed)

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