Diabetic vascular complications are caused by a diverse group of highly oxidant compounds(advanced glycation end(AGEs) produced by a modern heat-processed diet, inducing pathogenic significance in diabetes and several other chronic diseases.
Diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose. It is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Its complications may include renal failure and cardiovascular events.
Intake of Cruciferous Vegetables regularly may be beneficial in reducing the risk of diabetic vascular complications.
Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.
Dr, Yamagishi S, the lead author said, " the Inhibition of AGE formation, blockade of the AGE-RAGE interaction, and suppression of RAGE expression or its downstream pathways may be novel therapeutic strategies for the treatment of vascular complications in diabetes"
Some researchers insisted that diabetic vascular complications may be blocked if food-advanced glycation end-products aggravate diabetic vascular complications via modulating the RAGE receptors in the removal of AGE.
According to the Kurume University School of Medicine, sulforaphane, a phytochemical compound found in cruciferous vegetables showed a potential effect against diabetic vascular complications, through its interference with pro-inflammatory reactions, and reduction of oxidate stress.
In cultured cells and experimental animals, sulforaphane suppressed inflammatory activation of vascular cells, and induced potential beneficial effects to prevent vascular inflammation and atherosclerosis complication of diabetics.
Therefore, intake of Cruciferous Vegetables may reduce the risk of diabetic vascular complications as sulforaphane, a phytochemical compound in cruciferous vegetables not only inhibited the levels of advanced glycation end but also enhanced the production of Nrf2 in controlling over 500 genes expression of cellular defense mechanisms.
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Sources
(1) Protective role of sulforaphane against vascular complications in diabetes by Yamagishi S1, Matsui T1. (PubMed)
(2) Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications by Yamagishi S1, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S.(PubMed)
(3) The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease by Paul C. Evans(PMC)
(4) Food-advanced glycation end products aggravate diabetic vascular complications via modulating the AGEs/RAGE pathway by Lv X1, Lv GH1, Dai GY1, Sun HM2, and Xu HQ3. (PubMed)
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