Lycopene Protects the Lung Against Cancer Developing

By Kyle J. Norton

The lung is a vital organ located near the backbone on either side of the heart with major functions to inhale oxygen from the air to the bloodstream that nourishes the body cells and exhale carbon dioxide from the bloodstream.

Other functions of the lung are to maintain the right levels of pH, filter out blood clots, protect the heart against shock, infection, and speech.


Cancer is a class of diseases caused by cells growth and multiplication disorderly and uncontrollably due to the alternation of the DNA.

After colonizing the entire tissues of the specific organ, the oversize tumor cell can travel a distance away from the originated site to invade other healthy tissues, via lymph or blood.

Most advanced stage of cancer may result in the death of the patients.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers is derived from epithelial cells.

According to the statistics provided by the American Lung Cancer Association, lung cancer is the leading cancer killer in both men and women in the U.S. in 2018, 154,050 Americans died from lung cancer in 2018, accounting for approximately 25 percent of all cancer deaths.

The exact causes of lung cancer are unknown. However, passive smoking, tobacco smoking are 2 of the most common risk factors were found in patients with the disease.

Dr. wrote, "Tobacco smoking remains the most established cause of lung carcinogenesis and other disease processes. Over the last 50 years, tobacco refinement and the introduction of filters have brought a change in histology, and now adenocarcinoma has become the most prevalent subtype".

And, "Over the last decade, smoking also has emerged as a strong prognostic and predictive patient characteristic along with other variables:.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potential compound for the treatment of cancer, researchers examined the protective effects of tomato lycopene against the formation and the development of lung cancer.

According to the tested analysis, lycopene inhibited the growth of several cultured lung cancer cells and prevent lung tumorigenesis in animal models through various mechanisms.

More precisely, lycopene efficacy in the prevention and treatment of lung cancer by promoting the balanced ratio of free radicals and antioxidant enzymes produced by the host.

Lycopene exerted cell cycle arrest and/or apoptotic activity by regulating abnormal growth factor signaling, and inhibiting the changes in cell growth-related enzymes.

Smoke-induced inflammation-induced abnormal cell growth associated with the risk of lung cancer also inhibited by the application of lycopene.

Lycopene also inhibited the lung cancer invasion, angiogenesis, and metastasis in the tested animal model through its metabolites.

Based on the findings, researchers said, "The study reviews data on the cancer-preventive activities of lycopene, possible mechanisms involved, and the relationship between lycopene consumption and human cancer risk." and " More well-controlled clinical intervention trials are needed to further clarify the exact role of lycopene in the prevention of lung cancer cell growth".

Taken altogether, lycopene found in tomato combined with conventional medicine may be considered an anti lung cancer remedy, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(2) Tomato lycopene and lung cancer prevention: from experimental to human studies by Palozza P1, Simone RE, Catalano A, Mele MC. (PubMed)
(3) Tobacco Smoking and Lung Cancer. Perception-changing facts by Muhammad Furrukh. (PMC)