Healthy Food Onion Reduces The Risk of Esophageal cancer

By Kyle J. Norton

Esophagus or gullet, an organ in vertebrates, is the tube that leads foods from the pharynx to the stomach.

Esophageal cancer is a medical condition caused by cell growth disorderly and uncontrollably in the tissue of the esophagus due to the alternation of the cell DNA.

More precisely, esophageal cancer can be a result of DNA alternation of the cells that line the upper part of the esophagus or glandular cells that line the lower part of the esophagus, connecting to the stomach.

Patients with esophageal cancer at the very early stage due to the very small size of the tumor are asymptomatic. However, at the advanced stage, esophageal cancer tends to travel a distance away to infect other healthy tissue and organ, leading to the secondary metastasis.

Most common areas of metastasis of esophageal cancer are lymph node around the bottom of the esophagus, stomach and the chest.

According to the statistic, esophageal cancer is the seventh most common cause of cancer death among men. In 2019, about 17,650 new esophageal cancer cases will bed diagnosed, including 13,750 men and 3,900 women.

Esophageal cancer will cause the death of 16,080 Americans, including 13,020 men and 3,060  women.

Believe it or not, esophageal cancer is more common among men than among women. The lifetime risk of esophageal cancer in the US is 1 in 132 in men and about 1 in 455 in women.

 Esophageal cancer can be classified into, depending on the location which cancer starts
* Squamous cancer
If the cancer cell starts in the upper part of the esophagus caused by the DNA alternation of the squamous cell.

* Adenocarcinomas

If the cancer cell starts in the lower part of the esophagus caused by the DNA and alternation of the glandular cells.

Most common symptoms of the esophageal cancer are difficulty swallowing or pain caused by refluxing or swallowing, pain in the throat or back, behind the breastbone, heartburn, hoarseness or coughing, coughing blood and accompanied by the general symptoms shared by other types of cancer.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of esophageal cancer, researchers examined the effect of raw garlic/onion consumed at least one time per week on the development of squamous cell carcinoma (SCC) in three different sections of the esophagus.

The study included a total of A 343 patients with SCC of the esophagus and 755 cancer-free control subjects recruited for this study from 1996 to 2005.

According to the results of tested assays, intake of raw onions/garlic, and fruits are significantly protective against esophageal SSC risk compared to the increased risk of hot foods.

In other words, adding additional certain dietary components may affect carcinogenesis locally and systemically.

Furthermore, according to the study of the Istituto di Ricerche Farmacologiche "Mario Negri",
consumption of onions showed a protective effect on esophageal cancer, compared to garlic and other vegetables.

More precisely, onion and garlic intake improved the relative risk ratio by 0.12 and 0.43, respectively.

The results strongly suggested the inverse association between the frequency of use of allium vegetables such as onion and garlic against the risk of several common cancers, inclduing esophageal cancer

Dr. Galeone C wrote in the final report, "Allium vegetables are a favorable correlate of cancer risk in Europe".

Taken altogether, onion may be considered a remedy for the prevention and treatment of adjuvant esophageal cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources

(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Cancer of Esophagus/Esophageal cancer by Kyle J. Norton