Phytochemicals may be the next potential sources of a new medicine for the treatment of diseases with little or no side effects.
Phytochemical allicin may be the next natural ingredient for the prevention and treatment of colon cancer with no side effects, some scientists suggested.
Colon is a large intestine formed part of the digestive system where water is reabsorbed and waste material is stored as feces before being removed.
Colon cancer is the medical condition characterized by the cell growth irregularly and disorderly due to change of DNA.
Most cases of colon cancer start in the cell on the surface of the inner lining of the colon. However, at the later stage, colon cancer may cause secondary metastasis, leading to cancers forming on other tissues and organs, a distance away through lymph and blood.
According to the statistics, the risk of colon cancer has been rising in younger age groups coincidently with the declining rate in older age groups.
Sadly, the proportion of cases diagnosed in individuals younger than age 50 increased from 6% in 1990 to 11% in 2013. Most of these cases (72%) occur in people who are in their 40s.
The causes of colon cancer are unknown, Some researchers suggested that the widespread colon cancer over the past few decades in the developed world probably is the result of the promotion of the Western diet that leads to obesity.
Dr. E E Frezza, the lead scientist at the Texas Tech University Health Sciences Cente, in the study to examine obesity in the risk colon cancer wrote, "Obesity is a risk factor for many diseases" and "Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer".
And, "Although WC is better established as a measure of obesity than BMI, the evidence for colon cancer risk is not secure on this point; combining BMI and WC measurements would appear, at present, to be the wisest approach for colon cancer risk assessment".
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
With an aim to find a natural ingredient for the treatment of colon cancer with no side effects, researchers at The Hebrew University of Jerusalem examined the effects of allicin on cell proliferation of colon cancer cell lines HCT-116, LS174T, HT-29, and Caco-2.
Futhermore, allicin treatment also induced cell death through cancer cell degradation.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2 by Bat-Chen W, Golan T, Peri I, Ludmer Z, Schwartz B.(PubMed)
(2) [Allicin enhances cytotoxicity of CPT-11 to colon cancer LoVo cell in vitro]. [Article in Chinese] by Gao Y, Liu Y, Cao W, Deng Z, Liu H, Xu L, Chen X.(PubMed)
(3) Influence of obesity on the risk of developing colon cancer by E E Frezza, M S Wachtel, and M Chiriva‐Internati. (PMC)