Herbal Cascara sagrada processed a bioactive compound emodin may have a significant and potential effect in reducing the risk and treatment of liver cancer, according to studies.
Liver cancer is a medical and chronic condition caused by irregular cell growth in the liver tissues, due to the alternation of cell DNA.
The liver organ is one of the organs with a lack of nerve tissue, therefore liver cancer does not induce pain until the later stage.
At the advanced stage of liver cancer, the cancer cell may travel a distance away to infect other tissues and organs, leading to secondary metastasis.
According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding a natural compound for the treatment of liver cancer examined the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada against CXCL12-CXCR4 signaling cascade which plays an important role in the process of invasion and metastasis of liver cancer.
Where The CXCL12/CXCR4 axis is a pathway involved in tumor progression, angiogenesis, metastasis, and survival.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma by Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G.(PubMed)
(2) Emodin regulates apoptotic pathway in human liver cancer cells by Yu JQ, Bao W, Lei JC.(PubMed)
(3) Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells by Jeon W, Jeon YK, Nam MJ.(PubMed)
(4) Alcohol consumption and liver cancer risk: a meta-analysis by Chuang SC1, Lee YC, Wu GJ, Straif K, Hashibe M. (PubMed)