Wednesday, 6 February 2019

Celery Essential Oil, May Be the Next Generation of Natural Antibiotic Alternative

By Kyle J. Norton

Scientists may have just found a natural alternative antibiotic whole food for the treatment of microbial infection with no side effects, according to studies.

Antibiotics are a group of conventional medicines used for the treatment of bacterial, fungal parasitic,... infection.

Infection is a disease caused by microorganism invasion.

After entering the body, the organisms selectively find a specific tissue or organ to start their multiplication.

Most infectious diseases can be passed from infected person to person or transmitted by bites from insects or animals. 

However, the acquired infectious diseases can also be caused by ingesting contaminated food or water or being exposed to organisms in the environment.

Most organisms before having a chance to induce infection are killed off by the immune system response in the acute phase of infection, through stimulating the production of a proinflammatory cytokine. 

Unfornutely, if the immune system fails to destroy the invasive organism within a set period of times, normally in a few weeks, it will adapt to the change, causing chronic infection.

Dr. Sarah Schmidt Grant, the lead scientist in the examine the persistent bacterial infections, antibiotic tolerance in risk chronic diseases wrote, "Certain bacterial pathogens are able to evade the host immune system and persist within the human host" and " The consequences of persistent bacterial infections potentially include increased morbidity and mortality from the infection itself as well as an increased risk of dissemination of disease".

Why bacteria exerts antibiotic tolerance and induces persistent infections?. It may be a result of overuse of antibiotics, leading to a population or subpopulation of bacteria,  possibly in a non-replicating or metabolically altered state, the doctor explained.

The use of antibiotics most of the time is effective, but in a long-term, the medicine can induce serious side effects. If you are currently taking antibiotics, please make sure you know all the side effects for preventive measure.

Celery is a species of Apium graveolens, belong to the family Apiaceae. The plant is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

On finding a natural ingredient for the replacement of antibiotic for the prevention and treatment of microbial infection with no side effects, researchers at the Iowa State University evaluated the impact of pH and nitrite from celery juice concentrate (CJ) on the growth of Listeria monocytogenes in broth and on ham slices.

Injection of CJ showed a significant increase in the pH of both broth and ham. Compared to the conventional nitrite, The CJ was less effective at 100 mg/kg nitrite in broth.

However, in ham, the CJ treatments at both 100 and 200 mg/kg resulted in the growth of L. monocytogenes (p>0.05) similar to that of the conventional nitrite at the same concentrations.

Furthermore, researchers also discovered by reducing the pH of CJ before adding to the ham, the CJ demonstrated a greater impact on L. monocytogenes growth at 200 mg/kg nitrite than at 100 mg/kg. 

These results suggested celery juice depending on the concentrate may increase meat product pH associated with the antimicrobial activity in some products.

Additionally, in the investigation of Apium graveolens L. (wild celery), antimicrobial activity, researchers found that application of the essential oil fraction of wild celery displays a significant effect in inhibiting numbers of fungi, Candida albicans, Candida tropicalis, Candida krusei, Candida guilliermondii, Candida parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, Trichophyton mentagrophytes, T. mentagrophytes var. interdigitale, Trichophyton verrucosum, Microsporum Canis, Microsporum gypseum, Epidermophyton floccosum, Aspergillus niger, Aspergillus fumigatus and Aspergillus flavus. 

However, the oil from Italy rich in neophytadiene, member of the class of sesquiterpenoids was more active with the same concentration.

The methanolic extract and the aqueous extracts at the concentration of 300 mg kg(-1) dose exhibited highly significant inhibition of gastric lesions (91% and 95%, respectively), similar to those of conventional medicine omeprazole (94%).

In bacterial inhibition, essential oil of A. graveolens was strongly inhibitory against Escherichia coli and moderately inhibitory against Pseudomonas aeruginosa and Staphylococcus aureus.

The results of this efficacy were attributed to the major components identified were β-pinene, camphene, cumene, limonene, α-thuyene, α-pinene, β-phellendrene, p-cymene, γ-terpinene, sabinene, and terpinolene found in the celery.

Taken altogether, essential oil from the celery may be used for the prevention and treatment of bacterial and fungal infection with no side effects.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(b) The effect of pH and nitrite concentration on the antimicrobial impact of celery juice concentrate compared with conventional sodium nitrite on Listeria monocytogenes by Horsch AM1, Sebranek JG, Dickson JS, Niebuhr SE, Larson EM, Lavieri NA, Ruther BL, Wilson LA. (PubMed)
(c) Isolation of the volatile fraction from Apium graveolens L. (Apiaceae) by supercritical carbon dioxide extraction and hydrodistillation: chemical composition and antifungal activity by Marongiu B1, Piras A, Porcedda S, Falconieri D, Maxia A, Frau MA, Gonçalves MJ, Cavaleiro C, Salgueiro L.(PubMed)
(d) Antiulcerogenic and antibacterial activities of Apium graveolens essential oil and extract by Baananou S1, Bouftira I, Mahmoud A, Boukef K, Marongiu B, Boughattas NA(PubMed)

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