Sunday, 17 February 2019

Herbal Andrographis, the Anti Hepatitis Functional Remedy, According to Human Study

By Kyle J. Norton

Scientists may have found a herbal plant for the prevention and treatment of hepatitis infection with no side effects, according to studies.

Hepatitis is a condition characterized by the destruction of a number of liver cells and the presence of inflammatory cells in the liver tissue.

Mose cases of hepatitis are caused by infection of the hepatitis viruses. However, excessive alcohol drinking, disorders of the gallbladder or pancreas, and long-term use of certain medication are also associated with the onset of the disease.

The term is unfortunately commonly used to refer to a particular group of viruses such as Hepatitis A, B, and C.

If you are experiencing persistent symptoms of fatigue, flu-like symptoms, dark urine, pale stool abdominal pain, and jaundice. please check with your doctor to rule out the possibility of hepatitis.

In some cases, hepatitis can also be caused by to immune disease in which the immune system mistakenly attacks the liver, leading to mild to severe chronic inflammation that hinders the liver function.

Dr. Yoshio Aizawa, the lead author in the liver diseases research team at the Jikei University Katsushika Medical Center in the examination of the complication of autoimmune hepatitis, wrote, "Autoimmune hepatitis (AIH) is a chronic progressive liver disease characterized by high levels of aminotransferases and autoantibodies, hypergammaglobulinemia, and interface hepatitis" 

 "There is confusion as to the definition of the disease entity and its boundaries in the diagnosis of overlap syndrome, drug-induced autoimmune hepatitis, and AIH with concomitant nonalcoholic fatty liver disease (NAFLD) or chronic hepatitis C" and "Immunologically, disruption of the immune tolerance to autologous liver antigens may be a trigger of AIH".

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The herbal plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients of herbal Andrographis include diterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

With an aim to find a natural compound or remedy for the treatment of hepatitis with no side effects, researchers evaluated the anti-hepatitis C virus (HCV) activity of andrographolide, a diterpenoid lactone extracted from Andrographis paniculata.

In HCV replicon and HCVcc infectious systems, andrographolide time- and dose-dependently suppressed HCV replication.

Combined with anti-hepatitis medicines, such as IFN-α, an inhibitor targeting HCV NS3/4A protease (telaprevir), or NS5B polymerase (PSI-7977), andrographolide exhibited a significant synergistic effect.

The anti antiviral effects of the diterpenoid lactone extracted from Andrographis paniculata.were attenuated by an HO-1-specific inhibitor or the inhibition of HO-1 gene involved the production of oxidative in contributing the anti-HCV activity.

Furthermore, Andrographolide also activated the alternation of the protein (p38 MAPK) associated with the response to stress stimuli.

Additionally, the Banaras Hindu University, study in the evaluation of the anti-hepatitis effects of Kalmegh(Andrographis paniculata Nees) in the decoction form in patients of infective hepatitis.

Injection of the decoction showed a marked symptomatic improvement in the majority of the cases.

The decoction also showed a statistically highly significant decrease in various liver function.

Moreover, the application also increased significantly total serum globulin fraction protein which plays a critical role in liver functioning.

At the final day of the experiment, researchers said, "total assessment 80% cases of this series were cured and 20% of patients were relieved".

Taken altogether, herbal Andrographis may be considered a functional remedy for the prevention of liver infection and combined with primary medicine for the treatment of liver diseases, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells by Lee JC, Tseng CK, Young KC, Sun HY, Wang SW, Chen WC, Lin CK, Wu YH.(PubMed)
(2) Clinical studies on kalmegh (andrographis paniculata nees) in infective hepatitis by Chturvedi GN, Tomar GS, Tiwari SK, Singh KP.(PubMed)
(3) Autoimmune hepatitis: current challenges and future prospects by Yoshio Aizawa and Atsushi Hokari. (PMC)

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