Herbal Calendula, the Best in Speeding Up Wound Healing with No Side Effects

By Kyle J. Norton

Herbal may have a strong effect on speeding up wound healing, according to studies by a number of institutes.

Wound healing is a natural process of our body by restoring the function of the damage or injured tissue through several stages.

Most importantly, the early stage of wound healing is also known as an acute phase of infection, which starts as soon as the immune system sensing the tissue damage by stimulating the blood vessels to provide the damaged tissue with blood palette to cover the wound temporarily and activated the proteins associated with the production of inflammatory cytokines to the site of infection with an aim to kill off all micro invaders.

In most cases, the immune first line of defense can destroy the pathogens and speed up the recovery of the damage through inducing fiber tissue re construction, new blood vessels.

However, overproduction of a proinflammatory cytokine in this phase may cause damage and death of nearby cells, leading the formation of scars.

If the immune system can not kill off all the invaded pathogen within a set of time, normally in 3-8 weeks, it will adapt to the new change, leading to low-grade inflammation, a major cause of several chronic ailments, including diabetes, herat diseases.

If the process of wound healing is disrupted, it may also lead to improper wound healing with complications, including inadequate scar formation, excessive scar formation, and a contracture formation,  an exaggeration of normal wound edge contraction forming deformities.

Calendula is also known as pot marigold, a annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe. It has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.

Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

Researchers on finding a natural ingredient for speeding up wound healing examined the effect of Calendula officinalis, an annual herb from the Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent.

Injection of C. officinalis demonstrated significantly anti-inflammatory and antibacterial activities in protecting the wound against infection.

Furthermore, C. officinalis also speed up the wound healing process by enhancing the angiogenic and fibroplastic properties.

The findings strongly suggested that herbal Calendula can act in a positive way on the inflammatory and proliferative phases of the healing process.

Moreover, in the evaluation of the effects of oral and topical application of Calendula officinalis flower extract on excision wounds made in rats, compared to the control of 51.1%, oral and topical application of Calendula showed a wound closure was 90.0%.

The extract treatment at a dose of 20 or 100 mg/kg b.wt reduced the period needed for re-epithelization to 14 and 13 days, respectively compared to 17.7 days in the control.

Additonally, the extract-treated group also exhibited a significant increase in the concentration of collagen. compared to the untreated animals.

Interestingly, in a total of 36 rats and 90 embryonated eggs used to evaluate healing and angiogenic activities of extracts and fractions of Calendula, through the induction of skin wounds and the chorioallantoic membrane, respectively, researchers found that
* Injection of calendula extract exerted an angiogenic activity in speeding up wound healing in both experimental models.

* The efficacy was not attributed to the signal protein produced by cells that stimulate the formation of blood vessels, but other unknown pro-angiogenic factors.

Taken altogether, herbal Calendula may be considered a functional remedy for speeding up wound healing with no side effects.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil by Parente LM1, Lino Júnior Rde S, Tresvenzol LM, Vinaud MC, de Paula JR, Paulo NM.(PubMed)
(2) Angiogenic activity of Calendula officinalis flowers L. in rats by Parente LM1, Andrade MA, Brito LA, Moura VM, Miguel MP, Lino-Júnior Rde S, Tresvenzol LF, Paula JR, Paulo NM.(PubMed)
(3) Wound healing activity of flower extract of Calendula officinalis by Preethi KC1, Kuttan R.(PubMed)