Honey Speeds Up Wound Healing with Anti infection Activity

By Kyle J. Norton 

Honey may have a strong effect in speeding up wound healing, some scientists suggested.

Wound healing is the natural process by covering up the damage and injury of the body,

The process involves 4 phases
* The first phase of wound healing is cover up the wound. In this phase, the immune first line of defense white blood cells stimulates the emergency repair system in the production of blood clotting to block the drainage.

* In phase 2, the white blood cells activates the proteins associated with the inflammatory cytokines to destroy the pathogens before they can enter the body through the wound.

* In phase 3, new blood vessels and tissues are formed in the damage and injury area.

* The recovery phase.

However, the healing process is easier said than done, the complex process in many cases are interrupted by local and systemic factors, including moisture, infection, age, and nutritional status.

Some researchers also indicated that in phase 2, due to overexpression of inflammatory cytokine, some patients may experience symptoms of localized redness, swelling, and fever. 

And, the overexpression of inflammatory cytokines can also cause damage to the nearby healthy cells, leading to improper healing with the formation of large and irreversible scars.

However, people with a weakened immune system may compromise acute wound repair that promotes nonhealing wounds.

Dr. Amanda S. MacLeod, the lead author in the concerns of the immune responses to acute and chronic wound said, "The innate immune system comprises a network of interacting mechanisms that provide a rapid response to clear microbial contamination upon skin injury" and  "In the development of chronic wounds, this process stalls in the late inflammatory stage. The major defect in nonhealing wounds occurs at the phenotypic switch from inflammatory macrophages to an anti-inflammatory phenotype".

These results clearly, suggested, the failure to switch from the phase of proinflammatory cytokines to the phase of anti-inflammatory cytokines due to the weakened immune system in the activation of p38, can lead to delayed wound healing and abnormalities in chronic wounds.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In the referring traditional use of honey for wound healing and an alternative natural antibiotic due to the advent of antibiotic resistance in microbial pathogens, researchers reviewed articles outlined publications regarding honey and wound healing that have been published between June 2010 and August 2016. 

The findings suggested that multiple types of honey demonstrate their mechanisms of action as antimicrobial agents, immunologic modulators, and physiologic mediators.

In the evaluation to examine the healing effects of honey dressings compared to silver dressings for acute or chronic wounds, researchers launched a systematic review with meta-analysis consisted of six randomized controlled trial studies.


All studies showed that honey was more efficacious for wound healing than silver, as measured in the number of days needed for wounds to heal.

Honey turned out to have more antibacterial qualities than silver in-depth analysis.

Dr. Lindberg T, the lead scientist after taking into account co and confounders, said, "All the included studies based on burns showed the unequivocal result that honey had an even more positive effect than silver on wound healing".

The results pointed out that honey may have a potential effect in speeding up the wound healing and protect the wound against microorganisms infection.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Honey and Wound Healing: An Update by Saikaly SK1, Khachemoune A2. (PubMed)
(2) A systematic review and meta-analysis of dressings used for wound healing: the efficiency of honey compared to silver on burns by Lindberg T1, Andersson O1, Palm M1, Fagerström C, (PubMed)
(3) Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis by Oryan A1, Alemzadeh E2, Moshiri A3. (PubMed)
(4) The Innate Immune System in Acute and Chronic Wounds by Amanda S. MacLeod1, and Jonathan N. Mansbridge. (PMC)