Ginger, the Anti Liver Cancer Functional Remedy with No Side Effects, According to Studies

By Kyle J. Norton

Scientists may have found a pungent spice which processes potential to protect the liver against the onset of cancer, some studies suggested.

The liver is a large organ in human with the unique function in filtering the blood from the digestive tract, before passing to the rest of the body.

Liver cancer is a chronic condition characterized by cell growth irregularly in the tissue of the liver due to the alternation of cell DNA.

At the early stage of liver cancer, most patients do not experience any symptoms. However, at the advanced stage patients may experience symptoms of jaundice, abdominal sever pain and white, chalky stools accompanied by general cancer symptoms such as weight loss, loss of appetite and gastrointestinal discomforts.

If you are having some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver cancer.

In most cases, at this stage, liver cancer cell also can induce secondary metastasis through lymph and blood, leading to cancers of colon, pancreas, stomach, lung, and breast.

According to the statistics provided by the American Cancer Society, in 2018, approximately, 42,220 new cases, including 30,610 in men and 11,610 in women of liver cancer were diagnosed. The disease causes the death of 30,200 people, including 20,540 men and 9,660 women.

Liver cancer diagnosed at an early stage has a 5-year survival rate of 31%. Only 43% of patients are diagnosed at 0 and 1.

Although there are many risk factors associated with the onset of liver cancer, hepatitis infection is considered a major cause of the disease. 

Dr. Marc Ringehan and colleagues in the examine hepatitis in risk of liver cancer said, "Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC)".

And, "The majority of viral-associated HCC cases develop in subjects with liver cirrhosis; however, hepatitis B virus infection can promote HCC development without prior end-stage liver disease. Thus, understanding the role of hepatitis B and C viral infections in HCC development is essential for the future design of treatments and therapies for this cancer".

These results strongly suggested if you are hepatitis carrier, your risk of liver cancer increases substantially.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of liver cancer investigated 6-shogaol and 6-gingerol, two active compounds in ginger (Zingiber officinale) anti-invasive activity against highly metastatic hepatoma cells.

6-gingerol and 6-shogaol regulate the transcription. involved cell proliferation and inhibited differentiation.

6-gingerol at a concentration ≥ 10 μM directly decreased expression of urokinase-type plasminogen activator (uPA) in stimulating tumor invasion and development of metastases.

But the 6-shogaol at the concentration ≥ 10 μM -mediated decreased uPA was accompanied by the inhibiting tumor growth, invasion, and metastasis.

Futhermore, the efficacy of anti-liver cancer of both compounds was attributed to significantly inhibit the phosphorylation of proteins associated with cellular processes and activate proteins involved anti-proliferation and transcription of DNA, cytokine production.

These results suggested that 6-Shogaol and 6-gingerol effectively inhibit invasion and metastasis of hepatocellular carcinoma through complex and diverse molecular mechanisms.

In order to reveal additional information about ginger anti-liver cancer activity, researchers examine gingerol, a bioactive compound isolated from ginger for the potential chemo-modulatory effects in addition to potential vascular protective roles with doxorubicin.

Shogaol and 4'-methoxygingerol showed considerably cytotoxic effects against HepG2 cells, with IC50 values ranging from 3.1 to 19.4 µM.

Furthermore, gingerol significantly enhanced the cytotoxic profile of doxorubicin against HepG₂ and Huh7, cells decreasing its IC50s by 10- and 4-fold, respectively.

Doxorubicin alone induced cell accumulation at S-phase and G₂/M-phase, while in combination with gingerol it significantly induced cell cycle arrest at the G₂/M-phase.

Dr.Al-Abbasi FA and colleagues in the final report wrote, "gingerol protected from DOX-induced vascular damage, apparently not through a ROS scavenging mechanism".

The findings strongly suggested that gingerol not only exerts a significantly liver protective effect but also improves the doxorubicin efficiency and reduces chemo side effects.

Taken altogether, ginger processed abundantly bioactive compound may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol by Weng CJ1, Chou CP, Ho CT, Yen GC. (PubMed)
(2) Gingerol Synergizes the Cytotoxic Effects of Doxorubicin against Liver Cancer Cells and Protects from Its Vascular Toxicity by Fahad Al-Abbasi, Eman A Alghamdi, Mohammed A. Baghdadi.
Ahmed M Al-Abd, (PubMed)
(3) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)