Monday, 14 May 2018

How to Prevent Onset of Inflammatory Related Diseases Naturally, Medline Model Studies Show

Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk, progression and treatment of  inflammatory related diseases, some scientists suggested.

The results of the studies were conducted by numbers of best institutes including National Institute of Nutrition, Jamai Osmania and published on online medical literature.

Inflammation is a natural response of immune system to protect our body against foreign in induction of infection to the site of injure or damage.

However, over expression of proinflammatory cytokines is also associated to induce local cells death and formation of local scars.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

1. Carbohydrates
2. Sugars
3. Fibre
4. Fat
5. Protein
6. Vitamin A
7. Thiamine (VittaminB1)
8. Riboflavin (Vittamin B2)
9. Niacin (Vittamin B3)
10. Vitamin B6
11. Folate (Vittamin B9)
12. Vitamin C

13. Vitamin K
14. Calcium
15. Iron
16. Magnesium
17. Molybdenum
18. Phosphorus
19. Potassium
20. Sodium

In the investigation the function of adipose tissue in induction of various metabolic diseases including insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) involved initiation of inflammatory development, researchers at the National Institute of Nutrition, Jamai Osmania launched an study to examine the effect of carrot intake and inflammatory status in male weanling Wistar rats.

The tested group of rats were divided into four groups and fed either control or high fructose diet of AIN-93G composition with or without carrot juice ingestion for an 8 week period.

AIN-93G was the  formulation published by the American Institute of Nutrition (AIN) committee in 1993 improving the laboratory standard, with an aim to accommodate the increased nutritional demands of rat or mouse growth.

At the end of the experiment, researcher indicated that 
* Carrot juice displays insignificant effect in adiposity and cell size of visceral fat depot as well as the retroperitoneal white adipose tissue (RPWAT).

The role of white adipose tissue (WAT) is to store excess fat for future use as sources of energy.

* In high fructose diet, application carrot juice exerts a strong activity in inhibited elevation of plasma free fatty acid (FFA), macrophage chemoattractant protein 1 (MCP1) (P ≤ 0.01) and high sensitive C-reactive protein (hsCRP) (P ≤ 0.05) levels.

Macrophages chemoattractant protein-1 (MCP-1/CCL2) is a chemokine with function in regulated migration and infiltration of macrophages, the mobile white blood cells. 

Levels of high sensitive C-reactive protein (hsCRP) is associated to the inflammation of blood-vessel walls.

Further analysis suggested that carrot juice decreased over expression of free cholesterol and  immune response through its antioxidant in inhibited the elevation of ROS in production of pro inflammatory cytokines.

In other words, carrot juice activated production of anti inflammatory factors in reduced over expression of inflammatory cytokines in facilitated onset and progression of inflammatory related diseases, including insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).

More over, in the additional differentiation of the effect of root vegetables in Immune-inflammatory signaling and metabolic effects, researchers at the joint study lead by the Agriculture and Agri-Food Canada, conducted a study to assess the bioaccessibility and bioavailability of purple carrot and potato derived anthocyanins and the molecular mechanisms to ameliorate cellular inflammation in a mono- and co-culture cell models.

In vitro gastrointestinal model, application of bioaccessibility of 44.62 and 71.8% for anthocyanins of purple carrot and potato demonstrated a strong activity in inhibition of cellular inflammation in Caco-2 cells.

According to the assay, the effectiveness of anthocyanins injection was found to transport across a transmembrane cell model.

The inhibition of anthocyanins during the transportation also reduced expression of pro inflammatory factors of IL-8 and TNF-α secretion,and expression of pro-inflammatory cytokines by blocking NF-κB, and MAPK, the pro inflammatory proteins in mediated inflammatory cellular signaling cascades.

Interleukin 8 is a chemokine produced by macrophages and other cell types in initiated production of inflammatory expression.

Tumor necrosis factor is a cell signaling protein (cytokine) involved systemic inflammation in acute phase infection of tissue injure and damage.

Dr. Zhang H, the lead scientist after taking into account of other co and con founders said, "Anthocyanins from purple carrots and potatoes possess a promising anti-inflammatory effect in model gut system" and "They (Anthocyanins) can be absorbed and act differently but are in general beneficial for inflammation-mediated diseases".

Taken together, carrot juice containing high amount of anthocyanins may be considered as functional food in prevented onset of inflammatory related diseases.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Bioaccessibility, bioavailability, and anti-inflammatory effects of anthocyanins from purple root vegetables using mono- and co-culture cell models by Zhang H1, Hassan YI1, Renaud J2, Liu R1, Yang C1, Sun Y1, Tsao R(PubMed)
(2) Carrot juice ingestion attenuates high fructose-induced circulatory pro-inflammatory mediators in weanling Wistar rats by Mahesh M1, Bharathi M1, Raja Gopal Reddy M1, Pappu P1, Putcha UK2, Vajreswari A1, Jeyakumar SM(PubMed)
(3) The effect of lutein- and zeaxanthin-rich foods v. supplements on macular pigment level and serological markers of endothelial activation, inflammation and oxidation: pilot studies in healthy volunteers by Graydon R1, Hogg RE, Chakravarthy U, Young IS, Woodside J(PubMed)

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