Thursday, 24 May 2018

How to Improve Glucose Metabolism in Prevention of Obesity, CVD and Diabetes, MEDLINE Model Studies Show

Kyle J. Norton

Green tea may have a therapeutic and positive effect in improved glucose metabolism, some scientists suggested.

Green tea is a precious drink processed numbers of health benefit,  known to almost everyone in Asia and Western world.

Glucose metabolism is an action of the body to convert glucose intake to energy for the needs of body tissue and organs through oxidized glucose to carbon dioxide and water.

Stages of abnormal glucose metabolism stretches from mild forms of glucose intolerance (pre diabetes), to diabetes and finally to pregravid forms of diabetes associated with end-organ disease.

Long term abnormal glucose metabolism is considered as a leading cause of diabetes and diabetic complications.

Some researchers even suggested that abnormalities of glucose metabolism can induce excess body weight and increase potentially modifiable risk factors for cardiac morbidity and mortality.

And, long term of impaired glucose tolerance (IGT) is considered as a marker for the state of insulin resistance and prediction of vessel vascular complications, independent of a patient’s progression to diabetes.
Normal blood glucose level (tested while fasting) of healthy individuals are in the range of 3.9 and 5.5 mmol/L (70 to 100 mg/dL). ...and no more than 7.8 mmol/L (140 mg/dL) 2 hours after eating.

Green tea extract, in the evaluation of the carbohydrate metabolic key enzymes in control and streptozotocin high fat diet -induced diabetic rats in 30 days, demonstrated a significant activity in ameliorated over expression of plasma glucose, glycylated hemoglobin (HbA1c) and increase in the levels of insulin and hemoglobin.

Expression of hemoglobin A1c is the average level of blood sugar over the past 2 to 3 months.

The normal hemoglobin molecule measured in a volume of blood is 13.8 to 17.2 grams per deciliter (g/dL) for men and 12.1 to 15.1 g/dL for women.

Further analysis also found that the application exerted a profound effect to restore, in some extends, the function of altered activities of the key enzymes of carbohydrate metabolism, such as hexokinase, pyruvate kinase, lactate dehydrogenase in both diabetic and control groups.

Abnormal (over 10−5M or 0.9 mg%) function of hexokinase in converted glucose into glucose-6-phosphate was associated moderate to severe hypoglycemia.

Pyruvate Kinase is an enzyme with function in catalyzed last step of glycolysis.

Deficiency of pyruvate kinase is associated to risk of metabolic disorder.

Lactate dehydrogenase (LDH or LD) is an enzyme with function to catalyze the conversion of lactate to pyruvic acid and back.

In diabetic rats group, green tea extract strongly averted the abnormal expression of glycogen phosphorylase in liver to near normal levels.

Additionally, diabetic group after administration of green tea extract exhibited antihyperglycemic potential, observed through improved muscle and hepatic glycogen content.

Glycogen phosphorylase is an enzyme with function to release sugar from cells.

The findings showed that green tea extract has a directed implication in attenuated abnormal glucose metabolism in comparison to the effectiveness of conventional medicine metformin, a standard oral hypoglycemic drug.

Moreover, in the study to confirm the epidemiological studies' suggestion of green tea in improvement of glucose metabolism in diabetic mice, researchers found that injection of green tea in diabetic mice and streptozotocin-induced diabetic mice after 2-6 h expresses lower levels of glucose with no alternation of serum insulin level, at dose of 300 mg/kg in compared to normal and control mice.

In protein differentiation, green tea extract administration decreased the serum protein level with function in stimulated glucose production and minimized the increase of blood glucose levels through stimulating additional small amounts of insulin in the diabetes.

 These results addressed another impact of green tea function in exerted direct influence in modulation of glucose metabolism in the tested subjects.

Interestingly, in the investigation of green tea effect in glucose uptake inhibitory activity in Caco-2 cells, scientists also indicated that green tea at temperature of 60 degree in Celsius significantly improves capacity of antioxidant in inhibition of glucose uptake through regulation of cell glucose metabolism.

Incredibly, temperature over 60 degree Celsius, green tea application did not increased or showed a up ward trend in the inhibitory potential, the Huazhong Agricultural University suggested.

Taken together, green tea with abundant bioactive phytochemicals may be considered as a function food in improved glucose metabolism in reduced risk of diabetes onset.

People in high risk diabetes such as prediabetics may want to add 1 or 2 cups of green tea into their daily diet for preventive measure.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)
(2) Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans by Tsuneki H1, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I.(PubMed)
(3) Effect of steeping temperature on antioxidant and inhibitory activities of green tea extracts against α-amylase, α-glucosidase and intestinal glucose uptake by Liu S1, Ai Z2, Qu F3, Chen Y4, Ni D5.(PubMed)

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