Friday, 25 May 2018

Green Roasted Coffee in Prevention and Treatment of Obesity Naturally, US National Library of Medicine Human and Model Studies Suggest

By Kyle J. Norton

Coffee, a popular and social beverage, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Green roasted coffee intake may have a profound effect in reduced risk and treatment of obesity, some studies suggested.

In compared to regular roasted coffee, green coffee roasted beans contain substantial higher levels of chlorogenic acid.

The phytochemical is considered as weight loss plantbased supplement due to its effect in significantly lowered body weight, visceral fat mass and plasma leptin and insulin levels, according to the Sunchon National University.
A BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity.

According to the statistic, 68% of American population are either overweight or obese.

How to calculate your BMI index
BMI= weight (kg)/ height (m2)

According to the joint study of the health benefits of coffee studies over last 10 years, led by the Huanggang Normal University, injection of green bean coffee daily and regularly expressed a significant improvement of risk and treatment of obesity through its function in decreased lipid accumulation in cells during fat metabolism.

In form of animal and humans studies, green coffee consumption induced changes in transcription factors in fat deposit, decreased body weight and visceral fat

Furthermore, coffee influenced gut microbiota in obese animals and humans studies also expressed the importance of green coffee as a functional and integrated food in reduced risk and treatment of obesity as microbiota in the gastrointestinal tract are found to be altered in obese individuals.

Some researchers suggested that these alternation are associated to long term unhealthy diet in induction of abnormal function of microbiota in regulated energy harvest from food components and energy storage in the host.

Dr. Kyle J. Wolf, the lead authors in the study of Gut Microbiota and Obesity said, “…… by the fact that adult germ-free (GF) (ie, bacteria-free) C57BL/6 mice had a 60% increase in body fat content when they were conventionalized (ie, colonized) with cecal microbiota from a healthy, normal C57BL/6 mouse”.

Other in the study of obesity induced in mice using a HFD for four weeks, fed only HFD or HFD with GCBE at 50, 100, and 200 mg/kg suggested that
* Mice treated with green coffee showed a significantly decreased body weight gain, liver weight and white adipose tissue weights and regulated adipose tissue lipolysis hormones, such as adiponectin and leptin.

*. Mice treated with green coffee intake also demonstrated a decreased mRNA expression levels of adipogenesis and adipocyte metabolism related genes in adipose tissues and the liver, and decreased the corresponding protein expression.

*. GCBE treated mice had a lower fat mass with decreased relative body weight and fat mass in compared to HFD alone fed mice.

Increased liver weight was associated to toxic liver and liver dysfunction.

White adipose tissue weights increased are associated to metabolic changes that occur in white adipose tissue (WAT) with obesity.

Obese patients are found to associate to increased alipose tissue lipolysis hormones.

Obesity is associated with adverse alterations in adipose tissue that predispose to adipocyte metabolic dysregulation.

Adipogenesis is the process of cell differentiation of pre-adipocytes to adipocytes. These processes of adipose hypertrophy and hyperplasia are associated with intracellular abnormalities of adipocyte function that leads to clinical manifestations and sequelae of obesity.

According to the information collected, Dr. Choi BK, the led author said, “GCBE has a potential anti-obesity effect with lowering body fat accumulation by regulating adipogenesis and lipid metabolism-related genes and proteins in WAT and liver”.

More importantly, in the study of male ddy mice fed a standard diet containing GCBE and its principal constituents, namely, caffeine and chlorogenic acid, for 14 day, researchers at the Oryza Oil & Fat Chemical Co,, Ltd, indicated that
* . GCBE with 0.5% and 1% reduced visceral fat content and body weight
*. Caffeine and chlorogenic acid showed a tendency to reduce visceral fat and body weight
*. Oral administration of GCBE (100 and 200 mg/kg. day) for 13 days showed a tendency to reduce hepatic TG in mice
*. Chlorogenic acid (60 mg/kg. day) reduced hepatic TG level

The findings displayed a strong effect of coffee and its phytochemicals in promoted weight loss and reduced accumulation by inhibition of fat absorption and activation of fat metabolism in the liver.
Green coffee intake daily and regularly may be considered as a functional and integrated food against risk and treatment of obesity.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(3) Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice by Shimoda H1, Seki E, Aitani M.(PubMed)

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