Monday, 14 May 2018

How to Prevent Over Expression of Melanin in Induction of Age Spots Naturally, US National Library of Medicine Studies Reveal

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced age spot caused by over expression of melanin, some scientists suggested.

People with light complexion and lots of sun exposure over the years are found to associate with higher prevalent risk.

The results of these investigation were carried out by some world wide institutes, including the Chongqing Institute of Forensic Science.

You can view the publication through some online medical literature, if you want to know more of these subjects.

Age spot is the over expression of skin pigment in the surface of the skin, probably caused by Skin aging, sun exposure, or other forms of ultraviolet (UV) light exposure,....

Age spot may also be caused by hormone imbalance in induction of increased production of melanin, which is responsible for darkening the skin.

Green tea, is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world.

In the investigation of Epigallocatechin gallate (EGCG), used as a constituent of cosmetic products, researchers found that applicationg EGCG exerts a significant effect as an antioxidant in exhibited anti-pigmentation properties.

Through measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression, EGCG also promoted skin hydration, through increased the expression of natural moisturizing factor-related gene, including Hyaluronan synthase (HAS)-1, and (HAS)-2.

HA synthase enzymes (HAS) amolescule with function of synthesized hyaluronan (HA) plays an essential role in protected skin fibroblasts against apoptosis, due to environment stress exposure.

Hyaluronidase ((HYAL) is an enzyme that cleaves HA.

In UVB irradiation conditions, application of EGCG protected the expression of decreased level of HYAL found in all tissues with 50% present in skin, thus reducing HaCaT cells in formation of free radicals and decreased in cell viability.

Melanin produced in melanocytes, under exposure UVB irradiation  with an aim to protect skin cells aganist UVB radiation damage.

Years of frequent and prolonged sun exposure and over expression of melanin may inducent aging spot

In other words, EGCG not only exhibited a strong effect in reduced over secretion of melanin but also enhanced cells integrity against forming of aging spot due to exposure UVB irradiation

HaCaT widely used in scientific research of epidermis, is a spontaneously immortalized human keratinocyte cell line isolated from adult human skin.

Dr. Kim E, the lead authors said, "EGCG might be used as a cosmetic ingredient with positive effects on skin hydration, moisture retention, and wrinkle formation, in addition to radical scavenging activity and reduction of melanin generation".

Furthermore, in confirmation of green tea efficacy in reduced over expression of skin pigment by evaluating the fatty acids contents in the green tea oil,  researchers indicated that all 3 major fatty acids isolated from oil were oleic acid (87.93±0.19%), stearic (5.14±0.06%) and palmitic (5.08±0.12%) acids.

Single application of each fatty acid demonstrated a strong protection of the cell viabilities through their antioxidant activity.

Moreover, the antioxidant activity of 3% tea seed oil exerted a greater cellular protection with cell viability of 90.38±7.77% in compared to other concentrations.

Some researchers suggested that green tea polyphenols and theophylline as polyphenol nanoparticles (PNs) may reduce skin aging through nanoparticle formation process involved copolymerization of monomers through exhibiting its free radicals scavenging activities.

Taking altogether, green tea and its bioactive compound such as EGCG may be used as natural and functional food for reduced over expression of melanin and skin pigment in induction of age spots.

Reprint of this article is welcome with author name and link to the article sources intact

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Skin Protective Effect of Epigallocatechin Gallate by Kim E1, Hwang K2, Lee J3, Han SY4, Kim EM5, Park J6, Cho JY7.(PubMed)
(2) Green Tea Makes Polyphenol Nanoparticles with Radical-Scavenging Activities by Xiang S1, Yang P1, Guo H2, Zhang S1, Zhang X1, Zhu F1, Li Y1.(PubMed)
(3) Melanogenesis Inhibitory and Antioxidant Effects of Camellia oleifera Seed Oil by Chaikul P1,2, Sripisut T1,2, Chanpirom S1,2, Sathirachawan K1, Ditthawuthikul N1,2.(PubMed)

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