Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday, 9 January 2014

Food Thrapy - Strawberries and Hypertension

Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with suitable climate for commercial profits and for health benefits.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways. Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidney.

Nutrients and Chemicals constituents

1. Carbohydrate
2. Dietary fiber
3. Omega 3 fatty acid
4. Calcium
5. Iron
6. Magnesium
7. Phosphorus
8. Potassium
9. Sodium
10. Zinc
11. Copper
12. Manganese
13. Selenium
14. Vitamin C
15. Thiamin
16. Niacin
17. Pantothenic acid
18. Vitamin B-6
19. Folate
20. Vitamin B-12
21. Vitamin A
22. Vitamin E
23. Vitamin K
24. Etc.

The benefits

Purified ellagitannins from strawberries were found to be effective in lowering high blood pressure and may be considered as a potential agent in management of hypertension. In the study of alpha-amylase, alpha-glucosidase, and angiotensin-1-converting enzyme (ACE) activity using fruit extracts, in general, Strawberry cultivars with combined inhibitory potential against alpha-glucosidase and ACE and with moderate or low alpha-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension. Other in the study of the same above showed high alpha-glucosidase inhibitory activity in whole food but. However, very low in all cultivars thus low anti-hypertensive potential.

The Side effects
1. Some people may beexperience anaphylactoid reaction to the consumption of strawberries

2. Oxalation
Oxalates in high concentration can cause problem for people with kidney diseases.

3. Etc.

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References

(1) Evaluation of antiproliferative, anti-type 2 diabetes, and antihypertension potentials of ellagitannins from strawberries (Fragaria × ananassa Duch.) using in vitro models, by Pinto Mda S, de Carvalho JE, Lajolo FM, Genovese MI, Shetty K(PubMed)

(2) Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension. Cheplick S, Kwon YI, Bhowmik P, Shetty K.(PubMed)

(3) Functionality of bioactive compounds in Brazilian strawberry (Fragaria x ananassa Duch.) cultivars: evaluation of hyperglycemia and hypertension potential using in vitro models. by da Silva Pinto M, Kwon YI, Apostolidis E, Lajolo FM, Genovese MI, Shetty K.

(PubMed)

Herbal Anise and Antifungal activity

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to to Egypt and the Mediterranean region. The popular herb has been used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, carminative, digestive, expectorant, stimulant and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.
Candida albicans is a member of a large group of organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that does cause harmful effects, but overgrowth results in candidiasis.

Ingredients
Beside the main ingredient Anethole, it also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

The Benefits
P-anisaldehyde (1), o-anisaldehyde (2) found in anise is found to process the anti fungal activity against Candida, including azole-resistant strains, advocating further investigation for clinical applications in the treatment of fungal infections. In other study, anise fruits Pimpinella anisum L. (Apiaceae) extract showed antimycotic activity against Candida albicans and inhibited the growth of dermatophyte species (Trichophyton rubrum, T. mentagrophytes, Microsporum canis and M. gypseum). Anise essential oil also exhibited stronger antifungal activities against yeasts and dermatophytes with MIC values between 0.10 and 1.56%.

The Side Effects 1. If you have high blood pressure or pregnant please consult with your doctor or related field specialist before applying.
2. Star Anise is toxic.
3. Skin Irritation
4. Allergic reaction such as mouth and lip inflammation.
5. Etc.

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References
(1) "[Apparent life-threatening event in infants: think about star anise intoxication!].[Article in French] by Perret C, Tabin R, Marcoz JP, Llor J, Cheseaux JJ., (PubMed)
(2) Interesting anticandidal effects of anisic aldehydes on growth and proton-pumping-ATPase-targeted activity by Shreaz S, Bhatia R, Khan N, Ahmad SI, Muralidhar S, Basir SF, Manzoor N, Khan LA.(PubMed)
(3) Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae) by Kosalec I, Pepeljnjak S, Kustrak D.(PubMed)

Herbal Andrographis and Renoprotective effects

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Renoprotective effect is defined of a protection against harmful of the kidney.

The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

The Benefits
Renal failure is an increasingly common condition with limited treatment options in developing world. In the study to evaluate the antirenal failure activity of A. paniculata, aqueous extract of A. paniculata attenuated the gentamicin-induced increase in serum creatinine, serum urea, and blood urea nitrogen levels by 176.92%, 106.27%, and 202.90%, respectively by exhibiting a significant renoprotective effect in gentamicin-induced nephrotoxicity in rats. Other in the study of the effect of various herbal adaptogens, including on cadmium (Cd)-induced oxidative stress and its accumulation in broiler chicken, found that the increase in TBARS and decrease in GSH concentrations of liver and kidney tissues in cadmium intoxicated birds were significantly reversed by the above-said herbs. The liver and kidney functional markers were also restored to normal levels. Unfortunately, Andrographolide was found to cause acute kidney injury shortly after intravenous infusion of andrographolide, with symptoms including flank pain, decreased urine output, and nausea or vomiting.

The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.

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References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats by Singh P, Srivastava MM, Khemani LD.(PubMed)
(3) Andrographolide induced acute kidney injury: Analysis of 26 cases reported in Chinese Literature by Zhang WX, Zhang ZM, Zhang ZQ, Wang Y, Zhou W.(PubMed)
(4) Prevention of cadmium bioaccumulation by herbal adaptogens by Bharavi K, Reddy AG, Rao GS, Kumar PR, Kumar DS, Prasadini PP.(PubMed)

Phytochemical Anacardic acids and Prostate cancer

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

The health Benefits
Anacardic acid (6-pentadecylsalicylic acid), a natural chemical constituent from ancient plant Amphipterygium adstringens, also known as a non-specific histone acetyltransferase inhibitor of p300, beside exhibuts its anti-inflammatory, anticancer, antioxidative, and antimicrobial effects, but also revealed that Src protein expression, tumor cell proliferation, and microvessel density could be remarkably suppressed by anacardic acid and may be considered as a potent agent to treat prostate cancer. Other study of Anacardic acid (6-pentadecylsalicylic acid), also showed to inhibit of prostate cancer by down-regulates androgen receptor (AR) through supressing p300.

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References
(1) Anacardic acid (6-pentadecylsalicylic acid) inhibits tumor angiogenesis by targeting Src/FAK/Rho GTPases signaling pathway by Wu Y, He L, Zhang L, Chen J, Yi Z, Zhang J, Liu M, Pang X.(PubMed)
(2) Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling by Tan J, Chen B, He L, Tang Y, Jiang Z, Yin G, Wang J, Jiang X.(PubMed)

Phytochemicals Phytic acid and Alzheimer's disease (AD)

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Phytic acid (Inositol hexaphosphate) are phytichemicasl of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
Alzheimer's disease is a brain disorder named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

The benefits
In the study of the effects of Phytic acid (inositol hexakisphosphate), a phytochemical found in food grains an others, against amyloid-β (Aβ) pathology in MC65 cells and the Tg2576 mouse model. After 48-72-hour treatment, phytic acid is founf to be provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity. 2% phytic acid in drinking water for 70 days also showed a significant increase in brain levels of cytochrome oxidase and a decrease in lipid peroxidation. Other in the study of composition and method for the treatment of Alzheimer's disease and related amyloid plaque development and reduction of amyloid plaque, amyloidosis and amyotrophic lateral sclerosis with phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination showed that very low doses of phytic acid are effective in the treatment and prevention of aggregation of beta amyloid proteins as are commonly seen in the brains of Alzheimer's patients.

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References
(1) Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models by Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn JF.(PubMed)
(2) Prophylactic and therapeutic treatment of Alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein(Patnetdocs)

Phytochemical Piperine and antimicrobial activity

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.

The health benefits
In the study of piperine combination with mupirocin for antimicrobial activity against Staphylococcus aureus strains including meticillin-resistant S. aureus, the combination showed more effective against the tested subject when compared with the commercially available formulation of 2 % mupirocin alone. Other in the study of the same subject showed the enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine.

Chinese Secrets To Fatty Liver And Obesity Reversal
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Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus by Mirza ZM, Kumar A, Kalia NP, Zargar A, Khan IA.(PubMed)
(2) Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus by Khan IA, Mirza ZM, Kumar A, Verma V, Qazi GN.(PubMed)

Phytochemical Tartaric acid enhances intestinal absorption

Wednesday, 8 January 2014

Herbal Aloe Vera and Skin Aging

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herb studied in scientific ways with some conflicted results.

A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with other cell, which in turn, causes oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospho-lipids, DNA and RNA, etc., leading to aging of the organisms, as a result of widespread damage due to set of a chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls. Free radicals oxidative effects can damage to skin and speed up the skin aging process.

The Ingredients
The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
They all work together in a synergistic way to create healing and health giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

The benefits
Aging is a natural process, no one can stop but delay it. Aloe Vera Supplementation has long been promote by cosmetic industrial for reducing the progress of skin aging. The study of 30 healthy female subjects over the age of 45 received 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days. to determine the effect of aloe gel on the clinical signs and biochemical changes of aging skin, researchers found that the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group. In the photoprotected skin, the type I procollagen mRNA levels were increased in both groups, albeit without significance; the MMP-1 mRNA levels were significantly decreased in the higher-dose group. In UVB-Induced Skin Photoaging in vitro, aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, have a protective effect on UVB-induced skin photoaging in normal human dermal fibroblasts (NHDFs). As a anti-inflammatory agent, aloe vera, havs been identified as beneficial in the treatment of psoriasis and atopic dermatitis.

The Side effects
1. Hepatitis
Some researchers concerned that the over use of oral aloe vera may contribute to acute hepatitis, according to the study of "Oral aloe vera-induced hepatitis" by Bottenberg MM, Wall GC, Harvey RL, Habib S., posted in PubMed
2. Diarrhea, caused by the laxative effect of oral use of Aloe Vera
3. oral use of Aloe Vera may cause abdominal cramps and pain
4. It may cause of rheumatoid arthritis symptoms as a result of collagen in the plant, according to the study of "Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study" by Cazzola M, Antivalle M, Sarzi-Puttini P, Dell'Acqua D, Panni B, Caruso I., posted in PubMed
5. Etc.

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References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(3) Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. by Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH.(PubMed)
(4) A Comparative Study of Baby Immature and Adult Shoots of Aloe Vera on UVB-Induced Skin Photoaging in vitro. by Hwang E, Kim SH, Lee S, Lee CH, Do SG, Kim J, Kim SY.(PubMed)
(5) Innovations in natural ingredients and their use in skin care.

Fowler JF Jr, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)

(5) Oral aloe vera-induced hepatitis(PubMed)
(6) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)

Phytochemical Allicin and anti bacterial activity

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.

The Benefits
Garlic has been used as foods and medicine throughout human history. Allicin, major constituent of garlic in the test for the antimicrobial activity on oral pathogens associated with dental caries and periodontitis, showed an effectiveness against all types of bacteria, including Streptococcus mutans, S. sobrinus, and Actinomyces oris. Other in the study of Streptolysin O (SLO), a potent cytolytic toxin produced by almost all strains of group A streptococci, found that allicin likely inhibits the SLO by binding to the cysteine residue in the binding site and suggested that allicin and allicin may be a potential alternative drug against streptococcal diseases.

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References
(1) Garlic allicin as a potential agent for controlling oral pathogens by Bachrach G, Jamil A, Naor R, Tal G, Ludmer Z, Steinberg D.(PubMed)
(2) Inhibition of streptolysin O by allicin - an active component of garlic by Arzanlou M, Bohlooli S.(PubMed)

Phytochemical Allyl isothiocyanate and Brain Cancer

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.

Brain and spinal cord make up the nervous system. Brain and Spinal Cord tumors originating is not very common. Most primary tumors are caused by abnormal cells growth that surround and support neurons, with a small number may be caused by gene defect from exposure to radiation or toxic chemicals. Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in US are diagnosed with a brain tumor each year alone.

Allyl isothiocyanate and Brain Cancer
Allyl isothiocyanate (AITC) found in various cruciferous vegetables, beside has shown the inhibition of leukemia HL-60, bladder cancer UM-UC-3 and colon cancer HT-29 cells in vitro, it also significantly decreased proliferation and viability of human brain malignant glioma GBM 8401 cells in a dose-dependent manner. Allyl isothiocyanate (AITC) may be another potential source of anti-human brain malignant glioma drug. Other study insisted that intake of Allyl isothiocyanate (AITC) may reduce the risk of cancer but AITC at high-dose levels also exhibit a low degree of cytotoxicity and genotoxicity, but unlikely in humans exposed to dietary levels of AITC.

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References
(1) Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway by Chen NG, Chen KT, Lu CC, Lan YH, Lai CH, Chung YT, Yang JS, Lin YC.(PubMed)
(2) Allyl isothiocyanate as a cancer chemopreventive phytochemical by Zhang Y.(PubMed)

Herbal Arctostaphylos uva-ursi and Bladder cancer

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to the northern North America, Asia and Europe. The herb has been used in traditional medicine as diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.
Bladder cancer is most common type of cancer that effect men twice as frequently as it effects women. Usually it starts from the lining the bladder caused by several types of malignant growths of the urinary bladder cells.

The Ingredients
It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides and flavonoids.

The benefits
The search for alternative medicine for treatment of cancers has been growing worldwide, and herbs used in folk medicine may be a potential sources as it induced little or no side effects. Arbutin, a glycosylated hydroquinone extracted from the bearberry plant (Arctostaphylos species), is found significantly decreased TCCSUP human bladder cell proliferation in a concentration- and time-dependent manner by increased the expression of p21WAF1/CIP1 (p21), which involved in cell cycle regulation.

The Side effect
1. Overdoses may cause gastrointestinal discomfort, including cause nausea, vomiting, etc. and fever, chills, severe back pain, ringing in the ears, etc.
2. The herb may interact with other medicine, including diuretic
3. Do not use the herb in new born, children or if you are pregnant or breast feeding without approval from the related field specialist.
4. Etc.

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References
(1) Arbutin inhibits TCCSUP human bladder cancer cell proliferation via up-regulation of p21 By Li H, Jeong YM, Kim SY, Kim MK, Kim DS.(PubMed)

Herbal Arnica and Alleviated pain

Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, antive to Europe and Asia. It has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
Colon Cancer is defined as a condition of the abnormal proliferation of cells in the colon.
Pain is a feeling triggered in the nervous system as a result of often caused by intense or damaging stimuli.

The ingredients
Beside containing contain helenalin as it main ingredient used as anti-inflammatory agent in herbal medicine, it also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

The Benefits
Arnica has been used in folk medicine as a treatment for bruising and swelling. Arnica administration of the herb is significant reduction in pain experienced after 2 weeks in the Arnica-treated group. Other in the study to determine if topical Arnica is effective in reducing pain, showed although its application of topical Arnica did not affect any performance assessments or markers of muscle damage or inflammation, however it demonstrates the possibility of providing pain relief three days post-eccentric exercise and Pain scores on legs treated with arnica were also higher than scores on those receiving placebo 24 hours after exercise.

C. Side effects
1. Arnica can increase leg pain in a short term
2. Allergy
Arnica used as Cosmetics and herbal remedies with Compositae plant extracts may cause allergic effect in Compositae-allergic patients.
3. Atopic dermatitis
Patient with atopic dermatitis should use Arnica with care as the herb may increase the risk of a risk factor for Compositae allergy.
4. Toxicity
Arnica is toxic as it contains measurable amount of helenalin.
5. Etc.

Chinese Secrets To Fatty Liver And Obesity Reversal
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Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
1. The effect of topical arnica on muscle pain" by Adkison JD, Bauer DW, Chang T.(PubMed).
2. Cosmetics and herbal remedies with Compositae plant extracts - are they tolerated by Compositae-allergic patients?" by Paulsen E, Chistensen LP, Andersen KE.(PubMed)
(3) Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]" by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S.,(PubMed)
(4) Use of Arnica to relieve pain after carpal-tunnel release surgery by Jeffrey SL, Belcher HJ.(PubMed)
(5) The effects of topical Arnica on performance, pain and muscle damage after intense eccentric exercise by Pumpa KL, Fallon KE, Bensoussan A, Papalia S.(PubMed)
(6) The effect of topical arnica on muscle pain by Adkison JD, Bauer DW, Chang T.(PubMed)

Herbal Anise and Tongue squamous carcinoma

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to to Egypt and the Mediterranean region. The popular herb has been used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, carminative, digestive, expectorant, stimulant and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.
Tongue cancers is defined as an abnormal cell growth in the tongue.

Ingredients
Beside the main ingredient Anethole, it also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

The benefits
Safrole, a chemical component found in anise, induced apoptosis in human tongue squamous carcinoma SCC-4 cells and the The induction of apoptosis is involved in mitochondria- and caspase-dependent signal pathways. Aloe-emodin one of anthraquinones, found in aniseed, has been shown to have anticancer activity in different kinds of human cancer cell lines. In tough cancers, it induced apoptosis in the SCC-4 cells through the Fas/death-receptor, mitochondria and caspase cascade and may be considered as a potent agent in treating the disease.

The Side Effects
1. If you have high blood pressure or pregnant please consult with your doctor or related field specialist before applying.
2. Star Anise is toxic.
3. Skin Irritation
4. Allergic reaction such as mouth and lip inflammation.
5. Etc.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html

References
(1) "[Apparent life-threatening event in infants: think about star anise intoxication!].[Article in French] by Perret C, Tabin R, Marcoz JP, Llor J, Cheseaux JJ., (PubMed)
(2) Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways by Yu FS, Huang AC, Yang JS, Yu CS, Lu CC, Chiang JH, Chiu CF, Chung JG. (PubMed)
(3) Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells by Chiu TH, Lai WW, Hsia TC, Yang JS, Lai TY, Wu PP, Ma CY, Yeh CC, Ho CC, Lu HF, Wood WG, Chung JG.(PubMed)

Herbal Andrographis and malaria

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Malaria is a mosquito-borne infectious disease caused by parasitic protozoans.

The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

The benefits
The crude extract of E. alba and A. paniculata was an excellent potential for controlling An. stephensi mosquitoes which caused malaria by exerting its mosquito adulticidal and repellent activities. In the study to compare the anti-malarial effect among sambiloto extract, chloroquine and artemisinin-only as well as those of their combination showed that the extract of sambiloto in a single dose or in a combination evidently has the effect of anti-falciparum malaria. Other study of the extract of Andrographis paniculata (AP) and Hedyotis corymbosa (HC) showed that a 50% inhibitory concentration (IC50) of AP (7.2 microg/ml) was found better than HC (10.8 microg/ml). Combination of these two herbal drugs showed substantial enhancement in their anti-malarial activity.

The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed) (2) Comparative study of antimalarial effect of sambiloto (Andrographis paniculata) extract, chloroquine and artemisinin and their combination against plasmodium falciparum in-vitro by Zein U, Fitri LE, Saragih A.(PubMed)
(3) Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin by Mishra K, Dash AP, Swain BK, Dey N.(PubMed)
(4) Mosquito adulticidal and repellent activities of botanical extracts against malarial vector, Anopheles stephensi Liston (Diptera: Culicidae) by Govindarajan M, Sivakumar R.(PubMed)

Herbal Aloe Vera and Immunity

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herb studied in scientific ways with some conflicted results.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.

The Ingredients
The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
They all work together in a synergistic way to create healing and health giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

The benefits
Aloe Vera is best known for it anti-inflammatory effects, in the study to determine the effect of the inner gel on bacterial-induced pro-inflammatory cytokine production, Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. In the pharmacological study of Aloe arborescens Miller leaf components, The Aloe extract (1.2 mg ml(-1)) acted as a powerful immune stimulant in LPS- or poly I:C-activated SAF-1 cells, inducing a synergic effect on interconnected genes that are expected to be involved in different aspects of the immune responses. Aloe polymannose, a chemical compound found in Aloe Vera, also enhances the cognitive and immune functioning in patients of Alzheimer's disease by decreasing tumor necrosis factor-α, vascular endothelial growth factor, and interleukins-2 and-4

The Side effects
1. Hepatitis
Some researchers concerned that the over use of oral aloe vera may contribute to acute hepatitis, according to the study of "Oral aloe vera-induced hepatitis" by Bottenberg MM, Wall GC, Harvey RL, Habib S., posted in PubMed
2. Diarrhea, caused by the laxative effect of oral use of Aloe Vera
3. oral use of Aloe Vera may cause abdominal cramps and pain
4. It may cause of rheumatoid arthritis symptoms as a result of collagen in the plant
5. Etc.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(3) The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. by Habeeb F, Stables G, Bradbury F, Nong S, Cameron P, Plevin R, Ferro VA.(PubMed)
(4) Immune modulatory effects of Aloe arborescens extract on the piscine SAF-1 cell line. by Picchietti S, Bernini C, Belardinelli MC, Ovidi E, Taddei AR, Guerra L, Abelli L, Fausto AM.(PubMed)
(5) The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease. by Lewis JE, McDaniel HR, Agronin ME, Loewenstein DA, Riveros J, Mestre R, Martinez M, Colina N, Abreu D, Konefal J, Woolger JM, Ali KH.(PubMed)
(7) Oral aloe vera-induced hepatitis(PubMed)
(8) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)

Tuesday, 7 January 2014

Food Therapy - Beet (Beta vulgaris) and Cancers

Beet is best known as the beetroot or garden beet and belong to the amaranth family. It is a perennial plant with leafy stems growing to 1–2 m tall.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.

Nutrients and chemical Constituents
1. Energy
2. Carbohydrates
3. fiber
4. Protein
5. Vitamin A
6. Beta-carotene
7. Trytophan
8. Thiamine (Vitamin B1)
9. Riboflavin (Vitamin B2)
10. Niacin (Vitamin B3)
11. Pantothenic acid (Vitamin B5)
12. Vitamin B6
13. Folate (Vitamin B9)
14. Vitamin C
15. Calcium
16. Iron
17. Magnesium
18. Copper
19. Phosphorus
20. Potassium
21. Zinc
22. Magnesium
23. Betacyanin
24. Betaine
25. Etc.
Beside the major chemical constituents betalains and phenolics, it also contains lesser amount of isobetanin, probetanin, neobetanin, indicaxanthin, vulgaxanthins, etc.

The Benefits
Red beetroot (Beta vulgaris L.) extract (B), approved to be used as coloring by the FDA, and anticancer drug doxorubicin (D), when are tested for cytotoxic effects against the three cancer cells, showed both exerted the positive effects but the synergistic cytotoxicity was best when the B:D ratio of 1:5 was used in pancreatic (PaCa) cells at IC50, IC75 and IC90 dose levels and in breast (MCF-7) cells at IC90 dose level. Other in the study in the same comparison of the anti cancers effect of doxorubicin and the beetroot extract, both are found to exhibit a dose-dependent cytotoxic effect in the two cancer cell lines tested. Although the cytotoxicity of the beetroot extract was significantly lower when compared to doxorubicin in human prostate (PC-3), and breast (MCF-7) and cancer cell lines.

Side effects
1. Oxalates Oxalates in the beet can cause kidney and gallbadder problem. People with above diseases should contact their doctor before consuming.
2. Increase the rick of lowering calcium absorption for people with weak digestive system.
3. Etc.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html

References
(1) Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines by Kapadia GJ, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H.((PubMed)
(2) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines by Kapadia GJ, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)

Herbal Burdock and Cancer

Burdock is plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. It has been used over thousand of years in Chins and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

The ingredients
It contains carbonated water, sugar,, manloid colourings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.

The benefits
Arctium lappa or burdock has been used as a healthy and nutritive food in Chinese societies and therapeutically in Europe, North America and Asia for hundreds of years.
Lappaol F, the chemicals constituents from plant Arctium Lappa L. Lappaol F suppressed cancer cell growth in a time- and dose-dependent manner in human cancer cell lines. In the evaluation the cytotoxicity profiles of the extract of Arctium lappa L using various cancer and normal cell lines, arctigenin, showed cytotoxicity to lung cancer (A549), liver cancer (HepG2) and stomach cancer (KATO III) cells, while no cytotoxicity to several normal cell lines. Its antioxidants and antidiabetic compounds found in the root and some active compounds in the seed possessed anti-inflammatory effects and potent inhibitory effects on the growth of tumors.

The Side effects
1. Overdose can be poisoning and may lead to symptoms of acute poisoning include phenothiazines, tricyclic antidepressants, and antihistamines.
2. It may cause dermatitis and allergic/inflammatory responses to certain people with contact as a result of lactones which the plant produces.
3. Do not use burdock if you are pregnant or breast feeding.
4. Etc.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) Lappaol F, a Novel Anticancer Agent Isolated from Plant Arctium Lappa L by Sun Q, Liu K, Shen X, Jin W, Jiang L, Sheikh MS, Hu Y, Huang Y.(PubMed)
(2) Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L by Susanti S, Iwasaki H, Itokazu Y, Nago M, Taira N, Saitoh S, Oku H.(PubMed)
(3) A review of the pharmacological effects of Arctium lappa (burdock) by Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW.(PubMed)

Food Therapy - Strawberries and Diabetes

Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with suitable climate for commercial profits and for health benefits.
Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Nutrients and Chemicals constituents

The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin

The benefits
Study in a mouse model of diet-induced to test for the strawberry health effect, show a promising role for dietary strawberries in reducing the risks associated with obesity and diabetes. Phenolic constituent found in the fruit, including ellagitannins are found to be good potential for the management of hyperglycemia and hypertension linked to type 2 diabetes as purified ellagitannins from strawberries enhanced the antiproliferative activity and in vitro inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potential management of hyperglycemia and hypertension. Unfortunately, Glycemic effect of adding 10-g carbohydrate portions of apple, banana, grapes, honeydew, orange, or strawberries to a standard meal on found that Blood-glucose response to meals containing grapes, honeydew, orange, or strawberries was slightly higher than meals containing apple, banana, or no fruit.

The Side effects
1. Some people may beexperience anaphylactoid reaction to the consumption of strawberries

2. Oxalation
Oxalates in high concentration can cause problem for people with kidney diseases.

3. Etc.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice, and selectively lowers plasma C-reactive protein in lean mice by Parelman MA, Storms DH, Kirschke CP, Huang L, Zunino SJ.(PubMed)
(2) Evaluation of antiproliferative, anti-type 2 diabetes, and antihypertension potentials of ellagitannins from strawberries (Fragaria × ananassa Duch.) using in vitro models, by Pinto Mda S, de Carvalho JE, Lajolo FM, Genovese MI, Shetty K(PubMed)
(3) The glycemic response to meals with six different fruits in insulin-dependent diabetics using a home blood-glucose monitoring system by Hoover-Plow J, Savesky J, Dailey G. (PubMed)

Herbal Aloe Vera and Wound Healing

Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C.(PubMed)

(4) Aloe vera for treating acute and chronic wounds. by Dat AD, Poon F, Pham KB, Doust J.(PubMed)

(5) Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study, by Eshghi F, Hosseinimehr SJ, Rahmani N, Khademloo M, Norozi MS, Hojati O.(PubMed)

(6) Formulation development, optimization and evaluation of aloe vera gel for wound healing.

Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A, Ali J.(PubMed)

(7) Oral aloe vera-induced hepatitis(PubMed)
(8) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)