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Friday, 20 November 2015

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine: TCM treatment for toxins elimination - Herbal Milk thistle(Shui Fei Zi)

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.


Treatments in Traditional Chinese Herbal Medicine
B.5. Chinese Herbal medicine for toxins elimination
1. Shui Fei Zi or Milk thistle (Silybum marianum)
Shui fei zi, the bitter and cold herb, is also known as milk thistle, native to Western Europe and northern Africa, used in traditional Chinese medicine to improve liver function(1193)(1194)(1210), promote the flow of breast milk(1207), bile secretion(1200), anti depression(1201) and anti tumors(1196)(1197)(1198), inhibit allergic effects(1195)(1199), treat hepatitis C(1202)(1203), cirrhosis(1205) and liver fibrosis(1206), by enhancing function of liver and gallbladder channels(1204)

Phytochemicals
1. Flavonoid
2. Fumaric acid
3. Silymarin
4. Isosilybin,
5. Dehydrosilybin,
6. Silydianin
7. Silychristin
8. Cinnamic acid
9. Myristic acid
10. Palmitelaidic acid
10. Arachidic acid
11. Etc.

Shui Fei Zi or Milk thistle used in the treatment and prevention ofdementia(1218) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals Silymarin and Silibinin in ameliorated amyloid pathology(1216) and oxidative stress(1216)(1217) through attenuated levels of lipid peroxidation (malondialdehyde) and antioxidant (glutathione) in the hippocampus(1217).

1.1. In Alzheimer's disease
Alzheimer disease (AD). a neurodegenerative disorders is the most prevalent diseases in the United States, in aging population(1219). Silymarin, a phytochemical found abundantly in milk thistle, in age related disorders like neurodegenerative diseases improved locomotion rate, higher response to stimuli and tolerance to stress, in C.elegans Alzheimer's Model, through delayed paralysis via enhanced resistance to oxidative stress(1220). In rat induced Alzheimer's disease model, the phytochemical also inhibited amyloid formation(1222) and suppressed amyloid protein precursor (APP) expression(1222)and reduced neurotoxicity in PC12 cells(1222) in improvement memory(1223) and learning function(1221).

1.2. In Parkinson disease
In a mouse model of Parkinson's disease, causes of mitochondrial dysfunction and selective cells death of dopaminergic neurons, silibinin, derivative of silymarin, protected mitochondria through attenuated motor deficit and dopaminergic neuronal loss(1224) and anti oxidative and anti inflammatory pathways(1225).

1.3. In neuroprotective effects
In focal cerebral ischemia, silymarin (SM), a mixture of flavonolignans extracted from the milk thistle exerted it neuroprotective effects, in upregulating the antioxidant status and lowering the apoptotic response in slowing down the progression of neurodegeneration(1226) and preventing inflammation-related neurodegenerative disease(1227) and ROS causs of oxidative damage to macromolecules in the brain(1230).

1.4. In cognitive impairment
In cognitive deficit mice model, silibinin exhibited its anti cognitive impairment effects through amelioration of decreases in dopamine and serotonin levels in the prefrontal cortex and hippocampus, (1228). In amyloid beta peptide-induced memory impairment, the chemicals also improved cognitive memory deficits through attenuated the Abeta(25-35)- accumulation of malondialdehyde and depletion of glutathione in the hippocampus(1229).

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References
(1193) Milk thistle (Silybum marianum) for the therapy of liver disease by Flora K1, Hahn M, Rosen H, Benner K.(PubMed)
(1194) Milk thistle in liver diseases: past, present, future by Abenavoli L1, Capasso R, Milic N, Capasso F.(PubMed)
(1195) Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: therapeutic implications for autoimmune diseases. by Gharagozloo M1, Javid EN, Rezaei A, Mousavizadeh K.(PubMed)
(1196) Silibinin reverses drug resistance in human small-cell lung carcinoma cells by Sadava D1, Kane SE.(PubMed)
(1197) Silibinin inhibits accumulation of myeloid-derived suppressor cells and tumor growth of murine breast cancer. by Forghani P1, Khorramizadeh MR, Waller EK.(PubMed)
(1198) Silymarin induces cell cycle arrest and apoptosis in ovarian cancer cells. by Fan L1, Ma Y1, Liu Y1, Zheng D2, Huang G3.(PubMed)
(1199) Immunosuppressive effect of silymarin on mitogen-activated protein kinase signalling pathway: the impact on T cell proliferation and cytokine production by Gharagozloo M1, Jafari S, Esmaeil N, Javid EN, Bagherpour B, Rezaei A.(PubMed)
(1200) Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application by Wu JW1, Lin LC, Hung SC, Chi CW, Tsai TH.(PubMed)
(1201) Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice. by Khoshnoodi M1, Fakhraei N, Dehpour AR.(PubMed)
(1202) Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials by Yang Z1, Zhuang L2, Lu Y1, Xu Q1, Chen X1.(PubMed)
(1203) Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial by Fried MW1, Navarro VJ, Afdhal N, Belle SH, Wahed AS, Hawke RL, Doo E, Meyers CM, Reddy KR; Silymarin in NASH and C Hepatitis (SyNCH) Study Group.(PubMed)
(1204) Shui fei ji(Complementary and Alternative Healing University)
(1205) The clinical utility of milk thistle (Silybum marianum) in cirrhosis of the liver by Boerth J1, Strong KM.(PubMed)
(1206) Immunosuppressive effect of silymarin on mitogen-activated protein kinase signalling pathway: the impact on T cell proliferation and cytokine production by Gharagozloo M1, Jafari S, Esmaeil N, Javid EN, Bagherpour B, Rezaei A.(PubMed)
(1207) Systematic review of the efficacy of herbal galactogogues by Mortel M1, Mehta SD.(PubMed)
(1208) Effect of reinforcing kidney-essence, removing phlegm, and promoting mental therapy on treating Alzheimer'sdisease. by Liu P1, Kong M, Liu S, Chen G, Wang P.(PubMed)
(1209) Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment: a randomized, double-blind and parallel-controlled trial by Miao YC1, Tian JZ, Shi J, Mao M.(PubMed)
(1210) Effects of acupuncture on Chinese medicine syndromes of vascular dementia. by Shi GX1, Liu CZ, Guan W, Wang ZK, Wang L, Xiao C, Li ZG, Li QQ, Wang LP.(PubMed)
(1211) Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid β-amyloid 42: a cross-validation study against amyloid positron emission tomography by Palmqvist S1, Zetterberg H2, Blennow K2, Vestberg S3, Andreasson U2, Brooks DJ4, Owenius R5, Hägerström D6, Wollmer P7, Minthon L8, Hansson O8.(PubMed)
(1212) Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease by Lautner R1, Palmqvist S2, Mattsson N3, Andreasson U1, Wallin A1, Pålsson E1, Jakobsson J1, Herukka SK4, Owenius R5, Olsson B1, Hampel H6, Rujescu D7,Ewers M8, Landén M9, Minthon L2, Blennow K1, Zetterberg H10, Hansson O2; Alzheimer’s Disease Neuroimaging Initiative.(PubMed)
(1213) Immunity factors for two related tRNAGln targeting killer toxins distinguish cognate and non-cognate toxic subunits by Klassen R1, Kast A, Wünsche G, Paluszynski JP, Wemhoff S, Meinhardt, F. (PubMed)
(1214) Non structural protein of avian influenza A (H11N1) virus is a weaker suppressor of immune responses but capable of inducing apoptosis in host cells. by Mukherjee S1, Majumdar S, Vipat VC, Mishra AC, Chakrabarti AK.(PubMed)
(1215) The anorexia of aging in humans by Hays NP1, Roberts SB.(PubMed)
(1216) Silibinin: a novel inhibitor of Aβ aggregation by Yin F1, Liu J, Ji X, Wang Y, Zidichouski J, Zhang J.(PubMed)
(1217) Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice. by Lu P1, Mamiya T, Lu LL, Mouri A, Zou L, Nagai T, Hiramatsu M, Ikejima T, Nabeshima T.(PubMed)
(1218) Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer'sdisease mouse model by Murata N1, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T.(PubMed)
(1219) Is lithium a neuroprotective agent? by Vo TM1, Perry P, Ellerby M, Bohnert K.(PubMed)
(1220) Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer's model by Kumar J, Park KC, Awasthi A, Prasad B1.(PubMed)
(1221) Silymarin effect on amyloid-β plaque accumulation and gene expression of APP in an Alzheimer's disease rat model by Yaghmaei P1, Azarfar K, Dezfulian M, Ebrahim-Habibi A.(PubMed)
(1222) Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer'sdisease mouse model by Murata N1, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T.(PubMed)
(1223) Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice by Lu P1, Mamiya T, Lu LL, Mouri A, Niwa M, Hiramatsu M, Zou LB, Nagai T, Ikejima T, Nabeshima T.(PubMed)
(1224) Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease via mitochondrial stabilization by Lee Y1, Park HR, Chun HJ, Lee J.(PubMed)
(1225) Silibinin attenuates MPP⁺-induced neurotoxicity in the substantia nigra in vivo by Jung UJ1, Jeon MT, Choi MS, Kim SR.(PubMed)
(1226) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(1227) Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation. by Hou YC1, Liou KT, Chern CM, Wang YH, Liao JF, Chang S, Chou YH, Shen YC.(PubMed)
(1228) Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment by Lu P1, Mamiya T, Lu L, Mouri A, Niwa M, Kim HC, Zou LB, Nagai T, Yamada K, Ikejima T, Nabeshima T.(PubMed)
(1229) Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice. by Lu P1, Mamiya T, Lu LL, Mouri A, Zou L, Nagai T, Hiramatsu M, Ikejima T, Nabeshima T.(PubMed)