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Sunday, 15 February 2015

(4th edited )Most common diseases of Elders- Diseases of Central Nervous system(CNS): TCM Herbal Cinnamon treatments of Dementia Caused by Spleen Qi Deficiency



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By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                      Diseases of Central Nervous system


                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Treatments
C. In traditional Chinese Medicine Perspective(*)

Based on Chinese ancient medical records. causes of dementia are the results of (*)
C.3. Deficiency of Qi, mainly due to
B.3.3. Spleen Qi deficiency

Spleen is a vital organ, according to traditional Chinese medicine with function in absorbing nutrients and transport them to body's organs and cells. Spleen Qi deficiency is a condition of the inability of the spleen in maximized transportation of nutrients to body organs, including the brain. Prolong period of malnutrition of brain cells may induce abnormal functions in information transmitting or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842) and changes in brain tissues and behavior patterns(843)(842).

Herbal medicine for Spleen Qi deficiency  
4. Cinnamon bark (Rou gui)
Rou gui, an acrid, sweet, very hot herb, is also known as Cinnamon bark, used in TCM  as anti-spasmodic(1110), antibiotic(1111), antigastric ulcers(1112), anti impotent and anti diabetic(1113)(1114) agent and to treat hepatitis(1115), flatulence(1116), weak digestion(1116), pain in solar plexus(1110), breast cancer(1117)(1118), tuberculosis(1119)(1120), etc., as it drains the liver heat, eliminates Qi accumulation, disperses nodules, reduces stagnation, etc.by enhancing the functions of heart, lung, bladder channels(1121).

Ingredients
1. Cinnamic aldehyde
2. Cinnamyl acetate
3. Eugenol
4. Aldehyde
5. Pinene
6. Coumarin
7. Cinnamyl alcohol
8. Cinnamic acid
9. Cinnzeylanol
10. Cinnzeylanine
11. Etc.

Cinnamon bark (Rou gui) used in the treatment of symptoms of neurological impairment(1108)(1109) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals, including major constituent cinnamaldehyde (CA) and epicatechin (EC)(1122)  in exertion of its neuroprotective effects(1123)(1123), through anti oxidative stress(1125), anti inflammatory(1124)) activities, against β-amyloid (Aβ) accumulation(1126) induced neurotoxicity causes of  Alzheimer's disease.(1126)(1127) and neurodegeneration(1128).

4.1. In Alzheimer's disease 
Cinnamon, a multifaceted medicinal plant have shown to consist activities against neurological disorders, including Alzheimer's diseases(1129) by blocking and reversing tau modification and aggregation(1131)(1130) and ischemic stroke induced cell swelling(1130). In β-amyloid polypeptide (Aβ), associated to the development of Alzheimer's disease(AD), in mouses model, oral administration of cinnamon extract exhibited neuroroprotective effects in enhancing the fully recover of  locomotion defects and totally abolished tetrameric species of Aβ in their brain(1132). In a high fat/high fructose diet induced Alzheimer's disease(AD) symptoms, cinnamon (CN) ameliorated enzyme phosphatase and proteins tensin homolog (PTEN),  tau and amyloid precursor, associated to Alzheimer's disease(AD), through improved insulin sensitivity and related changes in the brain(1133).
According to The Business and Technology Center, West Lafayette, Chinese cinnamon, is one of the tested herb with potential  for prevention and treatment of early onset of Alzheimer's disease(AD)(1134).

4.2. In Parkinson's disease
In a mice model, oral administration of cinnamon (Cinnamonum verum) powder upregulaed and/or maintained the level of Parkin/DJ-1, a beneficial proteins associated to degeneration progression of Parkinson's disease(1135). through protection of dopaminergic neurons(1136). In oligomeriztion of α-synuclein (α-syn) formation associated with the symptoms of Parkinson's Disease, cinnamon extract precipitation (CEppt), inhibited oligomeric and fibrillar forms of α-syn through ameliorated aggregation of β-amyloid polypeptide(1137).

4.3. In neuroprotective effects
Oxidative stress has shown to associate to brain damage due to its high consumption of oxygen.
Cinnamon polyphenols, during oxidative stress, exhibited neuroprotective effects in glial cells by reduced overexpression of the proinflammatory factors(1138) and enhanced prosurvival proteins protein levels (sirtuin 1, 2, and 3, deacetylases) associated to glioma cells survival(1139). Cinnamaldehyde, a major chemical found in cinnamon, inhibited uncontrolled activation of microglia contributing to neuroinflammation involved in the development of neurodegenerative diseases(1140). The herbal water extract, also exerted neuro protective effect against glutamate-induced neuronal death through the inhibition of Ca(2+) influx(1141).

Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine by Kyle J. Norton  

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References
(*) http://www.hindawi.com/journals/ecam/2012/692621/ 
(842) http://www.ncbi.nlm.nih.gov/pubmed/25313575
(843) http://www.ncbi.nlm.nih.gov/pubmed/24224039
(844) http://www.ncbi.nlm.nih.gov/pubmed/23391905
(1108) http://www.ncbi.nlm.nih.gov/pubmed/24358170
(1109) http://www.ncbi.nlm.nih.gov/pubmed/23475543
(1110) http://www.ncbi.nlm.nih.gov/pubmed/?term=cinnamon+anti-spasmodic
(1111) http://www.ncbi.nlm.nih.gov/pubmed/24885682
(1112) http://www.ncbi.nlm.nih.gov/pubmed/22760889
(1113) http://www.ncbi.nlm.nih.gov/pubmed/25392573
(1114) http://www.ncbi.nlm.nih.gov/pubmed/25051315
(1115) http://www.ncbi.nlm.nih.gov/pubmed/24337968
(1116) http://www.ncbi.nlm.nih.gov/pubmed/23868387
(1117) http://www.ncbi.nlm.nih.gov/pubmed/25268975
(1118) http://www.ncbi.nlm.nih.gov/pubmed/19969552
(1119) http://www.ncbi.nlm.nih.gov/pubmed/22512578
(1120) http://www.ncbi.nlm.nih.gov/pubmed/23607932
(1121) http://alternativehealing.org/gui_zhi.htm
(1122) http://www.ncbi.nlm.nih.gov/pubmed/23531502
(1123) http://www.ncbi.nlm.nih.gov/pubmed/21360003
(1124) http://www.ncbi.nlm.nih.gov/pubmed/23497886
(1125) http://www.ncbi.nlm.nih.gov/pubmed/25301673
(1126) http://www.ncbi.nlm.nih.gov/pubmed/21305046
(1127) http://www.ncbi.nlm.nih.gov/pubmed/20061605
(1128) http://www.ncbi.nlm.nih.gov/pubmed/15229712
(1129) http://www.ncbi.nlm.nih.gov/pubmed/24817901
(1130) http://www.ncbi.nlm.nih.gov/pubmed/20513336
(1131) http://www.ncbi.nlm.nih.gov/pubmed/19433898
(1132) http://www.ncbi.nlm.nih.gov/pubmed/21305046
(1133) http://www.ncbi.nlm.nih.gov/pubmed/24349472 
(1134) http://www.ncbi.nlm.nih.gov/pubmed/17480132 
(1135) http://www.ncbi.nlm.nih.gov/pubmed/24946862
(1136) http://www.ncbi.nlm.nih.gov/pubmed/25284437
(1137) http://www.ncbi.nlm.nih.gov/pubmed/22575665
(1138) http://www.ncbi.nlm.nih.gov/pubmed/24631135
(1139) http://www.ncbi.nlm.nih.gov/pubmed/24239092
(1140) http://www.ncbi.nlm.nih.gov/pubmed/23497886
(1141) http://www.ncbi.nlm.nih.gov/pubmed/10960905