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Thursday, 19 February 2015

(4th edited )Most common diseases of Elders- Diseases of Central Nervous system(CNS): TCM Herbal Polygonum multiflorum (He shou wu) treatments of Dementia Caused by Blood Stasis

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By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                      Diseases of Central Nervous system


                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Treatments
C. In traditional Chinese Medicine Perspective(*)

Based on Chinese ancient medical records. causes of dementia are the results of (*)
 C.4.1. Dementia due to Blood Stasis
According to Chinese medical literaure over 3000 years of history, blood Stasis may be caused by spleen qi deficiency, but in most cases, it is due to heart qi deficiency cause of inability in transport nutrients to the body organs and cells, including the brain. Prolong period of malnutrition of brain cells may induce abnormal function of brain's cells in information transmitting  or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842) and changes in brain tissues and behavior patterns(843)(842). Blood statsis induced by cold(1142), emotional disorder(1143), aging(1144), chronic illnesses and consumptive disease(1145), can overload the heart capacity, contributing to long-term hypertension(1146) due to decreased or impeded blood flow(1147) causes of hypo-perfusion in cerebral blood flow or acute focal stroke in memory-related cerebral parenchyma induced progression of cognitive decline(*).

2. Polygonum multiflorum (he shou wu)
He Shu Wu or Ye Jiao Teng or Shu Wu is also known as Fleece flower root or  Fo-ti.
a. The prepared herb is astringent with some sweetness, mildly warm
b. The raw herb is bitter, sweet and neutral
used in TCM to treatment of hyperlipemia(1173), neurasthenia(1174), split personality(1174), promoted hair grown(1175) and prevent hair loss(1176) due to aging, skin rash due to inflammation(1177), etc., as the herb tonifies and benefits  the essence and blood, expels toxins, moistens the intestines, etc. by enhancing the (The prepared herb) liver and kidney channels and (The raw herb) liver, heart and large intestine channels(1178).

Phytochemicals
1. Polygoacetophenoside
2. Chrysophanol
3. Emodin
4. Rhein
5. Emodin-6
6. Physcion
7. Chrysophanic acid
8. Anthrone
9. beta-sitosterol
10. 2,3,5,4′-tetrahydroxystibene-2O-b-D-glucoside
11. Quercetin-3-O-galactoside
12. Querctin-3-O-arabinoside
13. Lecithin
14. Etc.

1. In  Alzheimer's disease
Polygonum multiflorum extract, significantly improved AD patients with total effective rate of 93.33% in clinical trial, according to Third Xiangya Hospital(1179). In rat model, induced Alzheimer's disease by injecting Abeta 1-40, exhibited improvement of learning and memory ability, through expression of the fluidity of mitochondria membrane and the activity of mitochondrial COX(1180) and ameliorated hippocampal synapses count and synaptophysin expression(1181). In cognitive deficits induced by Abeta25-35, Polygonum multiflorum water extract, also significantly ameliorated the cognitive deficits, probably due to its antioxidant properties(1182).

2. In Parkinson disease
Strong evidences suggested that agricultural chemicals and environment toxins, such as dithiocarbamate fungicides, impacted dopamine systems has shown to associate to the development of Parkinson's disease,(1184)(1185). In nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice model, ethanol-soluble PME (PME-I) water extracts from Polygonum multiflorum, improved locomotor activity, motor incoordination, and declines of dopamine level, probably through phytochemicals, in the ethanol-soluble fraction(1183).

3. In neuroprotective effects
In focal cerebral ischemia mice, hexane extracts of Polygonum multiflorum, exhibited its neuroprotective effects though significantly decreased infarct size and improved neurological and motor function, (1186) and attenuated glutamate-induced neurotoxicity in a concentration-dependent manner and prevented apoptosis of cortical neurons(1187), in HT22 hippocampal cells(1188), probably through it antioxidant activity. According to Xuanwu Hospital of Capital Medical University, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) extract from Polygonum multiflorum, also improved mitochondrial function, decreased oxidative stress and inhibited apoptosis against induced cytotoxicity in human dopaminergic neuroblastoma SH-SY5Y cells(1188).

4. In learning and memory
 Dietary supplementation with either ethanol or water extracts of Polygonum multiflorum has shown to reduce brain pathological changes and promote learning and memory ability(1191)(1192). In male Sprague-Dawley rats, injected with beta amyloid (Aβ), tetrahydroxystilbene glucoside, an active chemical constituent of extract from  Polygonum multiflorum, significantly improved the learning and memory, through protecting synaptic structure and function(1189) and learning and/or memory ability of aged rats by increased Beta-secretase 1 (BACE1), a beta-site amyloid precursor protein cleaving enzyme 1 and  decreased ADAM10 (metallopeptidase domain 10), a protein associated to the development of Alzheimer's disease(1190).

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Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of Central Nervous system(CNS): Dementia caused by Blood Stasis - Treatments  in Traditional Chinese Herbal Medicine by Kyle J. Norton

References
(*) http://www.hindawi.com/journals/ecam/2012/692621/ 
(842) http://www.ncbi.nlm.nih.gov/pubmed/25313575
(843) http://www.ncbi.nlm.nih.gov/pubmed/24224039
(844) http://www.ncbi.nlm.nih.gov/pubmed/23391905
(1142) http://www.ncbi.nlm.nih.gov/pubmed/24288569 
(1143) http://www.classicalchinesemedicine.org/2010/03/blood-blood-stasis-and-blood-path-disorders/
(1144) http://www.goodreads.com/book/show/2250018.Aging_Blood_Stasis 
(1145) http://www.tcvm.com/NewsArticles/TabId/245/ArtMID/1382/ArticleID/97/A-Look-at-Blood-Stasis.aspx
(1147) http://www.ncbi.nlm.nih.gov/pubmed/23893237
(1173) http://www.ncbi.nlm.nih.gov/pubmed/17455469
(1174) http://www.ncbi.nlm.nih.gov/pubmed/?term=Polygonum+multiflorum+cognitive+degeneration
(1175) http://www.ncbi.nlm.nih.gov/pubmed/25612775
(1176) http://www.ncbi.nlm.nih.gov/pubmed/22803359
(1177) http://www.ncbi.nlm.nih.gov/pubmed/?term=Polygonum+multiflorum+skin+rash
(1178) http://alternativehealing.org/he_shou_wu.htm
(1179) http://www.ncbi.nlm.nih.gov/pubmed/20622335
(1180) http://www.ncbi.nlm.nih.gov/pubmed/19060365
(1181) http://www.ncbi.nlm.nih.gov/pubmed/17935895
(1182) http://www.ncbi.nlm.nih.gov/pubmed/16219438
(1183) http://www.ncbi.nlm.nih.gov/pubmed/?term=Polygonum+multiflorum+Parkinson+disease
(1184) http://www.ncbi.nlm.nih.gov/pubmed/11124998
(1185) http://www.ncbi.nlm.nih.gov/pubmed/19729209
(1186) http://www.ncbi.nlm.nih.gov/pubmed/24534954
(1187) http://www.ncbi.nlm.nih.gov/pubmed/23164763
(1188) http://www.ncbi.nlm.nih.gov/pubmed/21497157
(1189) http://www.ncbi.nlm.nih.gov/pubmed/23181273
(1190) http://www.ncbi.nlm.nih.gov/pubmed/22032649
(1191) http://www.ncbi.nlm.nih.gov/pubmed/12775116
(1192) http://www.ncbi.nlm.nih.gov/pubmed/12856856