(4th edited)Most common diseases of Elders- Diseases of Central Nervous system(CNS): TCM herbal Du Zhong(Eucommia bark) treatments of Dementia Caused by Kidney Jing Depletion

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                      Diseases of Central Nervous system


                           Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
C. In traditional Chinese Medicine Perspective(*)
Based on Chinese ancient medical records. causes of dementia are the results of (*)
C.5.  According to TCM philosophy, dementia is also to be induced by the combination/or of Kidney essence vacuity and toxin (turbid phlegm).
C.5.2. Dementia due to aging depletion of Kidney Essence
Aging related to gradual lost of kidney essence effects the bone and bone marrow in production of red blood cells causes of nutrient and oxygen deficiency in the brain in induction of symptoms of dementia(1311)(1312).

3. Du Zhong(Eucommia bark)
Du Zhong, the sweet, slightly acrid, and warm, is also known as eucommia bark, used in traditional Chinese medicine as anti stress(1325)(1326), anti diuretic(1336), anti inflammatory(1327)(1328), anti infectious(1329), sedative and anesthesia and anti-aging(1336) agents and to treat hypertension(1330)(1331), chronic pain in lower back and knees(1332)(1336), lack of strength, dizziness, impotence(1337), irregular menses and frequent urination(1336) and protect against unstable pregnancy(1336),.... by enhancing the functions of liver and kidney channels(1333).


Phytochemicals
1. Eucommiol 
2. Eucommioside 
3. Eucommioside-I
4. Cpmoferom
5. Dehydrodiconife4ryl alcohol-4
6. Gamma'-di-O0betta-D-glucopyranoside
7. Liriodendrin
8. (+) -syringaresinol-di-O-Beta-D-glucopyranoside
9. (+)-syringa resinol  O-Beta-D-glucopyranoside
10. (+)-syringaresinol monoglucoside
11. syringin
12. Etc.

1. In learning and memory
In scopolamine-induced learning and memory impairments, and a single intracerebroventricular (i.c.v.) injection of Aβ(25-35) mice models, oral administration of aqueous extract of Eucommia bark or the whole  herb significantly reversed learning and memory deficits, through  inhibition of acetylcholinesterase (AChE)(1335) and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus and frontal cortex in a dose-dependent manner(1334)(1335).

2. In Alzheimer's disease (AD)
In hydrogen peroxide (H(2)O(2))-induced neuronal cell death in human SH-SY5Y neuroblastoma cells, eucommia ulmoides Oliv. Bark. (EUE), increased cell viability and inhibited cytotoxicity and DNA condensation, through attenuated the increase in ROS production and MMP involved increased risk of dementia reduction(1337).

3. In neuroprotective effects
In PC-12 cells injury mediated by Aβ(25-35) eucommia ulmoides Oliv. (EUO) bark and leaf's phytochemicals, geniposidic acid and chlorogenic acid, significantly protect PC-12 cells against the cytotoxicity(1338). In amyloid beta(25-35) (Aβ(25-35))-induced learning and memory impairments mice
model, the herb laso exhibited neuroprotective effects through inhibition of acetylcholinesterase (AChE) activity in the hippocampus and frontal cortex(1235).


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Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of Central Nervous system(CNS): Dementia -  Herbal Du Zhong(Eucommia bark)
Treatments in Traditional Chinese Herbal Medicine by Kyle J. Norton.

References
(1311) https://books.google.ca/books?id=oea9BQAAQBAJ&pg=PA70&lpg=PA70&dq=Kidney+Essence+and+aging+dementia&source=bl&ots=tOfAsR-Vrk&sig=hvLIdsWGFNBy2hDoeuB5YvIPQlU&hl=en&sa=X&ei=QcjsVKSiKoeeyASu4oHACg&ved=0CCgQ6AEwAQ#v=onepage&q=Kidney%20Essence%20and%20aging%20dementia&f=false
(1312) https://books.google.ca/books?id=bL4X1HiasqEC&pg=PA292&lpg=PA292&dq=Kidney+Essence+and+dementia+symptoms&source=bl&ots=zWx7MfG8r2&sig=5RFsTGmdj_6T3gJNWe0iHD5ww0Y&hl=en&sa=X&ei=tsnsVK6UMoekyASFhoDoBg&ved=0CFgQ6AEwBw#v=onepage&q=Kidney%20Essence%20and%20dementia%20symptoms&f=false
(1325) http://www.ncbi.nlm.nih.gov/pubmed/24440915
(1326) http://www.ncbi.nlm.nih.gov/pubmed/11749801
(1327) http://www.ncbi.nlm.nih.gov/pubmed/19735174
(1328) http://www.ncbi.nlm.nih.gov/pubmed/25575468
(1329) http://www.ncbi.nlm.nih.gov/pubmed/?term=Eucommia+bark+anti+infection
(1330) http://www.ncbi.nlm.nih.gov/pubmed/22214253
(1331) http://www.ncbi.nlm.nih.gov/pubmed/20347950
(1332) http://www.ncbi.nlm.nih.gov/pubmed/?term=Eucommia+bark++pain
(1333) (1317) http://alternativehealing.org/du_zhong.htm
(1334) http://www.ncbi.nlm.nih.gov/pubmed/24404337
(1335) http://www.ncbi.nlm.nih.gov/pubmed/20974223
(1336) http://www.ncbi.nlm.nih.gov/pubmed/22735663
(1337) http://www.ncbi.nlm.nih.gov/pubmed/24296089
(1338) http://www.ncbi.nlm.nih.gov/pubmed/21784025