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Friday, 27 February 2015

(4th edited)Most common diseases of Elders- Diseases of Central Nervous system(CNS): TCM herbal Shi Hu(Dendrobium) treatments of Dementia Caused by Kidney Jing Depletion

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                      Diseases of Central Nervous system


                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
C. In traditional Chinese Medicine Perspective(*)

Based on Chinese ancient medical records. causes of dementia are the results of (*)
C.5.  According to TCM philosophy, dementia is also to be induced by the combination/or of Kidney essence vacuity and toxin (turbid phlegm).
C.5.2. Dementia due to aging depletion of Kidney Essence
Aging related to gradual lost of kidney essence effects the bone and bone marrow in production of red blood cells causes of nutrient and oxygen deficiency in the brain in induction of symptoms of dementia(1311)(1312).
2.  Shi Hu(Dendrobium)
The sweet, bland, slightly cold herb, is also known as Dendrobiu, used in traditional Chinese medicine as anti diabetic(1315)(1316), anti-hyperglycemic((1317)(1318))and anti microbial(1319)(1320) agents caused by yin deficiency and to treat thirsty(1315)(1316), thromboangitis obliterans, chronic throat infection, blurry vision(1321)(1322), weak lower back,... by enhancing the lung, stomach channels(1323).

Phytochemicals
1. Ophiopogonin 
2. Ruscogenin 
3. β-sitosterol β
4. Stigmasterol 
5. Dendrobine 
6. Nobilonine 
7. 6-hydroxydendrobine 
8. Etc.

According to Zunyi Medical College,  alkaloids enriched extract from Dendrobium Nobile Lindl. (EDNLA), showed to inhibit paired helical filaments of  hyperphosphorylation of tau protein,  in neurofibrillary tangles, a pathological feature of Alzheimer's disease (AD)(1324). In rat model administrated intragastrically with different doses of DNLA (20, 40 mg/kg), attenuated lipopolysaccharide (LPS, 100 μg) injecting into the bilateral ventricle, induced hyperphosphorylation of tau protein in hippocampus and protected against LPS-induced apoptosis in brain(1325).

References
(1311) https://books.google.ca/books?id=oea9BQAAQBAJ&pg=PA70&lpg=PA70&dq=Kidney+Essence+and+aging+dementia&source=bl&ots=tOfAsR-Vrk&sig=hvLIdsWGFNBy2hDoeuB5YvIPQlU&hl=en&sa=X&ei=QcjsVKSiKoeeyASu4oHACg&ved=0CCgQ6AEwAQ#v=onepage&q=Kidney%20Essence%20and%20aging%20dementia&f=false
(1312) https://books.google.ca/books?id=bL4X1HiasqEC&pg=PA292&lpg=PA292&dq=Kidney+Essence+and+dementia+symptoms&source=bl&ots=zWx7MfG8r2&sig=5RFsTGmdj_6T3gJNWe0iHD5ww0Y&hl=en&sa=X&ei=tsnsVK6UMoekyASFhoDoBg&ved=0CFgQ6AEwBw#v=onepage&q=Kidney%20Essence%20and%20dementia%20symptoms&f=false
 (1315) http://www.ncbi.nlm.nih.gov/pubmed/25685822
(1316) http://www.ncbi.nlm.nih.gov/pubmed/24846859
(1317) http://www.ncbi.nlm.nih.gov/pubmed/15719686
(1318) http://www.ncbi.nlm.nih.gov/pubmed/18831216
(1319) http://www.ncbi.nlm.nih.gov/pubmed/22715718
(1320) http://www.ncbi.nlm.nih.gov/pubmed/21181405
(1321) http://www.ncbi.nlm.nih.gov/pubmed/23847958
(1322) http://www.ncbi.nlm.nih.gov/pubmed/19852302
(1323) http://alternativehealing.org/shi_hu.htm
(1324) http://www.ncbi.nlm.nih.gov/pubmed/?term=Dendrobium+and+Alzheimer's+disease