Endometriosis: The Effects of Chinese herb Chaste tree(revised edition with references)

By Kyle J. Norton  Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

Chaste tree used to treat hormone imbalance associated with pre-menstrual syndrome In Europe is a large shrub native to the Mediterranean and southern Europe.
The effects
1. Immune system
Chaste tree contains irioid glycoside (1), a plant element that helps to increase the secondary metabolism which strengthens our immune system to fight inflammation(3), abnormal cell growth(1), and the invasion of virus(1).

 2.  Nervous system(2)
Irioids also helps to release the tension of overactive cells in the brain during menstrual cycle resulting in lowering the symptoms of endometriosis such as depression, anxiety, craving, etc.(4).

 3. Isoflavones
Some women with endometriosis may experience heavy flow during menstruation caused by the breaking off of the small vein in the abdomen. Isoflavones in the chaste tree berry helps to strengthen the capillary wall, thus reducing the flow and the tension of overactive uterine muscles(5) that cause menstrual pain(5).

 4. Hormone balancing(6)
Chaste tree berry contains high levels of plant progesterone which is necessary for women with endometriosis to balance the levels of estrogen(6)(7) that cause menstrual cramps(8).

 5. Absence of period
Since absence of period may be caused by high levels of hyperprolactinaemia(10), affecting the function of ovaries in ovulation. Chaste tree reduces levels of prolactinaemia, which is necessary  to bring on the menstruation(9).
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References
(1) Iridoid glycoside from the leaves of Clerodendrum volubile beauv. shows potent antioxidant activity against oxidative stress in rat brain and hepatic tissues by Erukainure OL¹, Ebuehi OA, Choudhary IM, Adhikari A, Hafizur RM, Perveen S, Muhammad A, Elemo GN.(PubMed)
(2) [Effects of cornel iridoid glycoside on activity of cholinesterases in vitro].[Article in Chinese] By Chu SJ¹, Zhang L, Liu G, Zhou WX, Li L.(PubMed)
(3) Anti-inflammatory activity of iridoids and verbascoside isolated from Castilleja tenuiflora by Carrillo-Ocampo D¹, Bazaldúa-Gómez S, Bonilla-Barbosa JR, Aburto-Amar R, Rodríguez-López V.(PubMed)
(4) Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus by Loch EG¹, Selle H, Boblitz N.(PubMed)
(5) Associations of menstrual pain with intakes of soy, fat and dietary fiber in Japanese women by Nagata C¹, Hirokawa K, Shimizu N, Shimizu H.(PubMed)
(6) Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review by Laakmann E¹, Grajecki D, Doege K, zu Eulenburg C, Buhling KJ.(PubMed)
(7) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry) by Liu J¹, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR.(PubMed)
(8) Complementary and alternative medicine (CAM) in reproductive-age women: a review of randomized controlled trials by Fugh-Berman A¹, Kronenberg F.(PubMed)
(9) Evaluation and management of adolescent amenorrhea byDeligeoroglou E¹, Athanasopoulos N, Tsimaris P, Dimopoulos KD, Vrachnis N, Creatsas G.(PubMed)
(10) Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials by van Die MD¹, Burger HG, Teede HJ, Bone KM.(PubMed)