Monday, 11 August 2014

Vitamin A, Dehydroascorbic acid (DHA) and Vitamin E Rejuvenated Aging Forearms of Subjects Age of 57 - 62

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, The Alan Hopkinson Daily, etc,.
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal pharma and Bio science, ISSN 0975-6299. 
All right reserved

Who doesn't want to have  5, 10,15 or 20 years younger skins in comparison to people with the same age group.

The dream of finding the ingredients in maintaining and getting rid of aging skin has been ongoing since human civilization. Unfortunately, many ingredients with no commercial values have been discarded due to their effects in dampening the profits of all cosmetic companies.

In the 12 weeks of the study of 120 healthy subjects, the combinations of DHA and vitamin A, and E showed to rejuvenated forearms skin up to 90% if compared to the base line.

Mom and Pop, including people who like to dress with their arms exposed may delight to find out that scientists have discovered ingredients which have the potential in reduced visibility of the arteries in the back of the hand and getting rid of chapping skin, wrinkly, crinkly crepe-like skin texture due to the result of  little fat on the backs of the hands when even a small amount of collagen or elastin fibers begins to break down, of the forearms and the aging forehead and nosy find lines.

 Chapping of skin may be only simply the formation of fissures or cracks in the skin due to a combination of particularly dry and scaly skin and exposure to cold or wind but the loss of collagen due to progression of aging on the elder, may intensify over all appearance of the back of hand. moister cream may be helpful and can not delay the aging process.

Fine line is a result of effect of gravity in aging, and causes of slower process in cell rejuvenation and longer in elastic fibers replacement. Some researchers insisted that adding to the aging skin, free radicals and inflammatory molecules may degrade facial skin even quicker.

Vitamin A is a general term of Vitamin A Retinol, retinal, beta-carotene, alpha-carotene, gamma-carotene, and beta-cryptoxanthin best known for its functions for vision health and antioxidant scavenger and essential for growth and differentiation of a number of cells and tissues.

1. Retinols
Activation of both all-trans retinoic acid and 9-cis retinoic acid in nuclear retinoic acid receptors reduction of skin aging(1)and  significantly increased type I procollagen and reduced collagenase (matrix metalloproteinases-1, MMP-1)and suppressed recombinant human CCN1(3).
P-Dodecylaminophenol derived from the synthetic retinoid, in the skin of hairless mice study, exhibited the increased cytokeratin 16 expression which is essential in skin healing and maintenance, without causing the desquamation and erythema(4). Topical application of a ROL-containing product not only improved all major aging signs including wrinkles under the eyes, fine lines and tone evenness, but also promoted keratinocyte proliferation, induced epidermal thickening and alleviated skin aging signs, without any significant adverse reaction(5). Some researchers suggested that topical retinol improves fine wrinkles associated with natural aging, through its effects in induction of glycosaminoglycan, increased collagen production are most likely responsible for wrinkle effacement. Retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved appearance(7), including improving lines and wrinkles, pigmentation, elasticity, firmness and overall photodamage(8), disappearance of the wrinkles caused by UVB irradiation probably via RAR transactivation activity, but the synthetic agonist showed no adverse effect in causing skin irritation(9).

2. Carotenoids(beta-carotene, alpha-carotene, gamma-carotene and beta-cryptoxanthin) and Retinal
 Carotenoids, plant pigments, converted to vitamin A after intake, though to play an important role in prevention and treatment of some diseases through it antioxidant effects.
Nutrition rich in carotenoids is best known to prevent cell damage, premature skin aging, and skin cancer(10) and widely used in the skin care industry either as topically applied agents or oral supplements in an attempt to prolong youthful skin appearance(11)(12). Administration of carotenoids may interact with free radicals to enhance the protection system against that destructive(13).
The testing of high doses of sun-emitted UV-radiation induce reactive oxygen species (ROS),  Carotenoid-tablets combined with placebo-cream in induced less carotenoid accumulation than carotenoid-tablets alone(15). In fact, deficiency of vitamin A may result of induced premature aging. In skin of streptozotocin (STZ)-induced type 1 diabetic rats, showed over expression of matrix metalloproteinase -2 (MMP-2) and hyaluronidase (HAase) but not on vitamin A treated mice, through promoting the production of collagen in dermis and inducing cell growth and inhibition of epidermal differentiation in skin tissues(17).

Dehydroascorbic Acid (DHA) (vitamin C supplement oxidized form)
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin found in fresh fruits, berries and green vegetables. It is best known for its free radical scavenging activity and regenerating oxidized vitamin E for immune system support. In skin aging, the vitamin may improve solar radiation protection and epidermal aging (1) through production of collagen due to its antioxidant activity (2)(3).
Epidemiological studies linking vitamin C in prevention of skin damage and aging have produced some certain results (3a)(3b)(3c). Vitamin C oxidized form or dehydroascorbic acid (DHA) processed antiviral and virucidal effects (23), prevented H2O2-induced cell death by increasing the GSH levels mediated by the GPx and GR activities and PPP (17), and regulated neuronal energy metabolism, through facilitating the utilization of glucose via the PPP for antioxidant purposes (18) by increasing antioxidant potential in the central nervous system (19). Dehydroascorbic acid (DHA) may be a potential anti-cancer agent to treat aggressive cancers (20)(21). Dr. Toohey at the Cytoregulation Research said "rapidly-dividing tumour cells make unusually large amounts of homocysteine thiolactone and that administered dehydroascorbic acid enters the cells and converts the thiolactone to mercaptopropionaldehyde which kills the cancer cells" (22).

According to the Minghsin University of Science and Technology, in doses of a dependent manner, the concentration of L-ascorbic acid induced absorption of the collagen solution in exhibition of smoothing wrinkles and clear up spots(8). Ascorbic acid (AA) is essential in stimulating collagen gene expression. In type 1 and type 4 collagen and SVCT2, the vitamin was found to enhance the expression of type 1 and type 4 collagens and SVCT2 mRNA in cultured human skin fibroblasts at 100 μM AA placed every 24h for 5 days to prevent depletion(9). The Chiang Mai University study also supported the effects of ascorbic acid in the anti-aging process through exhibition pro and active MMP-2 inhibitory(10). Combined vitamins, including vitamin C in a single formulation had a slightly lower degradation rate and more stable formulations as compared to different preparations containing only one of the vitamins(11)(12). Application of vitamin C showed a significant reduction of oxidative stress in the skin, an improvement of the epidermal-dermal microstructure and a reduction of fine lines and wrinkles in aged skin within a relatively short period of time of product application(13). The Bruce and Associates study also insisted the effectiveness of vitamin C application over a 12 week period as the vitamin enhanced the overall intensity of pigmentation, fine lines and wrinkles, tactile roughness, and laxity with a 100% satisfaction of overall appearance of the tested subjects’ skin(14).
In fact, many studies have showed that vitamin C, the un oxidized form improved skin roughness and scaliness(26)(27), wrinkles(28)(29), skin elasticity and firming(30)(31)(32)(33)(34)(35), lightened Liver and aging spots(36)(37)(38)(39)(40)(41), Pigmentation(42)(43)(44), reduced Acne and Acne scars(45)(46).

 Vitamin E
 Vitamin E is a fat soluble vitamin consisting of eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrieno with varying levels of biological activity, found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower, safflower oils, etc.) which plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc.

Epidemiological studies linking vitamin E in reduced progression of aging have been inconclusive (47)(48)(49)(50), but some studies showed that vitamin delays cellular senescence of human diploid fibroblasts through the inhibition of intrinsic mitochondria-mediated pathway which involved the regulation of pro- and anti-apoptotic genes and proteins (51) and prevents cellular aging in human diploid fibroblasts (52), protects against oxidative stress-induced cellular ageing by modulating the telomere length possibly via telomerase(54), protects against H(2)O(2)-induced oxidative stress (55). and induced DNA damage and telomere shortening of normal human skin fibroblast cells derived from young and old individual donors(56), UVA(57).  In a study of Indian women with signs of facial aging, the composition of niacinamide, panthenol, and tocopheryl acetate significantly reduced the appearance of hyperpigmentation, improved skin tone evenness, and lightened the appearance of the skin in comparison to the control through 6 weeks(60).

Conducting a study is a very complicated business. Once ingredients were found, our researchers had to go through a lengthy searching for related studies, which had been published on PubMed data bases. Hundreds if not thousands of previous studies had been read with only hundreds selected to be used as references to out study, as you can see below.
The next step was to recruit some of our permanent-tested subjects. Only a few were chosen to ensure the efficacy of the ingredients or combination of ingredients (Save money). Only ingredients with efficacy up to our standard will be retested with large example size.  In this case, 12 healthy subjects were tested for 4 weeks as follow
Group 1 (2 subject, 1 mild, 1 severe)  to test for efficacy of Dehydroascorbic acid (DHA)
Group 2 (2 subject, 1 mild, 1 severe)   to test for efficacy of  Vitamin A
Group 3 (2 subject, 1 mild, 1 severe)  to test for efficacy of  Vitamin E
Group 4 (2 subject, 1 mild, 1 severe)   to test for efficacy of Combination of Dehydroascorbic acid (DHA) and vitamin A
Group 5 (2 subject, 1 mild, 1 severe)   to test for efficacy of combination Dehydroascorbic acid (DHA)  and vitamin E
Group 6 (2 subject, 1 mild, 1 severe)  to test for efficacy of Dehydroascorbic acid (DHA) and vitamin A and E.

Only group 4 - 6 had showed some good progresses, according to our standard. The combination of ingredients therefore were used for 12 weeks study with a sample of 120 healthy subjects. The recruiting of subjects between ages of 57 - 62 had been difficult due to 60% of general population are either over weight or obese.
Kyle J. Norton, the leader of the research team said " Anti aging products can not bring back the youthful skin at age of 20 or 30, its can only rejuvenate your skin to induced 5, 10, 15 or 20 years younger than people with the same age group who do not use any anti aging products"

The study had produced some astonished results as the combination of DHA, Vitamin A and E had showed to rejuvenate the forearms of tested subject as follow
1. Palm: 95%
2. Finger: 80%
3, Knuckles: 75%
4. Wrist: 75%
5. Back of the hand: 75%
6 From elbow to wrist: 85%
7. Reduced visibility of arterial vein: 70%
8. Improved 90% of firming, smoothness, elasticity

We believe,  this is the first time that the combination has been showed effectively in rejuvenation of forearms of aging subject between ages of 57 - 62.
The study also showed you
1. How to apply the combination of DHA, vitamin A and E for optimal result,
2. Why and how only the combination works but not individual ingredient,
3. How you can make DHA and types of vitamin A and E which you can purchase.
4. The Quantity and quality of amount usage.
5. What you can expect in 4, 8 and 12 weeks.

The pictures below were the forearms of a 58+ years tested subject after 12 weeks of applied Vitamin A, Dehydroascorbic acid (DHA) and Vitamin E. We would like to publish more of the results of tested subject pictures. Unfortunately, due to confidential agreement, we can not use the pictures for commercial profits without written permission of the pictured owners.
1. Against the wall

2. On the table

The efficacy of the combined solutions of in Group B and C showed comparable effectively in improvement of the forearms of aging subjects from ages of 57 - 62 probably through DHA detoxified, vitamin A improved skin texture and vitamin E moisturized activity via antioxidants and  cell cycle division pathways. Logically, long term applications of the  combined solutions in group B and C may continue in rejuvenated forearms skin but further study with a large group is necessary to rule out any adverse effects and validate the claims.
For limit time only, you can get this study with one time payment of only $3. We want everyone in the twitter world to have it, before putting the study on sale on GRIN with a normal price of $39.99. We guarantee, if you do not satisfy for what ever reason, we will gladly return your payment with NO question ask. The password to the download page is z5lp
Logically, It can be assumed that application of ingredients should produce more superior in the younger and lesser results in older age group in comparison to the tested subject age between 57 - 62.

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