Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
There are many causes of heart disease. Most heart diseases are caused by high blood pressure contributes to the hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of an uncontrolled diet with high levels of saturated fat and trans fat. Besides cancer, heart disease kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease.
Epidemiologic studies link the intake of garlic in association with reduced risk as well as the progression of cardiovascular disease(1).
According to the Institute of Preventive and Clinical Medicine, polysulfides from garlic are converted into hydrogen sulfide which has the unique property of relaxing vascular smooth muscle, inducing vasodilation of blood vessels, and significantly reducing blood pressure(2), probably through its anti-apoptotic, anti-inflammatory and antioxidant effects(3).
The Semmelweis University Institute of Human Physiology and Clinical Experimental Research suggested that H2S as a novel gasotransmitter in the central nervous and cardiovascular systems, similar to nitric oxide (NO) and carbon monoxide (CO), may be of value in cytoprotection during the evolution of myocardial infarction(4).
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References
(1) Garlic and cardiovascular disease: a critical review by Rahman K1, Lowe GM. (PubMed)
(2) Garlic (Allium sativum L.) and cardiovascular diseases by Ginter E1, Simko V.(PubMed)
(3) Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential by Lavu M1, Bhushan S, Lefer DJ.(PubMed)(4) The cardioprotective potential of hydrogen sulfide in myocardial ischemia/reperfusion injury (review) by Dongó E1, Hornyák I, Benko Z, Kiss L.(PubMed)
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