#Herbal #Arctostaphylos uva-ursi's Water extract (UW-ext) Processes a Strong Antiinflammatory Activity, Researchers Suggest

Kyle J. Norton

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe. The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc. Inflammation is a condition of the Immune system's self-protection to remove harmful stimuli, including damaged cells, irritants, and pathogens... from our body.

The Ingredients It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.


Water extract (UW-ext) collected from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf), is found to exhibit anti-inflammatory effects in ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema. arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng., when combined with indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis, found to be effective as arbutin may increase the inhibitory action of indomethacin on PC-CD, SRBC-DTH, carrageenin-induced edema, and adjuvant-induced arthritis, but further investigations are required to understand the mechanism involved. Other studies also indicated that 50% methanolic extract (U-ext), containing arbutin, possesses a therapeutic effect against immuno-inflammation induced by picryl chloride (PC-CD) and also increases the inhibitory effect of prednisolone.



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References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)