Kyle J. Norton
Gastric or stomach ulcer is a condition of localized tissue erosion in the lining of the stomach.
The most common symptoms of gastric ulcers are abdominal pain, bloating, septic shock, dyspepsia, and blood in the stool due to bleeding, unintended weight loss, loss of appetite, and gastrointestinal discomforts.
Some patients may also experience symptoms of mood disorder, leading to reduced quality of life in many patients.
The imbalance between stomach acid and upper GI tract mucosa is the main cause of the condition onset associated with the use of certain medications, including aspirin, non-steroidal anti-inflammatory drugs, Helicobacter pylori infection, and chronic gastritis.
Epidemiologically, periodontal disease, aging, smoking, long-term use of mechanical ventilation and critical illness are at an increased risk of gastric ulcer.
According to studies gastric ulcers can be preventable, you can protect yourself against the risk of gastric ulcers by
1. Adding dietary phytosterols and phospholipids
Experiments using animal peptic ulcer models showed that the lipid fraction in foods from the staple diets of low prevalence areas gave protection against both gastric and duodenal ulceration, including ulceration due to non-steroidal anti-inflammatory drugs (NSAIDs), and also promoted healing of ulceration.
2. Reducing intake of NSAID
NSAID has been proven to cause gastric Ulcer(9), by inhibiting the body’s production of prostaglandins, hormones that protect the stomach lining.
3. Quitting smoking
Cigarette smoking increases xanthine oxidase activity, leukotrienes, nitric oxide production, and neutrophil infiltration in the gastric mucosa(13).
4. Not missing your dental appointment
The study showed that a significantly higher proportion of subjects with peptic ulcer reported that they lost five or more teeth (35.3 vs. 17.4%, p<0.001) or that they were told they had periodontitis (33.5 vs. 20.7%, p<0.001)(8).
5. Reducing stress
Stress has been found to increase the onset of gastric ulcers in people who suffered from the Great East Japan earthquake and tsunami. The incidence of all types of peptic ulcers was 1.5-fold increased after the earthquake.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural compound for the treatment of gastric ulcers, researchers examined the intact (TrPP) and modified, and low-molecular-weight (MTrPP) forms of pectic polysaccharides isolated from turmeric against a gastric ulcer in vitro and in vivo models.
Compared to TrPP, MTrPP possessed a significantly better ulcer-preventive property by inhibiting ulcer scores up to 85%.
More precisely, MTrPP exerted an effective muco-protection, inhibited the expression of H(+), K(+)-ATPase in the ulcer forming and of H. pylori growth/adherence, and higher antioxidant/cytoprotective mechanisms associated with the gastric lesion.
By comparing the chemical contents in TrPP, and MTrPP, researchers suggested that the efficacy of MTrPP in the protection against the formation of gastric ulcer may be attributed to the levels of galacturonic acid (687mg/g; TrPP-544mg/g) and galactose (52.9%; TrPP-21.7%) in the inhibition of inflammation.
In other words, the low molecular weight of MTrPP (155kDa; TrPP-13kDa) possesses higher antiulcer potential compared to that of TrPP.
In order to reveal more information about turmeric anti-gastric ulcer activity, researchers evaluated the effect of C. Angustifolia and M. arundinacea on forced swimming-induced hypothermia and gastric ulceration in rats.
According to the observation of 72 hours periodically and mortality recorded up to seven days, the application of both drugs did not produce any toxic symptoms or mortality even up to the maximum dose level of 4400 mg/kg.
Both the test drugs showed a significantly reversed stress-induced gastric ulceration compared to stress-control rats.
Taken together, curcumin used in the intact (TrPP) and modified, and low-molecular-weight (MTrPP) forms may be considered a remedy for the prevention and treatment of gastric ulcers, pending large sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Modified pectic polysaccharide from turmeric (Curcuma longa): A potent dietary component against gastric ulcer by Harsha MR1, Chandra Prakash SV1, Dharmesh SM. (PubMed)
(2) Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of by Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.).
Rajashekhara N1, Ashok BK2, Sharma PP3, Ravishankar B. (PubMed)
(3) Gastric Ulcers: Preventions – The do and do not’s list by Kyle J. Norton
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