Phytochemical allicin isolated from garlic may be used for the prevention and treatment of osteosarcoma with no side effects, some scientists suggested.
Osteosarcoma is a bone cancer found mostly in teenagers and people over age 60.
Most cases of osteosarcoma are associated with genetic syndromes. In other words, the disease is the result of the conditions associated with inherited mutated genes from the parent.
However, an unhealthy lifestyle such as body weight, physical activity, diet, tobacco, gender, age, height, ethnicity, and exposure to bone radiation also play a major role in many adult cancers.
According to the statistics, in the US, osteosarcoma is rare and approximately 900 new cases of osteosarcoma are reported each year. and children and teens younger than 20 account for half of the numbers.
Dr. James J. Morrow, the lead scientist in the study of the genetic risk of osteosarcoma wrote, "Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life"
And, " Increased risk of osteosarcoma is associated with a number of well-defined genetic syndromes: hereditary retinoblastoma (germline mutation of the Rb gene), Li-Fraumeni syndrome (germline mutation of the p53 gene), Bloom syndrome (germline mutation of the RECQL2 gene), Werner syndrome (germline mutation of the RECQL3 gene), and Rothmund-Thomson syndrome (germline mutation of the RECQL4 gene)"
These results strongly suggested that young teenagers with genetic syndrome are more likely to be infected by the disease, compared to others.
Allicin is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.
With an aim to find a natural ingredient for the treatment of osteosarcoma with no side effects, researchers at the Wenling City Chinese Medicine Hospital looked into the anti-osteosarcoma activity of the main biologically active compound derived from garlic.
The combined treatment significantly suppressed the invasion, motility, and colony formation ability and activated the protein associated with a pro-apoptotic activity, compared to the lone treatment group.
Furthermore, in vivo. artesunate and allicin also inhibited tumor growth and cell proliferation
Dr.Jiang W, the lead scientist said, "Artesunate and allicin in combination exert synergistic effects on osteosarcoma cell proliferation and apoptosis".
Moreover, in examining the effects of diallyl sulfide (DAS) derived from allicin in vitro and in vivo on the proliferation of human osteosarcoma MG-63 cells, researchers found that in vivo, the nude mice MG-63 cells tumor-bearing model after twenty-one days of treatment with DAS inhibit proliferation of MG-63 cells in a time- and concentration-dependent manner.
DSA groups (different concentrations) showed significantly reduced expression levels of VEGF mRNA, associated with stimulating the formation of blood vessels. compared with those in the control group.
At the dose of 20 and 40 μg/mL, cell migration was significantly lower in the DAS groups (91.4±8.3 and 81.8±7.4, respectively) compared to the control group (150.4±14.7, both).
Also at the dose of 20 and 40 μg/mL, DAS also decreased the microvessel density (MVD) of MG-63 tumor-bearing tissue.
Taken together, phytochemical allicin may be considered a bioactive compound for the prevention and combined with the primary therapy for the treatment of osteosarcoma.
However, intake of allicin as a form of supplement should be taken with extreme care to prevent overdose toxicity
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
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Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo by Jiang W, Huang Y, Wang JP, Yu XY, Zhang LY.(PubMed)
(2) Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells by Hu Y, Chen L, Yi C, Yang F, Chen J.(PubMed)(3) Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies by James J. Morrowa and Chand Khannab. (PMC)
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