Kyle J. Norton
Scientists may have found a pungent spice that processes the potential for the prevention and treatment of prostate cancer, some studies suggested.
Prostate cancer is a chronic condition caused by the cell growth irregularly and disorderly in the prostate tissue due to the alternation of DNA.
Prostate cancer is a slow-growth of cancer and can be detected during an annual rectum exam.
At the early stage, prostate cancer cell which has grown on the surface of the inner lining of the prostate does not cause any symptoms due to the very small size of the tumor.
However, at the later stage, the large tumor size may suppress the nearby blood vessels and nerve cells, leading to internal bleeding and severe pain. Also, cancer cells may also travel a distance away from the stomach to infect other healthy tissue and organs, leading to a secondary metastasis.
Common sites metastases of prostate cancer are bone, lymph nodes, lung, and liver.
Researchers do not know the exact causes of prostate cancer. However, they do know the increase in age, family and personal history, ethnicity, genetic preposition, a poor diet, and being overweight or obese are some of the prevalent risk factors of prostate cancer.
According to the Canadian Cancer Society, in 2017, 21,300 men were diagnosed with prostate cancer, represented 21% of all new cancer cases and 4,100 men died from prostate cancer, and 10% of all cancer deaths.
The 5 years survival rate of localized prostate cancer is 100% and 98% of survivors are alive after 10 years compared to the advanced stage of only 31%.
Some researchers concerned the widespread prostate cancer in North America, northwestern Europe, Australia, and on Caribbean islands compared to Asia, Africa, Central America, and South America, said, "One of the most striking characteristics of prostate cancer is the degree of geographic variation in its patterns of occurrence and progression; this variation is apparent at local, national, and international levels".
And "the known factors influencing the biology and epidemiology of prostate cancer and some of the ways in which findings to date have benefited from geography".
The results strongly indicated there must be something happened in the Western world that does not found in the East and Africa, Central America, and South America.
Some researchers suggested it may be the Western diet.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the concern of prostate cancer risk in men in the Western world and its related mortality and morbidity, researchers in the cancer team at the The University of Texas at Austin examined the anti-prostate cancer effect of 6-Shogaol (6-SHO), a potent bioactive compound in ginger (Zingiber officinale Roscoe).
Injection of the bioactive compound effectively reduced survival and induced apoptosis of cultured human (LNCaP, DU145, and PC3) and mouse (HMVP2) prostate cancer cells.
6-SHO reduced the expression of pro-inflammatory cytokines in the activation of the proteins involved in cell proliferation and the capacity for metastasis.
Furthermore, 6-SHO also inhibited the expression of cytokines in the stimulation of proteins and genes associated with anti-apoptotic activity and tumor cell survival.
6-SHO was more effective than two other compounds found in ginger, 6-gingerol, and 6-paradol at reducing survival of prostate cancer cells.
Moreover, 6-SHO also showed significant tumor growth inhibitory activity in an allograft model in HMVP2 cells.
In other words, 6-SHO inhibited prostate cancer through several mechanisms, including chemokine, cytokine, cell cycle, apoptosis, and genes.
Dr. Saha A and colleagues wrote in the final report, "6-SHO may have potential as a chemopreventive and/or therapeutic agent for prostate cancer".
Additionally, in order to reveal more information about ginger as a promising chemopreventive agent, researchers examined ginger extract (GE) growth-inhibitory and death-inductive effects in a spectrum of prostate cancer cells.
Injection of the extract showed a significant effect on perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle, and apoptosis in human prostate cancer cells.
Daily oral feeding of 100 mg/kg body weight of GE inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice, observed by the tumor tissue from GE-treated mice compared to controls.
Most importantly, GE is safe as toxicity is not detected in normal, rapidly dividing tissues such as gut and bone marrow.
Taken together, ginger-processed 6-Shogaol (6-SHO) may be considered a functioning remedy for the prevention and combined with the primary medicine for the treatment of prostate cancer with no side effects, pending the confirmation of a larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling by Saha A1, Blando J1, Silver E1, Beltran L1, Sessler J1, DiGiovanni J. (PubMed)
(2) Benefits of whole ginger extract in prostate cancer by Prasanthi Karna,1 Sharmeen Chagani,1 Sushma R. Gundala,1 Padmashree C. G. Rida,1Ghazia Asif,1 Vibhuti Sharma,1 Meenakshi V. Gupta,2 and Ritu Aneja. (PubMed)
(3) What can geography tell us about prostate cancer? by Klassen AC1, Platz EA. (PubMed)
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