Dandelion (Taraxacum officinale) in the Management and Treatment of Type 2 Diabetes

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The most common forms of Diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin.

The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.

* Type 2 diabetes, the most common form of acquired diabetes in adulthood is a chronic condition that affects the body's metabolized glucose. In other words, most cases of type 2 diabetes are the result of insulin receptors clogged up by fat and cholesterol, leading to resisting the effects of the hormone insulin that regulates the movement of sugar into your cells.

* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.

Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.

* Latent autoimmune diabetes in adults (LADA), similar to type 1 diabetes, is a slow-progressing form of autoimmune diabetes. The disease is caused by the pancreas' inability to produce enough insulin, because of slowly die-off of insulin-producing cells in the pancreas.

LADA is also known as type 1.5 diabetes because the disease has characteristics of both type 1 (autoimmune in nature) and type 2 diabetes.

Therefore, LADA shares the same risk factors and symptoms similar to those types 1 and 2 diabetes.

Unlike type 2 diabetes, patients with LADA do not respond well to seems to lifestyle and medication as in type-2 diabetes in the long term. Medicine used for the treatment of type 2 diabetes does not halt or slow the progression of loss of pancreas beta cells.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of chronic low-grade inflammatory diseases, scientists examined the dandelion anti-type 2 diabetes (T2D) activity.

According to test differentiation, the root of dandelion contains inulin, including fructooligosaccharides (FOS), a complex carbohydrate that normalizes blood sugar levels.

Other compounds chlorogenic and chicoric acid found in dandelion not only prevent obesity and inflammation but also have a strong impact on insulin secretion and sensitivity.

Other active compounds isolated from dandelion such as sesquiterpene lactones, triterpenes/phytosterols (taraxasterol), phenols, flavonoids, and phenolic acids also have demonstrated a series of anti-diabetic effects, due to the pharmacological actions of components.

In hyperglycemia, a hallmark in T2D fructooligosaccharides (FOS) exerted a significant activity that affects glucose homeostasis in oxidative stress, leading to auto-oxidation and protein glycation and increasing the production of lipid peroxide which in turn decreases the anti-oxidative defense induce β-cell dysfunction.

Furthermore, dandelion also manifests its anti-diabetic properties, through the inhibited renal glucose reabsorption and potassium channel flow, reduced the activity of carbohydrate enzymes (α-amylase with β-galactosidase and α-glucosidase), and reduced dietary blood sugar (which stimulates hepatic glycolysis and glycogenesis).

Based on the findings, researchers said, "Dandelion has been considered a key anti-diabetic plant because of its anti-hyperglycemic, anti-oxidative, and anti-inflammatory properties [44]. This is due to the various bioactive components present in dandelion, including polyphenolics, sesquiterpenes, triterpenes, and phytosterols".

Taken altogether, dandelion may be considered a remedy for the management and treatment of type 2 diabetes, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes by Wirngo FE1, Lambert MN1, Jeppesen PB. (PubMed)

Antioxidant Omega3 Fatty Acids Are Effective Against Psoriasis, Studies Suggest

By Kyle J. Norton

Psoriasis is a skin condition characterized by the speed-up of the life cycle of skin cells, leading to cells building up rapidly on the surface of the skin.

Symptoms of psoriasis caused by the extra skin cells from scales and red patches can be itchy and painful.

Epidemiologically, psoriasis patches can range from a few spots or large areas. The most common form of psoriasis is plaque psoriasis, a condition that induces dry, raised, red skin lesions (plaques) covered with silvery scales.

The causes of psoriasis are not identified, however, researchers believed that genetic proposition exacerbated by certain factors such as weather, injury, illness, or stress are some of the most causative factors that induce the onset of the condition.

Certain risk factors such as family history, viral and bacterial infections, weakened immune systems, persistent stress, are associated with the risk of psoriasis.

Other risk factors associated with psoriasis may include skin injury that did not heal properly, people who are obese and side effects of long-term use of certain medicines such as oral steroids.

Some researchers suggested smoking that has a strong impact on the immune system may also be one of the major causes of psoriasis in smokers.

Conventionally, topical corticosteroids are the most commonly prescribed medication for the treatment of the condition, particularly in patients with mild to moderate psoriasis.


According to the joint study led by the University of Trieste, the increased incidence of a large number of diseases that share an inflammatory origin is probably due to the pro-inflammatory cytokine spillover from active psoriatic lesions, leading to a large inflammation on distant tissues(95).

Additionally, the Brigham and Women's Hospital, and Harvard Medical School, Boston joint study suggested, individuals with psoriasis have increased blood levels of uric acid. In the documented 2217 incident cases of gout during follow-up. Psoriasis was associated with an increased risk of subsequent gout with a multivariate HR of 1.71

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of skin diseases, researchers examined the efficacy and mechanism of action of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on psoriasis.


The Cochrane Central Register of Controlled Trials that searches the databases of the PubMed/MEDLINE and EMBASE all randomized controlled trials and prospective observational studies compared the 3 PUFAs effects versus control in adult patients with psoriasis.

Out of 12 articles identified in a total of 732 articles that were searched, some studies found that n-3 PUFAs were associated with improvements in the PASI score, erythema, scaling, itching, an area involved, and infiltration.

However, some studies did not find a reduction in scaling, erythema, area involved or thickness in the treatment group.

Based on the findings researchers said, "It is still inconclusive whether the use of n-3 PUFAs in patients with psoriasis is associated with improvements in the severity of psoriasis and other outcomes".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of psoriasis, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of omega-3 fatty acids on disease severity in patients with psoriasis: A systematic review by Upala S1,2, Yong WC1, Theparee T3, Sanguankeo A. (PubMed)
(2) Efficacy of ω-3 supplementation in patients with psoriasis: a meta-analysis of randomized controlled trials by Clark CCT1, Taghizadeh M2, Nahavandi M2, Jafarnejad S. (PubMed)
(3) Increased airway inflammation in patients with psoriasis by Damiani G1, Radaeli A2, Olivini A2, Calvara-Pinton P3, Malerba M2. (PubMed)(4) Psoriasis, psoriatic arthritis and risk of gout in US men and women by Merola JF1, Wu S2, Han J3, Choi HK4, Qureshi AA5.(PubMed)

Chaste Tree Berry May be a Valuable Remedy For theTreatment of Cancers, Researchers Suggest

By Kyle J. Norton

Chaste tree berry is found to exhibit a significant anti-cancer activity, a recent study by renowned study advised.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Cancer is a class of diseases characterized by cells growing and multiplying disordered and uncontrollable ways in our body. In the late stage, the cancer cells may travel away from the originated site to infect other tissues and organs.

According to the Tianjin Institute for Biomedicinal Research, in the evaluated the apoptosis-inducing effect of chaste tree berry, using observation under a light microscope, flow cytometric analysis, and agarose gel electrophoresis, Vitexicarpin, a flavonoid found in chaste tree berry significantly inhibited proliferation of human cancer cells lines A2780(human ovarian carcinoma), HCT-15(human, colon, colorectal adenocarcinoma), HT-1080(fibrosarcoma cell line) and K562(Human chronic myeloid leukemia cells), depending to the concentration.

Dr. Wang HY the lead researcher in the study said, "Vitexicarpin induces apoptosis.... via mitochondria(in regulated cell metabolism)-controlled apoptotic pathway".

In support of the above analysis, the crude extract prepared with ethanol from dried ripened Vitex agnus-castus fruits exerted strong cytotoxic effects against cancer cell lines of human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.

The inhibition of the extract is attributed to the effect on cell death through apoptosis and increased intracellular oxidation in the tumor cells.

Other researchers suggested that the cytotoxic effects of Chaste tree berry may be involved various aspects, including the JNK (apoptosis) pathway. as indicated in the new native lignan VB6 study.

Taking together, there is no doubt, that chaste tree berry may be considered as a valuable chemotherapeutic agent for the treatment of various types of cancer, depending on further evaluation.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway].[Article in Chinese] by Wang HY1, Cai B, Cui CB, Zhang DY, Yang BF.(PubMed)
(2) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(3) Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway by Zhou J1, Hu H, Long J, Wan F, Li L, Zhang S, Shi YE, Chen Y.(PubMed)

Broccoli Inhibits the Risk of Breast Cancer in Vitro

By Kyle J. Norton

The breast is the tissue overlying the chest muscles. in women, breasts are made of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of the women's breasts is totally determined by the amount of fat.

Breast cancer (malignant breast neoplasm) is a medical and chronic condition characterized by irregular cell growth in the breast tissue.

Most cases of breast cancer start either in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

There are also rare cases of breast cancer that start in other areas of the breast

The cause of breast cancer is the result of the alternation of DNA of the cells in the breast.

According to statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the US alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

The 5 years of the survival rate of localized breast cancer are closed to 100%.

As of today, the exact causes of breast cancer are still unknown. Researchers believed that
genetic mutation inherited from the parents and an unhealthy diet and lifestyle are the major factors that facilitate the early onset of the disease.

At the early stage of breast cancer, patients may experience symptoms of the lump (mass) in the breast. and in the armpit (lymph nodes), nipple discharge, inverted or retracted nipple, scaly or pitted skin on the nipple, persistent tenderness of the breast, and unusual breast pain or discomfort.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding a potential whole food for the treatment of cancer, researchers evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, efficacy to inhibit breast CSCs.

According to the results of differentiation, The application of sulforaphane (1-5 micromol/L) decreased the aldehyde dehydrogenase-positive cell population found in some cancers by 65% to 80% in human breast cancer cells. 

Furthermore, the size and number of primary mammospheres in the breast cancer cells were also reduced by 8- to 125-fold and 45% to 75% by the injection of sulforaphane.

More precisely, Daily injection with 50 mg/kg sulforaphane for 2 weeks reduced aldehyde dehydrogenase-positive cells by >50% in nonobese diabetic/severe combined immunodeficient xenograft tumors.

Moreover, sulforaphane also eliminated breast CSCs in vivo by inhibiting the tumor growth after the reimplantation of primary tumor cells into the secondary mice.

Additionally, sulforaphane also inhibited the expression of Wnt/beta-catenin associated with cellular functions like stem cell regeneration and organogenesis.

Based on the findings, researchers said, "These findings support the use of sulforaphane for the chemoprevention of breast cancer stem cells".

Taken altogether, broccoli processed a high amount of SFN may be considered a functional food for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells by Li Y1, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, Sun D. (PubMed)

Yoga May Process Anti-Alcoholism Activity

By Kyle J. Norton

Scientists may have found an integrated form of exercise used combined with standard treatment in alcoholism, a joint study led by the Section of Epidemiology and Public Health Intervention Research (EPHIR), postulated.

Yoga, the ancient technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement, and gesture..... has been well known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a study to examine 18 alcohol-dependent patients randomized received either treatment as usual or treatment as usual plus yoga has taken at baseline with six months follow-up for testing the effect of yoga therapy in reduced alcohol dependence, researchers filed the following results, after 10 weeks

1. Yoga was found to be a feasible and well-accepted adjunct treatment for alcohol dependence.

2. Yoga + conventional treatment showed a reduction in alcohol consumption from 6.32 to 3.36 drinks per day in comparison to other groups.

After taking into account other risk factors, researchers said, "Larger studies are needed to adequately assess the efficacy and long-term effectiveness of yoga as an adjunct treatment for alcohol dependence".

Other, in the study to evaluate the effect of a yoga intervention on alcohol and drug abuse behaviors in women with posttraumatic stress disorder (PTSD) through analyzed data from a pilot randomized controlled trial in comparing a 12-session yoga intervention and control of women age 18 to 65 years with PTSD, researchers found that
1. Yoga intervention at the end of the period expressed a significantly lower mean score of Alcohol Use Disorder Identification Test (AUDIT) in comparison to control
2. Yoga group also demonstrated a reduction in symptoms and improved symptom management. in most participants
3. Yoga participants expressed interest in psychological treatment

The findings suggested that yoga may play a role in attenuating the symptoms of PTSD, reducing the risk of alcohol dependence, and promoting interest in evidence-based psychotherapy.

More importantly, in the reviews, the philosophical origins, current scientific evidence, and clinical promise of yoga and mindfulness as complementary therapies for addiction, researchers at the joint study led by the Manipal University, said, " theoretical models suggest that the skills, insights, and self-awareness learned through yoga and mindfulness practice can target multiple psychological, neural, physiological, and behavioral processes implicated in addiction and relapse".

Further analysis, researchers concerned, "the clinical effectiveness and hypothesized mechanisms of action underlying mindfulness-based interventions for treating addiction" and "..very few studies have been conducted on the specific role of yoga in treating or preventing addiction".


Taking all together, yoga intervention may play an important role used in conjunction with standard therapy in treating alcoholism.


For More information on yoga lessons tailored to a complete well being for women, please visit: YOGA BURN


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Sources

Sources
(1)Yoga as an adjunct treatment for alcohol dependence: a pilot study by Hallgren M1, Romberg K2, Bakshi AS3, Andréasson S4.(PubMed)
(2) The effect of a yoga intervention on alcohol and drug abuse risk in veteran and civilian women with posttraumatic stress disorder by Reddy S1, Dick AM, Gerber MR, Mitchell K.(PubMed)
(3) A narrative review of yoga and mindfulness as complementary therapies for addiction by Khanna S1, Greeson JM.(PubMed)

Antioxidant Beta-Sitosterol Induces Apoptosis of Colon Cancer Cells in Vitro

By Kyle J. Norton

The colon is also known as the large intestine.
Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.

Colon cancer is relatively very common and slowly growing and progressing in a predictable way.

Most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.

However, at the advanced stage, the tumor not only can spread to other healthy tissue and organs a distance away through blood and fluid circulation but also suppress the nearby tissue and nerve cells.

The progression of colon cancer at this stage not only induces symptoms of the change in bowel habits, the change in the consistency of your stool, that lasts longer than four weeks but also causes rectal bleeding and persistent abdominal severe pain.

According to the statistic by the American Cancer Society, in the US, 
97,220 new cases of colon cancer were diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

The causes of colon cancer are unknown but certain risk factors, such as genetic preposition and chronic inflammation induced by colonic diseases are associated with the onset of the disease.

Patients with the early stage of colon cancer, may not experience any symptoms. But as the tumor spread and expanse, it may suppress the nearby tissue and nerve, causing symptoms of locally severe pain and discomforts.

Although there are many risk factors associated with the early onset of colon cancer, a poor diet high in saturated fat and trans fat, red meat and processed foods have been found to play a major role in the development and recurrence of colon cancer in the Western world.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of malignant tumors, researchers examined the anti-radical activity, cytotoxic on human colon adenocarcinoma cell lines (COLO 320 DM).

According to the experimental analysis, beta-sitosterol exerted a significant dose-dependent growth inhibition of COLO 320 DM cells at IC50 and a dose of 266.2 microM,

Furthermore, beta-sitosterol also induced apoptosis by scavenging reactive oxygen species and suppressed the expression of beta-catenin and PCNA antigens in human colon cancer cells.

Moreover, in vivo, the beta-sitosterol supplementation reduced the number of aberrant crypt and crypt multiplicity in DMH-initiated rats in a dose-dependent manner with no toxic effects.

More importantly, the doses of 10-20 mg/kg b.w. beta-sitosterol had chemopreventive potential by virtue of its radical quenching ability in vitro, with minimal toxicity to normal cells.

Taken altogether, beta-sitosterol may be considered a supplement for the prevention and treatment of colon cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemopreventive potential of beta-Sitosterol in experimental colon cancer model--an in vitro and In vivo study by Baskar AA1, Ignacimuthu S, Paulraj GM, Al Numair KS. (PubMed)

Broccoli Induces Lung Cancer Cells Apoptosis in Vitro and Vivo

By Kyle J. Norton

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common forms of primary lung cancers are derived from epithelial cells.

At the early stage, people with lung cancer may experience symptoms of a cough that doesn't go away, coughing up blood, even a small amount, shortness of breath, chest pain and unintended weight loss.

However, at the advanced stage, the cancer cell from the lung can travel a distance away to infect other healthy tissue and organs through the circulation of fluid and blood, leading to the secondary metastasis.

The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease and excessive drinking are some prevalent factors associated with lung cancer developing.

Lung cancer is the leading cause of death in both men and women. Lung cancer accounts for 26.7% of all deaths from cancer and 6.5% of all mortality.

According to the statistics provided by the American cancer society, lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 in women in the same year.

The 5-year survival rate for people with stage IB NSCLC is about 68%.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding a potential wholefood for the treatment of cancer researchers examined the effect of sulforaphane (SFN), an isothiocyanate isolated from broccoli on lung cancer.

In vitro, A549 and H1299 lung cancer cells treated with SFN for 48h showed a decrease of HDAC activity and increase of the levels of acetylated histones H3 and H4 associated with cellular proliferation in both lung cancer cells.

SFN also promoted the activity of genes involved in the induction of apoptosis, an increase of accumulation of cells at G0/G1 and G2/M and arrest cells at S phase.

In vivo, SFN suppressed lung cancer growth in a xenograft mouse model.

Based on the evidence, researchers said, " the chemopreventive effect of SFN is associated with inhibition of HDAC activity, thereby attenuating lung cancer growth. Therefore, these findings suggest that SFN may be a therapeutic agent for lung cancer through the inhibition of HDAC".

Taken altogether, broccoli processed a high amount of SFN may be considered a functional food for the prevention and treatment of lung cancer pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity by Jiang LL1, Zhou SJ1, Zhang XM2, Chen HQ2, Liu W. (PubMed)