Showing posts with label Herbal Medicine. Show all posts
Showing posts with label Herbal Medicine. Show all posts

Tuesday, 7 June 2022

Herbal Butterbur May Process Anti Acute and Chronic Migraine Activity

By Kyle J. Norton

Herbal butterbur may be considered a functional herb in the protection of neurons against change in the brain and its surrounding blood vessels in the initiated onset of migraine, some scientists suggested.

Migraine headache is one most common headaches defined as a condition of a chronic neurological disorder of moderate to severe headaches, and nausea that usually develops gradually over 5–20 minutes and lasts for less than 60 minutes.

According to statistics, the syndrome affects over 15% of the population in the US. If you are a woman your risk of migraine headaches is 2 times higher in compared to men.

Sadly, 1 in 7 people in the world population will develop migraine headache at some point in their lifetime, And, chronic migraine affects about 2% of the world population.

Some patients during migraine attacks also suffer symptoms of visual disturbances, nausea, vomiting, dizziness, extreme sensitivity to sound, light, touch, and smell, and tingling or numbness in the extremities or face.

Believe it or not, 10% of school-age children also suffer from undiagnosed migraine headaches.

Conventional medicine in reducing symptoms of pain during attacks such as Sumatriptan, Rizatriptan,..and Eletriptan may be effective but they may induce certain side effects, including gastrointestinal discomfort, dizziness, drowsiness,... and muscle weakness.


Please make sure that you discuss these side effects with your doctor before taking them.


Butterbur, found in wet, marshy, damp land, including wetland, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.

The herb has been used in herbal medicine used as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.

The Chemical constituents
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.

Although the herb is used as a nutritional supplement in the US, scientific studies suggested that it may be used as the prevention of allergic rhinitis and treatment of migraine.

In a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients with migraine, satisfied the International Headache Society criteria, researchers found that by calculating the migraine attack frequency per month as percentage change from baseline over a 4-month treatment period

* Migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), in compared to 26% of placebo group.

* The proportion of patients with a > or =50% reduction in attack frequency after 4 months was 68% for patients in the Petasites extract 75-mg arm and 49% for the placebo arm (p < 0.05).
* In comparison to the baseline, patients, intake of Petasites 75 mg also expressed a significant effect in reduced migraine at 1, 2, and 3 months.

* Mild adverse effects such as gastrointestinal events, predominantly burping. were also reported.

These results suggested that butterbur Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine.

Furthermore, in the review to confirm the strength of evidence of effectiveness for Petasites hybridus in treating prophylaxis of migraine by searching several databases and other sources to identify randomized-controlled trials, the Headache Center Hirslanden in Zürich, Switzerland found 2 trials totaling 293 patients (60 and 233 patients).

According to the selected trials, oral administrated butterbur extract at a higher dose (150 mg) expressed a greater decreased frequency of migraine attacks and a greater number of responders (improvement>50%) after treatment over 3-4 months compared to the extract at a lower dose (100 mg) and placebo.

Additional differentiation also found some evidences that higher than the recommended dose may be more effective in treating prophylaxis of migraine.

More profoundly, in the study of 60 patients who received either the special Petasites hybridus extract Petadolex or placebo at a dosage of two capsules (each capsule contains 25 mg) twice daily over 12 weeks, researchers found that

* Oral injection of the capsules Petadolex reduces the frequency of migraine attacks decreased by a maximum of 60 percent compared to the baseline.

* No adverse events were reported. Petasites were exceptionally well tolerated.

Taking all together, herbal butterbur extract may be considered a therapeutic treatment for acute and chronic migraine headaches, however, the exact dose should only be prescribed by herbalists.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine by Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A.(PubMed)
(2) An extract of Petasites hybridus is effective in the prophylaxis of migraine by Grossman W, Schmidramsl H.(PubMed)
(3) Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review by Agosti R, Duke RK, Chrubasik JE, Chrubasik S.(PubMed)

Sunday, 5 June 2022

Herbal Chaste Tree Berry (Vitex Agnus-castus) May Process Anti-Leukemia Potency

By Kyle J. Norton

Scientists may have found a herbal ingredient for the treatment of leukemia with no side effects, some studies suggested.

Leukemia is a medical condition characterized by the production of high numbers of abnormal white blood cells. A disease is a group of cancers originating in the soft, inner part of the bones (bone marrow).

At the advanced stage, the cancerous cells can travel a distance away to infect other healthy cells of other tissue and organs, particularly, in the tissue of lymph nodes, spleen, liver, and central nervous system.


The exact causes of leukemia are unknown, however, researchers do know that smoking, and genetic disorders such as Down syndrome. blood disorders and previous treatment for cancer with chemotherapy or radiation are the most common risk factors associated with the onset of the disease.

Leukemia can be classified into acute and chronic leukemia. In acute and chronic leukemia, the abnormal cells can multiply quickly. On the other hand, chronic leukemia, progresses slowly and early symptoms may be very mild.

According to the statistic provided by the Leukemia and Lymphoma Society of Canada, in Canada, leukemia is the most common form of cancer in children 0-14 years of age and the 6th most common among young adults 15 to 29 years.


Every year over 900 children, 0-14 years of age are diagnosed with cancer, accounting for 11% of all childhood cancer.


The most common symptoms of leukemia include persistent fever or chills, fatigue, weakness, frequent or severe infections, unintentional weight loss, swollen lymph nodes, and enlarged liver or spleen.


If you are experiencing some of the above symptoms, please check with your doctor to rule out the possibility of leukemia.


Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region.

The tree has been used in herbal medicine for thousands of years as an aphrodisiac herb and is considered a Queen herb in treating menstrual problems and discomforts by taking it for a prolonged period of time.

There was a report suggested that chaste tree berry stems and leaves can be used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,

Chemical constituents
1. β-citronellol
2. Labdane-type diterpenoids,
3. Halimane-type diterpenoid,
4. Oleanane-type triterpenoids,
5. Ursane-type triterpenoids,
6. Sesquiterpenoid,
7. Flavonoid
8. Viteagnusins C, D, E, F, G, and H
9. Abietane-type diterpenoids

In the study to reaffirm the extract from the ripe fruit of Vitex Angus-cactus (Vitex), may be considered an anticancer candidate, researchers at the joint investigation led by the Tokyo University of Pharmacy and Life Sciences conducted a study to provide a molecular rationale for clinical development in anticancer therapy(SB203580, an inhibitor for p38 MAPK), a detailed mechanism underlying the efficacy of Vitex against HL-60 cells.

* Vitex and the addition of SB203580 induced a dose- and time-dependent decreased cancer cell viability associated with induction of apoptosis and G(2)/M cell cycle arrest.


* SB203580 significantly suppressed Vitex-induced phosphorylation of histone H3, a downstream molecule of p38 MAPK involved in the induction of tumor cells.

* Vitex inhibited HL-60 cancer cells through, the mediation of cytotoxicity.

* A decline in ROS levels along with enhanced apoptosis was observed after treatment with Vitex.


These results suggested that chaste tree berry inhibited the HL 60 cells by increasing the expression of ROS in the facilitated cytotoxicity and inducing apoptosis through cell cycle arrest.

In the summary of the findings, Dr. Kikuchi H, the lead author said, "These results may have important implications for appropriate clinical uses of Vitex and provide novel insights into the interaction between Vitex and other conventional drugs capable of affecting intracellular redox status".



Further differentiation of the cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin against the leukemia cell lines, HL-60 and U-937, researchers found that Vitex and casticin induced cytotoxicity on both cell lines in a dose depended on manner. and HL-60 cells were more sensitive to the cytotoxicity of Vitex/casticin compared to U-937 cells.


Since the HL-60 cell line is more immature than the U-937 cell line, these results suggested that the levels of cytotoxicity of Vitex/casticin were largely attributed to the types of leukemia cells.


Taken altogether, Chaste tree berry may be considered a functional food and an adjunct therapy combined with conventional medicine for the treatment of leukemia without inducing any side effects.

However, due to the limitation of the studies, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of chaste tree berry anti-leukemia possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract by chi H1, Yuan B1, Yuhara E1, Imai M1, Furutani R1, Fukushima S1, Hazama S1, Hirobe C2, Ohyama K1, Takagi N3, Toyoda H1.(PubMed)
(2) Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines by chi H1, Yuan B, Nishimura Y, Imai M, Furutani R, Kamoi S, Seno M, Fukushima S, Hazama S, Hirobe C, Ohyama K, Hu XM, Takagi N, Hirano T, Toyoda H.(PubMed)

Tuesday, 24 May 2022

Herbal Bilberry, an Anti-Psoriasis Remedy

Kyle J. Norton  

Psoriasis is an autoimmune disease caused by speeding up the life cycle of skin cells that leads to patches of abnormal skin.

Psoriasis may be localized which causes red, dry, itchy, and scaly skin patches in the affected area.

In cases of severity, psoriasis can cover the body completely.

Some patients also experience symptoms of thickened, pitted, or ridged nails and swollen and stiff joints.

If you experience some of the aforementioned symptoms, please check with your doctor for preventive measures.

The causes of psoriasis are not identified, however, researchers believed that genetic proposition exacerbated by certain factors such as weather, injury, illness, or stress are some of the most causable factors that induce the onset of the condition.

Other risk factors associated with psoriasis may include skin injury that did not heal properly, people who are obese and side effects of long-term use of certain medicines such as oral steroids.

Some researchers suggested smoking that has a strong impact on the immune system and may also be one of the major causes of psoriasis in smokers.

Dr. wrote, "A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis".


And, " Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences".

The findings strongly suggested, that if you smoke, you are at a higher risk of psoriasis

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, and kidney disease, psoriasis, diabetes, etc.

With an aim to find a natural and therapeutic ingredient for the treatment of psoriasis, researchers
a cosmeceutical formulation based on boswellic acids and Vaccinium myrtillus seed oil in patients with psoriasis.


The double-blind study is to compare a novel BA formulation (containing Bosexil(®), INCI [International Nomenclature of Cosmetic Ingredients]: lecithin, Boswellia serrata resin extract) with a placebo formulation and a formulation of Vaccinium myrtillus (Bilberry) seed oil.

More precisely, patients with psoriasis or erythematous eczema were randomly assigned, in a 1:1:1 ratio, to Bosexil(®), V. myrtillus seed oil, or placebo.

During the experiment, Bosexil(®) and the V. myrtillus seed oil treatment significantly improved psoriasis, scales in comparison with placebo.

Formulation of Vaccinium myrtillus seed oil exerted a similar effect as those of Bosexil(®) without any case of worsening compared to placebo.

Furthermore, V. myrtillus seed oil improved itch and erythema in 66.7% and 77.8% of patients, respectively compared to the Bosexil(®) formulation (60% of cases) and erythema (60% of cases) without any case of worsening, respectively.

The results clearly suggested that V. myrtillus seed oil and Bosexil(®) formulation process a strong anti-psoriasis activity without side effects.

Taken altogether, bilberry may be considered a functioning remedy for the treatment of psoriasis, pending the validation of larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis by Togni S1, Maramaldi G1, Di Pierro F2, Biondi M. (PubMed)
(2) Psoriasis and smoking: links and risks by Luigi Naldi. (PMC)

Sunday, 1 May 2022

Herbal Angelica Promotes Hematopoietic Function

By Kyle J. Norton

The hematopoietic system is a complex network including organs and tissues such as the bone marrow, liver, and spleen.

Hematopoiesis is the process by which blood cells are formed, including the formation of all of the cellular components of blood and blood plasma.

1. Red blood cells with a function to transport oxygen and hemoglobin to the body.

2. White blood cells that form parts of the immune system, including
* T cells and B cells, that fight viruses, and tumors.

* Neutrophils that fight bacteria and fungi.

* Eosinophils that fight some parasites and initiate an inflammatory response.

* Basophils that release the histamines necessary for the inflammatory response.

* Macrophages, are the first line of the immune response in the acute phase of infection.

3. Platelets (thrombocytes) for coagulation.

Dr. Risitano AM, the lead scientist in the study of  " Function and malfunction of hematopoietic stem cells in primary bone marrow failure syndromes", said," Constitutional marrow failure syndromes are conditions caused by intrinsic defects of HSCs; they are due to inherited germline mutations accounting for specific phenotypes, and often involve also organs and systems other than hematopoiesis".

And " By contrast, in acquired marrow failure syndromes hematopoietic stem cells are thought to be intrinsically normal, but subjected to extrinsic damage affecting their hematopoietic function".

Diseases of the bone marrow, spleen, lymph nodes, and thymus may affect the process of hematopoiesis, leading to various diseases of the hematopoietic system.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation, and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound that promotes hematopoietic functioning, researchers examined the neuroprotective effects of investigating the influence of AS on the metabolism of blood deficiency mice model.

Selected mice in the study were induced blood deficiency by being hypodermically injected with N-acetyl phenylhydrazine (APH) and intraperitoneally injected with cyclophosphamide (CTX) then treated with Angelica Sinensis (AS).

According to the tested assays, the administration of AS normalized the levels of white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), and platelet (PLT) compared to the untreated control group.

The dose of 10g/kg demonstrated the best effect compared to other doses.

Furthermore, the metabolic pathways biomarkers associated with an important role in regulating the hematopoietic function, such as arachidonic acid metabolism, valine, leucine, and isoleucine biosynthesis, glycine, serine and threonine metabolism, arginine and proline were also affected by the injection of AS.

In other words, AS promotes the production of all of the cellular components of blood and blood plasma in blood deficiency mice.

Taken altogether, herbal Angelica may be considered a neuroprotective remedy for the improvement of hematopoietic function, pending to larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Metabolomics study of hematopoietic function of Angelica Sinensis on blood deficiency mice model by Li PL1, Sun HG1, Hua YL1, Ji P1, Zhang L1, Li JX1, Wei Y. (PubMed)
(2) Function and malfunction of hematopoietic stem cells in primary bone marrow failure syndromes by Risitano AM1, Maciejewski JP, Selleri C, Rotoli B. (PubMed)

Tuesday, 12 April 2022

Turmeric Exerts Anti Hypertension Activity in Vivos

By Kyle J. Norton

High blood pressure or hypertension is a condition of abnormally high blood pressure in the arteries. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

High blood pressure is also a condition in the cluster of metabolic syndrome associated with the increased risk of cardiovascular disease (CVD), and diabetes.

Depending on the levels of blood pressure, most patients with high blood pressure are asymptomatic, However, long-term very high blood pressure has been found to induce dizziness and light head, shortness of breath, nosebleeds, flushing, chest pain, and visual changes.

Some medical conditions such as kidney disease and long-term stress are associated with high blood pressure.

According to the American hypertension Association, long-term untreated high blood pressure can induce complications that reduce or obstruct the function of the heart and blood vessels, leading to heart attack, stroke, and heart failure.

Conventional hypertensive medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects.

If you are currently taking hypertensive medicine, please make sure you know all the side effects of the preventive measure.

Some researchers also found that excessive energy intake and obesity are major causes of hypertension.

Dr. Savica V, the lead author in the study "The effect of nutrition on blood pressure" wrote, "Obesity is associated with increased activity of the renin-angiotensin-aldosterone and sympathetic nervous systems, possibly other mineralocorticoid activity, insulin resistance, salt-sensitive hypertension, and excess salt intake, and reduced kidney function. High sodium chloride intake strongly predisposes to hypertension".

And, "Increased alcohol consumption may acutely elevate blood pressure. High intakes of potassium, polyunsaturated fatty acids, and protein, along with exercise and possibly vitamin D, may reduce blood pressure".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.



The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

On findings of a potential compound for the treatment of high blood pressure, researchers examined the effects of ginger (Zingiber officinale) and turmeric (Curcuma longa) on a hypertensive animal model.

Selected rats induced hypertension by oral administration of Nω-nitro-L-arginine methyl ester hydrochloride, 40 mg/kg body weight to the study were divided into seven groups (n = 10).
* The groups 1-3 included normotensive control rats, hypertensive (Nω-nitro-L-arginine methyl ester hydrochloride) rats, and hypertensive control rats treated with atenolol (an antihypertensive drug).

* Groups 4 and 5 included normotensive and hypertensive (Nω-nitro-L-arginine methyl ester hydrochloride) rats treated with 4 % supplementation of turmeric, respectively.

* Groups 6 and 7 included normotensive and hypertensive rats treated with 4 % supplementation of ginger, respectively.

During the experiment, researchers found that Nω-nitro-L-arginine methyl ester hydrochloride hypertensive rats showed a significant increase in ATP and ADP hydrolysis, adenosine deaminase involved in purine metabolism, and acetylcholinesterase involved in the regulation of blood vessel tone compared to the control rats.

In other words, the injection of Nω-nitro-L-arginine methyl ester hydrochloride causes the increase of enzymes associated with the constriction of blood vessel tone, blocking the blood vessel dilatation and blood flow through the coronary blood vessels.

Furthermore, Nω-nitro-L-arginine methyl ester hydrochloride rats also demonstrated an elevated production of the pro-inflammatory cytokines such as interleukin-1 and - 6, interferon-γ, and tumor necrosis factor-α) and reduced levels of an anti-inflammatory cytokine such as interleukin-10, a leading cause of the increase in arterial stiffness and risk of CVD.

Moreover, increased butyrylcholinesterase activity associated with chronic inflammation was also found in the Nω-nitro-L-arginine methyl ester hydrochloride rats.

However, all parameters caused by the injection of Nω-nitro-L-arginine methyl ester hydrochloride involved in the onset of hypertension were totally inhibited by the application of ginger (Zingiber officinale) and turmeric (Curcuma longa).


Based on the findings, researchers said, "these activities could suggest a possible insight about the protective mechanisms of the rhizomes against hypertension-related inflammation."


Taken altogether, turmeric used alone or in combination with ginger may be considered supplements for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats by Akinyemi AJ1,2,3, Thomé GR3, Morsch VM3, Bottari NB3, Baldissarelli J3, de Oliveira LS3, Goularte JF4, Belló-Klein A4, Oboh G1, Schetinger MR. (PubMed)
(2) Effect of Ginger and Turmeric Rhizomes on Inflammatory Cytokines Levels and Enzyme Activities of Cholinergic and Purinergic Systems in Hypertensive Rats by Akinyemi AJ1, Thomé GR2, Morsch VM2, Bottari NB2, Baldissarelli J2, de Oliveira LS2, Goularte JF3, Belló-Klein A3, Duarte T4, Duarte M4, Boligon AA5, Athayde ML5, Akindahunsi AA1, Oboh G1, Schetinger MR. (PubMed)
(3) The effect of nutrition on blood pressure by Savica V1, Bellinghieri G, Kopple JD(PubMed)

Friday, 25 March 2022

Yoga Practices Show to Decrease Labor Pain and Improve Delivery Outcome, Studies Suggest

Kyle J. Norton

Yoga therapy may be considered as a secondary intervention combined with standard application in improved labor pain and delivery outcome and reduced risk of pregnancy complication.

Yoga, the accident technique practice for harmonized external and internal body well-being, through breath control, meditation, bodily movement, and gesture..... has been well known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes and supported by health advocates.

In a randomized control trial conducted with sixty primiparous women, aged 18-35 years old, randomly assigned to either an antenatal yoga program consisted of a 1-h supervised yoga class, three times a week, starting at 26 weeks gestation or control groups, researchers after taking into account of risk factors found that at the delivery stage
1. Yoga group experienced less intensive pain, and at 2 h after the first and the second measurements in compared to control.
2. Natural delivery was found more in the yoga intervention group compared to more percentage of cesarean section in control.
3. Yoga group also demonstrated a decreased frequency of labor induction.
4. And a shorter duration of the second and third stages of labor.

With all information collected, Dr. Jahdi F, the lead author said, "Yoga during pregnancy may contribute to a reduction pain of labor and improved adequacy of childbirth".


Another study in support of the above analysis, conducted by the Prince of Songkla University, in examining the effects of a yoga program involving six, 1-h sessions at prescribed weeks of gestation during pregnancy, on maternal comfort, labor pain, and birth outcomes. also suggested that
1. Yoga group expressed higher levels of maternal comfort during labor and 2h post-labor and
2. Less labor pain
3. Although both groups experienced the same pain increase and maternal comfort at the beginning, the yoga group showed decreased pain and discomfort as labor progressed.
4. Lastly, women in yoga class had a shorter duration of the first stage of labor and a total time of labor.

More importantly, In a total of 335 women between 18 and 20 weeks of pregnancy, attending the antenatal clinic at Gunasheela Surgical and Maternity Hospital in Bangalore, India, enrolled in a prospective, matched, observational study with 169 women in the yoga group and 166 women in the control group, researchers emphasized that women participated in yoga lesson illustrated fewer complications such as preterm labor, isolated intrauterine growth retardation and pregnancy-induced hypertension at the day of delivery in comparison to those in control.

Taking all together, yoga intervention not only improved labor pain and delivery outcome but also reduced the risk of pregnancy complications, therefore yoga may be recommended to pregnant women as a preventive measurement, particularly in high-risk groups.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Yoga during pregnancy: The effects on labor pain and delivery outcomes (A randomized controlled trial). by Jahdi F1, Sheikhan F2, Haghani H3, Sharifi B4, Ghaseminejad A5, Khodarahmian M6, Rouhana N7.(PubMed)
(2) Yoga during pregnancy: effects on maternal comfort, labor pain, and birth outcomes. by Chuntharapat S1, Petpichetchian W, Hatthakit U.(PubMed)
(3) Efficacy of yoga on pregnancy outcome by Narendran S1, Nagarathna R, Narendran V, Gunasheela S, Nagendra HR.(PubMed)

Wednesday, 16 March 2022

Herbal Chickweed Methanolic Extract, Maybe An Anti Obesity Supplement, Scientists Suggest

By Kyle J. Norton

Adding one or two portions of chickweed into the daily diet may have a positive and profound effect in inducing weight loss, particularly, in overweight and obese patients, some studies suggested.

Obesity is a medical condition of extreme overweight. The disease is an epidemic in the United States. According to the statistic, over 68% of the US population are overweight and half of these overweight people are obese.

According to epidemiological studies, patients with obesity are at a higher risk for serious diseases, such as type 2 diabetes, heart disease, and cancer.

According to Body Mass Index (BMI), the range of overweight is between 25 and 29.9. If your BMI is 30 or over you are considered obese.

The exact causes of obesity are unknown, however, there is a number of prevalent risk factors that cause the early onset of the condition including consuming too many calories than the body needs, a sedentary lifestyle, not sleeping enough, too much stress that leads to endocrine disruption and medication that cause patients to put on weight.

Genetic mutation inherited from the parents also is one of the major causes of obesity.

Dr. Hélène Choquet, the lead author in the study "Genetics of Obesity: What have we Learned?" In 2001, six genes were linked to monogenic human obesity and no common variants were reproducibly associated with polygenic obesity. By 2008, progress in the field led to the discovery of eight monogenic genes and four polygenic genes (FTO, PCSK1, MC4R, CTNNBL1) from associated studies at the genome-wide level of significance".

In the management of overweight and obese patients, researchers at the Park Nicollet Bariatric Surgery Center suggested, "lifestyle modifications should be recommended for every patient dealing with overweight or obesity" and " No single diet has proven to be superior to others overall in terms of weight loss outcomes. However, a low-carbohydrate (ie, ketogenic) diet has been shown to reduce insulin resistance in patients with diabetes and may be considered for this subgroup of patients".

" Exercise alone has not been shown to produce substantial weight loss, but it is helpful during the weight loss phase to preserve lean muscle mass, and it has a role in weight maintenance. Though sleep deprivation has been implicated in weight gain, the effect of improving sleep quality/duration on reducing excess weight has yet to be studied adequately".


These results indicated, actively engaging in low calory diet without causing nutrient deficiency and physical exercise on a long-term basis, and reducing stress levels may be considered good management for overweight and obese patients to lose weight.


Chickweed is a cool-season annual plant in the genus S. media, belonging to the family Caryophyllaceae, native to Europe.

The herb has been used in herbal medicine as astringent, carminative, demulcent, diuretic, expectorant, laxative, refrigerant, and to treat skin conditions, indigestion, eczema, cough, rashes,...

In the finding of a natural ingredient without a side effect in replacement of conventional medicine and surgery in obese patients researchers at the CMR College of Pharmacy, Medchal conducted an evaluation of the effect of chickweed (S. media (MESM)) on food consumption patterns, change in body weight, thermogenesis, lipid metabolism, and histology of fat pad, using progesterone-induced obesity model in female albino mice.

Methanolic and alcoholic extracts of the S. media were used in the experiment. At the final assessment, researchers suggested, the application of a methanolic extract of S. media (MESM) demonstrates a significant effect in preventing the increase in body weight, adipose tissue weight and size, and upturned obesity and associated complications, compared to the alcoholic extract.


Further analysis also discovered, the antiobesity activity produced by MESM is attributed to the anorexic property mediated by saponin and flavonoid and partly by its β-sitosterol content.

Moreover, β-sitosterol, a plant sterol having structural similarity with dietary fat isolated from the methanolic extract of S. media shows a physical competition in the gastrointestinal tract against fat absorption.

Other chemical compounds found in the methanolic extract such as saponin, flavonoids, steroids and triterpenoids, glycosides, and anthocyanidins are also found in aiding the results of weight reduction.

Additionally, the examining of numerous trials conducted by some institutes with an aim to find and develop new anti-obesity drugs through herbal sources with minimizing side effects compared to anti-obesity drugs, researchers at the University of Science and Technology launched an evaluation of the quality control parameters, quantitative phytochemical analysis (total phenolic, total flavonoids, and total saponin content), and the anti-obesity effect of lyophilized juice (LJ) of Stellaria media (Linn.) Vill. in vitro and in vivo models.

The anti-obesity effect of LJ was assessed at two doses, 400 mg/kg and 900 mg/kg body weight in mice fed a high-fat diet with or without LJ for 6 weeks.

Application of both doses in tested mice inhibited pancreatic amylase and lipase activity and elevated plasma triacylglycerol level.


At the dose of 900 mg/kg body weight of the mice fed with a high-fat diet, LJ suppressed the increase in body weight, retroperitoneal adipose tissue, liver weights, and serum parameters viz., total cholesterol, total triglyceride, LDL-cholesterol level

Dr. Rani N, the lead author of the final report, wrote, "The anti-obesity effects of LJ in high-fat-diet-fed mice may be partly mediated through delaying the intestinal absorption of dietary fat and carbohydrate by inhibiting digestive enzymes".


The findings suggested that chickweed methanolic extract may be considered an adjunct therapy in preventing weight gain in overweight and obese subjects.

Intake of methanolic extract of chickweed (S. media (MESM)) should be taken with extreme care, as acute liver toxicity has been reported in a number of cases.

However, further data collection on large example size and multi-centers studies performed with human consumption of chickweed during the course of the disease will be necessary to complete the picture of the wholefood anti-obesity possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1)Antiobesity effect of Stellaria media against drug induced obesity in Swiss albino mice by Chidrawar VR1, Patel KN, Sheth NR, Shiromwar SS, Trivedi P.(PubMed)
(2) Quality assessment and anti-obesity activity of Stellaria media (Linn.) Vill by Rani N1, Vasudeva N, Sharma SK. (PubMed)
(3) Genetics of Obesity: What have we Learned? by Hélène Choquet1 and David Meyre. (PMC)
(4) Obesity: dietary and lifestyle management by Vesely JM1, DeMattia LG. (PubMed)

Tuesday, 1 March 2022

Healthy Food Turmeric Inhibits the Brain Cell Damage Against the Onset of Memory Deficits

By Kyle J. Norton

Memory impairment is a condition associated with a slow decline in memory, thinking, and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.

Memory loss frequently is an early sign of memory deficit. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.

Some memory changes can be resolved on their own or cured by medical treatment if the underlining cause is found. However, loss or gradual loss of neurons capacity cannot be revered such as dementia.

According to statistics, in the US, approximately 5.7 million people are living with dementia. The most common form of dementia is Alzheimer's disease, affecting 5.5 million people of all ages.


The most common risk factor associated with memory deficit is increasing age, smoking the genetic preposition of APOE-e4, also linked to Alzheimer's disease, obesity, and medical conditions such as diabetes, high blood pressure and depression, and physical inactivity.

Out of many risk factors, aging may be one of the major culprits that cause memory deficit in large numbers of older adults, leading to irreversible memory impairment such as AD and PD.

Dr. Gary W Small, said, "Memory changes cause concern to many patients as they grow older.". However, there are some factors that can decrease the progression of the condition, including stress reduction, physical and mental activity, a healthy diet, and lifestyle choices.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound that processes anti-neuro-degeneration, researchers examined the effects of curcumin on the early stage amnesia of AD related to memory retrieval deficit.


Selected Male NMRI mice (20-25 g body weight) included in the study were treated with 50 or 100 mg/kg/po curcumin or its vehicle for 10 days. During the experiment, the animals were trained in passive avoidance apparatus ar days 10 and 30 min. before the retention test that performs after 24 hours of curcumin or its vehicle application, scopolamine (1 mg/kg/i.p.) or its vehicle was administrated.

According to the tested analysis, curcumin treatment at 50 and 100 mg/kg doses not only inhibited the activity of scopolamine in the induction of memory retrieval deficit but also restored Akt and GSK dephosphorylation associated with neuroprotection against scopolamine.


In other words, curcumin at the tested concentration effectively protect the Akt and GSK pathways which play are a critical role in enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis caused by scopolamine in the brain.

After taking others into account, Dr. Lv KJ, wrote in the final report, "pre-test scopolamine administration disrupts memory retrieval along with with with with the diminished Akt and GSK-3β phosphorylation in the hippocampus while curcumin administration prevented those changes."

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of memory retrieval deficit, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of estimated total number of hippocampal pyramidal cells of trimethyltin-exposed rats by Yuliani S1, Mustofa2, Partadiredja G. (PubMed)
(2) Curcumin ameliorates scopolamine-induced mice memory retrieval deficit and restores hippocampal p-Akt and p-GSK-3β by SoukhakLari R1, Moezi L2, Pirsalami F3, Ashjazadeh N4, Moosavi M. (PubMed)
(3) What we need to know about age related memory loss by Gary W Small, Parlow-Solomon professor on aging. (PMC)

Tuesday, 22 February 2022

Dandelion (Taraxacum officinale) in the Management and Treatment of Type 2 Diabetes

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The most common forms of Diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin.

The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.

* Type 2 diabetes, the most common form of acquired diabetes in adulthood is a chronic condition that affects the body's metabolized glucose. In other words, most cases of type 2 diabetes are the result of insulin receptors clogged up by fat and cholesterol, leading to resisting the effects of the hormone insulin that regulates the movement of sugar into your cells.

* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.

Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.

* Latent autoimmune diabetes in adults (LADA), similar to type 1 diabetes, is a slow-progressing form of autoimmune diabetes. The disease is caused by the pancreas' inability to produce enough insulin, because of slowly die-off of insulin-producing cells in the pancreas.

LADA is also known as type 1.5 diabetes because the disease has characteristics of both type 1 (autoimmune in nature) and type 2 diabetes.

Therefore, LADA shares the same risk factors and symptoms similar to those types 1 and 2 diabetes.

Unlike type 2 diabetes, patients with LADA do not respond well to seems to lifestyle and medication as in type-2 diabetes in the long term. Medicine used for the treatment of type 2 diabetes does not halt or slow the progression of loss of pancreas beta cells.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of chronic low-grade inflammatory diseases, scientists examined the dandelion anti-type 2 diabetes (T2D) activity.

According to test differentiation, the root of dandelion contains inulin, including fructooligosaccharides (FOS), a complex carbohydrate that normalizes blood sugar levels.

Other compounds chlorogenic and chicoric acid found in dandelion not only prevent obesity and inflammation but also have a strong impact on insulin secretion and sensitivity.

Other active compounds isolated from dandelion such as sesquiterpene lactones, triterpenes/phytosterols (taraxasterol), phenols, flavonoids, and phenolic acids also have demonstrated a series of anti-diabetic effects, due to the pharmacological actions of components.

In hyperglycemia, a hallmark in T2D fructooligosaccharides (FOS) exerted a significant activity that affects glucose homeostasis in oxidative stress, leading to auto-oxidation and protein glycation and increasing the production of lipid peroxide which in turn decreases the anti-oxidative defense induce β-cell dysfunction.

Furthermore, dandelion also manifests its anti-diabetic properties, through the inhibited renal glucose reabsorption and potassium channel flow, reduced the activity of carbohydrate enzymes (α-amylase with β-galactosidase and α-glucosidase), and reduced dietary blood sugar (which stimulates hepatic glycolysis and glycogenesis).

Based on the findings, researchers said, "Dandelion has been considered a key anti-diabetic plant because of its anti-hyperglycemic, anti-oxidative, and anti-inflammatory properties []. This is due to the various bioactive components present in dandelion, including polyphenolics, sesquiterpenes, triterpenes, and phytosterols".

Taken altogether, dandelion may be considered a remedy for the management and treatment of type 2 diabetes, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes by Wirngo FE1, Lambert MN1, Jeppesen PB. (PubMed)

Wednesday, 16 February 2022

Chaste Tree Berry May be a Valuable Remedy For theTreatment of Cancers, Researchers Suggest

By Kyle J. Norton

Chaste tree berry is found to exhibit a significant anti-cancer activity, a recent study by renowned study advised.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Cancer is a class of diseases characterized by cells growing and multiplying disordered and uncontrollable ways in our body. In the late stage, the cancer cells may travel away from the originated site to infect other tissues and organs.

According to the Tianjin Institute for Biomedicinal Research, in the evaluated the apoptosis-inducing effect of chaste tree berry, using observation under a light microscope, flow cytometric analysis, and agarose gel electrophoresis, Vitexicarpin, a flavonoid found in chaste tree berry significantly inhibited proliferation of human cancer cells lines A2780(human ovarian carcinoma), HCT-15(human, colon, colorectal adenocarcinoma), HT-1080(fibrosarcoma cell line) and K562(Human chronic myeloid leukemia cells), depending to the concentration.

Dr. Wang HY the lead researcher in the study said, "Vitexicarpin induces apoptosis.... via mitochondria(in regulated cell metabolism)-controlled apoptotic pathway".

In support of the above analysis, the crude extract prepared with ethanol from dried ripened Vitex agnus-castus fruits exerted strong cytotoxic effects against cancer cell lines of human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.

The inhibition of the extract is attributed to the effect on cell death through apoptosis and increased intracellular oxidation in the tumor cells.

Other researchers suggested that the cytotoxic effects of Chaste tree berry may be involved various aspects, including the JNK (apoptosis) pathway. as indicated in the new native lignan VB6 study.

Taking together, there is no doubt, that chaste tree berry may be considered as a valuable chemotherapeutic agent for the treatment of various types of cancer, depending on further evaluation.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway].[Article in Chinese] by Wang HY1, Cai B, Cui CB, Zhang DY, Yang BF.(PubMed)
(2) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(3) Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway by Zhou J1, Hu H, Long J, Wan F, Li L, Zhang S, Shi YE, Chen Y.(PubMed)

Tuesday, 1 February 2022

Herbal Ginger in Reducing the Risk of Hypertension and Hypertensive Complications

By Kyle J. Norton

Ginger may be considered a functional food for the prevention and treatment of hypertension and hypertension complications, some studies found.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Hypertension of high blood pressure is a chronic condition of abnormally high blood pressure.

It is one of the members of a cluster of metabolic syndrome associated with the onset of cardiovascular disease.

Believe it or not, people with high blood pressure are most likely to develop hyperglycemia (Anomaly high blood glucose) and hyperlipidemia (abnormally high blood cholesterol).

According to the statistic, approximately 1 in 3 adults in the US has high blood pressure, affecting over 75 million or 32% of the American adults (32%).


Some researchers suggested that high blood pressure can be caused by stress or an underlying condition, such as kidney disease.

However, an unhealthy diet is one of the most common risk factors in the development of the syndrome in the Western world that is caught the attention of many scientists.

Dr. Lydia A. Bazzano, the lead scientist in the study"Dietary Approaches to Prevent Hypertension", wrote, "Changes in diet can lower blood pressure, prevent the development of hypertension, and reduce the risk of hypertension-related complications".

"Dietary strategies for the prevention of hypertension include reducing sodium intake, limiting alcohol consumption, increasing potassium intake, and adopting an overall dietary pattern such as the DASH (Dietary Approaches to Stop Hypertension) diet or a Mediterranean diet".

These results clearly suggested that a diet rich in fruits and vegetables, whole grain, and less in saturated and trans fat, red meat, and processed foods are associated with the reduction of hypertension.

Unmanaged hypertension can lead to heart disease and stroke.

With an aim to find a natural ingredient or formula for the prevention and treatment of high blood pressure, researchers examine the effect of herbal treatment on blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM).

The clinical trial included 204 T2DM patients randomly assigned to four intervention groups receiving 3 g cinnamon, 3 g cardamom, 1 g saffron, or 3 g ginger with three glasses of black tea, and one control group consuming only three glasses of tea without any herbals, for 8 weeks.

All medicinal plants exerted a significant effect in lowering high blood pressure.

Ginger intake affected systolic BP compared to other medical plants' intake and control.

After taking into account co and confounders, Dr. Azimi P, the lead author said, "there was no significant difference between the plants in terms of ...... BP".

Additional differentiation of the anti-hypertension effect of ginger (Zingiber officinale) and turmeric (Curcuma longa), researchers examine the effect of dietary supplementation of these rhizomes in Nω-nitro-l-arginine methyl ester hydrochloride (l-NAME) induced hypertensive rats.


The study divided testes animals into seven groups (n = 10): normotensive control rats; induced (l-NAME hypertensive) rats; hypertensive rats treated with atenolol (10 mg/kg/day); normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively.

After 14 days of pre-treatment, the animals were induced with hypertension by oral administration of l-NAME (40 mg/kg/day).

Hypertensive rats significant (p < 0.05) showed hypertension-derived complications associated with platelet hyperactivity, a risk of cardiovascular disease compared to control.


In other words, ginger modulated the blood pressure and inhibited complications of high blood pressure in the initiation of the risk of cardiovascular disease.

Taken altogether, ginger used alone or combined with other medicinal plants may have a potential effect in reducing the risk of high blood pressure and high blood pressure complication.


However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of herbal ginger anti-hypertension possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Effect of cinnamon, cardamom, saffron and ginger consumption on bloodpressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. by Azimi P1,2, Ghiasvand R1,2, Feizi A3, Hosseinzadeh J1,2, Bahreynian M1,2, Hariri M1,2, Khosravi-Boroujeni H. (PubMed)
(2) Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats by Akinyemi AJ1,2,3, Thomé GR3, Morsch VM3, Bottari NB3, Baldissarelli J3, de Oliveira LS3, Goularte JF4, Belló-Klein A4, Oboh G1, Schetinger MR. (PubMed)
(3) Dietary Approaches to Prevent Hypertension by Lydia A. Bazzano, Torrance Green, Teresa N. Harrison, and Kristi Reynolds. (PMC)

Tuesday, 25 January 2022

Herbal Ashwagandha, the Best Antioxidant Functional Remedy

By Kyle J. Norton

Oxidative stress is a condition of imbalance of the ratio of antioxidants and free radicals in the body. In other words, the overproduction of free radicals accompanied by the decreased levels of antioxidants may cause cytotoxicity in the induction of oxidative stress.

Some researchers suggested long-term suppression by oxidative stress can activate the expression of over 500 different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules,...

Oxidative stress-activated inflammatory pathways have been found to induce the transformation of cell DNA to cause cancer and, chronic diseases.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radicals before they can cause a chain reaction in facilitating the protein, lipid, and cell DNA damage.

Antioxidants can either be produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

However, in people with a weakened immune system, intake of dietary sources of antioxidants may be necessary.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound that processes the antioxidant activity, researchers investigated the effects of Withania somnifera on copper-induced lipid peroxidation and antioxidant enzymes in the aging spinal cord of Wistar rats.

According to the tested differentiation, the application of Withania somnifera exerted a strong effect on the levels glutathione peroxidase (GPx) which were decreased significantly in the spinal cord from adult to aged mice.

Withania somnifera also successfully inhibited lipid peroxidation in a dose-dependent manner through its antioxidant activity.

Furthermore, these effects were found to be similar to those of superoxide dismutase and mannitol.

Based on the findings, researchers said, "The results indicate the therapeutic potential of Withania somnifera in aging and copper-induced pathophysiological conditions".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention of diseases associated with oxidative stress, pending the result of a larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidativemodifications by Gupta SK1, Dua A, Vohra BP. (PubMed)

Sunday, 16 January 2022

Herbal Dandelion (Taraxacum officinale) Effects on Rheumatoid Arthritis (RA)

By Kyle J. Norton

Arthritis, one of the Musculoskeletal disorders (MSDs) degenerative disease, is a general term of joint inflammation, affecting over 21% of the US population.


There are over 100 different forms of arthritis and related diseases. Rheumatoid arthritis (RA), is the common form of arthritis involved in chronic low-grade inflammation.

Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.

In other words, it is an autoimmune disorder caused by the immune system attacking some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.

Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.

According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.

Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many older adults.

According to the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.


Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined taraxasterol (TAR), a bioactive active compound pentacyclic triterpenes isolated from Chinese medicine herb Taraxacum officinale effects on rheumatoid arthritis (RA).

In Vitro and Vivo, the application of TRA significantly suppressed the proteins involved in the production of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), IL-6, and IL-8 by blocking NOD-like receptor protein 3 (NLRP3) inflammasomes, activators of IL-1β secretion, particularly in the joints tissues of collagen-induced arthritis (CIA) mice.

Furthermore, the application of TRA also inhibited the enzymes involved in the productions of matrix metalloproteinases (MMPs), like MMP-1 and MMP-3 in HFLS-RA in vitro, degradation of the normal tissues.

Moreover, the injection of TRA also blocked nuclear factor kappa B (NF-κB) activation via modulating inhibitors of kappa B (IκB), IκB kinase (IKK) in the control of cytokines production and cell survival and transforming growth factor-β-activated kinase 1 (TAK1) to prevent the accumulation of ROS, resulting in cell death and inflammation.

Taken altogether, dandelion may be considered a remedy for the treatment of rheumatoid arthritis, pending the confirmation of the larger sample size and multicenter human study.


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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritisfibroblast-like synoviocytes and rheumatoid arthritis progression in mice by Chen J1, Wu W2, Zhang M1, Chen C. (PubMed)

Monday, 10 January 2022

Herbal Angelica Protects the Neurons Against Traumatic Brain Injury (TBI)

By Kyle J. Norton

The central nervous system containing the brain and the spinal cord is the complex system of nerve tissues that controls the activities of the human body.

It is the center that controls our thoughts, the interpreter of our external environment, and body movement.

Traumatic brain injury (TBI) is a condition caused by sudden damage to the brain due to a blow or jolt to the head. 

Most cases of TBI are associated with car accidence and sports injuries.

The most common symptoms caused by TBI are the loss of consciousness induce-dazed, confusion or disorients, headache, dizziness or loss of balance, difficulty sleeping and the problem with speech

In severe cases, patients may also experience sensory problems, sensitivity to light or sound, memory or concentration problems, mood swings, and feeling depressed or anxious.

Conventionally, the treatment of TBI includes physical therapy, occupational therapy, speech therapy. psychological and vocational counseling, cognitive therapy,... depending on the location of the injury.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the prevention and treatment of diseases associated with brain injury, researchers examined the effects of Astragali Radix (AR)-Radix Angelica Sinensis (RAS) activity on traumatic brain injury (TBI).

According to the chemical analysis, researchers discover that the effects of the combination against the traumatic brain injury (TBI) may be attributed to the 14 bioactive ingredients in AR-RAS, while 33 potential targets hit by these ingredients related to TBI.

The effectiveness of the combined herbal medicines according to the GO annotation analysis, was involved in the regulation of multiple biological processes by AR-RAS.

Additionally, 89 novel signaling pathways (P<0.05) were also found to underlie the effects of AR-RAS for TBI treatment.

According to the animal experiment, in vivo AR-RAS showed significantly induced tissue recovery and improved neurological deficits in the hippocampus of TBIrats on the 14th day.

More precisely, AR-RAS target the neurotrophin signaling pathways as a major related pathway to improve axonal growth.

Based on the findings, researchers said, "Our work illuminates the "multi-compounds, multi targets, and multi pathways" curative action of AR-RAS in the treatment of TBI by network pharmacology".


Taken altogether, Herbal Angelica used alone or combined with Astragali Radix may be considered a functional herbal medicine for the treatment of traumatic brain injury,  pending a larger sample size and multicenter human study.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury by Xie G1, Peng W2, Li P1, Xia Z1, Zhong Y1, He F3, Tulake Y4, Feng D1, Wang Y1, Xing Z. (PubMed)

Thursday, 6 January 2022

Aloe Vera, the Anti-Microbial Herbal Medicine

By Kyle J. Norton

A recent study performed by a renowned institute suggested that intake of Aloe Vera or Aloe Vera supplement may reduce the risk of microbial infection and infectious diseases.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating many kinds of disease, including wound, burn- healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterols, etc.

In a total of Sixty students in the age group 6-12 years selected from an orphanage center, divided into four groups study, oral administration of Aloe Vera group showed a decrease of the bacterial count by 80.94% .

Dr. Bhati N, the lead author said, "Herbal dentifrices containing A. Vera... can be safely recommended as an alternative to fluoridated dentifrices in terms of antimicrobial efficacy".

In Streptococcus mutant strains, Aloe vera brushing showed a reduced bacteria contamination of Streptococcus mutant strains, without differentiation from the other chemical agents used.

In fact, Aloe vera in the study against pathogenic such as Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Salmonella Typhimurium, Proteus vulgaris, Klebsiella pneumonia, Escherichia coli, Streptococcus pyogenes and Candida albicans displayed a significantly antimicrobial inhibition rate zones ranging from 6.0 ± 0.57 to 16.6 ± 0.57 mm as the result of the expression of bioactive compounds with high 2,2-diphenyl-1-picrylhydrazyl (DPPH, stable free-radical molecules isolated from the herb), composed of scavenging properties.

Taking together, oral administration of Aloe Vera is found to associate to reduced risk of microbial infection and infectious diseases, but a large amount intake should only be prescribed by related field specialists.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Evaluation of antimicrobial efficacy of Aloe vera and Meswak containing dentifrices with fluoridated dentifrice: An in vivo study by Bhati N1, Jaidka S1, Somani R1(PubMed)
(2) Antimicrobial capacity of Aloe vera and propolis dentifrice against Streptococcus mutant strains in toothbrushes: an in vitro study by Bertolini PF1, Biondi Filho O, Pomilio A, Pinheiro SL, Carvalho MS.(PubMed)
(3) Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera by Akinsanya MA1, Goh JK2, Lim SP2, Ting AS3.(PubMed)