By Kyle J. Norton
Herbal butterbur may be considered a functional herb in the protection of neurons against change in the brain and its surrounding blood vessels in the initiated onset of migraine, some scientists suggested.
Migraine headache is one most common headaches defined as a condition of a chronic neurological disorder of moderate to severe headaches, and nausea that usually develops gradually over 5–20 minutes and lasts for less than 60 minutes.
According to statistics, the syndrome affects over 15% of the population in the US. If you are a woman your risk of migraine headaches is 2 times higher in compared to men.
Sadly, 1 in 7 people in the world population will develop migraine headache at some point in their lifetime, And, chronic migraine affects about 2% of the world population.
Some patients during migraine attacks also suffer symptoms of visual disturbances, nausea, vomiting, dizziness, extreme sensitivity to sound, light, touch, and smell, and tingling or numbness in the extremities or face.
Believe it or not, 10% of school-age children also suffer from undiagnosed migraine headaches.
Conventional medicine in reducing symptoms of pain during attacks such as Sumatriptan, Rizatriptan,..and Eletriptan may be effective but they may induce certain side effects, including gastrointestinal discomfort, dizziness, drowsiness,... and muscle weakness.
Please make sure that you discuss these side effects with your doctor before taking them.
Butterbur, found in wet, marshy, damp land, including wetland, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The herb has been used in herbal medicine used as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.
The Chemical constituents
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
Although the herb is used as a nutritional supplement in the US, scientific studies suggested that it may be used as the prevention of allergic rhinitis and treatment of migraine.
In a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients with migraine, satisfied the International Headache Society criteria, researchers found that by calculating the migraine attack frequency per month as percentage change from baseline over a 4-month treatment period
* Migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), in compared to 26% of placebo group.
* The proportion of patients with a > or =50% reduction in attack frequency after 4 months was 68% for patients in the Petasites extract 75-mg arm and 49% for the placebo arm (p < 0.05).
* In comparison to the baseline, patients, intake of Petasites 75 mg also expressed a significant effect in reduced migraine at 1, 2, and 3 months.
* Mild adverse effects such as gastrointestinal events, predominantly burping. were also reported.
These results suggested that butterbur Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine.
Furthermore, in the review to confirm the strength of evidence of effectiveness for Petasites hybridus in treating prophylaxis of migraine by searching several databases and other sources to identify randomized-controlled trials, the Headache Center Hirslanden in Zürich, Switzerland found 2 trials totaling 293 patients (60 and 233 patients).
According to the selected trials, oral administrated butterbur extract at a higher dose (150 mg) expressed a greater decreased frequency of migraine attacks and a greater number of responders (improvement>50%) after treatment over 3-4 months compared to the extract at a lower dose (100 mg) and placebo.
Additional differentiation also found some evidences that higher than the recommended dose may be more effective in treating prophylaxis of migraine.
More profoundly, in the study of 60 patients who received either the special Petasites hybridus extract Petadolex or placebo at a dosage of two capsules (each capsule contains 25 mg) twice daily over 12 weeks, researchers found that
* Oral injection of the capsules Petadolex reduces the frequency of migraine attacks decreased by a maximum of 60 percent compared to the baseline.
* No adverse events were reported. Petasites were exceptionally well tolerated.
Taking all together, herbal butterbur extract may be considered a therapeutic treatment for acute and chronic migraine headaches, however, the exact dose should only be prescribed by herbalists.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine by Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A.(PubMed)
(2) An extract of Petasites hybridus is effective in the prophylaxis of migraine by Grossman W, Schmidramsl H.(PubMed)
(3) Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review by Agosti R, Duke RK, Chrubasik JE, Chrubasik S.(PubMed)
Showing posts with label supplementations. Show all posts
Showing posts with label supplementations. Show all posts
Tuesday 7 June 2022
Sunday 29 May 2022
Phytochemical Beta-Sitosterol Inhibits the Symptoms of Benign prostatic hyperplasia (BPH)
By Kyle J. Norton
The prostate warped around the urethra is a gland of the male reproductive system found in front of the rectum and just below the bladder responsible for making some of the semen that carries sperm.
Most symptoms of an enlarged prostate are related to bladder function in urinary excretion. If you experience some of the symptoms of a weak stream of urine, difficulty starting urination, dribbling of urine, especially after urinating,..... and a sense of not fully emptying the bladder, you may develop enlarge prostate.
In severe cases, patients may also develop symptoms of night time frequent urination and a strong and sudden desire to urinate,.... and blood in the urine.
As the size of the prostate increase, the sex organ pressed on the urethra not only causes urinary problems but also induce urinary pain (dysuria or pain with urination).
Beta-Sitosterol is a phytochemical in the class of phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the protection of the prostate gland, researchers examined the effects of Azuprostat, a beta-sitosterol, in patients with symptoms of outlet obstruction caused by benign prostatic hyperplasia (BPH).
Treatment of beta-sitosterol showed a significant improvement of BPH symptoms over placebo.
The mean difference in the IPSS between placebo and beta-sitosterol, adjusted for the initial values, was 5.4 and the quality-of-life index was 0.9.
The prostate warped around the urethra is a gland of the male reproductive system found in front of the rectum and just below the bladder responsible for making some of the semen that carries sperm.
The muscle of the prostate gland also plays a critical in nourishing and protecting sperm by secreting fluid in perm ejaculation into the urethra.
Benign prostatic hyperplasia(BPH) is a condition that increases numbers of the cell of prostate tissues, causing partial, or sometimes virtually complete obstruction of the urinary tract.
According to statistics, BPH commonly starts at the age of 30 and symptoms usually can not be realized until the age of 50.
More than half of men between the age of 60-70 experience symptoms of BPH and only 10% is required treatment.
Benign prostatic hyperplasia(BPH) is a condition that increases numbers of the cell of prostate tissues, causing partial, or sometimes virtually complete obstruction of the urinary tract.
According to statistics, BPH commonly starts at the age of 30 and symptoms usually can not be realized until the age of 50.
More than half of men between the age of 60-70 experience symptoms of BPH and only 10% is required treatment.
Most symptoms of an enlarged prostate are related to bladder function in urinary excretion. If you experience some of the symptoms of a weak stream of urine, difficulty starting urination, dribbling of urine, especially after urinating,..... and a sense of not fully emptying the bladder, you may develop enlarge prostate.
In severe cases, patients may also develop symptoms of night time frequent urination and a strong and sudden desire to urinate,.... and blood in the urine.
As the size of the prostate increase, the sex organ pressed on the urethra not only causes urinary problems but also induce urinary pain (dysuria or pain with urination).
On finding a potential phytochemical for the protection of the prostate gland, researchers examined the effects of Azuprostat, a beta-sitosterol, in patients with symptoms of outlet obstruction caused by benign prostatic hyperplasia (BPH).
The randomized, double-blind and placebo-controlled clinical trial was conducted to assess the efficacy and safety of 130 mg free beta-sitosterol (phytosterol) daily, using the international prostate symptom score (IPSS) as the primary outcome variable in a total of 177 patients with BPH who were recruited for 6 months treatment in 13 study centers.
According to the secondary outcome variables, beta-sitosterol showed an increase in Qmax (4.5 mL/s) and a decrease in PVR (33.5 mL) after adjusting to the changes compared to the placebo.
Based on the findings, researchers said, "These results show that a beta-sitosterol is an effective option in the treatment of BPH".
Taken altogether, beta-Sitosterol may be considered a functional supplement for the prevention and treatment of benign prostatic hyperplasia (BPH), pending to the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol(phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group by Klippel KF1, Hiltl DM, Schipp B. (PubMed)
(2) Nutritional status and nutritional habits of men with benign prostatic hyperplasia or prostate cancer - preliminary investigation by Goluch-Koniuszy Z, Rygielska M, Nowacka I.(PubMed)
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol(phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group by Klippel KF1, Hiltl DM, Schipp B. (PubMed)
(2) Nutritional status and nutritional habits of men with benign prostatic hyperplasia or prostate cancer - preliminary investigation by Goluch-Koniuszy Z, Rygielska M, Nowacka I.(PubMed)
Wednesday 25 May 2022
Anthocyanin-Rich Red Cabbage Extract (ARCE) Processes Cardio-Protective Activity
By Kyle J. Norton
Cardioprotection is a process including the use of substances associated with the preservation of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.
Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage to blood vessels and the heart.
More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack), or stroke, depending on the location of the blockage or disruption,
According to the statistics provided by the American Heart Association, approximately 84 million people in the US live with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.
The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight, and smoking.
Believe it or not, most patients who suffered from CVD are also associated with atherosclerosis, a condition caused by long-term plaque build-up on artery walls, that leads to narrowing the arteries and reducing blood flow through your arteries to the heart.
Metabolic factors including hyperglycemia, hyperlipidemia, and hyperkalemia are the most common syndromes that have been found to promote CVD.
Where hyperglycemia, hyperlipidemia, and hyperkalemia are conditions of abnormally high levels of sugar, cholesterol, and potassium level in the bloodstream, respectively.
Dr. Gumbiner B, the lead scientist wrote, "Risk factors for cardiovascular disease (CVD) appear to cluster in individuals, possibly because of a single, underlying metabolic disorder".
And, " Abnormal metabolic risk factors were defined as (1) an abnormal glucose value (fasting blood sugar greater than 115 mg/dl); (2) abnormal lipids (high-density lipoprotein cholesterol under 35 mg/dl in men or under 45 mg/dl in women; or low-density lipoproteins of 160 or greater; or triglycerides greater than 250 mg/dl), and (3) hypertension (blood pressure systolic above 160 mmHg; or diastolic above 90 mmHg)".
Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
On findings of a natural whole for the prevention of cardiovascular disease, researchers examined the effects of Brassica vegetables such as red cabbage on the alleviation of experimentally induced myocardial infarction.
H2O2 induced rat neonatal cardiomyoblasts (H9c2 cells) treatment associated with cytotoxicity (48-50%) and apoptosis (57.3%), were reduced by the application of anthocyanin-rich red cabbage extract (ARCE).
Furthermore, in the isoproterenol (ISO) induced rodent model of myocardial infarction, pretreated ARCE for 30 days recorded a significant increase in heart body weight ratio as compared to the ISO-treated group.
ARCE pretreatment also prevents the effect of ISO on the induction of the depletion of enzymatic antioxidants and apoptosis.
Moreover, ISO-induced infracted areas (10%) and derangement of the myocardium were also inhibited by the pretreatment of ARCE.
Additionally, ISO-induced heart cell membrane damage and heart calcium imbalance were also attenuated by the pretreatment of ARCE.
In other words, ARCE protected heart integrity against the isoproterenol (ISO) induced damage to the heart muscle.
Based on the results, researchers wrote, "Overall this study elucidates the mechanism of ARCE mediated prevention of experimentally induced myocardial damage".
Taken altogether, red cabbage may process cardioprotective activity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anthocyanin rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction by Jana S1, Patel D1,2, Patel S1, Upadhyay K1, Thadani J1, Mandal R3, Das S3, Devkar R. (PubMed)
(2) Metabolic risk factors for cardiovascular disease in a working population: a retrospective cohort study by Gumbiner B1, Andresen EM, Hearne FT, Michaelson TE, Bryson M, Lednar WM, Cass R. (PubMed)
Cardioprotection is a process including the use of substances associated with the preservation of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.
Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage to blood vessels and the heart.
More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack), or stroke, depending on the location of the blockage or disruption,
According to the statistics provided by the American Heart Association, approximately 84 million people in the US live with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.
The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight, and smoking.
Believe it or not, most patients who suffered from CVD are also associated with atherosclerosis, a condition caused by long-term plaque build-up on artery walls, that leads to narrowing the arteries and reducing blood flow through your arteries to the heart.
Metabolic factors including hyperglycemia, hyperlipidemia, and hyperkalemia are the most common syndromes that have been found to promote CVD.
Where hyperglycemia, hyperlipidemia, and hyperkalemia are conditions of abnormally high levels of sugar, cholesterol, and potassium level in the bloodstream, respectively.
Dr. Gumbiner B, the lead scientist wrote, "Risk factors for cardiovascular disease (CVD) appear to cluster in individuals, possibly because of a single, underlying metabolic disorder".
And, " Abnormal metabolic risk factors were defined as (1) an abnormal glucose value (fasting blood sugar greater than 115 mg/dl); (2) abnormal lipids (high-density lipoprotein cholesterol under 35 mg/dl in men or under 45 mg/dl in women; or low-density lipoproteins of 160 or greater; or triglycerides greater than 250 mg/dl), and (3) hypertension (blood pressure systolic above 160 mmHg; or diastolic above 90 mmHg)".
Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
On findings of a natural whole for the prevention of cardiovascular disease, researchers examined the effects of Brassica vegetables such as red cabbage on the alleviation of experimentally induced myocardial infarction.
H2O2 induced rat neonatal cardiomyoblasts (H9c2 cells) treatment associated with cytotoxicity (48-50%) and apoptosis (57.3%), were reduced by the application of anthocyanin-rich red cabbage extract (ARCE).
Furthermore, in the isoproterenol (ISO) induced rodent model of myocardial infarction, pretreated ARCE for 30 days recorded a significant increase in heart body weight ratio as compared to the ISO-treated group.
ARCE pretreatment also prevents the effect of ISO on the induction of the depletion of enzymatic antioxidants and apoptosis.
Moreover, ISO-induced infracted areas (10%) and derangement of the myocardium were also inhibited by the pretreatment of ARCE.
Additionally, ISO-induced heart cell membrane damage and heart calcium imbalance were also attenuated by the pretreatment of ARCE.
In other words, ARCE protected heart integrity against the isoproterenol (ISO) induced damage to the heart muscle.
Based on the results, researchers wrote, "Overall this study elucidates the mechanism of ARCE mediated prevention of experimentally induced myocardial damage".
Taken altogether, red cabbage may process cardioprotective activity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anthocyanin rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction by Jana S1, Patel D1,2, Patel S1, Upadhyay K1, Thadani J1, Mandal R3, Das S3, Devkar R. (PubMed)
(2) Metabolic risk factors for cardiovascular disease in a working population: a retrospective cohort study by Gumbiner B1, Andresen EM, Hearne FT, Michaelson TE, Bryson M, Lednar WM, Cass R. (PubMed)
Tuesday 24 May 2022
Herbal Bilberry, an Anti-Psoriasis Remedy
Kyle J. Norton
Psoriasis is an autoimmune disease caused by speeding up the life cycle of skin cells that leads to patches of abnormal skin.
Psoriasis may be localized which causes red, dry, itchy, and scaly skin patches in the affected area.
In cases of severity, psoriasis can cover the body completely.
Some patients also experience symptoms of thickened, pitted, or ridged nails and swollen and stiff joints.
If you experience some of the aforementioned symptoms, please check with your doctor for preventive measures.
The causes of psoriasis are not identified, however, researchers believed that genetic proposition exacerbated by certain factors such as weather, injury, illness, or stress are some of the most causable factors that induce the onset of the condition.
Other risk factors associated with psoriasis may include skin injury that did not heal properly, people who are obese and side effects of long-term use of certain medicines such as oral steroids.
Some researchers suggested smoking that has a strong impact on the immune system and may also be one of the major causes of psoriasis in smokers.
Dr. wrote, "A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis".
And, " Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences".
The findings strongly suggested, that if you smoke, you are at a higher risk of psoriasis
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, and kidney disease, psoriasis, diabetes, etc.
With an aim to find a natural and therapeutic ingredient for the treatment of psoriasis, researchers
a cosmeceutical formulation based on boswellic acids and Vaccinium myrtillus seed oil in patients with psoriasis.
The double-blind study is to compare a novel BA formulation (containing Bosexil(®), INCI [International Nomenclature of Cosmetic Ingredients]: lecithin, Boswellia serrata resin extract) with a placebo formulation and a formulation of Vaccinium myrtillus (Bilberry) seed oil.
More precisely, patients with psoriasis or erythematous eczema were randomly assigned, in a 1:1:1 ratio, to Bosexil(®), V. myrtillus seed oil, or placebo.
During the experiment, Bosexil(®) and the V. myrtillus seed oil treatment significantly improved psoriasis, scales in comparison with placebo.
Formulation of Vaccinium myrtillus seed oil exerted a similar effect as those of Bosexil(®) without any case of worsening compared to placebo.
Furthermore, V. myrtillus seed oil improved itch and erythema in 66.7% and 77.8% of patients, respectively compared to the Bosexil(®) formulation (60% of cases) and erythema (60% of cases) without any case of worsening, respectively.
The results clearly suggested that V. myrtillus seed oil and Bosexil(®) formulation process a strong anti-psoriasis activity without side effects.
Taken altogether, bilberry may be considered a functioning remedy for the treatment of psoriasis, pending the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis by Togni S1, Maramaldi G1, Di Pierro F2, Biondi M. (PubMed)
(2) Psoriasis and smoking: links and risks by Luigi Naldi. (PMC)
Psoriasis may be localized which causes red, dry, itchy, and scaly skin patches in the affected area.
In cases of severity, psoriasis can cover the body completely.
Some patients also experience symptoms of thickened, pitted, or ridged nails and swollen and stiff joints.
If you experience some of the aforementioned symptoms, please check with your doctor for preventive measures.
The causes of psoriasis are not identified, however, researchers believed that genetic proposition exacerbated by certain factors such as weather, injury, illness, or stress are some of the most causable factors that induce the onset of the condition.
Other risk factors associated with psoriasis may include skin injury that did not heal properly, people who are obese and side effects of long-term use of certain medicines such as oral steroids.
Some researchers suggested smoking that has a strong impact on the immune system and may also be one of the major causes of psoriasis in smokers.
Dr. wrote, "A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis".
And, " Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences".
The findings strongly suggested, that if you smoke, you are at a higher risk of psoriasis
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, and kidney disease, psoriasis, diabetes, etc.
With an aim to find a natural and therapeutic ingredient for the treatment of psoriasis, researchers
a cosmeceutical formulation based on boswellic acids and Vaccinium myrtillus seed oil in patients with psoriasis.
The double-blind study is to compare a novel BA formulation (containing Bosexil(®), INCI [International Nomenclature of Cosmetic Ingredients]: lecithin, Boswellia serrata resin extract) with a placebo formulation and a formulation of Vaccinium myrtillus (Bilberry) seed oil.
More precisely, patients with psoriasis or erythematous eczema were randomly assigned, in a 1:1:1 ratio, to Bosexil(®), V. myrtillus seed oil, or placebo.
During the experiment, Bosexil(®) and the V. myrtillus seed oil treatment significantly improved psoriasis, scales in comparison with placebo.
Formulation of Vaccinium myrtillus seed oil exerted a similar effect as those of Bosexil(®) without any case of worsening compared to placebo.
Furthermore, V. myrtillus seed oil improved itch and erythema in 66.7% and 77.8% of patients, respectively compared to the Bosexil(®) formulation (60% of cases) and erythema (60% of cases) without any case of worsening, respectively.
The results clearly suggested that V. myrtillus seed oil and Bosexil(®) formulation process a strong anti-psoriasis activity without side effects.
Taken altogether, bilberry may be considered a functioning remedy for the treatment of psoriasis, pending the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis by Togni S1, Maramaldi G1, Di Pierro F2, Biondi M. (PubMed)
(2) Psoriasis and smoking: links and risks by Luigi Naldi. (PMC)
Monday 23 May 2022
Phytochemical Tocopherols, the Potential Anti-Cancer Remedies
By Kyle J. Norton
Cancer is a class of chronic and medical conditions caused by the alternation of cell DNA.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.
At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending on the location of the cancer.
Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.
According to the statistic provided by the American Cancer Society, in the US in 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are results from cancer.
Furthermore, from the age perspective, older adults although are accounted for only 8% of all cases diagnosed in the US, have a 17% mortality rate compared to other age groups.
The 3 most common types of cancer are
* Breast cancer, accounts for 25.4% of the total number of new cases diagnosed in 2018.
Breast cancer starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that which breast cancer starts in other areas of the breast. The risk of getting invasive breast cancer during the lifetime of women is 1/8.
Luckily, the 5 years survival rate of localized breast cancer is about 100%.
* Colorectal cancer and lung cancers are the second and third most common cancers, accounting for 43.9% of all cancers, excluding non-melanoma skin cancer.
Colorectal cancer is cancer in the colon, rectum, or vermiform appendix. Colorectal cancer is relatively very common and slowly growing and progressing cancer.
The 5-year survival rate of the localized stage of colorectal cancer is about 90%.
* Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed, or nut oils, etc.
On finding a potential phytochemical for the prevention and treatment of cancer, researchers examined the effect of tocopherols (TOCs) on tocotrienols (TTs). γ-TT and δ-TT have the highest anti-cancer activities.
According to the tested analysis, tocopherols (TOCs) showed a strong anti-tumor proliferative activity by targeting the common molecular pathways involved in the inhibition of the cell cycle.
Furthermore, tocopherols (TOCs) activated the pathways associated with the induction of apoptosis and autophagy, and the inhibition of invasion, metastasis, and angiogenesis.
Cancer is a class of chronic and medical conditions caused by the alternation of cell DNA.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.
At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending on the location of the cancer.
Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.
According to the statistic provided by the American Cancer Society, in the US in 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are results from cancer.
Furthermore, from the age perspective, older adults although are accounted for only 8% of all cases diagnosed in the US, have a 17% mortality rate compared to other age groups.
The 3 most common types of cancer are
* Breast cancer, accounts for 25.4% of the total number of new cases diagnosed in 2018.
Breast cancer starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that which breast cancer starts in other areas of the breast. The risk of getting invasive breast cancer during the lifetime of women is 1/8.
Luckily, the 5 years survival rate of localized breast cancer is about 100%.
* Colorectal cancer and lung cancers are the second and third most common cancers, accounting for 43.9% of all cancers, excluding non-melanoma skin cancer.
Colorectal cancer is cancer in the colon, rectum, or vermiform appendix. Colorectal cancer is relatively very common and slowly growing and progressing cancer.
The 5-year survival rate of the localized stage of colorectal cancer is about 90%.
* Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells
On finding a potential phytochemical for the prevention and treatment of cancer, researchers examined the effect of tocopherols (TOCs) on tocotrienols (TTs). γ-TT and δ-TT have the highest anti-cancer activities.
Moreover, γ-TT and δ-TT (solely or in combination) also induced anti-cancer molecular pathways when used in the combination with the conventional chemotherapeutic drugs
Taken altogether, tocopherols may process anti-cancer properties in Vitro and Vivo, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols by Constantinou C1, Charalambous C2, Kanakis D. (PubMed)
Taken altogether, tocopherols may process anti-cancer properties in Vitro and Vivo, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols by Constantinou C1, Charalambous C2, Kanakis D. (PubMed)
Wednesday 18 May 2022
Phytochemical Tocopherols Arrest Oral Cancer Cells in Vitro
By Kyle J. Norton
Oral cancer is a type of cancer associated with any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva), and the roof of the mouth (palate).
Oral cancer is a type of cancer associated with any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva), and the roof of the mouth (palate).
Most cases of oral cancer begin in the cells on the surface of the inner lining of oral tissue.
However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissue and organs, leading to secondary metastasis.
According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.
The 5-year survival rate of oral cancer is 66%, including all stages.
Family history, smoking, alcohol drinking, infection by the HPV virus, poor hygiene, and genetic preposition are some of the risk factors associated with the disease.
However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissue and organs, leading to secondary metastasis.
According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.
The 5-year survival rate of oral cancer is 66%, including all stages.
Family history, smoking, alcohol drinking, infection by the HPV virus, poor hygiene, and genetic preposition are some of the risk factors associated with the disease.
The most common types of oral cancer are
* Squamous cell carcinoma
Squamous cell carcinoma is one of the most common types of oral cancer accounting for over 90% of all cases and arises from the squamous cell layer in the lining of the oral cavity and oropharynx.
* Verrucous carcinoma
The low-grade and rarely-spread verrucous carcinoma accounts for only approximately 5% of all cases. Cancer can spread deeply into the surrounding tissue.
* Minor salivary gland cancers
Cancer originated from the salivary gland and accounted for less than 1% of all cases.
* Furthermore, despite the lower potency, α-tocopherol compared to Cisplatin showed signs of apoptosis associated with the shrinkage of cells and appearance of apoptotic bodies.
* Moreover, α-tocopherol demonstrated cell cycle arrest by inducing the high accumulation of cells in the G0/G1 phase.
* Squamous cell carcinoma
Squamous cell carcinoma is one of the most common types of oral cancer accounting for over 90% of all cases and arises from the squamous cell layer in the lining of the oral cavity and oropharynx.
* Verrucous carcinoma
The low-grade and rarely-spread verrucous carcinoma accounts for only approximately 5% of all cases. Cancer can spread deeply into the surrounding tissue.
* Minor salivary gland cancers
Cancer originated from the salivary gland and accounted for less than 1% of all cases.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed or nut oils, etc.
In finding a potential phytochemical for the treatment of malignant tumors researchers examined the effect of α-tocopherol against oral cancer.
In finding a potential phytochemical for the treatment of malignant tumors researchers examined the effect of α-tocopherol against oral cancer.
According to the analysis,
* In vitro, α-tocopherol exhibited the effective antitumor activity on Oral SquamousCarcinoma Cells ORL-48 at 2.5 ± 0.42 µg/mL, compared to Cisplatin exhibited stronger activity at 1.0 ± 0.15 µg/mL.
* In vitro, α-tocopherol exhibited the effective antitumor activity on Oral SquamousCarcinoma Cells ORL-48 at 2.5 ± 0.42 µg/mL, compared to Cisplatin exhibited stronger activity at 1.0 ± 0.15 µg/mL.
Based on the results, researchers said, "Both cisplatin and α-tocopherol displayed cell cycle arrest at the Sub G0 phase. α-tocopherol thus showed potential as an antitumor agent for the treatment of oral cancer and merits further research".
Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of oral cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Vitamin E (α-Tocopherol) Exhibits Antitumour Activity on Oral SquamousCarcinoma Cells ORL-48 by Zulkapli R1,2, Abdul Razak F1, Zain RB. (PubMed)
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Vitamin E (α-Tocopherol) Exhibits Antitumour Activity on Oral SquamousCarcinoma Cells ORL-48 by Zulkapli R1,2, Abdul Razak F1, Zain RB. (PubMed)
Monday 16 May 2022
Phytochemical Oleanolic Acid May Process Anti Cancer Property
By Kyle J. Norton
Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Cancers are the second leading cause of death worldwide besides heart diseases.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.
Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cell growth and proliferation.
Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.
On finding a potential plant for the treatment of chronic diseases, researchers examined the anti-cancer effect of Oleanolic acid (OA), a common pentacyclic triterpenoid.
According to the results of the analysis,
* Oleanolic acid exerted its effects as an inhibitor of the cellular inflammatory process, and the inducer of phase 2 xenobiotic biotransformation enzymes associated with cancer initiation.
* OA demonstrated its main anticancer effects mediated by caspases, 5' adenosine monophosphate-activated protein kinase in cellular energy homeostasis, extracellular signal-regulated kinase 1/2 in the regulation of cancer cell meiosis, mitosis, and postmitotic functions, matrix metalloproteinases in organogenesis, growth and normal tissue turnover, pro-apoptotic Bax.
* OA also promoted the overexpression of reactive oxygen species/apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase, nuclear factor-κB, in the induction of cancer cytotoxicity.
Collectively, researchers said, " In this work, we critically review the scientific literature on the molecular targets of oleanolic acid implicated in the prevention and treatment of several types of cancer".
Taken altogether, potato may be considered a functional food for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy by Žiberna L1, Šamec D2, Mocan A3,4, Nabavi SF5, Bishayee A6, Farooqi AA7, Sureda A8, Nabavi SM. (PubMed)
Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Cancers are the second leading cause of death worldwide besides heart diseases.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.
Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cell growth and proliferation.
Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.
On finding a potential plant for the treatment of chronic diseases, researchers examined the anti-cancer effect of Oleanolic acid (OA), a common pentacyclic triterpenoid.
According to the results of the analysis,
* Oleanolic acid exerted its effects as an inhibitor of the cellular inflammatory process, and the inducer of phase 2 xenobiotic biotransformation enzymes associated with cancer initiation.
* OA demonstrated its main anticancer effects mediated by caspases, 5' adenosine monophosphate-activated protein kinase in cellular energy homeostasis, extracellular signal-regulated kinase 1/2 in the regulation of cancer cell meiosis, mitosis, and postmitotic functions, matrix metalloproteinases in organogenesis, growth and normal tissue turnover, pro-apoptotic Bax.
* OA also promoted the overexpression of reactive oxygen species/apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase, nuclear factor-κB, in the induction of cancer cytotoxicity.
Collectively, researchers said, " In this work, we critically review the scientific literature on the molecular targets of oleanolic acid implicated in the prevention and treatment of several types of cancer".
Taken altogether, potato may be considered a functional food for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy by Žiberna L1, Šamec D2, Mocan A3,4, Nabavi SF5, Bishayee A6, Farooqi AA7, Sureda A8, Nabavi SM. (PubMed)
Friday 13 May 2022
Omega-3 Fatty Acids Relax the Vascular Smooth Muscles Against Vascular Diseases
By Kyle J. Norton
Vascular smooth muscle is the type of smooth muscle found within, and composing the majority of the wall of blood vessels.
According to the results of the experiment, the main components Docosahexaenoic acid (1-255 microM) and eicosapentaenoic acid (31-255 microM) inhibited phenylephrine-induced contractions, (8-63%) and (20-65%), respectively.
Vascular smooth muscle is the type of smooth muscle found within, and composing the majority of the wall of blood vessels.
Vascular smooth muscle plays a critical role in the distribution of blood to the cells of the organs and tissues by contracting or relaxing to change both the volume of blood vessels and the local blood pressure.
Compared to cardiac muscle, vascular smooth muscle undergoes slow, sustained, tonic contractions and relaxation.
Dysfunction of vascular smooth muscle cells is an important cause of vascular diseases, including atherosclerosis, hypertension, and circulatory shock.
Multisystemic smooth muscle dysfunction syndrome is a rare, genetic, vascular disease, including cerebrovascular disease, aortic anomalies, intestinal hypoperistalsis, hypotonic bladder, and pulmonary hypertension.
Vascular smooth muscle tone refers to the ratio of constriction experienced by a blood vessel relative to its maximally dilated state.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the prevention and treatment of vascular diseases, researchers compare the effects of omega-3, omega-6, and omega-9 fatty acids on vascular smooth muscle functioning.
On finding a potential phytochemical for the prevention and treatment of vascular diseases, researchers compare the effects of omega-3, omega-6, and omega-9 fatty acids on vascular smooth muscle functioning.
The efficacy of vascular smooth muscle relaxation was also not altered by the presence of indomethacin, NDGA, or by removal of the endothelium
Additionally, Linoleic acid (18:2n6) and arachidonic acid (20:4n6) found in omega 3, and 6 also induced significant relaxation.
Additionally, Linoleic acid (18:2n6) and arachidonic acid (20:4n6) found in omega 3, and 6 also induced significant relaxation.
Based on the findings, researchers said, " fatty acid-induced relaxation of the rat aorta is specific to polyunsaturated fatty acids, 20:5n3, 22:6n3, 18:2n6 and 20:4n6".
Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of vascular diseases by enhancing the vascular smooth muscle function, pending to the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscletone by Engler MB. (PubMed)
blood vessel
(1) Long-chain n-3 polyunsaturated fatty acids and blood vessel function by Abeywardena MY1, Head RJ. (PubMed)
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscletone by Engler MB. (PubMed)
blood vessel
(1) Long-chain n-3 polyunsaturated fatty acids and blood vessel function by Abeywardena MY1, Head RJ. (PubMed)
Tuesday 10 May 2022
Beta-Sitosterol in the Prevention of Lung Inflammation
By Kyle J. Norton
The lung is one of the vital organs in humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream and exhaling carbon dioxide from the bloodstream.
In CF airway epithelial CuFi-1 cells infected with P. aeruginosa. BSS (100 nM), BSS demonstrated a significant and consistent inhibitory activity on the expression of the P. aeruginosa-stimulated expression chemokines IL-8, GRO-α GRO-β, which play a pivotal role in the recruitment of neutrophils in CF inflamed lungs.
The lung is one of the vital organs in humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream and exhaling carbon dioxide from the bloodstream.
Lung diseases are medical conditions, affecting the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing.
People with lung diseases have breathing problems, preventing them to get enough oxygen for the body's needs.
Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.
Truly, the main focus of inflammation is to repair damage and injury.
Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.
However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.
Any inflammation that lasts more than 3 months is considered chronic inflammation.
Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms that participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.
Inflammation also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance in the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.
People with lung diseases have breathing problems, preventing them to get enough oxygen for the body's needs.
Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.
Truly, the main focus of inflammation is to repair damage and injury.
Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.
However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.
Any inflammation that lasts more than 3 months is considered chronic inflammation.
Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms that participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.
Inflammation also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance in the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.
Lung inflammation is a condition of acute or low-grade lung infection.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.
On finding a potential phytochemical for the prevention of lung diseases, researchers compared β-sitosterol, stigmasterol, and campesterol isolated from the extracts from Nigella arvensis L. seeds, on lung inflammation.
According to the tested analysis, β-sitosterol (BSS) was the only compound that significantly induce the inhibition of the P. aeruginosa-dependent expression of IL-8 associated with inflammatory activity at nanomolar concentrations.On finding a potential phytochemical for the prevention of lung diseases, researchers compared β-sitosterol, stigmasterol, and campesterol isolated from the extracts from Nigella arvensis L. seeds, on lung inflammation.
Furthermore, BSS partially inhibits the P. aeruginosa-dependent activation of Protein Kinase C isoform alpha, which is known to be involved in the transmembrane signaling activating IL-8 gene expression in bronchial epithelial cells.
Based on the findings, researchers said, "These data indicate BSS as a promising molecule to control excessive lung inflammation in CF patients".
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of lung inflammation, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) β-Sitosterol Reduces the Expression of Chemotactic Cytokine Genes in Cystic Fibrosis Bronchial Epithelial Cells by Lampronti I1, Dechecchi MC2, Rimessi A3, Bezzerri V2, Nicolis E2, Guerrini A1, Tacchini M1, Tamanini A2, Munari S2, D'Aversa E1, Santangelo A2, Lippi G2, Sacchetti G1, Pinton P3, Gambari R1, Agostini M4, Cabrini G. (PubMed)
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of lung inflammation, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) β-Sitosterol Reduces the Expression of Chemotactic Cytokine Genes in Cystic Fibrosis Bronchial Epithelial Cells by Lampronti I1, Dechecchi MC2, Rimessi A3, Bezzerri V2, Nicolis E2, Guerrini A1, Tacchini M1, Tamanini A2, Munari S2, D'Aversa E1, Santangelo A2, Lippi G2, Sacchetti G1, Pinton P3, Gambari R1, Agostini M4, Cabrini G. (PubMed)
Sunday 1 May 2022
Herbal Angelica Promotes Hematopoietic Function
By Kyle J. Norton
The hematopoietic system is a complex network including organs and tissues such as the bone marrow, liver, and spleen.
Hematopoiesis is the process by which blood cells are formed, including the formation of all of the cellular components of blood and blood plasma.
1. Red blood cells with a function to transport oxygen and hemoglobin to the body.
2. White blood cells that form parts of the immune system, including
* T cells and B cells, that fight viruses, and tumors.
* Neutrophils that fight bacteria and fungi.
* Eosinophils that fight some parasites and initiate an inflammatory response.
* Basophils that release the histamines necessary for the inflammatory response.
* Macrophages, are the first line of the immune response in the acute phase of infection.
3. Platelets (thrombocytes) for coagulation.
Dr. Risitano AM, the lead scientist in the study of " Function and malfunction of hematopoietic stem cells in primary bone marrow failure syndromes", said," Constitutional marrow failure syndromes are conditions caused by intrinsic defects of HSCs; they are due to inherited germline mutations accounting for specific phenotypes, and often involve also organs and systems other than hematopoiesis".
And " By contrast, in acquired marrow failure syndromes hematopoietic stem cells are thought to be intrinsically normal, but subjected to extrinsic damage affecting their hematopoietic function".
Diseases of the bone marrow, spleen, lymph nodes, and thymus may affect the process of hematopoiesis, leading to various diseases of the hematopoietic system.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation, and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound that promotes hematopoietic functioning, researchers examined the neuroprotective effects of investigating the influence of AS on the metabolism of blood deficiency mice model.
Selected mice in the study were induced blood deficiency by being hypodermically injected with N-acetyl phenylhydrazine (APH) and intraperitoneally injected with cyclophosphamide (CTX) then treated with Angelica Sinensis (AS).
According to the tested assays, the administration of AS normalized the levels of white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), and platelet (PLT) compared to the untreated control group.
The dose of 10g/kg demonstrated the best effect compared to other doses.
Furthermore, the metabolic pathways biomarkers associated with an important role in regulating the hematopoietic function, such as arachidonic acid metabolism, valine, leucine, and isoleucine biosynthesis, glycine, serine and threonine metabolism, arginine and proline were also affected by the injection of AS.
The hematopoietic system is a complex network including organs and tissues such as the bone marrow, liver, and spleen.
Hematopoiesis is the process by which blood cells are formed, including the formation of all of the cellular components of blood and blood plasma.
1. Red blood cells with a function to transport oxygen and hemoglobin to the body.
2. White blood cells that form parts of the immune system, including
* T cells and B cells, that fight viruses, and tumors.
* Neutrophils that fight bacteria and fungi.
* Eosinophils that fight some parasites and initiate an inflammatory response.
* Basophils that release the histamines necessary for the inflammatory response.
* Macrophages, are the first line of the immune response in the acute phase of infection.
3. Platelets (thrombocytes) for coagulation.
And " By contrast, in acquired marrow failure syndromes hematopoietic stem cells are thought to be intrinsically normal, but subjected to extrinsic damage affecting their hematopoietic function".
Diseases of the bone marrow, spleen, lymph nodes, and thymus may affect the process of hematopoiesis, leading to various diseases of the hematopoietic system.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation, and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound that promotes hematopoietic functioning, researchers examined the neuroprotective effects of investigating the influence of AS on the metabolism of blood deficiency mice model.
According to the tested assays, the administration of AS normalized the levels of white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), and platelet (PLT) compared to the untreated control group.
The dose of 10g/kg demonstrated the best effect compared to other doses.
In other words, AS promotes the production of all of the cellular components of blood and blood plasma in blood deficiency mice.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Metabolomics study of hematopoietic function of Angelica Sinensis on blood deficiency mice model by Li PL1, Sun HG1, Hua YL1, Ji P1, Zhang L1, Li JX1, Wei Y. (PubMed)
(2) Function and malfunction of hematopoietic stem cells in primary bone marrow failure syndromes by Risitano AM1, Maciejewski JP, Selleri C, Rotoli B. (PubMed)
Taken altogether, herbal Angelica may be considered a neuroprotective remedy for the improvement of hematopoietic function, pending to larger sample size and multicenter human study.
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Metabolomics study of hematopoietic function of Angelica Sinensis on blood deficiency mice model by Li PL1, Sun HG1, Hua YL1, Ji P1, Zhang L1, Li JX1, Wei Y. (PubMed)
(2) Function and malfunction of hematopoietic stem cells in primary bone marrow failure syndromes by Risitano AM1, Maciejewski JP, Selleri C, Rotoli B. (PubMed)
Friday 22 April 2022
Antioxidant Sinigrin Isolated From Brussel Sprouts, Broccoli,... May Be The Potential Anti Atherosclerosis Chemical Compound, According to Studies
By Kyle J. Norton
Sinigrin may be used as a bioactive ingredient for the prevention and treatment of atherosclerosis, according to studies.
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is made of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, the coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, unhealthy diet, family history of heart disease and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part of the plaque, an unhealthy diet with a high saturated trans fat, red meat, and processed meat may be the major cause of atherosclerosis.
In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.
Dr. Meifang Wang, the lead researcher in the study of "Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice" said, "....lowered circulating IGF-1 increases atherosclerosis progression in atherosclerosis-prone apolipoprotein E-deficient mice (ApoE−/−) while increased circulating IGF-1 downregulates vascular pro-inflammatory cytokine gene expression, reduces systemic and vascular oxidant stress, vascular cytokine expression, and decreases atherosclerosis progression".
And, "the pro-inflammatory phenotype that is enhanced by WD in ApoE−/− mice is further enhanced by specific IGF1R deficiency in monocytes/macrophages, and may consequently increase atherosclerosis progression".
The results suggested that the Western diet-induced atherosclerosis progression through the increase of production of pro-inflammatory cytokines and decrease of the function of insulin-like growth factor-1 (IGF-1) as a mediator of anabolic responses in many cells and tissues.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on finding a natural bioactive compound for the treatment of atherosclerosis examined the effect of sinigrin against plaque accumulation on the arterial walls.
On atherosclerosis in ApoE-/- mice, injection sinigrin exerted a significant effect in the inhibition of the serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines associated with plaque accumulated on the wall of the arteries.
Furthermore, oral administration of sinigrin attenuated the mRNA expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), which form a part of immunoglobulin superfamily in inflammatory and immune responses.
Moreover, injection also reduced the expression of genes C-C motif chemokine ligand 2 (CCL2), and CCL5 on aorta tissues associated with the risk of atherosclerosis.
The expression of low-density lipoprotein was also reduced by the injection of sinigrin observed by some keys regulators of cholesterol such as sterol regulatory element-binding protein-2 (SREBP-2).
Interestingly, increasing the concentration of sinigrin at the dose up to 100 μg/ml also significantly suppressed the levels of Tumor necrosis factor (TNF-α) and nuclear translocation of NF-κB, cell signaling protein (cytokine) involved in systemic inflammation.
Additionally, at a contraction ut to 100 μg/ml, sinigrin inhibited the c-Jun-NH (2)-terminal kinase (JNK) signaling pathway which plays a critical role in regulating cellular differentiation.
The findings strongly suggested that sinigrin inhibited the onset of atherosclerosis by lowering the low-density lipoproteins and mechanisms associated with inflammatory induction of plaque accumulation on the arterial wall.
Dr. Jang YJ, the lead scientist wrote, "sinigrin decreases the TNF-α-stimulated VCAM-1 expression through the suppression of NF-κB and MAP kinases signaling pathways, Overall, sinigrin has the potential to be used in reducing the risks of atherosclerosis".
Taken altogether, sinigrin may be considered a supplement for the prevention and combined with the primary therapy for the treatment of atherosclerosis, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice by Meifang Wang, Yusuke Higashi, Derek Wang, Ronald Korthuis, and Patrice Delafontaine. (FASEB Journal)
Sinigrin may be used as a bioactive ingredient for the prevention and treatment of atherosclerosis, according to studies.
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is made of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, the coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, unhealthy diet, family history of heart disease and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part of the plaque, an unhealthy diet with a high saturated trans fat, red meat, and processed meat may be the major cause of atherosclerosis.
In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.
Dr. Meifang Wang, the lead researcher in the study of "Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice" said, "....lowered circulating IGF-1 increases atherosclerosis progression in atherosclerosis-prone apolipoprotein E-deficient mice (ApoE−/−) while increased circulating IGF-1 downregulates vascular pro-inflammatory cytokine gene expression, reduces systemic and vascular oxidant stress, vascular cytokine expression, and decreases atherosclerosis progression".
And, "the pro-inflammatory phenotype that is enhanced by WD in ApoE−/− mice is further enhanced by specific IGF1R deficiency in monocytes/macrophages, and may consequently increase atherosclerosis progression".
The results suggested that the Western diet-induced atherosclerosis progression through the increase of production of pro-inflammatory cytokines and decrease of the function of insulin-like growth factor-1 (IGF-1) as a mediator of anabolic responses in many cells and tissues.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on finding a natural bioactive compound for the treatment of atherosclerosis examined the effect of sinigrin against plaque accumulation on the arterial walls.
On atherosclerosis in ApoE-/- mice, injection sinigrin exerted a significant effect in the inhibition of the serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines associated with plaque accumulated on the wall of the arteries.
Furthermore, oral administration of sinigrin attenuated the mRNA expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), which form a part of immunoglobulin superfamily in inflammatory and immune responses.
Moreover, injection also reduced the expression of genes C-C motif chemokine ligand 2 (CCL2), and CCL5 on aorta tissues associated with the risk of atherosclerosis.
The expression of low-density lipoprotein was also reduced by the injection of sinigrin observed by some keys regulators of cholesterol such as sterol regulatory element-binding protein-2 (SREBP-2).
Interestingly, increasing the concentration of sinigrin at the dose up to 100 μg/ml also significantly suppressed the levels of Tumor necrosis factor (TNF-α) and nuclear translocation of NF-κB, cell signaling protein (cytokine) involved in systemic inflammation.
Additionally, at a contraction ut to 100 μg/ml, sinigrin inhibited the c-Jun-NH (2)-terminal kinase (JNK) signaling pathway which plays a critical role in regulating cellular differentiation.
The findings strongly suggested that sinigrin inhibited the onset of atherosclerosis by lowering the low-density lipoproteins and mechanisms associated with inflammatory induction of plaque accumulation on the arterial wall.
Dr. Jang YJ, the lead scientist wrote, "sinigrin decreases the TNF-α-stimulated VCAM-1 expression through the suppression of NF-κB and MAP kinases signaling pathways, Overall, sinigrin has the potential to be used in reducing the risks of atherosclerosis".
Taken altogether, sinigrin may be considered a supplement for the prevention and combined with the primary therapy for the treatment of atherosclerosis, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice by Meifang Wang, Yusuke Higashi, Derek Wang, Ronald Korthuis, and Patrice Delafontaine. (FASEB Journal)
Thursday 21 April 2022
Phytochemical Beta-Sitosterol Inhibits the Risk and Treatment of Colon Cancer in Vitro and Vivo
By Kyle J. Norton
The colon-formed parts of the secretory system are also known as the large bowel or large intestine with a function to reabsorb fluids and process and secret waste products from the body.
The colon-formed parts of the secretory system are also known as the large bowel or large intestine with a function to reabsorb fluids and process and secret waste products from the body.
Cancer is a class of chronic diseases caused by cell growth disorderly and irregularly in the tissue of a specific organ as a result of the alternation of DNA.
Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.
Based on the findings, researchers said, " It (Beta-sitosterol) also attenuated beta-catenin and PCNA expression, making it a potential anticancer drug for colon carcinogenesis".
Taken altogether, beta-Sitosterol may be considered a functional food for the prevention and treatment of colon cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemopreventive potential of beta-Sitosterol in experimental colon cancer model--an in vitro and In vivo study by Baskar AA1, Ignacimuthu S, Paulraj GM, Al Numair KS. (PubMed)
Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.
Colon cancer is one most slow-growing cancer compared to other cancers. In some patients, colon cancer may exist in the colon more than 20 years before it is discovered. Therefore, only 39% of colon cancer is diagnosed in the early stage, which orchestrates more incidences of death compared to other cancers.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.
After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through the fluids and blood circulation.
At this stage, the increased size of the tumor may suppress the nearby tissue, organs, or nerve cells causing localized symptoms and severe pain.
The study included male Wistar rats injected with 1,2-dimethylhydrazine (DMH, 20 mg/kg b.w.) and supplemented with beta-sitosterol throughout the experimental period of 16 weeks at 5, 10, and 20 mg/kg b.w.
According to the tested analysis, beta-sitosterol induced significant growth inhibition of COLO 320 in a dose-dependent manner.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.
After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through the fluids and blood circulation.
At this stage, the increased size of the tumor may suppress the nearby tissue, organs, or nerve cells causing localized symptoms and severe pain.
According to the statistic provided by the American Cancer Society, in 2019, approximately, 101,420 new cases of colon cancer will be diagnosed. Colon cancer also causes the death of 51,020 deaths. during 2019.
The lifetime risk associated with the onset of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
The lifetime risk associated with the onset of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
The median age diagnosed with colon cancer is 68 in men and 72 in women compared to the age of 63 for rectal cancer in both men and women.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the treatment of malignant tumors, researchers examined the protective effect of beta-sitosterol isolated from A. curassavica against colon cancer in Vitro and Vivo.
On finding a potential phytochemical for the treatment of malignant tumors, researchers examined the protective effect of beta-sitosterol isolated from A. curassavica against colon cancer in Vitro and Vivo.
Beta-sitosterol supplementation also reduced the number of aberrant crypt and crypt multiplicity in DMH-initiated rats in a dose-dependent manner without inducing toxicity.
Additionally, the application of 10-20 mg/kg b.w. of beta-sitosterol not only is effective in vivo but also induced chemopreventive potential by inhibiting the expression of free radicals in vitro, with minimal toxicity to normal cells.
Taken altogether, beta-Sitosterol may be considered a functional food for the prevention and treatment of colon cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemopreventive potential of beta-Sitosterol in experimental colon cancer model--an in vitro and In vivo study by Baskar AA1, Ignacimuthu S, Paulraj GM, Al Numair KS. (PubMed)
Tuesday 19 April 2022
Beetroot's Betanin Enhances the Effects of Chemotherapy In Vitros
By Kyle J. Norton
Chemotherapy is an action in which a substance including drugs was used to treat any disease, particularly, cancer.
In cancers, chemotherapy is a treatment to kill or damage cancer cells in a specific area. Besides chemotherapy, the most common treatment for cancer in conventional medicine are surgery and radiation, depending on the severity of the condition.
The aim of chemotherapy is to cure or control the progression of cancer and improve the quality of life of patients by reducing symptoms.
In other words, chemotherapy is effective to shrink a tumor before surgery or kill the remaining cancer cells that cannot completely be removed by radiation and surgery.
Depending on the type and stage and grade of cancer, treatment may be a single chemo drug or several drugs.
Chemotherapy has been found to induce serious side effects, including fatigue. hair loss, easy bruising and bleeding, infection, anemia, nausea and vomiting, and constipation due to its nature to kill cells (cancer and healthy cells) indiscriminatingly.
Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
Researchers with an aim to discover a natural compound or whole food which enhances chemotherapy in the treatment of cancer examined the effects of betanin (BET) co-administration with the potent anticancer drugs e.g. doxorubicin (DOX) in reducing the side effects.
The study included the introduction of a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) by (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) loaded with 20.5 % of DOX and 16.25of BET that overcomes the restrictions of BET and provides the synergistic effect of DOX@BET.
At the adjusting of the pH of the environment, the stimulated release of DOX and BET from PGNPs showed a significant synergistic effect of DOX@BET not only inhibited the tested cancer cell line MCF-7 but also the side effect caused by DOX.
In other words, the betanin enhanced chemo drug efficacy and inhibited the treatment of drug toxicity.
Based on the findings, Dr. Amjadi S, the lead scientist said, "(The synergistic effect of DOX@BET may contribute to the) developed smart nanocarrier will be a hopeful nanocarrier for cancer therapy".
In order to find out more information about the enhanced chemotherapy researchers investigated the activity of extract of red beetroot (Beta vulgaris L.), the FDA approved red food color E162 with an anticancer drug, doxorubicin (adriamycin) in human prostate cancer cells (PC-3) and estrogen receptor-positive human breast cancer cells (MCF-7).
Individual treatment of doxorubicin and the beetroot extract exhibited a cytotoxic effect in the two tested cancer cell lines in a dose-dependent manner.
The cytotoxicity induced by beetroot extract at the concentration of 29 µg/ml was significantly lower compared to doxorubicin.
Beetroot extract inhibited the cancer proliferation at a trend of gradual decrease of the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) compared to doxorubicin completely inhibited the growth of the PC-3 cells in three days at the same concentration level.
In the additional differentiation of the results, researchers found that the cytotoxicity exhibited by the red beetroot extract is attributed to the effects of betanin, the major betacyanin constituent.
Based on the findings, betanin co-administration with chemo drug not only have a profound effect in enhancing the function of the anti-cancer drug but also reduce the side effect induced by conventional medicine.
Taken altogether, betanin used alone or combined with other chemo drugs may be considered medicine for the treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
Chemotherapy is an action in which a substance including drugs was used to treat any disease, particularly, cancer.
In cancers, chemotherapy is a treatment to kill or damage cancer cells in a specific area. Besides chemotherapy, the most common treatment for cancer in conventional medicine are surgery and radiation, depending on the severity of the condition.
The aim of chemotherapy is to cure or control the progression of cancer and improve the quality of life of patients by reducing symptoms.
In other words, chemotherapy is effective to shrink a tumor before surgery or kill the remaining cancer cells that cannot completely be removed by radiation and surgery.
Depending on the type and stage and grade of cancer, treatment may be a single chemo drug or several drugs.
Chemotherapy has been found to induce serious side effects, including fatigue. hair loss, easy bruising and bleeding, infection, anemia, nausea and vomiting, and constipation due to its nature to kill cells (cancer and healthy cells) indiscriminatingly.
Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
Researchers with an aim to discover a natural compound or whole food which enhances chemotherapy in the treatment of cancer examined the effects of betanin (BET) co-administration with the potent anticancer drugs e.g. doxorubicin (DOX) in reducing the side effects.
The study included the introduction of a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) by (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) loaded with 20.5 % of DOX and 16.25of BET that overcomes the restrictions of BET and provides the synergistic effect of DOX@BET.
At the adjusting of the pH of the environment, the stimulated release of DOX and BET from PGNPs showed a significant synergistic effect of DOX@BET not only inhibited the tested cancer cell line MCF-7 but also the side effect caused by DOX.
In other words, the betanin enhanced chemo drug efficacy and inhibited the treatment of drug toxicity.
Based on the findings, Dr. Amjadi S, the lead scientist said, "(The synergistic effect of DOX@BET may contribute to the) developed smart nanocarrier will be a hopeful nanocarrier for cancer therapy".
In order to find out more information about the enhanced chemotherapy researchers investigated the activity of extract of red beetroot (Beta vulgaris L.), the FDA approved red food color E162 with an anticancer drug, doxorubicin (adriamycin) in human prostate cancer cells (PC-3) and estrogen receptor-positive human breast cancer cells (MCF-7).
Individual treatment of doxorubicin and the beetroot extract exhibited a cytotoxic effect in the two tested cancer cell lines in a dose-dependent manner.
The cytotoxicity induced by beetroot extract at the concentration of 29 µg/ml was significantly lower compared to doxorubicin.
Beetroot extract inhibited the cancer proliferation at a trend of gradual decrease of the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) compared to doxorubicin completely inhibited the growth of the PC-3 cells in three days at the same concentration level.
In the additional differentiation of the results, researchers found that the cytotoxicity exhibited by the red beetroot extract is attributed to the effects of betanin, the major betacyanin constituent.
Based on the findings, betanin co-administration with chemo drug not only have a profound effect in enhancing the function of the anti-cancer drug but also reduce the side effect induced by conventional medicine.
Taken altogether, betanin used alone or combined with other chemo drugs may be considered medicine for the treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
Friday 15 April 2022
Phytochemical Tocopherols Have No Effects on Platelet Aggregation in Patients with Metabolic Syndrome
By Kyle J. Norton
A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and type 2 diabetes, including high blood pressure, sugar, cholesterol, triglyceride levels, and excess body fat around the waist.
Epidemiological studies suggested if you have 3 of the above syndromes you have metabolic syndrome.
According to statistics, in the US, 30% of Americans are living with metabolic syndrome,
and, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.
A randomized, double-blind, crossover, and the placebo-controlled trial included 32 metabolic syndrome adults supplemented with 200 mg (69% tocotrienols and 31% α-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days and consumed 200 mg PTT mixture or placebo capsule after a meal, after 14 days, after15-day washout period.
Fasting platelet aggregation reactivity stimulated with adenosine diphosphate (ADP) which is essential to the flow of energy in living cells, did not show substantial changes after supplementation with PTT mixture compared to placebo.
A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and type 2 diabetes, including high blood pressure, sugar, cholesterol, triglyceride levels, and excess body fat around the waist.
Epidemiological studies suggested if you have 3 of the above syndromes you have metabolic syndrome.
According to statistics, in the US, 30% of Americans are living with metabolic syndrome,
and, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.
The CDC statistic suggested, that among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.
There are certain risk factors associated with the onset of metabolic syndrome besides the five mentioned above including age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.
Untreated metabolic syndrome epidemiologically may induce complications of chronic illness such as atherosclerosis, nonalcoholic fatty liver disease, and kidney diseases.
Platelet aggregation is a condition of platelets clumping together in the blood. The process also is necessary for the cover of vascular injury.
Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of cardiovascular diseases and diabetes, researchers examined the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity.
There are certain risk factors associated with the onset of metabolic syndrome besides the five mentioned above including age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.
Untreated metabolic syndrome epidemiologically may induce complications of chronic illness such as atherosclerosis, nonalcoholic fatty liver disease, and kidney diseases.
Platelet aggregation is a condition of platelets clumping together in the blood. The process also is necessary for the cover of vascular injury.
On finding a potential phytochemical for the treatment of cardiovascular diseases and diabetes, researchers examined the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity.
Fasting platelet aggregation reactivity stimulated with adenosine diphosphate (ADP) which is essential to the flow of energy in living cells, did not show substantial changes after supplementation with PTT mixture compared to placebo.
There are no changes in postprandial platelet aggregation reactivity compared to PTT mixture and placebo interventions.
Based on the findings, researchers said, "The results of this study highlight the lack of inhibitory effect on platelet aggregation after short-term supplementation of PTT mixture in participants with metabolic syndrome".
Taken altogether, tocopherols have no effect on platelet aggregation in patients with metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial by Gan YL1,2, Fu JY3, Lai OM1,4, Chew BH5, Yuen KH6, Teng KT2, Nesaretnam K2, Selvaduray KR2, Meganathan P. (PubMed)
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial by Gan YL1,2, Fu JY3, Lai OM1,4, Chew BH5, Yuen KH6, Teng KT2, Nesaretnam K2, Selvaduray KR2, Meganathan P. (PubMed)
Wednesday 13 April 2022
Pungent Spice Onions Suppress Weight Gain in Obese Animals in Vivos
By Kyle J. Norton
Obesity is a medical and chronic condition caused by long-term excessive body fat accumulated. Overweight is a condition of excess body weight relative to height.
According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 are considered overweight and a BMI of over 30 is an indication of obesity.
The formula of the BMI indexBMI= weight (kg)/ height (m2)
According to the statistic, 68% of the American population is either overweight or obese. However,
in 2016, more than 1.9 billion adults, 18 years and older, were overweight, including over 650 million were obese worldwide.
The most common causes of obesity are associated with
* An increased intake of energy-dense foods that are high in saturated and trans fat, processed foods, and red meat.
* An increase in physical inactivity.
The WHO in the explanation of the causes of obesity wrote, "Changes in dietary and physical activity patterns are often the result of environmental and societal changes associated with the development and lack of supportive policies in sectors such as health, agriculture, transport, urban planning, environment, food processing, distribution, marketing, and education".
Certain medical conditions such as hypothyroidism, polycystic ovary syndrome, Cushing's syndrome,..., genetic preposition, and the use of certain medications that can cause weight gain or water retention, such as corticosteroids, antidepressants, or some seizure medications, also increases the risk of overweight and obesity.
Epidemiologically, obese people are associated with an increased risk of diseases and health problems, including heart disease, diabetes, and high blood pressure.
Some researchers suggested that dietary changes, increased physical activity, and behavior changes have been found to enhance weight loss in obesity. In extremely obese subjects, prescription medications and weight-loss surgery may be the only options.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
On finding a potential compound for the treatment of obesity, researchers examined the effects of
garlic oil and onion oil on serum lipid levels in hyperlipidemia in an animal model.
The study included 96 Sprague-Dawley rats randomly allocated into eight groups that received repeated oral administration of volatile oils extracted from garlic and onion for 60 days, based on their body weight and serum levels of triglycerides (TG) and total cholesterol (TC).
According to the tested assays compared to the baseline, the volatile oils of garlic and onion suppressed weight gain induced by HFD accompanied by the decrease of adipose tissue weight.
The decreased levels of TG, TC, and LDL-C and increased serum level of HDL-C were also found in the treatment group compared to rats in the hyperlipidemia model groups.
Furthermore, treatment with volatile oil also protects the liver against hepatic steatosis by improving the effects of the lipid profile.
In other words, volatile oils extracted from garlic and onion inhibit the risk of obesity by improving the liver and adipose tissue in fat metabolisms.
Dr. Yang C, the lead scientist after taking other factors into account wrote, "Our results implied that garlic oil and onion oil have anti-obesity properties that can counteract the effects of an HFD on body weight, adipose tissue weight, and serum lipid profiles".
Moreover, the assessment of the effect of onion peel tea (OPT) in a mouse model of high-fat-diet-induced obesity suggested that BALB/c mice fed a high-fat diet for three weeks, followed by a normal diet with or without OPT for 28 days suppresses the increases in body weight and level of epididymal fat tissue, similar to those of the aforementioned results.
Additionally, OPT administration also significantly reduced the serum concentrations of total cholesterol on day 14 and those of glucose and leptin on day 28.
These results suggested OPT inhibits the parameters associated with the onset of obesity.
Taken altogether, onion used alone or combined with garlic may be considered functional food/foods for the prevention and treatment of obesity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-obesity and Hypolipidemic effects of garlic oil and onion oil in rats fed a high-fat diet by Yang C1, Li L1, Yang L1, Lǚ H1,2, Wang S1, Sun G. (PubMed)
(2) Onion peel tea ameliorates obesity and affects blood parameters in a mouse model of high-fat-diet-induced obesity by Matsunaga S1, Azuma K1, Watanabe M2, Tsuka T1, Imagawa T1, Osaki T1, Okamoto Y. (PubMed)
(3) Obesity and overweight by WHO
Obesity is a medical and chronic condition caused by long-term excessive body fat accumulated. Overweight is a condition of excess body weight relative to height.
According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 are considered overweight and a BMI of over 30 is an indication of obesity.
The formula of the BMI indexBMI= weight (kg)/ height (m2)
According to the statistic, 68% of the American population is either overweight or obese. However,
in 2016, more than 1.9 billion adults, 18 years and older, were overweight, including over 650 million were obese worldwide.
The most common causes of obesity are associated with
* An increased intake of energy-dense foods that are high in saturated and trans fat, processed foods, and red meat.
* An increase in physical inactivity.
The WHO in the explanation of the causes of obesity wrote, "Changes in dietary and physical activity patterns are often the result of environmental and societal changes associated with the development and lack of supportive policies in sectors such as health, agriculture, transport, urban planning, environment, food processing, distribution, marketing, and education".
Certain medical conditions such as hypothyroidism, polycystic ovary syndrome, Cushing's syndrome,..., genetic preposition, and the use of certain medications that can cause weight gain or water retention, such as corticosteroids, antidepressants, or some seizure medications, also increases the risk of overweight and obesity.
Epidemiologically, obese people are associated with an increased risk of diseases and health problems, including heart disease, diabetes, and high blood pressure.
Some researchers suggested that dietary changes, increased physical activity, and behavior changes have been found to enhance weight loss in obesity. In extremely obese subjects, prescription medications and weight-loss surgery may be the only options.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
On finding a potential compound for the treatment of obesity, researchers examined the effects of
garlic oil and onion oil on serum lipid levels in hyperlipidemia in an animal model.
The study included 96 Sprague-Dawley rats randomly allocated into eight groups that received repeated oral administration of volatile oils extracted from garlic and onion for 60 days, based on their body weight and serum levels of triglycerides (TG) and total cholesterol (TC).
According to the tested assays compared to the baseline, the volatile oils of garlic and onion suppressed weight gain induced by HFD accompanied by the decrease of adipose tissue weight.
The decreased levels of TG, TC, and LDL-C and increased serum level of HDL-C were also found in the treatment group compared to rats in the hyperlipidemia model groups.
Furthermore, treatment with volatile oil also protects the liver against hepatic steatosis by improving the effects of the lipid profile.
In other words, volatile oils extracted from garlic and onion inhibit the risk of obesity by improving the liver and adipose tissue in fat metabolisms.
Dr. Yang C, the lead scientist after taking other factors into account wrote, "Our results implied that garlic oil and onion oil have anti-obesity properties that can counteract the effects of an HFD on body weight, adipose tissue weight, and serum lipid profiles".
Moreover, the assessment of the effect of onion peel tea (OPT) in a mouse model of high-fat-diet-induced obesity suggested that BALB/c mice fed a high-fat diet for three weeks, followed by a normal diet with or without OPT for 28 days suppresses the increases in body weight and level of epididymal fat tissue, similar to those of the aforementioned results.
Additionally, OPT administration also significantly reduced the serum concentrations of total cholesterol on day 14 and those of glucose and leptin on day 28.
These results suggested OPT inhibits the parameters associated with the onset of obesity.
Taken altogether, onion used alone or combined with garlic may be considered functional food/foods for the prevention and treatment of obesity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-obesity and Hypolipidemic effects of garlic oil and onion oil in rats fed a high-fat diet by Yang C1, Li L1, Yang L1, Lǚ H1,2, Wang S1, Sun G. (PubMed)
(2) Onion peel tea ameliorates obesity and affects blood parameters in a mouse model of high-fat-diet-induced obesity by Matsunaga S1, Azuma K1, Watanabe M2, Tsuka T1, Imagawa T1, Osaki T1, Okamoto Y. (PubMed)
(3) Obesity and overweight by WHO
Saturday 9 April 2022
Cruciferous vegetables Inhibit Oral Cancer in Vitro
By Kyle J. Norton
Oral cancer is a medical condition characterized by irregular cell growth in the oral cavity. In the early stage, the abnormal cells only appear in the surface lining of the cavity. However, in the late stage, the infectious cells may travel a distance away from the original site to invade other cells and tissue.
Early diagnosed oral cancer may have a close to 100% recovery.
Oral cancer is a medical condition characterized by irregular cell growth in the oral cavity. In the early stage, the abnormal cells only appear in the surface lining of the cavity. However, in the late stage, the infectious cells may travel a distance away from the original site to invade other cells and tissue.
Early diagnosed oral cancer may have a close to 100% recovery.
Most cases of oral cancer begin in the cells on the surface of the inner lining of oral tissue.
However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissue and organs, leading to secondary metastasis.
According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.
The 5-year survival rate of oral cancer is 66%, including all stages.
Family history, smoking, alcohol drinking, infection by the HPV virus, poor hygiene, and genetic preposition are some of the risk factors associated with the disease.
According to the cancer society, the 5 survival rate of oral cancer is about 60% plus without taking into consideration the stage of cancer.
The early symptoms of oral cancer include lip or mouth sores and persistent pain,... Check with a dentist, if you experience the above unexplained or persistent symptoms, particularly, if the sore mouth does not heal in 2 weeks.
However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissue and organs, leading to secondary metastasis.
According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.
The 5-year survival rate of oral cancer is 66%, including all stages.
Family history, smoking, alcohol drinking, infection by the HPV virus, poor hygiene, and genetic preposition are some of the risk factors associated with the disease.
According to the cancer society, the 5 survival rate of oral cancer is about 60% plus without taking into consideration the stage of cancer.
The early symptoms of oral cancer include lip or mouth sores and persistent pain,... Check with a dentist, if you experience the above unexplained or persistent symptoms, particularly, if the sore mouth does not heal in 2 weeks.
On finding potential and natural foods for the prevention and treatment of cancer, researchers investigated the effect of sulforaphane, a predominant isothiocyanate in Brassica oleracea, a family of cruciferous vegetables on oral carcinoma cell lines.
Based on the Multiplex protein analysis kits, the impairment of the migration and invasion induced by sulforaphane were attributed to associated with the anti-orchestration in the secretion of metalloprotease levels including MMP-1 and MMP-2.
In other words, sulforaphane demonstrated a therapeutic potency as an inhibitor of metastasis in oral carcinoma cell lines.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane inhibits oral carcinoma cell migration and invasion in vitro by Jee HG1, Lee KE, Kim JB, Shin HK, Youn YK. (PubMed)
Taken altogether, cruciferous vegetables processed abundantly sulforaphane, may be considered functional remedies for the prevention of oral cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane inhibits oral carcinoma cell migration and invasion in vitro by Jee HG1, Lee KE, Kim JB, Shin HK, Youn YK. (PubMed)
Tuesday 5 April 2022
Phytochemical Beta-Sitosterol Alleviates the Progression of Fatty Liver in Vivo
By Kyle J. Norton
The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.
The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.
Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.
A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.
There are two main types of fatty liver disease:
* Nonalcoholic fatty liver disease is a medical condition characterized by fat accumulated in the liver tissue other than excessive consumption of alcohol.
According to the American liver foundation, Nonalcoholic Fatty Liver Disease is one of the most common causes of liver disease, and approximately 30% (100 million) individuals in the United States are estimated to have nonalcoholic fatty liver disease.
The causes of Nonalcoholic Fatty Liver Disease are unknown. Also, as of today researchers do not understand why some people are susceptible to liver fat accumulation while others are not.
The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH) and acute fatty liver of pregnancy (AFLP), a relatively rare disorder that happens only during pregnancy.
* Alcoholic fatty liver diseases is a condition caused by lifelong heavy alcohol use.
In other words, substances found in alcohol damage liver cells, promote inflammation and weaken your body's natural defenses. More precisely, the more alcohol that you drink, the more you damage your liver.
Alcoholic fatty liver disease is the earliest stage of alcohol-related liver disease.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
In finding a potential phytochemical for the prevention and treatment of liver diseases, researchers elucidated the effects of stigmasterol and β-sitosterol on a high-fat Western diet (HFWD)-induced nonalcoholic fatty liver disease (NAFLD).
According to the results after 33 weeks of treatment* stigmasterol and β-sitosterol were effective in protecting the liver against HFWD-induced NAFLD.
* The parameters that contributed to the onset of NAFLD are triacylglycerols (TGs), phosphatidylcholines, cholesteryl esters, diacylglycerols, and free fatty acids (FFAs).
* The efficacy of stigmasterol and β-sitosterol in the alleviation of NAFLD was mainly associated with decreases in hepatic cholesterol, TGs with polyunsaturated fatty acids, and alterations of free hepatic FFA.
Based on the findings, researchers said, "phytosterols, at a dose comparable to that suggested for humans by the FDA for the reduction of plasma cholesterol levels, are shown to protect against NAFLD in this long-term (33-week) study".
Beta-Sitosterol may be considered a remedy for the prevention and treatment of NAFLD, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis by Feng S1,2,3, Gan L1, Yang CS2, Liu AB2, Lu W4, Shao P1, Dai Z5, Sun P1, Luo Z. (PubMed)
The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.
The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.
Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.
A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.
There are two main types of fatty liver disease:
* Nonalcoholic fatty liver disease is a medical condition characterized by fat accumulated in the liver tissue other than excessive consumption of alcohol.
According to the American liver foundation, Nonalcoholic Fatty Liver Disease is one of the most common causes of liver disease, and approximately 30% (100 million) individuals in the United States are estimated to have nonalcoholic fatty liver disease.
The causes of Nonalcoholic Fatty Liver Disease are unknown. Also, as of today researchers do not understand why some people are susceptible to liver fat accumulation while others are not.
The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH) and acute fatty liver of pregnancy (AFLP), a relatively rare disorder that happens only during pregnancy.
* Alcoholic fatty liver diseases is a condition caused by lifelong heavy alcohol use.
In other words, substances found in alcohol damage liver cells, promote inflammation and weaken your body's natural defenses. More precisely, the more alcohol that you drink, the more you damage your liver.
Alcoholic fatty liver disease is the earliest stage of alcohol-related liver disease.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
In finding a potential phytochemical for the prevention and treatment of liver diseases, researchers elucidated the effects of stigmasterol and β-sitosterol on a high-fat Western diet (HFWD)-induced nonalcoholic fatty liver disease (NAFLD).
According to the results after 33 weeks of treatment* stigmasterol and β-sitosterol were effective in protecting the liver against HFWD-induced NAFLD.
* The parameters that contributed to the onset of NAFLD are triacylglycerols (TGs), phosphatidylcholines, cholesteryl esters, diacylglycerols, and free fatty acids (FFAs).
* The efficacy of stigmasterol and β-sitosterol in the alleviation of NAFLD was mainly associated with decreases in hepatic cholesterol, TGs with polyunsaturated fatty acids, and alterations of free hepatic FFA.
Based on the findings, researchers said, "phytosterols, at a dose comparable to that suggested for humans by the FDA for the reduction of plasma cholesterol levels, are shown to protect against NAFLD in this long-term (33-week) study".
Beta-Sitosterol may be considered a remedy for the prevention and treatment of NAFLD, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis by Feng S1,2,3, Gan L1, Yang CS2, Liu AB2, Lu W4, Shao P1, Dai Z5, Sun P1, Luo Z. (PubMed)
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