Herbal Angelica Promotes Hematopoietic Function

By Kyle J. Norton

The hematopoietic system is a complex network including organs and tissues such as the bone marrow, liver, and spleen.

Hematopoiesis is the process by which blood cells are formed, including the formation of all of the cellular components of blood and blood plasma.

1. Red blood cells with a function to transport oxygen and hemoglobin to the body.

2. White blood cells that form parts of the immune system, including
* T cells and B cells, that fight viruses, and tumors.

* Neutrophils that fight bacteria and fungi.

* Eosinophils that fight some parasites and initiate an inflammatory response.

* Basophils that release the histamines necessary for the inflammatory response.

* Macrophages, are the first line of the immune response in the acute phase of infection.

3. Platelets (thrombocytes) for coagulation.

Dr. Risitano AM, the lead scientist in the study of  " Function and malfunction of hematopoietic stem cells in primary bone marrow failure syndromes", said," Constitutional marrow failure syndromes are conditions caused by intrinsic defects of HSCs; they are due to inherited germline mutations accounting for specific phenotypes, and often involve also organs and systems other than hematopoiesis".

And " By contrast, in acquired marrow failure syndromes hematopoietic stem cells are thought to be intrinsically normal, but subjected to extrinsic damage affecting their hematopoietic function".

Diseases of the bone marrow, spleen, lymph nodes, and thymus may affect the process of hematopoiesis, leading to various diseases of the hematopoietic system.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation, and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound that promotes hematopoietic functioning, researchers examined the neuroprotective effects of investigating the influence of AS on the metabolism of blood deficiency mice model.

Selected mice in the study were induced blood deficiency by being hypodermically injected with N-acetyl phenylhydrazine (APH) and intraperitoneally injected with cyclophosphamide (CTX) then treated with Angelica Sinensis (AS).

According to the tested assays, the administration of AS normalized the levels of white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), and platelet (PLT) compared to the untreated control group.

The dose of 10g/kg demonstrated the best effect compared to other doses.

Furthermore, the metabolic pathways biomarkers associated with an important role in regulating the hematopoietic function, such as arachidonic acid metabolism, valine, leucine, and isoleucine biosynthesis, glycine, serine and threonine metabolism, arginine and proline were also affected by the injection of AS.

In other words, AS promotes the production of all of the cellular components of blood and blood plasma in blood deficiency mice.

Taken altogether, herbal Angelica may be considered a neuroprotective remedy for the improvement of hematopoietic function, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Metabolomics study of hematopoietic function of Angelica Sinensis on blood deficiency mice model by Li PL1, Sun HG1, Hua YL1, Ji P1, Zhang L1, Li JX1, Wei Y. (PubMed)
(2) Function and malfunction of hematopoietic stem cells in primary bone marrow failure syndromes by Risitano AM1, Maciejewski JP, Selleri C, Rotoli B. (PubMed)