Monday, 10 January 2022

Herbal Angelica Protects the Neurons Against Traumatic Brain Injury (TBI)

By Kyle J. Norton

The central nervous system containing the brain and the spinal cord is the complex system of nerve tissues that controls the activities of the human body.

It is the center that controls our thoughts, the interpreter of our external environment, and body movement.

Traumatic brain injury (TBI) is a condition caused by sudden damage to the brain due to a blow or jolt to the head. 

Most cases of TBI are associated with car accidence and sports injuries.

The most common symptoms caused by TBI are the loss of consciousness induce-dazed, confusion or disorients, headache, dizziness or loss of balance, difficulty sleeping and the problem with speech

In severe cases, patients may also experience sensory problems, sensitivity to light or sound, memory or concentration problems, mood swings, and feeling depressed or anxious.

Conventionally, the treatment of TBI includes physical therapy, occupational therapy, speech therapy. psychological and vocational counseling, cognitive therapy,... depending on the location of the injury.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the prevention and treatment of diseases associated with brain injury, researchers examined the effects of Astragali Radix (AR)-Radix Angelica Sinensis (RAS) activity on traumatic brain injury (TBI).

According to the chemical analysis, researchers discover that the effects of the combination against the traumatic brain injury (TBI) may be attributed to the 14 bioactive ingredients in AR-RAS, while 33 potential targets hit by these ingredients related to TBI.

The effectiveness of the combined herbal medicines according to the GO annotation analysis, was involved in the regulation of multiple biological processes by AR-RAS.

Additionally, 89 novel signaling pathways (P<0.05) were also found to underlie the effects of AR-RAS for TBI treatment.

According to the animal experiment, in vivo AR-RAS showed significantly induced tissue recovery and improved neurological deficits in the hippocampus of TBIrats on the 14th day.

More precisely, AR-RAS target the neurotrophin signaling pathways as a major related pathway to improve axonal growth.

Based on the findings, researchers said, "Our work illuminates the "multi-compounds, multi targets, and multi pathways" curative action of AR-RAS in the treatment of TBI by network pharmacology".


Taken altogether, Herbal Angelica used alone or combined with Astragali Radix may be considered a functional herbal medicine for the treatment of traumatic brain injury,  pending a larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury by Xie G1, Peng W2, Li P1, Xia Z1, Zhong Y1, He F3, Tulake Y4, Feng D1, Wang Y1, Xing Z. (PubMed)

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