Kyle J. Norton
Scientists may have found a kitchen spice that has the potential to treat colon cancer, according to studies.
Colon cancer is a medicinal condition associated with irregular cell growth in the colon tissues.
According to the statistics provided by Stat-Canada, 1 in 16 Canadian men and 1 in 18 women will develop colorectal cancer over their lifetime. Cancer is the third leading cause of death behind prostate and lung cancer.
Every year, approximately 26,,000 Canadians are diagnosed with colorectal cancer, representing 13% of all new cancer cases.
Colon cancer is a slow-growth cancer, therefore, most colon cancer is detected in the later stage after experiencing symptoms of blood in your stool or an ongoing change in bowel habits. In other words, only 39% of colorectal cancer is detected in the early stage.
The 5-year survival rate of localized-stage colorectal cancer is 90%.
The cause of colon cancer is a result of the alternation of cell DNA. Researchers do not why? people with the same health conditions and family history, are susceptible to the onset of the disease, while others do not.
Although there are many factors associated with the onset of colon cancer, aging may be one of the most prevalent risks. It probably is due to the disease taken over 10 to 15 years before the patients experience some related symptoms. In other words, according to epidemiological studies, the majority of colorectal cancers occur in people older than 50.
"70% of colorectal cancer is diagnosed in patients over 65. Evaluation of the influence of age and comorbidity on survival and cause of death in a non-selected population".
And, "In colon cancer patients age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis-defining illness in the majority of patients".
The result strongly suggested that colon cancer affects mostly the aging population over 65 years of age. The simultaneous presence of two chronic diseases or conditions in elderly patients is associated with a poor survival rate.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on the finding of a bioactive compound to replace the chemo medication which induces serious side effects to cancer patients examined 6-Gingerol, a natural component of ginger, anti-colon cancer activity.
Injection of 6-gingerol treatment significantly reduced the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner.
Furthermore, 6-gingerol induced significant G2/M phase arrest and had a slight influence on the sub-G1 phase in LoVo cells, according to the flow cytometric analysis and observed by the reduced levels of a protein involved cancer cell cycle.
Moreover, 6-gingerol also induced cancer cell apoptosis by elevating the functions of levels of tumor-suppressive genes and exhibiting cytotoxicity through elevated intracellular reactive oxygen species (ROS).
These results strongly suggested that 6-gingerol should be beneficial to the treatment of colon cancer, according to Dr. Lin CB and colleagues.
In order to understand more the effect of ginger on colon cancer, researchers investigated a novel prodrug of aspirin, [6]-gingerol aspirinate (GAS) against colon cancer.
GAS exerted enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice. by suppressing the enzymes involved mediation of tumor repopulation.
Importantly, GAS was also able to survive stomach acid and decompose in intestinal linings or after absorption simultaneously release ASA and [6]-gingerol.
Dr. Yingdong Zhu, the lead scientist said in the final report, "Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS, suggesting that GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa".
Taken altogether, ginger processed as a highly active bio-compound may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of colon cancer with no side effects, pending the confirmation of large sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest by Lin CB1, Lin CC, Tsay GJ.(PubMed)
(2) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Yingdong Zhu, Fang Wang, Yantao Zhao, Pei Wang & Shengmin Sang. (Scientific Report)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)
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