Kyle J. Norton
Coffee consumption may have a strong association with the potential risk of bladder cancer development, some scientists suggested.
Bladder cancer is a medical condition of cell growth irregularly and disorderly in the bladder. Cancer may spread to distant tissues and organs in the later stage.
Depending on the originated and infected tissue, bladder cancer can be classified into 3 types(4), including
* Transitional cell carcinoma
In the early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder beginning in cells in the lining of the bladder.
* Squamous cell carcinoma
Cancer begins in squamous cells found in the tissues of the surface of the bladder, due to long-term infection or irritation
* Adenocarcinoma
Cancer begins originates in the glandular tissue of the bladder, including the surface layer of skin, glands, and a variety of other tissue, due to long-term irritation and inflammation.
Deepening to the stage, patients with bladder can experience some of the below symptoms, bladder spasms, blood in urine, frequent urination, pain or burning sensation during urination, pain in the lower back and/or abdomen, reduced bladder capacity, difficulty in urination,.... and common symptoms of loss of appetite and weight.
If you experience some of the symptoms above, please check with your doctor right way.
Although the single cause of bladder cancer is still debatable, some scientists suggested that smoking,
chemicals exposure, a diet high in fried meats and fat, aging are substantial risk factors in the development of bladder cancer.
According to statistic
* Bladder cancer is the ninth most common cancer in the world.
* Every year over 430,000 new cases are diagnosed in 2012. And
* Men are 4 times more likely to develop bladder cancer compared to women.
Coffee, a popular and social beverage worldwide, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
According to Shandong University, in the review literature published online satisfied the criteria and guidelines to investigate the risk of bladder cancer among coffee consumption adults. Selected studies, numbers of cups/day, and relative risk RR as follow
For 23 case-control studies
1. for 1 cup/day, RR=1.07
2 for 2 cups/day, RR=1.15
3 for 3 cups/day, RR=1.22
4. for 4 cups/day RR= 1.29
and
For 5 cohort studies
1. for 1 cup/day, RR=1.09
2. for 2 cups/day, RR=1.13
3. for 3 cups/day, RR= 1.09
4 for 4 cups/day, RR=1.01
The findings in both case-control and cohort studies showed a positive association between coffee intake and the risk of bladder cancer.
In nonsmokers, according to the pooled dataset comprises 564 cases and 2929 hospital or population controls enrolled in ten studies conducted in Denmark, Germany, Greece, France, Italy, and Spain. risk of bladder cancer did not increase monotonically with dose but for heavy coffee drinkers of over 10 cups per days, the risk of bladder cancer increases substantially.
Dr. Sala M, the lead author said, "Nonsmokers who are heavy coffee drinkers may have a small excess risk of bladder cancer".
Others, in analyzed a case-control study in two different areas of northern Italy (555 cases and 855 controls), coffee intake and risk of bladder cancer showed that
compared to nondrinkers (RR: relative risk ratio)
1. RR 1.2 for one cup of coffee per day,
2. RR 1.4 for two,
3. RR 1.5 for three and
4 RR 1.4 for four or more
5. RR 1.5 (0.9-2.4) for decaffeinated coffee.
But in never smoked participants, the risk of bladder cancer increased significantly
1. RR 1.9 for one or two cups per day,
2. RR 1.8 for three and
3 RR 1.5 for four or more
Taken together, there is no doubt that coffee and coffee caffeine consumption have a mild risk in the exhibited incidence of bladder cancer regardless of numbers of cups intake daily and regularly.
However, Due to the small size of the studies, some researchers suggested that a sample size of a clinical trial with multi-centers involved are necessary to rule out or reconfirm the side effect of coffee intake possibility.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A dose-response meta-analysis of coffee consumption and bladder cancer by Zhou Y1, Tian C, and Jia C.(PubMed)
(2) Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case-control studies in European countries by Sala M1, Cordier S, Chang-Claude J, Donato F, Escolar-Pujolar A, Fernandez F, González CA, Greiser E, Jöckel KH, Lynge E, Mannetje A, Pohlabeln H, Porru S, Serra C, Tzonou A, Vineis P, Wahrendorf J, Boffetta P, Kogevina M.(PubMed)
(3) Coffee consumption and bladder cancer risk by D'Avanzo B1, La Vecchia C, Franceschi S, Negri E, Talamini R, Buttino I.(PubMed)
(4) Bladder Cancer by Kyle J. Norton
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