Cholesterol, a waxy substance produced by the liver or the dietary plays a critical role to aid digestive function in absorbing nutrients and fluids, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts of cholesterol in the blood have been found to induce plaque built-up on the arterial wall, leading to hypercholesterolemia, a leading cause of heart disease, and stroke.
Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.
The condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
People with hypercholesterolemia at the early stage are asymptomatic. However, patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US.
In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.
Sadly, only 50% of people with hypercholesterolemia are getting treatment.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the treatment of high blood cholesterol, researchers examined the ashwagandha root extract's anti-hypercholesteremic effects in an animal model.
Selected hypercholesteremic male albino rats were given root powder of WS added to the diet at 0.75 and 1.5 gm/rat/day.
During the experiment, researchers found that the root powder of WS showed a strong anti-hypercholesteremic activity by significantly decreasing levels of total lipids, cholesterol, and triglycerides, in blood plasma.
Furthermore, WS also reduced the levels of cholesterol by significantly increasing plasma HDL-cholesterol levels, HMG-CoA reductase activity, and bile acid content of the liver.
Moreover, lipid-peroxidation associated with liver stress was inhibited by WS administration in hypercholesteremic animals, compared to other normal counterparts.
Based on the findings, researchers said, "It appeared that WS root powder is also effective in normal subjects for decreasing lipid profiles".
Taken together, Ashwagandha may be considered a functional herb for the treatment of hypercholesterolemia, pending the result of a larger sample size and multicenter study
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hypocholesterolemic and antioxidant effects of Withania somnifera (Dunal) in hypercholesteremic rats by Visavadiya NP1, Narasimhacharya AV. (PubMed)
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