Wednesday 15 July 2020

Omega -3 Fatty Acids, the Anti-Prostate Cancer Antioxidants

By Kyle J. Norton


The prostate gland is a gland that makes and stores semen, located below the bladder and surrounds the tube that carries urine out of your body.

The most common diseases associated with the aging prostate gland are prostatic hyperplasia(BPH).

Benign prostatic hyperplasia(BPH) is a condition caused by the increased number of cells of the prostate gland, leading to partial, or sometimes virtually complete obstruction of the urinary tract.

According to statistics, BPH commonly starts at the age of 30 and symptoms usually can not be realized until the age of 50. 

More than half of men between the age of 60-70 are experience symptoms of BPH and only 10% is required treatment.

Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue. In the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.

Inherited genes such as RNASEL and BRCA1 and BRCA2 have been found to increase the risk of prostate cancer

Researchers do not know what causes prostate cancer. 

However, there are a number of factors that may increase the risk of prostate cancer onset, including age, family history, obesity,... an unhealthy diet.

Most prostate cancers are slow-growing. Prostate cancer may be detected during physical (rectum) exams.

According to the statistic in Canada, prostate cancer is the 3rd leading cause of death from cancer in men. in Canada.
In 2017(2)
* 21,300 men were diagnosed with prostate cancer. This represents 21% of all new cancer cases in men in 2017.
* 4,100 men died from prostate cancer. This represents 10% of all cancer deaths in men in 2017.
* On average, 58 Canadian men were diagnosed with prostate cancer every day.
* On average, 11 Canadian men died from prostate cancer every day.


Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of prostate diseases, researchers examined the efficiency of α-linolenic acid (ALA) is an n-3 polyunsaturated fatty acid (PUFA) uptake from a vegetable oil source in a prostate cancer animal model.

According to the tested analysis of Pten-knockout mice which were given low-ALA (L-ALA, 2.5%) and high-ALA (H-ALA, 7.5%) diets,
* Dietary ALA triggered significant increases in ALA, EPA, docosapentaenoic acid (DPA) and DHA levels and a significant decrease in arachidonic acid levels during the mice's growth stage.

* More precisely, a dose-dependent effect was observed for ALA, EPA, and DPA, but not DHA.

* The average prostate weights in the L-ALA and H-ALA groups were lower than those in the control and n-6 groups, and similar to those in the EPA and n-3 groups.

In other words, α-linolenic acid (ALA) demonstrated significant prostate protective effects against the enlarged prostate, one of the risks of prostate cancer.

Collectively, researchers said, "Our data suggest that dietary supplementation with ALA is an efficient means of improving n-3 LCPUFAs in vivo, and it has a biologically effective role to play in prostate cancer, similar to that of fish oils".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary supplementation of α-linolenic acid induced conversion of n-3 LCPUFAs and reduced prostate cancer growth in a mouse model by Li J1,2, Gu Z3,4, Pan Y1,2, Wang S1,2, Chen H1,2, Zhang H1,2, Chen W1,2,5, Chen YQ. (PubMed)

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