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Tuesday, 2 June 2015

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: Foods for Kidney Yang deficiency -Walnut In TCM


By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women. Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

              In Traditional Chinese Perspective

While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches. Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).

PCOs Treatment according traditional Chinese medicine
Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

           Kidney yang deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yang deficiency may also experience yang vacuity induced cold expressive syndrome, including lumbago, cold limbs, fatigue, cold aversion, feverish sensation in chest, palms and soles(1573), difficulty in urination, enuresis, incontinence, declining libido and edema(1574) as a result of kidneys no longer perform their function in store fluid to moister and warm the body for healthy function in the body's organs and tissues, inducing adrenal insufficient chronic lower back pain(1575)(1580), depression(1575), hypothyroidism(1579)(1575), nephritis(1578)(1575), ...(1575), leading to failure in transform damp heat expression, promoted accentuation of inflammatory development of phlegm(1583). Kidney yang deficiency has shown to alter carbohydrate and lipid metabolisms (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), indued anovulatory infertility( 1581) and hypertension(1582) of which related to symptoms of PCOs(1576)(1577).

Foods for kidney yang deficiency

Kidney yang deficiency can be managed and treated in part with a diet of fresh and cooked warming foods.

3. Walnut
Walnut, nut of tree, including Brazil nuts, cashews, hazelnuts (filberts), macadamia nuts, pecans, pine nuts, pistachios, etc,.. is the genus Juglans  belongings to the family Juglandaceae, used in traditional medicine to sooth skin(1647)(1650), and to treat toothache(1648), rheumatism(1648), fungal infections(1648)., anti neuro-aging(1649), allergic dermatitis(1651), etc,... Its bark is also claim to promote blood purifying(1652), anticancer(1652), depurative(1652), diuretic(1652) and laxative(1652) activities, according to Jamia Hamdard (Hamdard University).

Phytochemical constituents
1. Ferulic acid
2. Vanillic acid
3. Coumaric acid
4. Syringic acid
5. Myricetin
6. Regiolon
7. Ellagic
8. Gallic acid 
9. Alpha-linoleic acid (ALA)
10. Arginine
11. Histidine
12. Isoleucine
13. Leucine
14. Lysine
15. Methionine
16. Phenylanine
17. Threonine
18. Tryptophan
19. Valine
20. Etc. (1638).

Consumption of walnuts and other nuts have been found to be associated with reduced risk of metabolic syndrome, including lowered total cholesterol and non-high-density lipoprotein cholesterol levels(1639), probably through its effects related to inflammation, oxidative stress, and endothelial function(1639), enhanced weight loss(1640), increased high-density lipoprotein cholesterol levels(1640), reduced systolic blood pressure(1641) and fasting blood sugar (FBS)(1642), etc,.. and its complications including diabetes(1643)(1644) and cardiovascular disease(1645)(1646).


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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1638) Phytochemical and nutritional composition of Walnut (M. D. idea)
(1639) Nut consumption has favorable effects on lipid profiles of Korean women with metabolic syndrome by Lee YJ1, Nam GE2, Seo JA3, Yoon T1, Seo I1, Lee JH1, Im D1, Bahn KN1, Jeong SA1, Kang TS1, Ahn JH3, Kim do H4, Kim NH5.(PubMed)
(1640) Clustering of haemostatic variables and the effect of high cashew and walnut diets on these variables in metabolic syndrome patients by Pieters M1, Oosthuizen W, Jerling JC, Loots DT, Mukuddem-Petersen J, Hanekom SM.(PubMed)
(1641) Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial by Katz DL1, Davidhi A, Ma Y, Kavak Y, Bifulco L, Njike VY.(PubMed)
(1642) Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats by Nammi S1, Sreemantula S, Roufogalis BD.(PubMed)
(1643) Walnut consumption is associated with lower risk of type 2 diabetes in women by Pan A1, Sun Q, Manson JE, Willett WC, Hu FB.(PubMed)
(1644) Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice by Fukuda T1, Ito H, Yoshida T.(PubMed)
(1645) Effects of walnut consumption on blood lipids and other cardiovascular risk factors: a meta-analysis and systematic review by Banel DK1, Hu FB.(PubMed)
(1646) Effects of walnut consumption as part of a low-fat, low-cholesterol diet on serum cardiovascular risk factors by Morgan JM1, Horton K, Reese D, Carey C, Walker K, Capuzzi DM.(PubMed)
(1647) Enzymatically interesterified fats based on mutton tallow and walnut oil suitable for cosmetic emulsions by Kowalska M1, Mendrycka M, Zbikowska A, Stawarz S.(PubMed)
(1648) Juglans regia and J. nigra, two trees important in traditional medicine: A comparison of leaf essential oil compositions and biological activities by Paudel P1, Satyal P1, Dosoky NS1, Maharjan S2, Setzer WN1.(PubMed)
(1649) Walnut diet reduces accumulation of polyubiquitinated proteins and inflammation in the brain of aged rats by Poulose SM1, Bielinski DF, Shukitt-Hale B.(PubMed)
(1650) Juglans mandshurica leaf extract protects skin fibroblasts from damage by regulating the oxidative defense system by Park G1, Jang DS, Oh MS.(PubMed)
(1651) Inhibitory effects of Juglans mandshurica leaf on allergic dermatitis-like skin lesions-induced by 2,4-dinitrochlorobenzene in mice by Park G1, Oh MS2.(PubMed)
(1652) In vitro antioxidant activity of Juglans regia L. bark extract and its protective effect on cyclophosphamide-induced urotoxicity in mice by Bhatia K1, Rahman S, Ali M, Raisuddin S.(PubMed)