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Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women. Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Traditional Chinese Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches. Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).
PCOs Treatment according traditional Chinese medicine
Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into
Kidney yin deficiency
Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yin deficiency may also experience yin vacuity induced cold expressive syndrome, including soreness of waist and knees(1848), lassitude(1848) and fatigue(1848), short breath(1848), poor appetite(1848), aversion to cold(184), cold extremities(1848), ringing in the ears(1850), migraine(1849), hearing problems(1850), a dry mouth and throat(1851), pale fingernails(1851), tidal fever(1851)and night sweating(1851), soles(1851) and chest(1851), constipation(1852),,......... as the kidneys no longer perform their functions of regulating fluid in moistening and nourishing organs and tissues of the body. According to TCM, too much cold/raw foods can aggravate the condition.
In the review of the Data base provided by PubMed, kidney yin deficiency may induce functional impairment or metabolic derangements in vital organs/tissues(1853) persuaded a conglomeration of sundry chronic disease state(1853), cognitive dysfunction(1854), vasomotor symptoms(1855),..... leading to accumulation of fluid in the body organ, promoted accentuation of inflammatory development of phlegm.
Kidney yin deficiency has shown to alter amino acid metabolism(1856), energy metabolism(1856) and gut microflora(1856), anovulatory infertility(1857) and
hypertension(1858), hyperinsulinemia(1859) and hyperandrogenia(1859)..... of which related to symptoms of PCOs(1859).
2. Lycium chinense(Qi Zi)(1759)
See kidney yang tonified TCM herbal medicine
[Gou Qi Zi or Qi Zi is also known as wolfberry fruit. The sweet and neutral herb has been used in TCM as anti cancer(1748)(1749)(1750), antiviral(1751), and antiinflammatory(1751) agent and to treat weakness(1768) mental acuity(1768), shortness of breath(1768), memory and neurogenesis impairments(1752), relieve pain(1753) improve vision(1754)(1755), anemia(1754), diabetes(1756), promote antiaging(1757), enhance immune system(1751), heart function(1751), lower blood lipids(1751), modulate estrogen receptors(1750) etc., as it nourishes and tonifies liver and kidneys by enhancing the functions of liver, lung and kidney channels(1758).
Chemical constituents(1758)
1. Betaine
2. β-sitosterol
3. Linoleic acid
4. Physalien
5. Cryptoxanthin
6. Atropine
7. Hyoscyamine
8. Scopoletin
9. Amino acids
10. Physalein
11. Zeaxanthin
12. Dipalmitate
13. Carotene
14. Etc.
Epidemiologically, wolfberry also processed anti oxidant(1763)(1762) and anti inflammatory(1765)(1764), anti insulin resistance(1760)(1761), anti depression(1767), sleep disorder(1768), anti stress(1768), anti mental deficits(1768) and anti metabolic syndrome(1766), through its enhanced carbohydrate(1770), lipid(1766) and other metabolic(1766) mechanisms, including fasting glucose(1770), hypertensive(1771)(1772), anti hyperglycaemic(1769)(1770)(1774), anti hyperlipidemic(1773)(1774), weight gain(1770), obesity,........ of which induced protective effects against the development of diabetes(1775)(1776) and cardiovascular disease(1777)(1751)(1778).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao(1848) ontrolled trail on moxibustion for maintenance hemodialysis patients in deficiency syndrome]. [Article in Chinese] Li N1, Qiu MY, Hao JR, Zhang QM, Wang SH, Liang F, Yin Y, Luan J, Ge GZ, Qin T, Li BQ.(PubMed)
(1848) ontrolled trail on moxibustion for maintenance hemodialysis patients in deficiency syndrome]. [Article in Chinese] Li N1, Qiu MY, Hao JR, Zhang QM, Wang SH, Liang F, Yin Y, Luan J, Ge GZ, Qin T, Li BQ.(PubMed)
(1849) [Observation on therapeutic effect of the new Bianshi (stone needle) therapy on migraine]. [Article in Chinese] Yin ZJ1, Yan YJ, Bao HL(PubMed)
(1850) [Study on relation of kidney-deficiency with hearing damage and serum trace elements in patients with chronic nephropathy]. [Article in Chinese] by Yu J1, Xu Y, Fu XD.(PubMed)
(1851) [A family survey of syndromes of traditional Chinese medicine in patients with beta-thalassemia]. [Article in Chinese] by Wang WJ1, Wu ZK, Zhang XH, Liu WJ, Liu YM, Fang SP, Wang RX, Zhang C, Li PP, Luo RG.(PubMed)
(1852) The clinical experiences of Dr. CAI Gan in treating chronic constipation by Zhang ZL1, Zhu MP, Liu Q, Lei YX.(PubMed)
(1853) [Analysis of 35 cases of pathology in yin deficiency syndrome]. [Article in Chinese] by Dai HL, Chen ZL, Song QL.(PubMed)
(1854) Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors by Huang Y1, Zhang H, Yang S, Qiao H, Zhou W, Zhang Y.(PubMed)
(1855) Diagnosis of symptomatic postmenopausal women by traditional Chinese medicine practitioners by Zell B1, Hirata J, Marcus A, Ettinger B, Pressman A, Ettinger KM.(PubMed)
(1856) An integrated metabonomic and proteomic study on Kidney-Yin Deficiency Syndrome patients with diabetes mellitus in China by Jiang N1, Liu HF2, Li SD1, Zhou WX1, Zhang YX1, Zhang Q3, Yan XZ3.(PubMed)
(1857) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan J.(PubMed)
(1858) Traditional chinese medicine syndromes for essential hypertension: a literature analysis of 13,272 patients by Wang J1, Xiong X1, Liu W1.(PubMed)
(1859) [Clinical observation on treatment of hyperinsulinemia and hyperandrogenism anovulatory patient with replenishing kidney-yin drugs]. [Article in Chinese] by Zhou LR1, Yu J.(PubMed)
(1748) Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer by Luo Q1, Li Z, Yan J, Zhu F, Xu RJ, Cai YZ.(PubMed)
(1749) [Observation of the effects of LAK/IL-2 therapy combining with Lycium barbarum polysaccharides in the treatment of 75 cancer patients]. [Article in Chinese] by Cao GW1, Yang WG, Du P.(PubMed)
(1750) Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism by Li G1, Sepkovic DW, Bradlow HL, Telang NT, Wong GY.(PubMed)
(1751) An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides by Cheng J1, Zhou ZW2, Sheng HP3, He LJ4, Fan XW5, He ZX6, Sun T7, Zhang X8, Zhao RJ9, Gu L10, Cao C2, Zhou SF11.(PubMed)
(1752) Lycium barbarum polysaccharides prevent memory and neurogenesis impairments in scopolamine-treated rats by Chen W1, Cheng X2, Chen J3, Yi X2, Nie D4, Sun X5, Qin J2, Tian M2, Jin G2, Zhang X2.(PubMed)
(1753) [Effects of lycium barbarum polysaccharide on formation of traumatic neuroma and pain after transection of sciatic nerve in rats]. [Article in Chinese] by Fan H1, Deng C, Fu J, Ding L, Yin G, Ma Y.(PubMed)
(1754) Lycium (Lycium barbarum) by Cassileth B1.(PubMed)
(1755) Goji berry effects on macular characteristics and plasma antioxidant levels by Bucheli P1, Vidal K, Shen L, Gu Z, Zhang C, Miller LE, Wang J.(PubMed)
(1756) Anti-diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat-rich combination diet by Cheng Q1, Zhang X, Wang O, Liu J, Cai S, Wang R, Zhou F, Ji B.(PubMed)
(1757) Comparative evaluation of the antioxidant effects of the natural vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from Goji berry fruit by Zhang Z1, Liu X, Zhang X, Liu J, Hao Y, Yang X, Wang Y.(PubMed)
(1758) Qi Zi(Complementary and Alternative Healing University)
(1759) Chinese Herbs – Gou Qi Zi or Qi Zi (Fructus Lycii) by Kyle J. Norton
(1760) A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cellsby Liu J1, Zhang H, Ji B, Cai S, Wang R, Zhou F, Yang J, Liu H.(PubMed)
(1761) Dietary Lycium barbarum polysaccharide induces Nrf2/ARE pathway and ameliorates insulin resistance induced by high-fat via activation of PI3K/AKT signaling by Yang Y1, Li W2, Li Y2, Wang Q2, Gao L3, Zhao J4.(PubMed)
(1762) Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults by Amagase H1, Sun B, Borek C.(PubMed)
(1763) Effect of drying methods on physicochemical properties and antioxidant activities of wolfberry (Lycium barbarum) polysaccharide by Zhao Q1, Dong B2, Chen J2, Zhao B3, Wang X1, Wang L1, Zha S4, Wang Y1, Zhang J5, Wang Y5.(PubMed)
(1764) Anti-inflammatory effect of Lycii radicis in LPS-stimulated RAW 264.7 macrophages by Song MY1, Jung HW, Kang SY, Kim KH, Park YK.(PubMed)
(1765) Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells by Oh YC1, Cho WK, Im GY, Jeong YH, Hwang YH, Liang C, Ma JY.(PubMed)
(1766) Metabolic Signatures of Kidney Yang Deficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GC/TOF by MS. Zhao L1, Wu H, Qiu M, Sun W, Wei R, Zheng X, Yang Y, Xin X, Zou H, Chen T, Liu J, Lu L, Su J, Ma C, Zhao A, Jia W.(PubMed)
(1767) Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats(1) by Zhang E1, Yau SY, Lau BW, Ma H, Lee TM, Chang RC, So KF.(PubMed)
(1760) A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cellsby Liu J1, Zhang H, Ji B, Cai S, Wang R, Zhou F, Yang J, Liu H.(PubMed)
(1761) Dietary Lycium barbarum polysaccharide induces Nrf2/ARE pathway and ameliorates insulin resistance induced by high-fat via activation of PI3K/AKT signaling by Yang Y1, Li W2, Li Y2, Wang Q2, Gao L3, Zhao J4.(PubMed)
(1762) Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults by Amagase H1, Sun B, Borek C.(PubMed)
(1763) Effect of drying methods on physicochemical properties and antioxidant activities of wolfberry (Lycium barbarum) polysaccharide by Zhao Q1, Dong B2, Chen J2, Zhao B3, Wang X1, Wang L1, Zha S4, Wang Y1, Zhang J5, Wang Y5.(PubMed)
(1764) Anti-inflammatory effect of Lycii radicis in LPS-stimulated RAW 264.7 macrophages by Song MY1, Jung HW, Kang SY, Kim KH, Park YK.(PubMed)
(1765) Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells by Oh YC1, Cho WK, Im GY, Jeong YH, Hwang YH, Liang C, Ma JY.(PubMed)
(1766) Metabolic Signatures of Kidney Yang Deficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GC/TOF by MS. Zhao L1, Wu H, Qiu M, Sun W, Wei R, Zheng X, Yang Y, Xin X, Zou H, Chen T, Liu J, Lu L, Su J, Ma C, Zhao A, Jia W.(PubMed)
(1767) Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats(1) by Zhang E1, Yau SY, Lau BW, Ma H, Lee TM, Chang RC, So KF.(PubMed)
(1768) A meta-analysis of clinical improvements of general well-being by a standardized Lycium barbarum by Paul Hsu CH1, Nance DM, Amagase H.(PubMed)
(1769) Evaluation of hypoglycemic activity of the polysaccharides extracted from Lycium barbarum by Jing L1, Cui G, Feng Q, Xiao Y.(PubMed)
(1770) Hypoglycemic effects and mechanisms of action of Cortex Lycii Radicis on alloxan-induced diabetic mice by Gao D1, Li Q, Liu Z, Li Y, Liu Z, Fan Y, Li K, Han Z, Li J.(PubMed)
(1771) Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension by Mi XS1, Feng Q, Lo AC, Chang RC, Lin B, Chung SK, So KF.(PubMed)
(1772) Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity by Potterat O1.(PubMed)
(1773) Effects of Lycium barbarum polysaccharides on oxidative stress in hyperlipidemic mice following chronic composite psychological stress intervention by Zhu X1, Hu S1, Zhu L1, Ding J1, Zhou Y1, Li G1.(PubMed)
(1774) Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum by Luo Q1, Cai Y, Yan J, Sun M, Corke H..(PubMed)
(1775) Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes by Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, Lu H, Guo F, Han C, Sun G1.(PubMed)
(1776) Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L. by Zhu J1, Liu W, Yu J, Zou S, Wang J, Yao W, Gao X.(PubMed)
(1777) Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats by Yang X1, Bai H, Cai W, Li J, Zhou Q, Wang Y, Han J, Zhu X, Dong M, Hu D.(PubMed)
(1778) [Effect of Lycium ruthenicum anthocyanins on atherosclerosis in mice]. [Article in Chinese] by Lin L1, Li J, Lv H, Ma Y, Qian Y.(PubMed)]
(1769) Evaluation of hypoglycemic activity of the polysaccharides extracted from Lycium barbarum by Jing L1, Cui G, Feng Q, Xiao Y.(PubMed)
(1770) Hypoglycemic effects and mechanisms of action of Cortex Lycii Radicis on alloxan-induced diabetic mice by Gao D1, Li Q, Liu Z, Li Y, Liu Z, Fan Y, Li K, Han Z, Li J.(PubMed)
(1771) Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension by Mi XS1, Feng Q, Lo AC, Chang RC, Lin B, Chung SK, So KF.(PubMed)
(1772) Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity by Potterat O1.(PubMed)
(1773) Effects of Lycium barbarum polysaccharides on oxidative stress in hyperlipidemic mice following chronic composite psychological stress intervention by Zhu X1, Hu S1, Zhu L1, Ding J1, Zhou Y1, Li G1.(PubMed)
(1774) Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum by Luo Q1, Cai Y, Yan J, Sun M, Corke H..(PubMed)
(1775) Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes by Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, Lu H, Guo F, Han C, Sun G1.(PubMed)
(1776) Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L. by Zhu J1, Liu W, Yu J, Zou S, Wang J, Yao W, Gao X.(PubMed)
(1777) Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats by Yang X1, Bai H, Cai W, Li J, Zhou Q, Wang Y, Han J, Zhu X, Dong M, Hu D.(PubMed)
(1778) [Effect of Lycium ruthenicum anthocyanins on atherosclerosis in mice]. [Article in Chinese] by Lin L1, Li J, Lv H, Ma Y, Qian Y.(PubMed)]
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