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Wednesday, 17 June 2015

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: TCM Foods Suggestion for Kidney Yin deficiency - Blueberry

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

            Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women. Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

In Traditional Chinese Perspective

While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches. Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).

PCOs Treatment according traditional Chinese medicine 


Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into 

Kidney yin deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yin deficiency may also experience yin vacuity induced cold expressive syndrome, including soreness of waist and knees(1848), lassitude(1848) and fatigue(1848), short breath(1848), poor appetite(1848), aversion to cold(184), cold extremities(1848), ringing in the ears(1850), migraine(1849), hearing problems(1850), a dry mouth and throat(1851), pale fingernails(1851), tidal fever(1851)and night sweating(1851), soles(1851) and chest(1851), constipation(1852),,......... as the kidneys no longer perform their functions of regulating fluid in moistening and nourishing organs and tissues of the body. According to TCM, too much cold/raw foods can aggravate the condition.

In the review of the Data base provided by PubMed, kidney yin deficiency may induce functional impairment or metabolic derangements in vital organs/tissues(1853) persuaded a conglomeration of sundry chronic disease state(1853), cognitive dysfunction(1854), vasomotor symptoms(1855),..... leading to accumulation of fluid in the body organ, promoted accentuation of inflammatory development of phlegm.
Kidney yin deficiency has shown to alter amino acid metabolism(1856), energy metabolism(1856) and gut microflora(1856), anovulatory infertility(1857) and
hypertension(1858), hyperinsulinemia(1859) and hyperandrogenia(1859)..... of which related to symptoms of PCOs(1859).


         Foods for Kidney yin deficiency

List of foods suggested by TCM doctors for management and treatment of PCOs' women diagnosed with kidney yin deficiency, including

6. Blueberry
Blueberry is a flower plant, belongings to the family Eriaceae, native to Northern America, cultivated worldwide in suitable climate for commercial profits and health product, because of its effects on cancers(1913)(1914)(1915), digestive(1917)(1918)(1919) and central nervous system(1920)(1921), weight loss(1922)(1924), bone loss(1923)(1925) and healthy ageing(1926)(1927)(1928),.........

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Vitamin A
6. Lutein and zeaxanthin
7. Thiamine (Vitamin B1)
8. Riboflavin (Vitamin B2)
9. Niacin (Vitamin B3)
10. Pantothenic acid (Viamin B5)
11. Vitamin B6
12. Folate (Vitamin B9)
13. Vitamin C
14. Vitamin E
15. Calcium
16. Iron
17. Magnesium
18. Phosphorus
19. Potassium
20. Zinc
21. Manganese
22. Vitamin K
23. Etc.
Strong epidemiological data suggested that blueberry may be used for treatment of metabolic syndrome(1929)(1930)(1931) in women with PCOs due to its antioxidant(1922)(1924)(1933) and anti inflammatory effects(1932)(1933) on endothelial function(1929), on carbohydrate metabolism(1937)(1938)[ such as fasting glucose(1934)(1935), insulin resistance(1916)(1935), hyperglycaemia(1934),...], hypercholesterolemia(1939)(1940)[increased plasma HDL and reduced total cholesterol and LDL], hypertension(1941)(1942). obesity(1916)(1924)(1936),..... The edible berry also was found to be a pharmrteutical candidate  for prevention and treatment of diabetes(1936)(1938) and cardiovascular disease(1914),

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To 
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao(1848) ontrolled trail on moxibustion for maintenance hemodialysis patients in deficiency syndrome]. [Article in Chinese] Li N1, Qiu MY, Hao JR, Zhang QM, Wang SH, Liang F, Yin Y, Luan J, Ge GZ, Qin T, Li BQ.(PubMed)
(1848) ontrolled trail on moxibustion for maintenance hemodialysis patients in deficiency syndrome]. [Article in Chinese] Li N1, Qiu MY, Hao JR, Zhang QM, Wang SH, Liang F, Yin Y, Luan J, Ge GZ, Qin T, Li BQ.(PubMed)
(1849) [Observation on therapeutic effect of the new Bianshi (stone needle) therapy on migraine]. [Article in Chinese] Yin ZJ1, Yan YJ, Bao HL(PubMed)
(1850) [Study on relation of kidney-deficiency with hearing damage and serum trace elements in patients with chronic nephropathy]. [Article in Chinese] by Yu J1, Xu Y, Fu XD.(PubMed)
(1851) [A family survey of syndromes of traditional Chinese medicine in patients with beta-thalassemia]. [Article in Chinese] by Wang WJ1, Wu ZK, Zhang XH, Liu WJ, Liu YM, Fang SP, Wang RX, Zhang C, Li PP, Luo RG.(PubMed)
(1852) The clinical experiences of Dr. CAI Gan in treating chronic constipation by Zhang ZL1, Zhu MP, Liu Q, Lei YX.(PubMed)
(1853) [Analysis of 35 cases of pathology in yin deficiency syndrome]. [Article in Chinese] by Dai HL, Chen ZL, Song QL.(PubMed)
(1854) Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors by Huang Y1, Zhang H, Yang S, Qiao H, Zhou W, Zhang Y.(PubMed)
(1855) Diagnosis of symptomatic postmenopausal women by traditional Chinese medicine practitioners by Zell B1, Hirata J, Marcus A, Ettinger B, Pressman A, Ettinger KM.(PubMed)
(1856) An integrated metabonomic and proteomic study on Kidney-Yin Deficiency Syndrome patients with diabetes mellitus in China by Jiang N1, Liu HF2, Li SD1, Zhou WX1, Zhang YX1, Zhang Q3, Yan XZ3.(PubMed)
(1857) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan J.(PubMed)
(1858) Traditional chinese medicine syndromes for essential hypertension: a literature analysis of 13,272 patients by Wang J1, Xiong X1, Liu W1.(PubMed)
(1859) [Clinical observation on treatment of hyperinsulinemia and hyperandrogenism anovulatory patient with replenishing kidney-yin drugs]. [Article in Chinese] by Zhou LR1, Yu J.(PubMed)
(1913) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro by Seeram NP1, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(1914) Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases by Neto CC1.(PubMed)
(1915) Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway by Adams LS1, Phung S, Yee N, Seeram NP, Li L, Chen S.(PubMed)
(1916) Blueberry and mulberry juice prevent obesity development in C57BL/6 mice by Wu T1, Tang Q, Gao Z, Yu Z, Song H, Zheng X, Chen W.(PubMed)
(1917) Lowbush wild blueberries have the potential to modify gut microbiota and xenobiotic metabolism in the rat colon by Lacombe A1, Li RW, Klimis-Zacas D, Kristo AS, Tadepalli S, Krauss E, Young R, Wu VC.(PubMed)
(1918) Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mdr1a(-/-) mice, a model of inflammatory bowel diseases by Paturi G1, Mandimika T, Butts CA, Zhu S, Roy NC, McNabb WC, Ansell J.(PubMed)
(1919) Stability and biological activity of wild blueberry (Vaccinium angustifolium) polyphenols during simulated in vitro gastrointestinal digestion by Correa-Betanzo J1, Allen-Vercoe E2, McDonald J2, Schroeter K2, Corredig M1, Paliyath G3.(PubMed)
(1920) Nutraceutical intervention improves older adults' cognitive functioning by Small BJ1, Rawson KS, Martin C, Eisel SL, Sanberg CD, McEvoy CL, Sanberg PR, Shytle RD, Tan J, Bickford PC.(PubMed)
(1921) Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor by Rendeiro C1, Vauzour D, Rattray M, Waffo-Téguo P, Mérillon JM, Butler LT, Williams CM, Spencer JP.(PubMed)
(1922) Anthocyanins, phenolics and antioxidant capacity after fresh storage of blueberry treated with edible coatings by Chiabrando V1, Giacalone G.(PubMed)
(1923) Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis by Devareddy L1, Hooshmand S, Collins JK, Lucas EA, Chai SC, Arjmandi BH.(PubMed)
(1924) Antioxidative Activity of Blueberry Leaf Extract Prevents High-fat Diet-induced Obesity in C57BL/6 Mice by Lee IC1, Kim DY2, Choi BY2.(PubMed)
(1925) Rabbiteye blueberry prevents osteoporosis in ovariectomized rats by Li T, Wu SM, Xu ZY1, Ou-Yang S.(PubMed)
(1926) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans by Wilson MA1, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA.(PubMed)
(1927) Blueberries and neuronal aging by Shukitt-Hale B1.(PubMed)
(1928) Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Rendeiro C1, Vauzour D, Kean RJ, Butler LT, Rattray M, Spencer JP, Williams CM.Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficits by Galli RL1, Shukitt-Hale B, Youdim KA, Joseph JA.(PubMed)
(1929) Blueberries improve endothelial function, but not blood pressure, in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial by Stull AJ1,2, Cash KC3, Champagne CM4, Gupta AK5, Boston R6, Beyl RA7, Johnson WD8,9, Cefalu WT10,11.(PubMed)
(1930) A blueberry-enriched diet improves renal function and reduces oxidative stress in metabolic syndrome animals: potential mechanism of TLR4-MAPK signaling pathway by Nair AR1, Elks CM2, Vila J3, Del Piero F4, Paulsen DB4, Francis J1.(PubMed)
(1931) Wild blueberry (Vaccinium angustifolium) consumption improves inflammatory status in the obese Zucker rat model of the metabolic syndrome by Vendrame S1, Daugherty A, Kristo AS, Riso P, Klimis-Zacas D.(PubMed)
(1932) Anti-inflammatory and antinociceptive properties of blueberry extract (Vaccinium corymbosum) by Torri E1, Lemos M, Caliari V, Kassuya CA, Bastos JK, Andrade SF.(PubMed)
(1933) Phenolic acids of the two major blueberry species in the US Market and their antioxidant and anti-inflammatory activitie by Kang J1, Thakali KM, Jensen GS, Wu X.(PubMed)
(1934) Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice by Roopchand DE1, Kuhn P, Rojo LE, Lila MA, Raskin I.(PubMed)
(1935) Alternate day fasting impacts the brain insulin-signaling pathway of young adult male C57BL/6 mice by Lu J1, E L, Wang W, Frontera J, Zhu H, Wang WT, Lee P, Choi IY, Brooks WM, Burns JM, Aires D, Swerdlow RH.(PubMed)
(1935) Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women by Stull AJ1, Cash KC, Johnson WD, Champagne CM, Cefalu WT.(PubMed)
(1936) Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKA(y) mice by Vuong T1, Benhaddou-Andaloussi A, Brault A, Harbilas D, Martineau LC, Vallerand D, Ramassamy C, Matar C, Haddad PS.(PubMed)
(1937) Cultivar evaluation and effect of fermentation on antioxidant capacity and in vitro inhibition of α-amylase and α-glucosidase by highbush blueberry (Vaccinium corombosum) by Johnson MH1, Lucius A, Meyer T, de Mejia EG.(PubMed)
(1938) Anthocyanins and proanthocyanidins from blueberry-blackberry fermented beverages inhibit markers of inflammation in macrophages and carbohydrate-utilizing enzymes in vitro by Johnson MH1, de Mejia EG, Fan J, Lila MA, Yousef GG.(PubMed)
(1939) Efficiency of pharmacologically-active antioxidant phytomedicine Radical Fruits in treatment hypercholesteremia at men by Abidov M1, Jimenez Del Rio M, Ramazanov A, Kalyuzhin O, Chkhikvishvili I.(PubMed)
(1940) Effect of blueberry feeding on lipids and oxidative stress in the serum, liver and aorta of guinea pigs fed on a high-cholesterol diet by Çoban J1, Evran B, Özkan F, Çevık A, Doğru-Abbasoğlu S, Uysal M.(PubMed)
(1941) Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. Johnson SA by Figueroa A, Navaei N, Wong A, Kalfon R, Ormsbee LT, Feresin RG, Elam ML, Hooshmand S, Payton ME, Arjmandi BH.(PubMed)
(1942) Antihypertensive activity of blueberries fermented by Lactobacillus plantarum DSM 15313 and effects on the gut microbiota in healthy rats by Ahrén IL1, Xu J2, Onning G1, Olsson C3, Ahrné S4, Molin G4.(PubMed)