Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday 7 January 2018

Food Therapy: Eggplant in Ameliorated Risk and Treatment of Liver Cancer

Eggplant may have a therapeutic and positive effect in reduced risk and treatment of liver cancer, some scientists suggested.

Eggplant is a species of S. melongena with deeply purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

Liver cancer is medical condition characterized by irregular cell growth in the issues of liver. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissue and organs.

According to statistic, approximately 40,710 new cases (29,200 in men and 11,510 in women) of liver cancer and and intrahepatic bile duct cancer will be diagnosed in US 2017.

Glycoalkaloids (α-solamargine and α-solasonine), nitrogen-containing secondary plant metabolites found in eggplants and numerous Solanaceous plants including potatoes, and tomatoes expressed a strong inhibition of the growth of the liver tumor cells in culture and tumor growth in vivo.

More specifically, α-solamargine and α-solasonine induced apoptosis in cancer cells but not normal cells through functions in eliminated old cells, unnecessary cells, unhealthy cells and cancer cells without causing harm to healthy cells in the surrounding area.

Further differentiation, also suggested that α-solamargine also suppressed liver cancer cell proliferation and induced apoptosis through cell cycle arrest.

Additionally, in HCT-116 cell line, anthocyanins isolated from eggplant displayed a substantial antioxidant effect in inhibited reactive oxygen species(ROS) expression in promoting oxidative stress and cytotoxicity in induction of healthy cellular DNA damage in initiated early onset of liver cancer.

In compared to anthocyanins, administration of nasunin with glycosylation on C3 and C5 and an acyl group (p-coumaric acid) derivatives demonstrated the least effect on ROS reduction but exhibited ROS over expression in induction of cytotoxicity in colon cell lines, thus ameliorating tumor proliferation and site expansion, according to microculture tetrazolium (MTT) assay.

Further differentiation, also indicated that nasunin and its deacylated derivatives protected healthy cells from DNA damage through antioxidant capacity in a dose-dependent manner.

Importantly, in the valuations carried out with four concentrations each (0.1, 1, 10, and 100 microg/mL) of the the potato trisaccharide glycoalkaloids alpha-chaconine and alpha-solanine; the disaccharides beta(1)-chaconine, beta(2)-chaconine, and beta(2)-solanine; the monosaccharide gamma-chaconine and their common aglycon solanidine; the tetrasaccharide potato glycoalkaloid dehydrocommersonine; the potato aglycon demissidine; the tetrasaccharide tomato glycoalkaloid alpha-tomatine, the trisaccharide beta(1)-tomatine, the disaccharide gamma-tomatine, the monosaccharide delta-tomtine, and their common aglycon tomatidine, and the eggplant glycoalkaloids solamargine and solasonine and their common aglycon solasodine; and the nonsteroidal alkaloid jervine, researchers found that the glycoalkaloids isolated from all vegetables demonstrated as the most active compound in inhibited liver cancer in compared to colon cells.

In compared to anticancer drugs doxorubicin and camptothecin, all isolated compounds also exerted significant activity in decreased cancer cell proliferation and induced apoptosis in concentration dependent manner.

Taking altogether, eggplant with abundant bioactive phytochemicals may be considered as a functional food used as secondary therapy to reduce risk and in combination of with standard chemo medicine for treatment of liver cancer.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells by Lee KR1, Kozukue N, Han JS, Park JH, Chang EY, Baek EJ, Chang JS, Friedman M.(PubMed)
(2) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1.(PubMed)
(3) Solasodine, Solamargine and Mixtures of Solasodine Rhamnosides: Pathway to Expansive Clinical Anticancer Therapies Bill E. Cham by International Journal of Clinical Medicine, 2017, 8, 692-713

Saturday 6 January 2018

Herbal Therapy: Green Tea and Lower Dose of Its Bioactive Polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in Reduced Cardiac Fibrosis in Induction of Heart Failure

Green tea may have a therapeutic and positive effect in reduced risk and treatment of cardiac fibroids some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Cardiac fibrosis is a uncommon condition of abnormal thickening of the heart valves caused by inappropriate proliferation of cardiac fibroblasts but commonly, it is the excess deposition of molecules outside a cell or cells with structural and biochemical support to the surrounding cells in the cardiac muscle, leading to cardiac dysfunction and eventually heart failure.

The study of rat cardiac fibroblasts caused by injected by angiotensinII (AngII) also revealed that green tea inhibited the abnormal increase in level of connective tissue growth factor CTGF by decreased expression of the nuclear translocation of NF-κB p65 subunit and degradation of IκB-α in induced promotion of fibroblast proliferation and extracellular matrix (ECM) accumulation, thereby exacerbating cardiac hypertrophy and subsequent failure were attributed to bioactive polyphenol EGCG expression in significantly reduced collagen synthesis, fibronectin (FN) expression and cell proliferation.

In deed, due to the activity of CTGF as a matricellular protein modulating the fibrotic process in cardiac remodelling, some researchers suggested that the gowth factor may be considered as a biomarker for cardiac fibrosis for therapeutic intervention to mitigate fibrosis in the heart.

Interestingly, in the evaluated the effect of GABA tea, containing a high level of gamma-aminobutyric acid (GABA) in cardiac function with male Wistar rats injected with 55 mg/kg streptozotocin (STZ) to induce diabetes for 2 weeks and then orally given dosages of 4.55 and 45.5 mg/kg/day GABA tea extract for 6 weeks, researchers revealed that rats treated with injection of GABA tea not only induces fasting blood glucose levels returned to normal levels but also inhibits cardiac fibrosis in compared to untreated group.

Further experiments also showed that GABA tea in ameliorated cardiac deposit risk was attributed to inhibited the protein levels of tumor necrosis factor-alpha (TNF-alpha), Fas and activated caspase-8 and caspase-3 induced in STZ rats in mediated cardiomyocyte apoptosis which has been found in elevation in patient with cardiac dysfunction such as cardiac fibrosis and an indication of chronic hemodynamic overloading and early cardiac decompensation.

Dr. Cherng SH, the lead authors suggested," (GABA tea reduced)cardiac fibrosis (expression) in diabetic rats may be mediated by reducing blood glucose and further attenuating TNF-alpha expression and/or Fas/Fas ligand (FasL)-mediated apoptosis".

Unfortunately, injection of bioactive polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in high dose was found to induce the oppositely effect by increasing cardiac fibroids.

According to the study of green tea bioactive polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in risk of cardiac fibroids induction of myocardiotoxicity in animal model, at the the joint study lead by the Guangzhou Medical University, injection of EGCG 500 and 1000 mg/kg demonstrated a significant effect in initiated cardiac collagen synthesis involved in the formation of filtration systems, through cells differentiation in connective tissue growth factor (CTGF) mRNA expression and protein produced by fibroblasts.

Further more, the application of green tea extract also displayed an exhibited fibrosis-related protein expression in induction of cardiac fibroids deposit through stimulating function of fibronectin (FN), a ubiquitous extracellular matrix (ECM) glycoprotein circulated in the blood to initiated heart muscle repair.

After taking into account of other con confounders, Dr. Cai Y, the lead scientist said, "high oral doses of EGCG could induce cardiac fibrosis, and shed new light on the understanding of EGCG-mediated myocardiotoxicity".

The information findings suggested that green tea with bioactive poluphenols EGCG at lower dose may be used as function food in reduced risk of cardiovascular diseases caused by cardiac fibroids. In take of green tea supplement EGCG mus be taken with care as overdoses-toxicity has been reported in some cases.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Sources
(1) GABA tea prevents cardiac fibrosis by attenuating TNF-alpha and Fas/FasL-mediated apoptosis in streptozotocin-induced diabetic rats by Cherng SH1, Huang CY2, Kuo WW3, Lai SE4, Tseng CY5, Lin YM6, Tsai FJ7, Wang HF8.(PubMed)
(2) High doses of (-)-epigallocatechin-3-gallate from green tea induces cardiac fibrosis in mice by Cai Y1, He SQ2, Hong HQ3, Cai YP4, Zhao L5, Zhang M2.(PubMed)
(3) EGCG inhibits CTGF expression via blocking NF-κB activation in cardiac fibroblast by Cai Y1, Yu SS, Chen TT, Gao S, Geng B, Yu Y, Ye JT, Liu PQ.(PubMed)

Herbal Therapy: Green tea and Its Bioactive Polyphenols in Ameliorated Risk Human Immunodeficiency Virus -1 (HIV-1) Infection

Green and black tea may have a therapeutic and positive effect in reduced risk of HIV 1 infection, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated of acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,....

According to statistic, approximately 36.7 million people worldwide living with HIV/AIDS in 2016, including, 2.1 million of children less than 15 years of age.

According to the investigation of Theaflavins, the major components of tea polyphenols extracted from brewed black tea and green tea inhibited inhibited HIV-1 entry by targeting gp41 which is a transmembrane protein with function in embedded with outer coat of HIV to enter and infected host cells.

However, due to the unstable and purified of the individual theaflavins, natural preparation containing 90% of theaflavins (TFmix) in most study was used to experiment of its effect against HIV-1 microbide for preventing HIV sexual transmission.

In vitro using p24 production and luciferase assays, TFmix exhibited potent anti-HIV-1 activity on lab-adapted and primary HIV-1 strains with IC(50), the concentration of an application that gives half-maximal response in dose of less than 1.20 μM, through targeting the gp41 in inhibited virus-host membrane fusion during infection mediated by the formation of six helix bundle (6HB).

In other words, theaflavins administration was found to initiate potent anti-HIV-1 activity by targeting the viral entry step through the disruption of gp41 6-HB core structure,

Further more, application of theaflavins (TFmix) also inhibited reverse transcriptase (RT) activity, an RNA-dependent DNA, which is the process in replication of RNA from a DNA template through polymerase (DNAP) enzyme in forming new copies of DNA, in the form of nucleic acid molecules, with the IC(50) about 8-fold higher of theaflavins (TFmix) concentration than that for inhibiting gp41 6-HB formation.

In peptide fragments, derived from prostatic acidic phosphatase secreted in large amounts into human semen to form amyloid fibrils plaques with function to induced viral infection (SEVI), through capturing the HIV virions and direct them to target cells into liver cell to initiated entry step, during sexual activity, injection of green tea epigallocatechin-3-gallate (EGCG) inhibited the expression of SEVI and revoked semen in mediated enhancement of HIV-1 infection through precipitated viral degradation without induced healthy cell toxicity.

Further analysis of green tea EGCG activity using HIV-1 infectivity on human CD4+ T cells, at a physiologic concentration of 6μM, EGCG significantly inhibited HIV-1 p24 antigen production in expression of acute infection in both HIV-1 clinical isolates and laboratory-adapted subtypes B C, D, and G.

Particularly, EGCG-induced inhibition of HV-1 infectivity was not due to cytotoxicity, cell growth inhibition, nor apoptosis but blocking the HIV activity in attachment of HIV-1-gp120, a glycoprotein exposed on the surface of the HIV envelope to the CD4 molecule in the entry point in initiated infectivity.

Dr. Christina L., the lead author concluded, "(by) preventing the attachment of HIV-1-gp120 to the CD4 molecule, EGCG inhibits HIV-1 infectivity. As this inhibition can be achieved at physiologic concentrations, the natural anti-HIV agent, EGCG, is a candidate as an alternative therapy in HIV-1 therapy".

The information findings suggested that green tea with abundant bioactive polyphenols Theaflavins including epigallocatechin-3-gallate (EGCG) may be considered as a function food to ameliorated risk of HIV 1 infection by blocking the complex process in initiation.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Sources
(1) The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection by Hauber I1, Hohenberg H, Holstermann B, Hunstein W, Hauber J.(PubMed)
(2) A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection by Yang J1, Li L, Tan S, Jin H, Qiu J, Mao Q, Li R, Xia C, Jiang ZH, Jiang S, Liu S.(PubMed)
(3) Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41 by Liu S1, Lu H, Zhao Q, He Y, Niu J, Debnath AK, Wu S, Jiang S.(PubMed)
(4) Preclinical Development of the Green Tea Catechin, Epigallocatechin Gallate, as an HIV-1 Therapy by Christina L. Nance, Ph.D.,a Edward B. Siwak, Ph.D.,b and William T. Shearer, MD, Ph.Da(PMC)
(5) The HIV-1 gp41 N-terminal heptad repeat plays an essential role in membrane fusion by Sackett K1, Shai Y.(PubMed)

Friday 5 January 2018

Alternative Therapy: Yoga Intervention in Reduced Incidence of Intrauterine Growth Retardation(IUGR)

Kyle J. Norton

Just drinking the pounds away

Weight Loss Experts Are Baffled of Losing 14 Lbs in 14 days

By Ancient African Red Tea Recipe & Its Fat Melting Powers

Yoga intervention may have a profound effect in reduced risk of giving birth of an intrauterine growth retardation (IUGR) infant, particularly in high risk women, the study by the Yoga Anusandhana Samsthana (sVYASA) postulated.

Intrauterine growth restriction(IUGR) is a condition characterized by smaller unborn baby due to not growing at a normal rate inside the womb.

Yoga, the practical ancient technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a prospective, matched, observational study of a total of 121 women attending antenatal clinic at Gunasheela Surgical and Maternity Hospital (GSMH) in Bangalore, India, enrolled between 18-20 weeks of pregnancy with women assigned to the yoga group (including physical postures, breathing and meditation were practised by the yoga group, one hour daily, from the date of entry into the study until delivery period) and 53 women to the control group (walked half an hour twice a day during the study), researchers found that yoga group scores a significant higher in giving birth to a baby of normal birth-weight, as well as decreasing complications of pregnancy in compared to control group.

Indeed, growth of the baby depends upon the diet of pregnant women, expecting mom’s physical health as well as providing nutrients to the baby needed.

Yoga breathing and relaxation reduced daily and pregnancy stress through calming the central nervous system by connecting the mind and body, bringing back the present moment while letting go of them or deal them in the positive way.
Further more, the relaxation of psychological aspect also decreased the hormone expression during pregnancy in induced psychological symptoms to the expect mother, thus ameliorating mood swings caused by stress, fatigue and attenuating negative influence to the natural response of the body to increase circulation of blood to carry oxygen and nutrients to the womb for the baby to grow naturally.

Additionally, in the review literature published on the PubMed database from January 1970 to January 2011 to evaluate the peripartum outcomes of yoga during pregnancy, including the postpartum period and lactation, five prospective observational studies (n = 575) and three randomized clinical trials (RCTs; n = 298), met the criteria and guidelines were selected in the analysis, after taking into account of other co founders, researchers found that yoga intervention significantly lowered pain and discomfort (p < 0.05) and perceived stress (p = 0.001) and improved quality of life in physical domains.

Many pregnant women experience lower back pain as well as neck and muscle tension as the result of the body trying to cope the growth of the fetus and expansion of uterus. Yoga mind-body practices that cultivated general health, diminished distress, increased self-awareness and mind relaxation also calm the nervous tension and bring back the self consciousness of the mother hood, thus reducing pain caused psychological stress and dealing the physical pain in active and positive ways.

Additional differentiation also found that yoga breathing exercises to relax the body and help free the mind of worries and distractions, thus promoting blood to circulate in the uterus and creating a space for the baby to grow, improving self consciousness of being motherhood in reduction of psychological and physical discomfort.

Some researchers also suggested that maternal yoga participation not only relieves physical pain such as upper and back pain but also alleviates anxiety around labor and builds strength in the legs to prepare for the date of labor.

More profoundly, in the total of 335 women attending the antenatal clinic at Gunasheela Surgical and Maternity Hospital in Bangalore, India, enrolled between 18 and 20 weeks of pregnancy in a prospective, matched, observational study with 169 women in the yoga group and 166 women in the control group, researchers found that yoga group expressed improvement of all aspects in compared to control, including higher number of babies with normal birth weight > or = 2500 grams, reduced significant cases of preterm labor and complications of isolated intrauterine growth retardation (IUGR) (p < 0.003) and pregnancy-induced hypertension (PIH) with associated IUGR (p < 0.025) in compared to control.

The findings suggested that yoga therapy is safe and may be used as integrated approach during pregnancy to decreases IUGR either in isolation or associated with PIH, with no increased risk of complications.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Efficacy of yoga in pregnant women with abnormal Doppler study of umbilical and uterine arteries by Narendran S1, Nagarathna R, Gunasheela S, Nagendra HR.(PubMed)
(2) Yoga during pregnancy: a review by Babbar S1, Parks-Savage AC, Chauhan SP.(PubMed)
(3) Efficacy of yoga on pregnancy outcome by Narendran S1, Nagarathna R, Narendran V, Gunasheela S, Nagendra HR.(PubMed)

Thursday 4 January 2018

Herbal Therapy: Green Tea and Its Bioactive Polyphenols Epigallocatechin-3 Gallate (EGCG) in Attenuated Risk and Treatment of Hepatitis B

Kyle J. Norton

Green tea may have a therapeutic and positive effect in reduced risk and treatment of hepatitis B, some scientists suggested.

Hepatitis B is a viral infection of acute and chronic liver disease, caused by a double stranded DNA virus HBV transmitted through infected blood, semen, or other body fluid.

According to the statistic, positive carriers among Canadian is estimated to be 0.5% to 1.0%., depending to ethnicity.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the evaluation of the effect of green tea bioactive polyphenos epigallocatechin-3 gallate (EGCG) and risk of hepatitis B, application of the phytochemical inhibited HBV replication in the testing Hep3B2.1-7 hepatocellular carcinoma cell line, through a significant effect in reduced prevalence of liver damage caused by hepatitis B virus.

Interesting, injection of EGCG at the dose of less than 100 μM in the observed liver cancer cell line showed no effect in induced cell apoptosis and decreased proliferation but exhibited a strong effect in ameliorated expression of surface antigen of the hepatitis B virus (HBsAg) and antigen of hepatitis B virus circulated in infected blood (HBeAg) levels found by the ELISA method and the polymerase chain reaction (PCR)assay.

Further differentiation in different HepG2 2.2.15 cells to compare the effective of green tea with standard antiretroviral medication lamivudine (3TC), researchers indicated that administration of EGCG shows a significant inhibition of viral proliferation through attenuated expression of levels of HBsAg and HBeAg in the supernatant and extracellular HBV DNA in a dose- and time-dependent manner. At doses of 50-200 μg/ml EGCG displayed strong effects in compared to lamivudine (3TC) at dose of 200 μg/ml.

More importantly, application of EGCG also suppressed the extracellular HBV DNA, a nutrient source for viral cell proliferation and survival through attachment, aggregation, and stabilization of microcolonies.

The results of the experiments pointed out that green tea EGCG consists a potential anti-HBV activity with low toxicity.

Additional investigation of green tea EGCG effect in the early stages of infection caused by four different Hepatitis B virus genotypes A and D also found that at dose of more than 80%, the phyochemical inhibited both DMSO-differentiated HuS-E/2 cells and HA-NTCP-expressing Huh7 cells involved cancer cell process in early stage of proliferation through induced protein degradation and ameliorated serum of tansferrin.(the iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids)which isconsidered as a liver fibrosis biomarker in patients with chronic hepatitis B.

However, Treatment of cells with EGCG had no effect on HBV genome replication or virion secretion and the characteristic of HBV virion and the expression of known HBV entry factors were unaltered out side of the host before attacking the liver tissue.

All these results suggested that the green tea-derived molecule EGCG potently inhibits HBV entry and could be used in prevention and treatment of Hepatitis B. Intake of green tea supplement should be taken with to prevent overdoses cause of acute liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Sources
(1) (-)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes by Huang HC1, Tao MH2, Hung TM3, Chen JC4, Lin ZJ5, Huang C6.(PubMed)
(2) Preventive effects of a major component of green tea, epigallocathechin-3-gallate, on hepatitis-B virus DNA replication by Karamese M1, Aydogdu S, Karamese SA, Altoparlak U, Gundogdu C.(PubMed)
(3) Green tea polyphenol, epigallocatechin-3-gallate, possesses the antiviral activity necessary to fight against the hepatitis B virus replication in vitro by Pang JY1, Zhao KJ, Wang JB, Ma ZJ, Xiao XH.(PubMed)

Herbal Therapy: Green Tea and Its Bioactive Polyphenols in Reduced Risk, Progression and Treatment of Oral Cancer

Kyle J. Norton

Green tea may have a profound and sustainable effect in reduced risk and treatment of oral cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will neutralize the risk.

Oral cancer is medical condition characterized by irregular cell growth in the issues of mouth area. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, 1 in 75 men and 1 in 150 women will be diagnosed with oral cancer during their lifetime

In the review of medical literature online, green tea extract green tea catechin, (-)-epigallocatechin-3-gallate (EGCG) showed to reduced risk and treatment of oral cancers through some particular mechanisms.

In human oral squamous carcinoma cells (SCC-25, SCC-9), application of green tea catechin, (-)-epigallocatechin-3-gallate (EGCG) suppressed SIRT3 mRNA and protein expression in induction of SCC-25 cells proliferation, through antioxidant effect in attenuated function of SIRT3 in contribution to cancer cell survival via mRNA transmitting by modulating oxidative stress..

Some reserachers also insisted that SIRT 3 may be considered as a bio-maker for targeting stage and grade of cancer progression.

Further analysis, suggested that green tea bioactive EGCG also up regulated the nuclear localization of the estrogen-related receptor α (ERRα) in inhibited oral cell carcinoma tumors by regulating SIRT3 in expression of cancer cellular metabolism.

Interestingly, EGCG application also displayed a significant effect in modulated the mRNA expressions of SIRT3-associated to cancer cell in induction of cell proliferation through inhibiting the production of reactive oxidative species in precipitated chain reactive in initiation of cancer cell division.

More importantly, in ROS perspective, oral administration of green tea EGCG by targeting the protein SIRT3 in exhibited antioxidant effect in protect healthy cells without affecting formation of ROS to facilitate oral cancer cell apoptosis through cytotoxicity.

Dr. Tao L, after taking into account of other cofounders, said, "SIRT3 represents a novel potential target through which EGCG exerts differential prooxidant effects in cancer and normal cells".

Further observation of the efficacy of green tea extract EGCG, also indicated that EGCG treatment increased the production of mitochondrial H2O2 in SCC-25 cells within 6 hours before inducing cancer cells apoptosis.

In antioxidant activity. green extract EGCG induced differential expression of genes related to antioxidant defense in oral cancer cell and gingival fibroblasts, which are critical in sustaining inflammation in periodontal disease through ameliorated expression of metallothionein 3 in induction of degeneration of cells and superoxide dismutase 2/3, and thioredoxin reductase 2 in facilitate oxidative stress to induce oncogenesis without increased cell proliferation of human gingival fibroblast -1 (HGF-1).

Additional examination indicated that the application also exhibited anti oral cancer apoptosis by increased expression of mitochondrial ROS and mitochondrial dysfunction in facilitated intoxicate effect without causing harm to the gingival fibroblasts through antioxidant selective activities.

Green tea with promising chemo properties due to their decreased dose and limited toxicity profiles, Dr. Ramshankar V1, the lead author said, "It is worthwhile to include green tea extract in an oral screening program for evaluating the pre-malignant lesions comparing the results between the treated and untreated group. Given the wide acceptance of green tea, its benefits may help in effective chemo-prevention oral cancer".

Taken together, green tea with abundant bioactive polyphennols may be considered as a function for prevention and used as adjunct therapy in combination with standard treatment of oral cancer. Intake of green tea extract as supplement are not recommended as toxicity has been reported in numbers of case.

For More information of yoga lessons tailor to a complete wellbeing for women, please visit: YOGA: WOMEN HEALTH and WEIGHT LOSS

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling by Tao L1, Park JY, Lambert JD.(PubMed)
(2) The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (-)-epigallocatechin-3-gallate, in oral cells.by Tao L1, Forester SC, Lambert JD.(PubMed)
(3) Chemoprevention of oral cancer: Green tea experience by Ramshankar V1, Krishnamurthy A2.(PubMed)

Alternative Therapy: Maternal Yoga in Reduced Risk of Preeclampsia

Kyle J. Norton

Epidemiological studies suggested that yoga intervention may be used to assist standard care treatment in reduced risk of pre-eclampsia onset during pregnancy.

Pre-eclampsia (PE) is a disorder of pregnancy characterized by abnormal high blood pressure and often a significant amount of protein in the urine.

Yoga, the ancient practical technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In the review literature published electronic database, PubMed, studies met the criteria and guideline selected included 54 citations in eight studies (10 reports) in the final analysis, after talking into account of other risk factors, researchers found that prenatal yoga displayed a significant effect in improvement of many aspects including pre-eclampsia in healthy women in 4 studies in compared to control.

Further differentiation also suggested that high-risk pregnant women with morbidity factors such as obesity or advanced age, participated in yoga lesson were found to induce significantly fewer cases of pregnancy-induced hypertension, gestational diabetes, and intrauterine growth restriction, as well as a decrease in perceived stress levels in compared to control

In deed, yoga class focused on poses, breathing exercises, meditation, visualization, guided imagery, and deep relaxation not only reduced psychological stress caused by previous pregnancy and various reasons in induction of nervous tension to precipitate hormone imbalance, particularly in keeping in check of Ang-(1-7), angiotensin I, angiotensin II and renin hormone which played a critical role in expression of high blood pressure in pregnancy but also improved blood circulation into the cervical region to provide necessary nutrients and oxygen for the fetus to growth normally.

Additionally, yoga lessons also brought back the rest with awareness of presence, while letting them go or solved them in a positive way.

Moreover, yoga breathing, meditation in reduced stress also normalized the heart rate which has a strong implication in improved blood pressure and enhanced daily energy for a happy pregnancy outcome.

Interestingly, the study to examine the effect of stretching exercise in autonomic cardiac response, and the development of preeclampsia, conducted by the school of nursing at the University of North Carolina at Chapel Hill of total of 124 women randomized to either stretching (n=60) or walking (n=64), after taking into other co founders, found that yoga stretching may be used as a physiologic framework for possible beneficial effects in enhancing autonomic responses on reducing risks for preeclampsia as fewer cases of high blood pressure were observed in women participated in the yoga class in compared to control.

Promisingly, in a randomized clinical trial of the effects of the two types of physical exercises was conducted between November 2001 and July 2006 in Washtenaw County, Michigan with participants assigned to either the walking group (n = 41) or the stretching group (n = 38). walkers exercised an average of 36 (SD, 6) minutes at 18 weeks gestation, 34 (SD, 7) minutes at 28 weeks gestation, and 31 (SD, 12) minutes at the last week of the intervention, within target heart rate ranges 35% (SD, 32%) at 18 weeks gestation, 22% (SD, 25%) at 28 weeks gestation, and 17% (SD, 25%) at the last week of the intervention, researchers showed that at 20 weeks gestation and 4,848 (SE, 452) steps at 34 weeks gestation (p 0.05), the prevalence of preeclampsia risk of yoga group with stretched exercise was 2.6% in compared to 14.6% among the walkers.

However, observation after taking into account of other con founders and including means of all gestation periods, the incidence of gestational hypertension was 22 % for the walkers and 40% for the stretchers with no significant differences in birth outcomes of both groups.

The decreased incidence of preeclampsia in the yoga group was found to associate with increased antioxidant activity in reduced risk inflammatory expression in elevated risk high blood pressure caused by oxidative stress induced bylipid hydroperoxide production.

With all the information collected, Dr. Yeo S, the led researchers said " Regular stretching exercises may promote endogenous antioxidants among women at risk for preeclampsia."

The findings suggested that yoga intervention as an integrated form of stretched exercise may have a positive and profound effect in reduced onset of preeclampsia, particularly in women in group of high risk pregnancy.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA: WOMEN HEALTH and WEIGHT LOSS

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) [Effects of prenatal yoga: a systematic review of randomized controlled trials].[Article in Japanese] by Kawanishi Y1, Hanley SJ, Tabata K, Nakagi Y, Ito T, Yoshioka E, Yoshida T, Saijo Y.(PubMed)
(2) Prenatal Stretching Exercise and Autonomic Responses: Preliminary Data and a Model for Reducing Preeclampsia by SeonAe Yeo, RNC, PhD, FAAN1(PubMed)
(3) A comparison of walking versus stretching exercises to reduce the incidence of preeclampsia: a randomized clinical trial by Yeo S1, Davidge S, Ronis DL, Antonakos CL, Hayashi R, O'Leary S.(PubMed)

Wednesday 3 January 2018

Food Therapy: Eggplant In Reduced Risk of Acute Inflammation and Treatment of Chronic Inflammatory Diseases

Eggplant may be used as a therapeutic and positive anti inflammatory functional food without alernating the immune activity in the acute phase of infection, some scientists opinionated.

Eggplant with deeply purple colcor, is a species of S. melongena, belongs to the family Solanaceae cultivated in southern and eastern Asia since prehistory, and native to India.

Inflammation is a natural expression by immune system in induction of while blood cells for protection our body against infection caused by foreign invasion.

In the differentiation of water extract of Solanum melongena L. (Solanaceae) effect in induction of antioxidant, analgesic, hypolipidemic and antiallergic activity in mice induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH(2) (tc-NH(2)) into the hindpaw scientists found that oral administration of the extract at doses of 5, 10, and 100 mg/kg displayed a strong effect in inhibition of both paw edema and vascular permeability.

Further analysis also showed that the highest dose injection of 10 mg/kg expressed a greatest activity in compared to the others in significantly inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity in stimulated immune function activated pro inflammatory cytokines and tumor necrosis factor (TNF)-alpha expression to precipitate inflammation in response to the acute phase of infection.

After taking into account of other confounders, Dr. Umamageswari MS suggested that water extract of the S. melongena (SMWE) inhibits PAR2 agonist-induced mouse paw edema, through its anti inflammatory expression.

According to the investigated the inflammatory activities of aqueous extract of leaves of Solanum melongena Linn in arrageenan induced paw oedema, in compared to standard medicne aspirin, oral application of Solanum melongena L. in different doses of 100mg/kg, 200mg/kg, 400mg/kg at 1(st) h, 3(rd) h, and 5(th) after injection revealed a significant effect in reduced inflammation linearly induced by carrageenan toxicity in dose dependent manner.

Additional differentiation, also suggested that the doses of 200mg/kg and 400 mg/kg of aqueous extract of S. melongena L showed the percentage of inhibition of 42.62% which is less than the standard drug aspirin which showed 64.5% inhibition.

In free radical perspective, the investigation of 4 our new lignanamides, melongenamides A-D (1-4), together with six known ones (5-10) isolated from the roots of Solanum melongena L. also demonstrated a significant activity in inhibitions of inflammatory effect caused by free radical species nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages through their antioxidant effect.

Interestingly, the study also found out that not all compound extracted from the roots expressed the same levels of antioxidant properties in reduced inflammatory induced by ROS. In compared to other compounds, compound 1 exerted antioxidant effect without inhibited free radical nitric oxide production.

The findings suggested that eggplant may be used as function food in reduced risk of inflammation in acute infection and as a adjunct therapy in combination with standard treatment of chronic inflammatory diseases.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Sources
(1) The aqueous extract of Solanum melongena inhibits PAR2 agonist-induced inflammation by Han SW1, Tae J, Kim JA, Kim DK, Seo GS, Yun KJ, Choi SC, Kim TH, Nah YH, Lee YM.(PubMed)
(2) Evaluation of anti-inflammatory activity of aqueous extract of leaves of solanum melongena linn. In experimental animals by Umamageswari MS1, Maniyar YA2.(PubMed)
(3) Anti-inflammatory lignanamides from the roots of Solanum melongena L by Sun J1, Gu YF1, Su XQ1, Li MM1, Huo HX1, Zhang J1, Zeng KW2, Zhang Q3, Zhao YF3, Li J4, Tu PF5.(PubMed)

Food Therapy: Lentils(Pulses) in Ameliorated Risk of Cardiovascular Disease

Kyle J. Norton

Lentils may have a substantial and positive effect in reduced risk of cardiovascular disease.

Lentil, a type of pulse of tiny legume that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens the Fabaceaefamily, native to Middle East.

Cardiovascular disease (CVD) is a group of disorders caused by heart dysfunction and abnormal blood vessels.

According to statistic from World Health Organization, approximately,17.7 million people died from CVDs in 2015, representing 31% of all deaths.

The evaluation of lectin activity in CVD reduction was found to facilitate various mechanisms through numbers of expression.

According to a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of dietary pulse (beans, chickpeas, lentils and peas) intake on established therapeutic lipid targets for cardiovascular risk reduction, by reviewing literature published through Feb. 5, 2014, included RCTs of at least 3 weeks' duration that compared a diet emphasizing dietary pulse intake with an isocaloric diet, 26 studies met the criteria and guideline showed that a median dose of 130 g/d (about 1 serving daily) decreased significantly LDL cholelsesterol levels in compared to the control diets, without affecting the apolipoprotein B and non-HDL cholesterol levels.

Abnormal high levels of LDL cholelsesterol level is considered as one of major risk factor marker in the development of cardiovascular disease.

Further evaluation of the effect of dietary pulse fiber's low density lipoprotein implication of risk of CVD, indicated that antioxidant compound of bioactive polyphenolics inhibits the reactive oxygen species in induction oxidative stress in stimulated cholesterol accumulated in the large blood vessels in increased risk of heart disease through lipid per-oxidation.

Interestingly, the testing of low-GLoad foods effect in metabolic syndrome occurrence with 131 male Nile rats aged 3 weeks to 15 months randomly assigned to 15 dietary exposures of varied Glycemic Index indicated that lentil diets with low GLoads (102, 202) displayed a significant effect in reduced onset and treatment of metabolic syndrome in compared to other food with higher glycemic index.

More specifically, the benefit from lentils in reduced risk of metabolic syndrome exceeded dietary factors of combination of macronutrient composition + total fiber or dietary caloric density in the legume.

Additionally, the experiment also found that lentil diet even reverse the progression of metabolic syndrome in the tested Nile rats.

Metabolic syndrome is a set of conditions of increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels which are considered as risk factors of cardiovascular disease.

Dr. Havemeier S, the lead author in the differentiation of Dietary guidance for pulses: the challenge and opportunity to be part of both the vegetable and protein food groups, said, "The last two revisions of the Dietary Guidelines saw the transformation from the MyPyramid "meat and beans group" to the MyPlate "protein foods group," a nutrient name rather than a food source". and "The 2015 Dietary Guidelines also came with a new area: sustainable diets. Encouraging the consumption of sustainable food sources, like pulses, is imperative to ensuring a secure, healthy food supply for the U.S. population over time and for future generations".

Moreover, the study to explore the association of legume intake (beans, chickpeas, lentils and so on), as part of a low-glycemic index diet, with the risk of cardiovascular events in the Iranian middle- and old-aged people contacted every 2 years for possible occurrence of CVD events in 7 years of follow-up, after considering other con founders showed that in compared to intake of legumes in different tertiles, risk of CVD was lower by 34% in tested subject of old-aged people, according to the returned food frequency questionnaire.

However, frequency of consuming legumes exerted less significant effect in CVD events in the middle-aged people.

The findings suggested that intake of lentils frequently may have a potential effect in reduced risk of cardiovascular disease.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Dietary guidance for pulses: the challenge and opportunity to be part of both the vegetable and protein food groups by Havemeier S1, Erickson J1, Slavin J1.(PubMed)
(2) Intake of legumes and the risk of cardiovascular disease: frailty modeling of a prospective cohort study in the Iranian middle-aged and older population by Nouri F1,2, Sarrafzadegan N1, Mohammadifard N3, Sadeghi M4, Mansourian M2.(PubMed)
(3) Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized controlled trials by Ha V, Sievenpiper JL, de Souza RJ, Jayalath VH, Mirrahimi A, Agarwal A, Chiavaroli L, Mejia SB, Sacks FM, Di Buono M, Bernstein AM, Leiter LA, Kris-Etherton PM, Vuksan V, Bazinet RP, Josse RG, Beyene J, Kendall CW, Jenkins DJ.(PubMed)
(4) Low glycemic load diets protect against metabolic syndrome and Type 2 diabetes mellitus in the male Nile rat by Bolsinger J1, Landstrom M2, Pronczuk A3, Auerbach A4, Hayes KC5.(PubMed)

Tuesday 2 January 2018

Alternative Therapy: Yoga, An Integrated Form of Exercise in Treatment of Behavioral Addiction

Kyle J. Norton

Epidemiological studies strongly suggested that yoga as an integrated form of exercise may be used for treatment of behavioral addiction.

Yoga, the ancient practical technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

According to the joint study lead by the University of Florida, yoga may be considered as an adjunct treatment in behavioral addiction through induce "dopamine homeostasis", or in simpler terms "normalcy".

Prevention of addictive diseases is a complex and systematic strategies including training of social skills, decision in-making skills, family intervention, etc. particularly, in making the treatment more effective.

Combination of physical exercise and yoga may be useful components of comprehensive programs, especially in treatment of patients in substance dependent patients and pathological gambles.

Yoga and other forms of treatment may regulate the resting state functional connectivity (rsfMRI), a method of functional brain imaging, used to evaluate regional interactions and restore this impaired cross talk between various brain regions (e.g. Nucleus accumbens, cingulate gyrus, hippocampus etc.)

Truly, physical exercise, a planned, organized, and repeated body movement and yoga practice not only promoted physical fitness but also alleviated the stress and anxiety in induction of impulsive behavior, thus relieving craving behavior, suppressing abstinence symptoms, through ameliorating hormone production in response to stress and activated implusive behavior, such as hormone cortisol, dopamine, ghrelin,....

Moreover, intensities of exercise study showed a two- to three fold longer time to the next cigarette, reduced substantially cravings withdrawal symptoms and decreased heart rate reserve (HRR) (lasting 30-40 minutes) from 60-85% to as low as 24% HRR (lasting 15 minutes).

Dr. Taylor AH, the lead author in the study of "The acute effects of exercise on cigarette cravings, withdrawal symptoms, affect and smoking behaviour: a systematic review", said, "withdrawal symptoms and negative affect decreased rapidly during exercise and remained reduced for up to 50 minutes after exercise. Effect sizes for seven studies that assessed "strength of desire to smoke" showed a mean reduction, 10 minutes after exercise, of 1.1".

Some researchers also suggested that yoga intervention directly and indirectly drive the attention and energy to the root of suffering by restoring the balances of the mind and body, bringing back the presence and dealing how to control impulsive behaviors in positive way through breathing and body control.

Indeed, in compared to yoga intervention, competitive professional sport rather increased the number of risk factors for substance-related problems.

More interestingly, in the study of 17 clients from the Problem Gambling Institute of Ontario at the Centre for Addiction and Mental Health (88% male) to evaluate the feasibility of teaching problem gamblers about mindfulness meditation as part of regular treatment for problem gambling by 8-week mindfulness group program, researchers found that in the comparison of the first group session and after the final group session, yoga mindfulness increase the Mindfulness Attention Awareness Scale (MAAS) scores from a pre-test score of 3.65 (SD = 1.01) to a post-test score of 4.40 (SD = 0.78) and

participants also highlighted a number of improvements being more in control, relaxed and able to stay in the now.

In fact, yoga mindfulness participated demonstrated a high levels of positive instinctive or intuitive feeling with improvement of the ability to control emotion and acted, according to the values while experiencing negative emotions, by adapting to the change of environment.

Additionally, yoga attendees also expressed to gain a management skill in controlled poor emotion regulation which may lead to impulse behavior.

Participants with difficulty in appropriate management of emotions were found to associate with a variety of psychiatric illnesses, including depression and anxiety

Further analysis of yoga mindfulness effectiveness, researchers opinionated, "the suitability of mindfulness as an intervention as part of a problem gambling treatment service. However, the study did not evaluate whether mindfulness improved the clients’ ability to resist relapse".

Taking altogether, yoga may be considered as a secondary and integrated form of treatment used combined with standard therapy in treatment of behavioral addiction.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Addiction Treatment in America: After Money or Aftercare? by Miller D1, Miller M1, Blum K2, Badgaiyan RD3, Febo M4.(PubMed)
(2) [Physical exercise and yoga in prevention and treatment of addictive diseases].[Article in Czech] by Nespor K1.(PubMed)
(3) Mindfulness and problem gambling treatment by Peter Chen, Farah Jindani, Jason Perry, Nigel L Turner(Springker link)
(4) Mindfulness-Based Approaches to Impulsive Behaviors Kelcey J. Stratton, M.A.(The New School Psychology BulletinVolume 4, No. 2, 2006)
(5) The acute effects of exercise on cigarette cravings, withdrawal symptoms, affect and smoking behaviour: a systematic review by Taylor AH1, Ussher MH, Faulkner G.(PubMed)

Food Therapy: The Hetapoprotective Activities of Eggplant and its Bioactive Total Phenolics and Flavonoids

Eggplant, bioactive phytochemicals were found to process hetapoprotective activity against formation of liver diseases, some scientists suggested.

Eggplant with deeply purple color, is a species of S. melongena, belongs to the family Solanaceae, native to India.

Liver diseases are groups of liver disorders, including cirrhosis, or scarring of the liver. inflammation (hepatitis) from infectious (hepatitis B, hepatitis C) or non-infectious causes (chemical or autoimmune hepatitis) tumors and liver cancer.

According to statistic, among population of aged 45–64 years, the death rates of chronic liver disease and cirrhosis in the United States increased by 31% (from 20.1 per 100,000 to 26.4) from 2000 to 2015.

Eggplant, bioactive total phenolic and flavonoid content in reduced risk and treatment of liver diseases were found to associate to numbers of implication through various mechanisms.

According to the evaluation of 25 male Wistar rats randomly divided into five groups, and adapted for 7 days before the experimental study, including negative and positive groups fed with aquadest, Group III−V given Solanum melongena fruit infusion containing 1.125 grams, 2.25 grams and 4.5 grams orally for 9 days, respectively, suggested that at day 11 after the 9th day injection of 8 mL/kgBW of 10% CCl4 in paraffin carried out to all rats, except for the negative group,

treatment of Solanum melongena fruit infusion groups display a significant improvement of reduced hepatocyte necrosis in compared to positive group.

Surprisingly, under the observation of Mann-Whitney test, Solanum melongena fruit infusion did not express a linear dependent to the doses injection through the comparison to the effect in negative group, group III, and group V (p<0.05), as well as insignificant difference was found between the positive group and group IV (p>0.05).

Liver examination also suggested that liver cells death were found more common in the positive group of 37.26% in compared to negative group with the fewest necrotic hepatocyte of 1.27%.

In reactive oxygen species perspective, application of CCl4 stimulated by cytochrome p450 with function involved toxic substances metabolism to initiate forming of free radicals trichloromethyl radical (CCl3 -) in binding with lipid to induce lipid peroxidation in facilitated liver tissue damage.

Moreover, in reaction with oxygen in the liver tissue, CCl4 also precipitated the production of trichloromethylperoxy radical (CCl3 O2 -) to cause necrotic hepatocyte in the periportal space of the liver.

Additional analysis also discovered that Solanum melongena fruit infusion demonstrated a significant antioxidant activities in decreased and prevented the formation of free radical oxidation, through the expression of flavonoids in inhibition of CCl3 in reaction with oxygen to induce covalent bonds with fat.

After taking into account of other con founders, Dr. Nabhan Komara. the lead author said, "Solanum melongena fruit infusion has hepatoprotective effects against acute hepatitis in rat model histopathologically".

Interestingly, in the evaluated total phenolic and flavonoid antioxidant activity and hepatoprotection against cytotoxicity of tert-butyl hydroperoxide (t-BuOOH) in human hepatoma cell lines HepG2, scientists showed that pretreatment of HepG2 cells with 50 and 100 μg/mL of chemical compounds significantly increased expressions of t-BuOOH-exposed HepG2 cells to induced tumor cell apoptosis by 14.49 ± 1.14% to 44.95 ± 2.72%. without harming to the nearby healthy cells.

According to the experiment, application of total phenolic and flavonoid not only increased antioxidant activities in protect liver cell against damage caused by over facilitation of tert-butyl hydroperoxide (t-BuOOH) in induction of ROS but also exhibited free radical cytotoxic effect to initiated cell death in HepG2 cell lines.

Further more, the hepatoprotective activities on t-BuOOH-induced toxicity was attributed to total phenolic/flavonoid content at both 50 and 100 lg/mL and antioxidant activities at both 50 lg/mL and 100 lg/mL observed by two most common radical scavenging assays, namely, 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.

Tert-Butyl hydroperoxide (tBuOOH) is an organic compound used widely as a peroxide in a variety of oxidation processes.

Taken together, there is no doubt that eggplant and its btoactive total phenolic and flavonoid may have therapeutic effect in protected liver against infectious and non infectious agents and irregular growth causes of benign and malignant cancers through over expression of antioxidant activities in protected healthy cells and induction of ROS cytotoxicity to tumor cells.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Sources
(1) Antioxidant and hepatoprotective activities of five eggplant varieties by Akanitapichat P1, Phraibung K, Nuchklang K, Prompitakkul S.(PubMed)
(2) Hepatoprotective Effect of Solanum melongena/Eggplant against Acute Hepatitis by Nabhan Komara, Herri S. Sastramihardja, Afiati Afiati(Althea medical Journal)

Monday 1 January 2018

Food Therapy: Green Tea Bioactive Polyphenols in Inhibited β-amyloid Accumulation in Neuro Degeneration

Kyle J. Norton

Green tea may have a potential and therapeutic effect in protected neurons of the brain against deposit of β-amyloid in initiated neuro degenerative diseases, some researchers postulated.

β-amyloid are plaques found in the brains of Alzheimer patients derived from the amyloid precursor protein (APP) with function in binding to other proteins on the surface of cells.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

The differentiation of green tea activities in risk of plagues deposit in certain parts of the brain to induce development and neuropathogenesis of dementia was found to associate to numbers of implication through several mechanisms.

In the study to clarify the effect of green tea Epigallocatechin-3-gallate (EGCG) in inhibited activities of nitrosative as well as oxidative stress in induction of Abeta-cause of damages in neurons and glial cells surround neurons, researchers at the Daegu Haany University found that application of the phytophenols exerts a significant interference in ameliorated the elevation of Abeta-induced by oxidative and/or nitrosative to facilitate cell death through its antioxidant and anti-inflammatory properties.

Further analysis found that green tea bioactive compound reduced activities of Abeta injection in induction of nitrosative stress on BV2 cells caused by increased expression of inducible nitric oxide synthase (iNOS) in production of nitric oxide (NO) and peroxynitrite, in elevated cytotoxicity to precipitate apoptosis, though inhibited reactive nitrogen species act together with reactive oxygen species to establish chain reaction in damage to BV2 cells.

In cellular metabolism, pretreatment of green tea EGCG also demonstrated a strong antioxidant properties in induction of neuroprotective effect by fortified cellular GSH over expression through elevated mRNA expression of galuatehe eva-glutamylcysteine ligase (GCL) with functions involved production of cellular antioxidant glutathione (GSH).

Additionally, the examine the inhibitory effect of l-theanine, a component of green tea (Camellia sinensis), on Abeta(1-42) with oral treatment of l-theanine (2 and 4 mg/kg) for 5 weeks in the drinking water of mice, followed by injection of Abeta(1-42) (2 microg/mouse, icv), suggested that green tea bioactive l-theanine component exerts a significantly attenuated Abeta(1-42) levels induced memory impairment by precipitated neuronal cell death in the cortex and hippocampus of the brain.

Moreover, l-theanine also inhibited Abeta(1-42)-induced extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase and activity of nuclear factor kappaB (NF-kappaB) in initiated cellular apoptosis caused by reactive nitrogen species hyper activities.

Further more, the bioactive l-theanine also significantly reduced oxidative protein and lipid damage and elevated glutathione levels in the brain, thus reducing macromolecular oxidative damage in improved memory.

Additional study of green tea effect in attenuated accumulation of β-amyloid (Aβ) peptide plaques is a major pathogenic event in Alzheimer's disease (AD) opinionated that in the wild type amyloid precursor protein (APP) transfected (N2a/APP695) cell line, Epigallocatechin gallate (EGCG), a highly active catechin found in green tea, significantly reinforce the activity of nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ), a regulator of adipocyte differentiation by promoting its mRNA and protein expressions in N2a/APP695 cells, thus attenuated Aβ generation in N2a/APP695 cells in induction of Alzheimer's disease (AD).

Intriguingly, the efficacy of Epigallocatechin gallate (EGCG) in inhibited β-amyloid (Aβ) peptide plaques accumulation was found to be attributed by its antioxidant activity in decreased the expression of pro-apoptotic proteins (Bax, caspase-3) activated by Aβ insults, the activity of the anti-inflammatory agent NF-κB triggered by β-amyloid (Aβ) peptide and inhibited the oxidative stress by decreasing the levels of ROS and MDA and increased the expression of antioxidant enzyme MnSOD.

These results suggest that EGCG may have preventive and/or therapeutic potential to prevent accumulated β-amyloid in initiated neuro degenerative patients by increasing cellular antioxidant defense capacity in inhibited Abeta-mediated oxidative and/or nitrosative stress to induce cell death. Intake of green tea extract should be taken with great care, as overdoses have been reported to cause liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(*) Neuroprotective effect of epigallocatechin-3-gallate against beta-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity by Kim CY1, Lee C, Park GH, Jang JH.(PubMed)
(*) l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways by Kim TI1, Lee YK, Park SG, Choi IS, Ban JO, Park HK, Nam SY, Yun YW, Han SB, Oh KW, Hong JT.(PubMed)
(*) Epigallocatechin Gallate Attenuates β-Amyloid Generation and Oxidative Stress Involvement of PPARγ in N2a/APP695 Cells by Zhang ZX1, Li YB2, Zhao RP3.(PubMed)
(1) Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice by Rezai-Zadeh K1, Arendash GW, Hou H, Fernandez F, Jensen M, Runfeldt M, Shytle RD, Tan J.(PubMed)

Herbal Therapy: Green Tea and Its' Polyphenols (GTPs) in Attenuated Risk, Progression and Treatment of Skin Cancer

Green tea may have a strong and positive effect in reduced risk and treatment of skin cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Skin cancer is medical condition characterized by irregular cell growth in the issues of skin. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, approximately, 87,110 new cases of invasive melanoma are diagnosed in the U.S every years

The evaluation of green tea effect in overexposure to environmental solar ultraviolet (UV) radiation (290-400 nm) which has been found to increase risk of the development of melanoma and non-melanoma skin cancers in mice model showed that oral administration of green tea pylophenols (GTPs) in drinking water or the topical application of EGCG prevents UVB-induced skin tumor development in tested subjects.

Particularly, (-)-Epigallocatechin-3-gallate (EGCG), the major and most photoprotective polyphenolic component of green tea also exhibited a protective activity against UV in induction of skin cancer, through induction of immunoregulatory cytokine interleukin (IL) 12 in differentiation of naive T cells into Th1 cells and acted as T cell-stimulating factor in stimulate the growth and function of T cells.

Moreover, interleukin (IL) 12 also demonstrated a significant effect as an antagonist against immunosuppression induced by solar/ultraviolet (UV) radiation by restoring immune responses and also stimulating DNA repair.

Further analysis also indicated that green tea (-)-Epigallocatechin-3-gallate (EGCG) also inhibited UV in induction of skin tumors; angiogenetic effect in stimulated production of new blood vessels to

provide nutrients and oxygen for cancer cells proliferation and survivals and initiated cytotoxic T lymphocyte cells in induced cancer and infectious and damage cells apoptosis.

Interestingly, additional study of green tea polyphenols (GTPs) in prevention of UVB irradiated (80 mJ/cm(2)) 3 times each week for 24 wk in induced skin cancer in mice divided in to group consumed water and group fed with water containing 2 g/L GTPs, showed that group treated with GTPs displayed a significant reduced UVB-induced tumor incidence by 35%, tumor multiplicity by 63%, and tumor growth by 55% in compared to non treatment group.

Group treated with GTPs+UVB also demonstrated a reduced expression of the matrix metalloproteinases (MMP)-2 and MMP-9, which are activator associated with progression from benign to advanced cancer and enhanced expression of specific endogenous tissue inhibitors of metalloproteinases (TIMPs), tissues inhibitor of MMP in skin tumors in compared to mice treated with UVB alone.

Further more, GTPs+UVB group also reduced expressions of CD31 and vascular endothelial growth factor, in activated development of new blood vessel to nourish skin tumor cells proliferation and site expansion and inhibited expression of proliferating cell nuclear antigen, a key factor in DNA replication and cell cycle regulation in skin cancer in compared to UVB group.

More importantly, mice treated with GTPs+UVB group also showed more cytotoxic CD8(+) T cells in the tumors in compared to UVB group by exhibited greater activation of caspase-3 epression in induced apoptosis of the tumor cells.

The information findings suggested a potential and therapeutic effect of green tea and its bioactive polyphenols (GTPs) in attenuated risk, progression and treatment of melanoma and non-melanoma skin cancers.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green Tea Prevents Skin Cancer by Two Mechanisms by Navid Bouzari, Yvonne Romagosa, Robert S. Kirsner(PubMed)
(2) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair by Katiyar S1, Elmets CA, Katiyar SK.(PubMed)
(3) Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors by Mantena SK1, Meeran SM, Elmets CA, Katiyar SK.(PubMed)

Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Pages

Questions or Enquiries?

Sunday 7 January 2018

Food Therapy: Eggplant in Ameliorated Risk and Treatment of Liver Cancer

Saturday 6 January 2018

Herbal Therapy: Green Tea and Lower Dose of Its Bioactive Polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in Reduced Cardiac Fibrosis in Induction of Heart Failure

Herbal Therapy: Green tea and Its Bioactive Polyphenols in Ameliorated Risk Human Immunodeficiency Virus -1 (HIV-1) Infection

Friday 5 January 2018

Alternative Therapy: Yoga Intervention in Reduced Incidence of Intrauterine Growth Retardation(IUGR)

Thursday 4 January 2018

Herbal Therapy: Green Tea and Its Bioactive Polyphenols Epigallocatechin-3 Gallate (EGCG) in Attenuated Risk and Treatment of Hepatitis B

Herbal Therapy: Green Tea and Its Bioactive Polyphenols in Reduced Risk, Progression and Treatment of Oral Cancer

Alternative Therapy: Maternal Yoga in Reduced Risk of Preeclampsia

Wednesday 3 January 2018

Food Therapy: Eggplant In Reduced Risk of Acute Inflammation and Treatment of Chronic Inflammatory Diseases

Food Therapy: Lentils(Pulses) in Ameliorated Risk of Cardiovascular Disease

Tuesday 2 January 2018

Alternative Therapy: Yoga, An Integrated Form of Exercise in Treatment of Behavioral Addiction

Food Therapy: The Hetapoprotective Activities of Eggplant and its Bioactive Total Phenolics and Flavonoids

Monday 1 January 2018

Food Therapy: Green Tea Bioactive Polyphenols in Inhibited β-amyloid Accumulation in Neuro Degeneration

Herbal Therapy: Green Tea and Its' Polyphenols (GTPs) in Attenuated Risk, Progression and Treatment of Skin Cancer