Herbal Dandelion (Taraxacum officinale), a Natural Anti-Colitis Remedy

By Kyle J. Norton

Colitis is medical a condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.

Depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis, particularly in those associated with inflammatory bowel disease (IBD), such as ulcerative colitis (UC).

* Inflammatory bowel disease (IBD) is the inflammation of chronic inflammation of digestive tract associated with symptoms of severe diarrhea, abdominal pain, fatigue, and weight loss.

* Microscopic colitis is a disease involved in the inflammation of the colon or large intestine, associated with symptoms of watery diarrhea and cramping. Microscopic colitis is much less severe than other types of inflammatory bowel disease.

* Ischemic colitis is an inflammation of the large intestine caused by the injury-induced inadequate blood supply to the colon, leading to pain on the left side of the abdomen.

* Segmental colitis associated with diverticula is an inflammation that affects colonic luminal mucosa in segments due to diverticulosis, causing symptoms of bloody stools, sometimes accompanied by abdominal pain, cramping discomfort, or diarrhea.

* Radiation colitis is an inflammation of the large intestines in patients with radiation therapy, leading to symptoms of diarrhea, nausea, vomiting, and stomach cramps.

* Diversion colitis is an inflammation of the large intestines as a complication of ileostomy or colostomy. Most cases of diversion colitis often occur within the year following the surgery.

* Eosinophilic colitis is a rare disease associated with a type of white blood cell, due to injury and inflammation to the large intestine.

* Behcet's colitis is chronic immune-mediated, inflammatory disorder that only affect the intestines but also the joints, skin, eyes, and biliary tracts

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of inflammatory diseases, scientists examined the taraxacum officinale extract (TOE) effects on colitis.

According to the results of DSS-induced colitis treated with different concentrations of TOE for 8 days, TOE showed significant activity in the attenuation of the clinical symptoms, by lowering the inflammatory scoring and inhibiting the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

In other words, the efficacy of TOE in the treatment of colitis was associated with the activity in the induction of fatty acid degradation through the increased of the expression levels of Adh5, Aldh3a2, and Acox in breaking down fat and decreased the levels of CCL20, CCR6, and CXCL1 in cytokine-receptor signaling.

Additionally, TEO also enhanced the levels of S24-7 and adlercreutzia but decreased the number of anerostipes, Enterococcus, Enterobacteriaceae and peptostreptococcaceae to promote microbial imbalance or maladaptation

Based on the findings, researchers said, "TOE ameliorated DSS-induced colitis by regulating fatty acid degradation and microbial dysbiosis".

Taken altogether, dandelion may be considered a remedy for the protection against colitis, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxacum officinale extract ameliorates dextran sodium sulphate-induced colitisby regulating fatty acid degradation and microbial dysbiosis by Chen W1, Fan H1, Liang R1, Zhang R1, Zhang J1, Zhu J. (PubMed)

Healthy Fruits and Vegetables Intake Daily May be Potent Against the Risk of Hypertension

By Kyle J. Norton

Hypertension is a condition characterized by persistent high blood pressure.

In the US,  approximately, one-third of the adults have hypertension, affecting over 77 million people in the country. 

Additionally, among adults age 20 and older in the United States, in the non-Hispanic whites community, 33.4 percent of men and 30.7 percent of women are infected by the syndrome.

Hypertension is a slowly developed condition. Unless the syndrome has caused damage to the blood vessel, otherwise symptoms cannot be detected.

The cause of hypertension is a result of the hardening and thickening of the arteries (atherosclerosis), due to the slow progression of plaques accumulated on the wall of the arteries.

According to the American Heart Association (AHA) patients with blood pressure that is higher than 130 over 80 millimeters of mercury (mmHg) are considered to have hypertension.

Untreated hypertension may induce complications of heart attack, stroke, and other health conditions.

Some researchers suggested that unhealthy dietary and lifestyle factors highlight the importance of environmental factors in the induction of hypertension onset and progression.

However, according to a special issue of the Journal of Human Hypertension primarily, in the concerns of dietary, lifestyle, and alternative factors in the risk of hypertension and blood pressure control, focusing on dietary and lifestyle factors, complementary and alternative approaches may have a strong impact in prevention and treatment of hypertension.

On finding a potential compound for the treatment of high blood pressure, researchers examined the prospective association between baseline intake of fruits and vegetables and the risk of hypertension in a large cohort of middle-aged and older women.

Participants included in the study are 28,082 US female health professionals aged ≥39 years, free of cardiovascular disease, cancer, and hypertension at baseline. 

According to the dietary information collected using a validated FFQ, 13,633 women who developed incident hypertension occurred during 12.9 years of follow-up.

However, after adjustment for potential confounders, including age, race, and total energy intake, the hazard ratio and 95% CI of hypertension was 0.97  and 0.86 comparing women who consumed 2-<4, 4-<6, 6-<8, and ≥8 servings/day of total fruits and vegetables with those consuming <2 servings/day, even after additionally adjusting for lifestyle factors.

Furthermore, in the analysis of individual fruits and vegetables separately, researchers found that higher intake of all fruits but not all vegetables remained significantly associated with reduced risk of hypertension after adjustment for lifestyle and dietary factors. 

Based on the findings, researchers said, "Higher intake of fruits and vegetables, as part of a healthy dietary pattern, may only contribute a modest beneficial effect to hypertension prevention, possibly through improvement in body weight regulation".

Taken altogether, increased intake of fruits and certain vegetables may be considered functional foods for the prevention of hypertension, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fruit and vegetable intake and the risk of hypertension in middle-aged and older women by Lu Wang, MD, PhD, JoAnn E. Manson, MD, DrPH, J. Michael Gaziano, MD, MPH, Julie E. Buring, ScD, and Howard D. Sesso, ScD, MPH. (PubMed)
(2) A Tasty Fruit That is Similar to Those of Clonidine, Guanfacine and Metabolite of Methyldopa for Treatment of Hypertension, With No Side Effects by Kyle J. Norton

Phytochemical Tocopherols Suppress Esophageal Cancer Cells in Vitro

By Kyle J. Norton

An esophagus or gullet, an organ in vertebrates, is the tube that leads foods from the pharynx to the stomach.

Esophageal cancer is not very uncommonly caused by malignant of the esophagus due to abnormal cell growth as a result of the DNA alternation of the cells that line the upper part of the esophagus or glandular cells presented at the lower part of the esophagus that connected with the stomach.

Esophageal cancer tends to spread if left untreated and starts from the lining of the esophagus, then later penetrates the wall of the esophagus and spread to the lymph node around the bottom of the esophagus, stomach, and the chest, then to the distant parts of the body.

The most common types of esophageal cancer are
* Squamous cancer
In the upper part of the esophagus caused by the squamous cell of which has become malignant caused by mutation of DNA in cells replication of division uncontrollably.

* Adenocarcinomas
In the lower part of the esophagus caused by the glandular cells of which have become malignant caused by mutation of DNA in cells replication of division uncontrollably.

According to the statistics provided by the American Cancer Society, in 2019, approximately 17,650 new esophageal cancer cases will be diagnosed, including 13,750 in men and 3,900 in women.

Also, in 2019, esophageal cancer will also cause the death of 16,080 Americans, including 13,020 in men and 3,060 in women.

The 5-year survival rate of people diagnosed in the local stage of esophageal cancer is 45%, much less than other cancer, including 100% of breast cancer.

The most common areas of metastasis of esophageal cancer are the lymph node around the bottom of the esophagus, stomach, and chest.

Believe it or not, esophageal cancer is more common among men than among women. The lifetime risk of esophageal cancer in the US is 1 in 132 in men and about 1 in 455 in women.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the preventive activity of α-Tocopherol against esophageal squamous cell carcinoma (ESCC).

According to the analysis,
* Early-stage supplementation with α-Tocopherol significantly prevented esophageal carcinogenesis induced by N-nitrosomethylbenzylamine (NMBA) in the ESCC rat model.

* In the Het-1A cell model, α-Tocopherol markedly suppressed cell proliferation, promoted cell cycle G2-phase arrest, and increased apoptosis by targeting cellular survival and growth.

* Furthermore, α-Tocopherol increased the expression of PPARγ in regulating cellular differentiation, and its downstream tumor suppressor PTEN.

Based on the results, researchers said, " These results were closely correlated with the ineffectiveness of α-Tocopherol in the late stage of ESCC carcinogenesis. Taken together, our study suggested that α-Tocopherol may serve as a PPARγ agonist for the chemoprevention of esophageal cancer".

Taken altogether, tocopherols may be considered a supplement for reducing the risk of esophageal cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alpha-Tocopherol prevents esophageal squamous cell carcinoma by modulating PPARγ-Akt signaling pathway at the early stage of carcinogenesis by Xu M#1, Yang H#2, Zhang Q2, Lu P3, Feng Y2, Geng X2, Zhang L1, Jia X. (PubMed)

Beta-Sitosterol Reduces the Risk of Liver Injury

By Kyle J. Norton

The liver is the largest internal organ in the human body, played an essential role in filtering blood from the intestine before passing them to other parts of the body.

The organ also produced cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones and vitamins.

Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.

Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of injury may be necessary.

Most cases of liver injury can lead to abdominal pain and tenderness caused by bleeding blood in the abdomen that irritates the abdominal tissue.

The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.

According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.

The most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale, or bluish skin.

In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain and swelling, and tenderness.

Depending on the size of the wound, most cases of liver injury are healed by themselves. However, in severe cases, hospitalization may be necessary if the bleeding does not stop.

Out of many risk factors, an overdose of medicine has been found to be the number 1 factor involved in liver injury.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of liver diseases, researchers examined the hepatoprotective effects of Beta-sitosterol (Sit) and its derivatives on acute liver injury induced by lipopolysaccharide/d-galactosamine (LPS/GalN) in mice.

According to the chemical analysis,
* Among its derivatives, 2-naphthoyl Sit ester (Sit-N) (50 mg/kg) showed the strongest activities against acute liver injury.

* More precisely, Sit-N significantly decreased the serum activity of aspartate transaminase (AST) and alanine aminotransferase (ALT) associated with liver injury

* Sit-N also markedly reduced tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels involved in liver inflammation.

* Sit-N drastically improved the activities of antioxidant enzymes such as superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) and suppressed the expression of malondialdehyde (MDA), liver oxidative stress marker by increasing the expression of nuclear respiratory factor2 (Nrf2) and heme oxygenase-1 (HO-1).

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of liver injury, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Beta-sitosterol and its derivatives repress lipopolysaccharide/d-galactosamine-induced acute hepatic injury by inhibiting the oxidation and inflammation in mice by Yin Y1, Liu X2, Liu J3, Cai E1, Zhu H4, Li H3, Zhang L1, Li P3, Zhao Y. (PubMed)
(2) Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats by Mondal A1, Maity TK, Pal D, Sannigrahi S, Singh J. (PubMed)

Cruciferous Vegetables Protect the Stomach Against Stomach Cancer

By Kyle J. Norton

Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.

The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.

The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.

Stomach cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

Most patients with stomach cancer in the early stage are asymptomatic. 

However, at the later stage, patients may experience symptoms of pain and/or discomfort in the stomach area, mild ache in the upper part of the body, difficulty swallowing, feeling full or bloated after a small mealy, and vomiting blood or having blood in the stool accompanied by general symptoms shared by other types of cancer, including unintentional weight loss, loss of energy, tiredness, nausea, and vomiting and loss of appetite.

According to the statistics, most cases of gastric/stomach cancer are found in older people. The average age of people when they are diagnosed is 68. The risk of developing gastric/stomach cancer in a man lifetime is about 1 in 95.

Localized stomach cancer has a 5-year survival rate of 68%. However, If cancer has spread to surrounding tissues or organs and/or the regional lymph nodes, the 5-year survival rate is 31%.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding potential and natural foods for the prevention and treatment of cancer, researchers investigated the risk of regular cruciferous vegetable intake on stomach cancer.

The hospital-based, case-control study conducted at Roswell Park Comprehensive Cancer Center in Buffalo, NY, included 292 stomach cancer patients and 1168 cancer-free controls recruited between 1992 and 1998 as part of the Patient Epidemiology Data System (PEDS).

According to the dietary and other epidemiologic and confounding variables collected by the questionnaire, there were strong inverse associations between stomach cancer and the highest versus lowest intakes of total cruciferous vegetables with the odds ratio (OR) of 0.59.

In the comparison test assay, raw cruciferous vegetables have an OR = 0.53, compared to raw broccoli with an OR = 0.61, raw cauliflower with an OR = 0.51, and Brussels sprouts with an OR = 0.66.

Increased portions of total cruciferous vegetable intake are associated linearly to a reduced risk of stomach cancer.

After taking other factors into account, researchers wrote, "These data suggest that consuming raw cruciferous vegetables may be associated with a lower odds of stomach cancer, even after considering other dietary characteristics".

Taken altogether, dietary cruciferous vegetables may be considered functional remedies for the prevention of stomach cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous Vegetable Consumption and Stomach Cancer: A Case-Control Study by Morrison MEW1, Joseph JM2, McCann SE2, Tang L2, Almohanna HM2, Moysich KB. (PubMed)

Tocopherols Promote Cytotoxic Activity Against Cancer Cells

By Kyle J. Norton


Cytotoxicity is the process that induces cell death through toxins.

In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy the living cells.

In normal, cytotoxicity can cause the death of healthy cells

In cancers, cytotoxicity can be beneficial to humans by destroying the cancer cells and preventing them from proliferation.

For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.

However, stimulation of ROS expression to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.

Scientifically, most cases of cancer cell cytotoxicity are associated with the stimulation of protein and pathways involved in either gene suppression or cell death programming.

Chemotherapy is a type of cancer treatment that uses one or more toxic chemicals to kill cancer cells.

Chemotherapeutic cytotoxicity is the process that interferes with cell division (mitosis) through cell cycle arrest to include apoptosis.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cancer researchers examined protective effects of α- and γ-tocopherols and α- and γ-tocotrienols on the oxidative stress induced by LPS on human lung carcinoma A549 cells.

Application of α- and γ-tocopherols and α- and γ-tocotrienols showed strong suppression of the intracellular reactive oxygen formation, lipid peroxidation, and induction of inflammatory mediator cytokines, and cell death.

More precisely, the application of tocopherols incorporated into cultured cells could suppress LPS-induced oxidative stress at much lower intracellular concentration than tocotrienols compared to the much slower tocotrienols.

In other words, tocopherols demonstrated the strongest cytotoxicity against the tested cancer cells compared to that of tocotrienols.

Collectively, researchers wrote, "α-tocopherol may exhibit the highest protective capacity among the vitamin E isoforms against LPS-induced oxidative stress".

Taken altogether, tocopherols may process cytotoxicity against the onset of cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols by Nishio K1, Horie M, Akazawa Y, Shichiri M, Iwahashi H, Hagihara Y, Yoshida Y, Niki E. (PubMed)

Antioxidant Alliin Isolated From Garlic May Processes Immunomodulatory Effects

By Kyle J. Norton

The immunomodulatory effect is an action in which the immune function is modulated to the needs of the body.

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including the spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, which is the body's defense against infectious organisms and foreign invaders.

In the acute phase of infection, the immune macrophages, the first line of defense stimulate the production of a blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.

Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.

However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.

Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.

Out of many low-grade inflammatory risk factors, some researchers suggested that an unhealthy diet may be one of the major culprits involved in facilitating the onset of the diseases.

Dr. Casas R, Sacanella E, the lead scientist wrote, "Dietary patterns high in refined starches, sugar, and saturated and trans-fatty acids, poor in natural antioxidants and fiber from fruits, vegetables, and whole grains, and poor in omega-3 fatty acids may cause an activation of the innate immune system, most likely by excessive production of proinflammatory cytokines associated with a reduced production of anti-inflammatory cytokines".

In other words, if you follow the diet pattern of a high-fat diet, you are at a higher risk of low-grade inflammatory disease, compared to those who follow the diet pattern of the Mediterranean diet.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a natural ingredient with immunomodulatory activity, researchers examined the effect of the garlic derivative alliin, on mitogen-induced peripheral blood mononuclear cell (PBMC) proliferation and cytokine production in vitro.


Before being treated with garlic derivative alliin, pokeweed mitogen (PWM) injection induced cell proliferation, production of proinflammatory cytokines, including IL-1beta and TNF-alpha.

Furthermore, the pokeweed mitogen (PWM) treated group also showed reduced levels of both percentage of phagocyting cells and the number of latex particles associated with the immune functions of phagocytosis.

Administration of garlic derivative alliin not only decreased the production of proinflammatory cytokines induced by pokeweed mitogen (PWM) but also improved the levels of antioxidant enzymes.


In other words, alliin exerted an immunomodulatory effect on the peripheral blood cells in vitro.


In order to reveal more information of alliin effect on the immune system, researchers investigated whether different plant-derived components with similar anti-oxidative and anti-inflammatory function such as quercetin and alliin in traditional Asian diet consumed in an alternate style cooperatively affect health including the growth of host and the status of the gut microbiota and colonic epithelial immunity.

Compared to the traditional Asian diet significantly increased the rat body weight and reshaped the gut microbiota composition by significantly increasing the relative abundance of fecal Firmicutes and Cyanobacteria but decreased that of Bacteroidetes (P < 0.05) and increased the relative abundance of Candidatus Arthromitus, Lactococcus, Geobacillus, and Ruminococcus at the genus level that benefits the host's health, the consumption of quercetin and alliin also altered 13 genes expression involved in the KEGG pathways of complement and coagulation cascades and hematopoietic cell lineage to improve the gut immunity.

In other words, the alternate consumption of quercetin and alliin can contribute beneficial metabolic effects by optimizing gut microbiota and altering the immunologic function of colonic epithelial cells.

Taken altogether, alliin may be considered supplements for the immune-modulatory activity depending on the body needs, pending the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of a garlic derivative (alliin) on peripheral blood cell immune responses by Salman H1, Bergman M, Bessler H, Punsky I, Djaldetti M. (PubMed)
(2) The Alternate Consumption of Quercetin and Alliin in the Traditional Asian Diet Reshaped Microbiota and Altered Gene Expression of Colonic Epithelial Cells in Rats by Yu J1, Guo H1, Xie J1, Luo J1, Li Y1, Liu L1, Ou S1, Zhang G1, Peng X. (PubMed)
(3) The immune protective effect of the Mediterranean diet against chronic low-grade inflammatory diseases by Casas R, Sacanella E, Estruch R. (PubMed)