The liver is the largest internal organ in the human body, played an essential role in filtering blood from the intestine before passing them to other parts of the body.
The organ also produced cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones and vitamins.
Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.
Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of injury may be necessary.
Most cases of liver injury can lead to abdominal pain and tenderness caused by bleeding blood in the abdomen that irritates the abdominal tissue.
The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.
According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.
The most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale, or bluish skin.
In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain and swelling, and tenderness.
Depending on the size of the wound, most cases of liver injury are healed by themselves. However, in severe cases, hospitalization may be necessary if the bleeding does not stop.
Out of many risk factors, an overdose of medicine has been found to be the number 1 factor involved in liver injury.
* Among its derivatives, 2-naphthoyl Sit ester (Sit-N) (50 mg/kg) showed the strongest activities against acute liver injury.
* More precisely, Sit-N significantly decreased the serum activity of aspartate transaminase (AST) and alanine aminotransferase (ALT) associated with liver injury
* Sit-N also markedly reduced tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels involved in liver inflammation.
* Sit-N drastically improved the activities of antioxidant enzymes such as superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) and suppressed the expression of malondialdehyde (MDA), liver oxidative stress marker by increasing the expression of nuclear respiratory factor2 (Nrf2) and heme oxygenase-1 (HO-1).
In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain and swelling, and tenderness.
Depending on the size of the wound, most cases of liver injury are healed by themselves. However, in severe cases, hospitalization may be necessary if the bleeding does not stop.
Out of many risk factors, an overdose of medicine has been found to be the number 1 factor involved in liver injury.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the prevention and treatment of liver diseases, researchers examined the hepatoprotective effects of Beta-sitosterol (Sit) and its derivatives on acute liver injury induced by lipopolysaccharide/d-galactosamine (LPS/GalN) in mice.
According to the chemical analysis,On finding a potential phytochemical for the prevention and treatment of liver diseases, researchers examined the hepatoprotective effects of Beta-sitosterol (Sit) and its derivatives on acute liver injury induced by lipopolysaccharide/d-galactosamine (LPS/GalN) in mice.
* Among its derivatives, 2-naphthoyl Sit ester (Sit-N) (50 mg/kg) showed the strongest activities against acute liver injury.
* More precisely, Sit-N significantly decreased the serum activity of aspartate transaminase (AST) and alanine aminotransferase (ALT) associated with liver injury
* Sit-N also markedly reduced tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels involved in liver inflammation.
* Sit-N drastically improved the activities of antioxidant enzymes such as superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) and suppressed the expression of malondialdehyde (MDA), liver oxidative stress marker by increasing the expression of nuclear respiratory factor2 (Nrf2) and heme oxygenase-1 (HO-1).
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of liver injury, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Beta-sitosterol and its derivatives repress lipopolysaccharide/d-galactosamine-induced acute hepatic injury by inhibiting the oxidation and inflammation in mice by Yin Y1, Liu X2, Liu J3, Cai E1, Zhu H4, Li H3, Zhang L1, Li P3, Zhao Y. (PubMed)
(2) Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats by Mondal A1, Maity TK, Pal D, Sannigrahi S, Singh J. (PubMed)
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Beta-sitosterol and its derivatives repress lipopolysaccharide/d-galactosamine-induced acute hepatic injury by inhibiting the oxidation and inflammation in mice by Yin Y1, Liu X2, Liu J3, Cai E1, Zhu H4, Li H3, Zhang L1, Li P3, Zhao Y. (PubMed)
(2) Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats by Mondal A1, Maity TK, Pal D, Sannigrahi S, Singh J. (PubMed)
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